{"id":"https://openalex.org/W3210752935","doi":"https://doi.org/10.3390/s21217106","title":"Automated Mouse Pupil Size Measurement System to Assess Locus Coeruleus Activity with a Deep Learning-Based Approach","display_name":"Automated Mouse Pupil Size Measurement System to Assess Locus Coeruleus Activity with a Deep Learning-Based Approach","publication_year":2021,"publication_date":"2021-10-26","ids":{"openalex":"https://openalex.org/W3210752935","doi":"https://doi.org/10.3390/s21217106","mag":"3210752935","pmid":"https://pubmed.ncbi.nlm.nih.gov/34770410"},"language":"en","primary_location":{"id":"doi:10.3390/s21217106","is_oa":true,"landing_page_url":"https://doi.org/10.3390/s21217106","pdf_url":"https://www.mdpi.com/1424-8220/21/21/7106/pdf?version=1635399934","source":{"id":"https://openalex.org/S101949793","display_name":"Sensors","issn_l":"1424-8220","issn":["1424-8220"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sensors","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/1424-8220/21/21/7106/pdf?version=1635399934","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5048211863","display_name":"Alejandro Lara-Do\u00f1a","orcid":"https://orcid.org/0000-0002-8342-9907"},"institutions":[{"id":"https://openalex.org/I39147953","display_name":"Universidad de C\u00e1diz","ror":"https://ror.org/04mxxkb11","country_code":"ES","type":"education","lineage":["https://openalex.org/I39147953"]},{"id":"https://openalex.org/I4210123493","display_name":"Biomedical Research and Innovation Institute of Cadiz","ror":"https://ror.org/02s5m5d51","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210123493"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Alejandro Lara-Do\u00f1a","raw_affiliation_strings":["Biomedical Engineering and Telemedicine Research Group, Systems and Automation Engineering Area, Department of Automation Engineering, Electronics and Computer Architecture and Networks, Universidad de C\u00e1diz, 11009 C\u00e1diz, Spain","Instituto de Investigaci\u00f3n e Innovaci\u00f3n Biom\u00e9dica de C\u00e1diz (INiBICA), 11009 C\u00e1diz, Spain"],"raw_orcid":"https://orcid.org/0000-0002-8342-9907","affiliations":[{"raw_affiliation_string":"Biomedical Engineering and Telemedicine Research Group, Systems and Automation Engineering Area, Department of Automation Engineering, Electronics and Computer Architecture and Networks, Universidad de C\u00e1diz, 11009 C\u00e1diz, Spain","institution_ids":["https://openalex.org/I39147953"]},{"raw_affiliation_string":"Instituto de Investigaci\u00f3n e Innovaci\u00f3n Biom\u00e9dica de C\u00e1diz (INiBICA), 11009 C\u00e1diz, Spain","institution_ids":["https://openalex.org/I4210123493"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025388625","display_name":"Sonia Torres-S\u00e1nchez","orcid":"https://orcid.org/0000-0003-0255-6558"},"institutions":[{"id":"https://openalex.org/I2801357902","display_name":"Instituto de Salud Carlos III","ror":"https://ror.org/00ca2c886","country_code":"ES","type":"funder","lineage":["https://openalex.org/I2801357902","https://openalex.org/I4387152914"]},{"id":"https://openalex.org/I39147953","display_name":"Universidad de C\u00e1diz","ror":"https://ror.org/04mxxkb11","country_code":"ES","type":"education","lineage":["https://openalex.org/I39147953"]},{"id":"https://openalex.org/I4210090703","display_name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Salud Mental","ror":"https://ror.org/009byq155","country_code":"ES","type":"facility","lineage":["https://openalex.org/I2801357902","https://openalex.org/I4210090703","https://openalex.org/I4387152914"]},{"id":"https://openalex.org/I4210123493","display_name":"Biomedical Research and Innovation Institute of Cadiz","ror":"https://ror.org/02s5m5d51","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210123493"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Sonia Torres-Sanchez","raw_affiliation_strings":["Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Salud Mental (CIBERSAM), Instituto de Salud Carlos III, 28029 Madrid, Spain","Instituto de Investigaci\u00f3n e Innovaci\u00f3n Biom\u00e9dica de C\u00e1diz (INiBICA), 11009 C\u00e1diz, Spain","Neuropsychopharmacology & Psychobiology Research Group, Psychobiology Area, Department of Psychology, Universidad de C\u00e1diz, 11003 C\u00e1diz, Spain"],"raw_orcid":"https://orcid.org/0000-0003-0255-6558","affiliations":[{"raw_affiliation_string":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Salud Mental (CIBERSAM), Instituto de Salud Carlos III, 28029 Madrid, Spain","institution_ids":["https://openalex.org/I2801357902","https://openalex.org/I4210090703"]},{"raw_affiliation_string":"Instituto de Investigaci\u00f3n e Innovaci\u00f3n Biom\u00e9dica de C\u00e1diz (INiBICA), 11009 C\u00e1diz, Spain","institution_ids":["https://openalex.org/I4210123493"]},{"raw_affiliation_string":"Neuropsychopharmacology & Psychobiology Research Group, Psychobiology Area, Department of Psychology, Universidad de C\u00e1diz, 11003 C\u00e1diz, Spain","institution_ids":["https://openalex.org/I39147953"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053663641","display_name":"Blanca Priego","orcid":"https://orcid.org/0000-0003-1609-0429"},"institutions":[{"id":"https://openalex.org/I39147953","display_name":"Universidad de C\u00e1diz","ror":"https://ror.org/04mxxkb11","country_code":"ES","type":"education","lineage":["https://openalex.org/I39147953"]},{"id":"https://openalex.org/I4210123493","display_name":"Biomedical Research and Innovation Institute of Cadiz","ror":"https://ror.org/02s5m5d51","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210123493"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Blanca Priego-Torres","raw_affiliation_strings":["Biomedical Engineering and Telemedicine Research Group, Systems and Automation Engineering Area, Department of Automation Engineering, Electronics and Computer Architecture and Networks, Universidad de C\u00e1diz, 11009 C\u00e1diz, Spain","Instituto de Investigaci\u00f3n e Innovaci\u00f3n Biom\u00e9dica de C\u00e1diz (INiBICA), 11009 C\u00e1diz, Spain"],"raw_orcid":"https://orcid.org/0000-0003-1609-0429","affiliations":[{"raw_affiliation_string":"Biomedical Engineering and Telemedicine Research Group, Systems and Automation Engineering Area, Department of Automation Engineering, Electronics and Computer Architecture and Networks, Universidad de C\u00e1diz, 11009 C\u00e1diz, Spain","institution_ids":["https://openalex.org/I39147953"]},{"raw_affiliation_string":"Instituto de Investigaci\u00f3n e Innovaci\u00f3n Biom\u00e9dica de C\u00e1diz (INiBICA), 11009 C\u00e1diz, Spain","institution_ids":["https://openalex.org/I4210123493"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070426401","display_name":"Esther Berrocoso","orcid":"https://orcid.org/0000-0003-0208-7472"},"institutions":[{"id":"https://openalex.org/I2801357902","display_name":"Instituto de Salud Carlos III","ror":"https://ror.org/00ca2c886","country_code":"ES","type":"funder","lineage":["https://openalex.org/I2801357902","https://openalex.org/I4387152914"]},{"id":"https://openalex.org/I39147953","display_name":"Universidad de C\u00e1diz","ror":"https://ror.org/04mxxkb11","country_code":"ES","type":"education","lineage":["https://openalex.org/I39147953"]},{"id":"https://openalex.org/I4210090703","display_name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Salud Mental","ror":"https://ror.org/009byq155","country_code":"ES","type":"facility","lineage":["https://openalex.org/I2801357902","https://openalex.org/I4210090703","https://openalex.org/I4387152914"]},{"id":"https://openalex.org/I4210123493","display_name":"Biomedical Research and Innovation Institute of Cadiz","ror":"https://ror.org/02s5m5d51","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210123493"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Esther Berrocoso","raw_affiliation_strings":["Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Salud Mental (CIBERSAM), Instituto de Salud Carlos III, 28029 Madrid, Spain","Instituto de Investigaci\u00f3n e Innovaci\u00f3n Biom\u00e9dica de C\u00e1diz (INiBICA), 11009 C\u00e1diz, Spain","Neuropsychopharmacology & Psychobiology Research Group, Psychobiology Area, Department of Psychology, Universidad de C\u00e1diz, 11003 