{"id":"https://openalex.org/W4210294641","doi":"https://doi.org/10.3390/s22031144","title":"Opto-Microfluidic Integration of the Bradford Protein Assay in Lithium Niobate Lab-on-a-Chip","display_name":"Opto-Microfluidic Integration of the Bradford Protein Assay in Lithium Niobate Lab-on-a-Chip","publication_year":2022,"publication_date":"2022-02-02","ids":{"openalex":"https://openalex.org/W4210294641","doi":"https://doi.org/10.3390/s22031144","pmid":"https://pubmed.ncbi.nlm.nih.gov/35161887"},"language":"en","primary_location":{"id":"doi:10.3390/s22031144","is_oa":true,"landing_page_url":"https://doi.org/10.3390/s22031144","pdf_url":"https://www.mdpi.com/1424-8220/22/3/1144/pdf?version=1644389966","source":{"id":"https://openalex.org/S101949793","display_name":"Sensors","issn_l":"1424-8220","issn":["1424-8220"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sensors","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/1424-8220/22/3/1144/pdf?version=1644389966","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5022594537","display_name":"Leonardo Zanini","orcid":"https://orcid.org/0000-0001-8256-7366"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Leonardo Zanini","raw_affiliation_strings":["Physics and Astronomy Department, University of Padova, Via Marzolo 8, 35131 Padova, Italy"],"raw_orcid":"https://orcid.org/0000-0001-8256-7366","affiliations":[{"raw_affiliation_string":"Physics and Astronomy Department, University of Padova, Via Marzolo 8, 35131 Padova, Italy","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031283439","display_name":"Annamaria Zaltron","orcid":"https://orcid.org/0000-0002-5633-809X"},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Annamaria Zaltron","raw_affiliation_strings":["Physics and Astronomy Department, University of Padova, Via Marzolo 8, 35131 Padova, Italy"],"raw_orcid":"https://orcid.org/0000-0002-5633-809X","affiliations":[{"raw_affiliation_string":"Physics and Astronomy Department, University of Padova, Via Marzolo 8, 35131 Padova, Italy","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022191297","display_name":"Enrico Turato","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Enrico Turato","raw_affiliation_strings":["Physics and Astronomy Department, University of Padova, Via Marzolo 8, 35131 Padova, Italy"],"raw_orcid":"https://orcid.org/0000-0002-6454-5988","affiliations":[{"raw_affiliation_string":"Physics and Astronomy Department, University of Padova, Via Marzolo 8, 35131 Padova, Italy","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084834021","display_name":"Riccardo Zamboni","orcid":"https://orcid.org/0000-0001-8087-7539"},"institutions":[{"id":"https://openalex.org/I22465464","display_name":"University of M\u00fcnster","ror":"https://ror.org/00pd74e08","country_code":"DE","type":"education","lineage":["https://openalex.org/I22465464"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Riccardo Zamboni","raw_affiliation_strings":["Institute of Applied Physics, University of M\u00fcnster, Corrensstrasse 2/4, 48149 Muenster, Germany"],"raw_orcid":"https://orcid.org/0000-0001-8087-7539","affiliations":[{"raw_affiliation_string":"Institute of Applied Physics, University of M\u00fcnster, Corrensstrasse 2/4, 48149 Muenster, Germany","institution_ids":["https://openalex.org/I22465464"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5024356243","display_name":"C. Sada","orcid":"https://orcid.org/0000-0002-7607-0481"},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Cinzia Sada","raw_affiliation_strings":["Physics and Astronomy Department, University of Padova, Via Marzolo 8, 35131 Padova, Italy"],"raw_orcid":"https://orcid.org/0000-0002-7607-0481","affiliations":[{"raw_affiliation_string":"Physics and Astronomy Department, University of Padova, Via Marzolo 8, 35131 Padova, Italy","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5024356243","https://openalex.org/A5031283439"],"corresponding_institution_ids":[],"apc_list":{"value":2400,"currency":"CHF","value_usd":2598},"apc_paid":{"value":2400,"currency":"CHF","value_usd":2598},"fwci":1.0625,"has_fulltext":true,"cited_by_count":16,"citation_normalized_percentile":{"value":0.72393043,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":96,"max":99},"biblio":{"volume":"22","issue":"3","first_page":"1144","last_page":"1144"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10412","display_name":"Microfluidic and Capillary Electrophoresis Applications","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10412","display_name":"Microfluidic and Capillary Electrophoresis Applications","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11393","display_name":"Biosensors and Analytical Detection","score":0.9995999932289124,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11407","display_name":"Innovative Microfluidic and Catalytic Techniques Innovation","score":0.9995999932289124,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/microfluidics","display_name":"Microfluidics","score":0.822157621383667},{"id":"https://openalex.org/keywords/absorbance","display_name":"Absorbance","score":0.8169589042663574},{"id":"https://openalex.org/keywords/lithium-niobate","display_name":"Lithium niobate","score":0.5883238315582275},{"id":"https://openalex.org/keywords/bradford-protein-assay","display_name":"Bradford protein