C\u00e1diz, Spain"],"raw_orcid":"https://orcid.org/0000-0003-0208-7472","affiliations":[{"raw_affiliation_string":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Salud Mental (CIBERSAM), Instituto de Salud Carlos III, 28029 Madrid, Spain","institution_ids":["https://openalex.org/I2801357902","https://openalex.org/I4210090703"]},{"raw_affiliation_string":"Instituto de Investigaci\u00f3n e Innovaci\u00f3n Biom\u00e9dica de C\u00e1diz (INiBICA), 11009 C\u00e1diz, Spain","institution_ids":["https://openalex.org/I4210123493"]},{"raw_affiliation_string":"Neuropsychopharmacology & Psychobiology Research Group, Psychobiology Area, Department of Psychology, Universidad de C\u00e1diz, 11003 C\u00e1diz, Spain","institution_ids":["https://openalex.org/I39147953"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5072880316","display_name":"Daniel Morillo","orcid":"https://orcid.org/0000-0001-5603-0936"},"institutions":[{"id":"https://openalex.org/I39147953","display_name":"Universidad de C\u00e1diz","ror":"https://ror.org/04mxxkb11","country_code":"ES","type":"education","lineage":["https://openalex.org/I39147953"]},{"id":"https://openalex.org/I4210123493","display_name":"Biomedical Research and Innovation Institute of Cadiz","ror":"https://ror.org/02s5m5d51","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210123493"]}],"countries":["ES"],"is_corresponding":true,"raw_author_name":"Daniel Sanchez-Morillo","raw_affiliation_strings":["Biomedical Engineering and Telemedicine Research Group, Systems and Automation Engineering Area, Department of Automation Engineering, Electronics and Computer Architecture and Networks, Universidad de C\u00e1diz, 11009 C\u00e1diz, Spain","Instituto de Investigaci\u00f3n e Innovaci\u00f3n Biom\u00e9dica de C\u00e1diz (INiBICA), 11009 C\u00e1diz, Spain"],"raw_orcid":"https://orcid.org/0000-0001-5603-0936","affiliations":[{"raw_affiliation_string":"Biomedical Engineering and Telemedicine Research Group, Systems and Automation Engineering Area, Department of Automation Engineering, Electronics and Computer Architecture and Networks, Universidad de C\u00e1diz, 11009 C\u00e1diz, Spain","institution_ids":["https://openalex.org/I39147953"]},{"raw_affiliation_string":"Instituto de Investigaci\u00f3n e Innovaci\u00f3n Biom\u00e9dica de C\u00e1diz (INiBICA), 11009 C\u00e1diz, Spain","institution_ids":["https://openalex.org/I4210123493"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5072880316"],"corresponding_institution_ids":["https://openalex.org/I39147953","https://openalex.org/I4210123493"],"apc_list":{"value":2600,"currency":"CHF","value_usd":3137},"apc_paid":{"value":2600,"currency":"CHF","value_usd":3137},"fwci":0.9009,"has_fulltext":true,"cited_by_count":8,"citation_normalized_percentile":{"value":0.73874214,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"21","issue":"21","first_page":"7106","last_page":"7106"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10977","display_name":"Optical Imaging and Spectroscopy Techniques","score":0.996999979019165,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10977","display_name":"Optical Imaging and Spectroscopy Techniques","score":0.996999979019165,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12236","display_name":"Photoreceptor and optogenetics research","score":0.9940000176429749,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10581","display_name":"Neural dynamics and brain function","score":0.9933000206947327,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pupillometry","display_name":"Pupillometry","score":0.9600611329078674},{"id":"https://openalex.org/keywords/locus-coeruleus","display_name":"Locus coeruleus","score":0.6775363087654114},{"id":"https://openalex.org/keywords/pupil","display_name":"Pupil","score":0.6522483229637146},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.6215767860412598},{"id":"https://openalex.org/keywords/pupillary-response","display_name":"Pupillary response","score":0.6201290488243103},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.49971771240234375},{"id":"https://openalex.org/keywords/pupil-diameter","display_name":"Pupil diameter","score":0.44465237855911255},{"id":"https://openalex.org/keywords/computer-vision","display_name":"Computer