assay","score":0.5852391123771667},{"id":"https://openalex.org/keywords/lab-on-a-chip","display_name":"Lab-on-a-chip","score":0.4863753616809845},{"id":"https://openalex.org/keywords/substrate","display_name":"Substrate (aquarium)","score":0.4594704806804657},{"id":"https://openalex.org/keywords/nanotechnology","display_name":"Nanotechnology","score":0.4572645127773285},{"id":"https://openalex.org/keywords/materials-science","display_name":"Materials science","score":0.4421871602535248},{"id":"https://openalex.org/keywords/chromatography","display_name":"Chromatography","score":0.3932446241378784},{"id":"https://openalex.org/keywords/optoelectronics","display_name":"Optoelectronics","score":0.36197859048843384},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.35307762026786804}],"concepts":[{"id":"https://openalex.org/C8673954","wikidata":"https://www.wikidata.org/wiki/Q138845","display_name":"Microfluidics","level":2,"score":0.822157621383667},{"id":"https://openalex.org/C98015330","wikidata":"https://www.wikidata.org/wiki/Q907315","display_name":"Absorbance","level":2,"score":0.8169589042663574},{"id":"https://openalex.org/C2777207636","wikidata":"https://www.wikidata.org/wiki/Q424481","display_name":"Lithium niobate","level":2,"score":0.5883238315582275},{"id":"https://openalex.org/C160845552","wikidata":"https://www.wikidata.org/wiki/Q247562","display_name":"Bradford protein assay","level":2,"score":0.5852391123771667},{"id":"https://openalex.org/C138942068","wikidata":"https://www.wikidata.org/wiki/Q633261","display_name":"Lab-on-a-chip","level":3,"score":0.4863753616809845},{"id":"https://openalex.org/C2777289219","wikidata":"https://www.wikidata.org/wiki/Q7632154","display_name":"Substrate (aquarium)","level":2,"score":0.4594704806804657},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.4572645127773285},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.4421871602535248},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.3932446241378784},{"id":"https://openalex.org/C49040817","wikidata":"https://www.wikidata.org/wiki/Q193091","display_name":"Optoelectronics","level":1,"score":0.36197859048843384},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.35307762026786804},{"id":"https://openalex.org/C111368507","wikidata":"https://www.wikidata.org/wiki/Q43518","display_name":"Oceanography","level":1,"score":0.0},{"id":"https://openalex.org/C127313418","wikidata":"https://www.wikidata.org/wiki/Q1069","display_name":"Geology","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D001681","descriptor_name":"Biological Assay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001681","descriptor_name":"Biological Assay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001681","descriptor_name":"Biological Assay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009556","descriptor_name":"Niobium","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009556","descriptor_name":"Niobium","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009556","descriptor_name":"Niobium","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010087","descriptor_name":"Oxides","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010087","descriptor_name":"Oxides","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010087","descriptor_name":"Oxides","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D044085","descriptor_name":"Microfluidics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D044085","descriptor_name":"Microfluidics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D044085","descriptor_name":"Microfluidics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D046210","descriptor_name":"Microfluidic Analytical Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D046210","descriptor_name":"Microfluidic Analytical Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D046210","descriptor_name":"Microfluidic Analytical Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D056656","descriptor_name":"Lab-On-A-Chip Devices","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056656","descriptor_name":"Lab-On-A-Chip Devices","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056656","descriptor_name":"Lab-On-A-Chip Devices","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.3390/s22031144","is_oa":true,"landing_page_url":"https://doi.org/10.3390/s22031144","pdf_url":"https://www.mdpi.com/1424-8220/22/3/1144/pdf?version=1644389966","source":{"id":"https://openalex.org/S101949793","display_name":"Sensors","issn_l":"1424-8220","issn":["1424-8220"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sensors","raw_type":"journal-article"},{"id":"pmid:35161887","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35161887","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sensors (Basel, Switzerland)","raw_type":null},{"id":"pmh:oai:doaj.org/article:0ba6ac73cd324c6ea0f5f8ae109e3003","is_oa":true,"landing_page_url":"https://doaj.org/article/0ba6ac73cd324c6ea0f5f8ae109e3003","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Sensors, Vol 22, Iss 3, p 1144 (2022)","raw_type":"article"},{"id":"pmh:oai:mdpi.com:/1424-8220/22/3/1144/","is_oa":true,"landing_page_url":"https://dx.doi.org/10.3390/s22031144","pdf_url":null,"source":{"id":"https://openalex.org/S4306400947","display_name":"MDPI (MDPI AG)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210097602","host_organization_name":"Multidisciplinary Digital Publishing Institute (Switzerland)","host_organization_lineage":["https://openalex.org/I4210097602"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Sensors; Volume 22; Issue 3; Pages: 1144","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:8840398","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8840398","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Sensors (Basel)","raw_type":"Text"},{"id":"pmh:oai:www.research.unipd.it:11577/3417668","is_oa":true,"landing_page_url":"https://hdl.handle.net/11577/3417668","pdf_url":null,"source":{"id":"https://openalex.org/S4306402547","display_name":"Padua Research Archive (University of Padova)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I138689650","host_organization_name":"University of Padua","host_organization_lineage":["https://openalex.org/I138689650"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.3390/s22031144","is_oa":true,"landing_page_url":"https://doi.org/10.3390/s22031144","pdf_url":"https://www.mdpi.com/1424-8220/22/3/1144/pdf?version=1644389966","source":{"id":"https://openalex.org/S101949793","display_name":"Sensors","issn_l":"1424-8220","issn":["1424-8220"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sensors","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4210294641.pdf","grobid_xml":"https://content.openalex.org/works/W4210294641.grobid-xml"},"referenced_works_count":40,"referenced_works":["https://openalex.org/W1506043065","https://openalex.org/W1512306811","https://openalex.org/W1964574933","https://openalex.org/W2008654270","https://openalex.org/W2010780711","https://openalex.org/W2015462281","https://openalex.org/W2024921796","https://openalex.org/W2045638435","https://openalex.org/W2068190630","https://openalex.org/W2072821145","https://openalex.org/W2078060668","https://openalex.org/W2101133081","https://openalex.org/W2123090265","https://openalex.org/W2128635872","https://openalex.org/W2145754403","https://openalex.org/W2157745373","https://openalex.org/W2170001106","https://openalex.org/W2188285942","https://openalex.org/W2398706664","https://openalex.org/W2419095119","https://openalex.org/W2484606001","https://openalex.org/W2520255402","https://openalex.org/W2530376881","https://openalex.org/W2560575855","https://openalex.org/W2622817946","https://openalex.org/W2899220526","https://openalex.org/W2938154346","https://openalex.org/W2982577919","https://openalex.org/W3024314157","https://openalex.org/W3085249213","https://openalex.org/W3087328251","https://openalex.org/W3196897419","https://openalex.org/W3210557078","https://openalex.org/W3210619080","https://openalex.org/W3213704159","https://openalex.org/W4232534952","https://openalex.org/W4245177871","https://openalex.org/W4293247451","https://openalex.org/W6654099443","https://openalex.org/W6825152834"],"related_works":["https://openalex.org/W2088718888","https://openalex.org/W2335596810","https://openalex.org/W2363991044","https://openalex.org/W1967895359","https://openalex.org/W2035798093","https://openalex.org/W2140522072","https://openalex.org/W2021085378","https://openalex.org/W2733260917","https://openalex.org/W2009860895","https://openalex.org/W2790011628"],"abstract_inverted_index":{"This":[0,90],"paper":[1],"deals":[2],"with":[3,76,83],"the":[4,10,54,59,63,73,77,93,106,131,175,179,189,193],"quantification":[5,56,119,143],"of":[6,32,62,118,120,161,164],"proteins":[7,97],"by":[8,30,98,147,155],"implementing":[9],"Bradford":[11,74],"protein":[12,21,55,142,180],"assay":[13],"method":[14],"in":[15,72,166],"a":[16,37,42,84,116,137],"portable":[17],"opto-microfluidic":[18,194],"platform":[19],"for":[20,185],"concentrations":[22],"lower":[23,129],"than":[24,105,130,168],"1.4":[25],"mg/mL.":[26],"Absorbance":[27],"is":[28,50,126,144],"measured":[29],"way":[31],"optical":[33],"waveguides":[34],"integrated":[35],"to":[36,52,95,192],"cross-junction":[38],"microfluidic":[39,151],"circuit":[40],"on":[41,58],"single":[43,150],"lithium":[44],"niobate":[45],"substrate.":[46],"A":[47],"new":[48],"protocol":[49,91],"proposed":[51,172],"perform":[53],"based":[57],"high":[60],"correlation":[61],"light":[64],"absorbance":[65],"at":[66,80,121],"595":[67],"nm,":[68],"as":[69,110,134,136,153],"commonly":[70],"used":[71],"method,":[75],"one":[78,149],"achieved":[79],"633":[81],"nm":[82],"cheap":[85],"commercially":[86],"available":[87],"diode":[88],"laser.":[89],"demonstrates":[92],"possibility":[94],"quantify":[96],"using":[99,148],"nL":[100],"volumes,":[101],"1000":[102],"times":[103,128],"less":[104,167],"standard":[107],"technique":[108],"such":[109],"paper-analytical":[111],"devices.":[112],"Moreover,":[113],"it":[114],"shows":[115],"limit":[117],"least":[122],"0.12":[123],"mg/mL,":[124],"which":[125],"four":[127],"last":[132],"literature,":[133],"well":[135,154],"better":[138],"accuracy":[139],"(98%).":[140],"The":[141,171],"obtained":[145],"either":[146],"droplet":[152],"performing":[156],"statistical":[157],"analysis":[158],"over":[159],"ensembles":[160],"several":[162],"thousands":[163],"droplets":[165],"1":[169],"min.":[170],"methodology":[173],"presents":[174],"further":[176],"advantage":[177],"that":[178],"solutions":[181],"can":[182],"be":[183],"reused":[184],"other":[186],"investigations":[187],"and":[188],"same":[190],"pertains":[191],"platform.":[195]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":7},{"year":2023,"cited_by_count":3}],"updated_date":"2026-05-15T08:27:34.491423","created_date":"2025-10-10T00:00:00"}