vision","score":0.42678719758987427},{"id":"https://openalex.org/keywords/pupil-size","display_name":"Pupil size","score":0.42431461811065674},{"id":"https://openalex.org/keywords/segmentation","display_name":"Segmentation","score":0.42279088497161865},{"id":"https://openalex.org/keywords/ranging","display_name":"Ranging","score":0.4162302017211914},{"id":"https://openalex.org/keywords/pattern-recognition","display_name":"Pattern recognition (psychology)","score":0.36239588260650635},{"id":"https://openalex.org/keywords/neuroscience","display_name":"Neuroscience","score":0.25961828231811523},{"id":"https://openalex.org/keywords/psychology","display_name":"Psychology","score":0.19688621163368225}],"concepts":[{"id":"https://openalex.org/C2778711042","wikidata":"https://www.wikidata.org/wiki/Q3410891","display_name":"Pupillometry","level":3,"score":0.9600611329078674},{"id":"https://openalex.org/C2778468602","wikidata":"https://www.wikidata.org/wiki/Q1470452","display_name":"Locus coeruleus","level":3,"score":0.6775363087654114},{"id":"https://openalex.org/C2777394604","wikidata":"https://www.wikidata.org/wiki/Q173318","display_name":"Pupil","level":2,"score":0.6522483229637146},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.6215767860412598},{"id":"https://openalex.org/C149288182","wikidata":"https://www.wikidata.org/wiki/Q7260673","display_name":"Pupillary response","level":3,"score":0.6201290488243103},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.49971771240234375},{"id":"https://openalex.org/C2987277156","wikidata":"https://www.wikidata.org/wiki/Q173318","display_name":"Pupil diameter","level":3,"score":0.44465237855911255},{"id":"https://openalex.org/C31972630","wikidata":"https://www.wikidata.org/wiki/Q844240","display_name":"Computer vision","level":1,"score":0.42678719758987427},{"id":"https://openalex.org/C3019054092","wikidata":"https://www.wikidata.org/wiki/Q7260673","display_name":"Pupil size","level":3,"score":0.42431461811065674},{"id":"https://openalex.org/C89600930","wikidata":"https://www.wikidata.org/wiki/Q1423946","display_name":"Segmentation","level":2,"score":0.42279088497161865},{"id":"https://openalex.org/C115051666","wikidata":"https://www.wikidata.org/wiki/Q6522493","display_name":"Ranging","level":2,"score":0.4162302017211914},{"id":"https://openalex.org/C153180895","wikidata":"https://www.wikidata.org/wiki/Q7148389","display_name":"Pattern recognition (psychology)","level":2,"score":0.36239588260650635},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.25961828231811523},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.19688621163368225},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.0},{"id":"https://openalex.org/C76155785","wikidata":"https://www.wikidata.org/wiki/Q418","display_name":"Telecommunications","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000077321","descriptor_name":"Deep Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000077321","descriptor_name":"Deep Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000077321","descriptor_name":"Deep Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008027","descriptor_name":"Light","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008027","descriptor_name":"Light","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008027","descriptor_name":"Light","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008125","descriptor_name":"Locus Coeruleus","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008125","descriptor_name":"Locus Coeruleus","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008125","descriptor_name":"Locus Coeruleus","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011680","descriptor_name":"Pupil","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011680","descriptor_name":"Pupil","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011680","descriptor_name":"Pupil","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":7,"locations":[{"id":"doi:10.3390/s21217106","is_oa":true,"landing_page_url":"https://doi.org/10.3390/s21217106","pdf_url":"https://www.mdpi.com/1424-8220/21/21/7106/pdf?version=1635399934","source":{"id":"https://openalex.org/S101949793","display_name":"Sensors","issn_l":"1424-8220","issn":["1424-8220"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sensors","raw_type":"journal-article"},{"id":"pmid:34770410","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34770410","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sensors (Basel, Switzerland)","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8588114","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8588114","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Sensors (Basel)","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:e2400d018c254fb1878b6b9113677e1c","is_oa":true,"landing_page_url":"https://doaj.org/article/e2400d018c254fb1878b6b9113677e1c","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Sensors, Vol 21, Iss 21, p 7106 (2021)","raw_type":"article"},{"id":"pmh:oai:rodin.uca.es:10498/26106","is_oa":true,"landing_page_url":"http://hdl.handle.net/10498/26106","pdf_url":null,"source":{"id":"https://openalex.org/S4306400506","display_name":"RODIN (Universidad de C\u00e1diz)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I39147953","host_organization_name":"Universidad de C\u00e1diz","host_organization_lineage":["https://openalex.org/I39147953"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Sensors 2021, 21(21), 7106","raw_type":"journal article"},{"id":"pmh:oai:www.repositoriosalud.es:10668/4297","is_oa":true,"landing_page_url":"http://hdl.handle.net/10668/4297","pdf_url":null,"source":{"id":"https://openalex.org/S4377196114","display_name":"RISalud Institutional Health Repository of Andaluc\u00eda","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"research article"},{"id":"pmh:oai:zenodo.org:10471897","is_oa":true,"landing_page_url":"https://hdl.handle.net/10498/26106","pdf_url":null,"source":{"id":"https://openalex.org/S4306400562","display_name":"Zenodo (CERN European Organization for Nuclear Research)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I67311998","host_organization_name":"European Organization for Nuclear Research","host_organization_lineage":["https://openalex.org/I67311998"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Sensors, 21(21), 7106, (2021-10-26)","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.3390/s21217106","is_oa":true,"landing_page_url":"https://doi.org/10.3390/s21217106","pdf_url":"https://www.mdpi.com/1424-8220/21/21/7106/pdf?version=1635399934","source":{"id":"https://openalex.org/S101949793","display_name":"Sensors","issn_l":"1424-8220","issn":["1424-8220"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sensors","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3210752935.pdf","grobid_xml":"https://content.openalex.org/works/W3210752935.grobid-xml"},"referenced_works_count":63,"referenced_works":["https://openalex.org/W1601100579","https://openalex.org/W1981302370","https://openalex.org/W2004084449","https://openalex.org/W2008497075","https://openalex.org/W2015795623","https://openalex.org/W2019361862","https://openalex.org/W2078440247","https://openalex.org/W2080275784","https://openalex.org/W2096435716","https://openalex.org/W2144214580","https://openalex.org/W2194775991","https://openalex.org/W2210396547","https://openalex.org/W2232373047","https://openalex.org/W2234163201","https://openalex.org/W2395611524","https://openalex.org/W2412646938","https://openalex.org/W2531409750","https://openalex.org/W2551360963","https://openalex.org/W2565639579","https://openalex.org/W2624285448","https://openalex.org/W2758014172","https://openalex.org/W2761425918","https://openalex.org/W2767077660","https://openalex.org/W2783832094","https://openalex.org/W2788239274","https://openalex.org/W2788770082","https://openalex.org/W2803790813","https://openalex.org/W2806070179","https://openalex.org/W2884561390","https://openalex.org/W2889334143","https://openalex.org/W2912582499","https://openalex.org/W2918456385","https://openalex.org/W2949442988","https://openalex.org/W2950100524","https://openalex.org/W2952216243","https://openalex.org/W2952451491","https://openalex.org/W2952632681","https://openalex.org/W2963163009","https://openalex.org/W2963881378","https://openalex.org/W2964104722","https://openalex.org/W2964297960","https://openalex.org/W2964309882","https://openalex.org/W2980532222","https://openalex.org/W2982161360","https://openalex.org/W2990672573","https://openalex.org/W2993182889","https://openalex.org/W2998784361","https://openalex.org/W3005958183","https://openalex.org/W3015792865","https://openalex.org/W3034428102","https://openalex.org/W3034549805","https://openalex.org/W3035555092","https://openalex.org/W3039906298","https://openalex.org/W3081243754","https://openalex.org/W3092162390","https://openalex.org/W3101287485","https://openalex.org/W3105391992","https://openalex.org/W3111524067","https://openalex.org/W3113410735","https://openalex.org/W3121640062","https://openalex.org/W4211186612","https://openalex.org/W6622964371","https://openalex.org/W6755970747"],"related_works":["https://openalex.org/W3118311032","https://openalex.org/W4390199550","https://openalex.org/W2769989926","https://openalex.org/W4231680044","https://openalex.org/W4234136168","https://openalex.org/W2920823963","https://openalex.org/W2990629526","https://openalex.org/W2983375525","https://openalex.org/W2143385068","https://openalex.org/W2036530483"],"abstract_inverted_index":{"Strong":[0],"evidence":[1],"from":[2],"studies":[3],"on":[4,71],"primates":[5],"and":[6,37,89,131,146,158,167,183],"rodents":[7,61,117],"shows":[8],"that":[9,30,208],"changes":[10,43],"in":[11,18,44,46,60,94,108,115,233,241],"pupil":[12,215],"diameter":[13],"may":[14],"reflect":[15],"neural":[16],"activity":[17,48],"the":[19,25,45,50,53,72,78,87,110,113,137,140,147,153,173,175,179,184,192,210,220,230],"locus":[20],"coeruleus":[21],"(LC).":[22],"Pupillometry":[23],"is":[24,62,118],"only":[26],"available":[27],"non-invasive":[28],"technique":[29],"could":[31,238],"be":[32,239],"used":[33,80,240],"as":[34],"a":[35,101,123,132,165,205],"reliable":[36],"easily":[38],"accessible":[39],"real-time":[40,214],"biomarker":[41],"of":[42,49,55,69,75,77,86,112,152,219,229],"vivo":[47],"LC.":[51],"However,":[52],"application":[54],"pupillometry":[56,103],"to":[57,105,135,160],"preclinical":[58],"research":[59],"not":[63],"yet":[64],"fully":[65],"standardized.":[66],"A":[67],"lack":[68],"consensus":[70],"technical":[73],"specifications":[74],"some":[76],"components":[79],"for":[81,143,191,213],"image":[82],"recording":[83,231],"or":[84,225,247],"positioning":[85],"animal":[88],"cameras":[90,142],"have":[91],"been":[92],"recorded":[93],"recent":[95],"scientific":[96],"literature.":[97],"In":[98,172],"this":[99],"study,":[100],"novel":[102],"system":[104,121,211],"indirectly":[106],"assess,":[107],"real-time,":[109],"function":[111],"LC":[114],"anesthetized":[116],"presented.":[119],"The":[120,150,195,202,236],"comprises":[122],"deep":[124],"learning":[125],"SOLOv2":[126],"instance-based":[127],"fast":[128],"segmentation":[129],"framework":[130,237],"platform":[133],"designed":[134],"place":[136],"experimental":[138],"subject,":[139],"video":[141],"data":[144],"acquisition,":[145],"light":[148,223],"source.":[149],"performance":[151],"proposed":[154],"setup":[155],"was":[156,181,189],"assessed":[157],"compared":[159],"other":[161],"baseline":[162],"methods":[163],"using":[164],"validation":[166],"an":[168,199],"external":[169],"test":[170],"set.":[171],"latter,":[174],"calculated":[176],"intersection":[177],"over":[178],"union":[180],"0.93":[182],"mean":[185],"absolute":[186],"percentage":[187],"error":[188],"1.89%":[190],"selected":[193],"method.":[194],"Bland-Altman":[196],"analysis":[197],"depicted":[198],"excellent":[200],"agreement.":[201],"results":[203],"confirmed":[204],"high":[206],"accuracy":[207],"makes":[209],"suitable":[212],"size":[216],"tracking,":[217],"regardless":[218],"pupil's":[221],"size,":[222],"intensity,":[224],"any":[226,242],"features":[227],"typical":[228],"process":[232],"sedated":[234,246],"mice.":[235],"neurophysiological":[243],"study":[244],"with":[245],"fixed-head":[248],"animals.":[249]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":1}],"updated_date":"2026-08-27T14:10:00.468798","created_date":"2025-10-10T00:00:00"}