{"id":"https://openalex.org/W3119423008","doi":"https://doi.org/10.3390/s21020522","title":"Visualization Method for the Cell-Level Vesicle Transport Using Optical Flow and a Diverging Colormap","display_name":"Visualization Method for the Cell-Level Vesicle Transport Using Optical Flow and a Diverging Colormap","publication_year":2021,"publication_date":"2021-01-13","ids":{"openalex":"https://openalex.org/W3119423008","doi":"https://doi.org/10.3390/s21020522","mag":"3119423008","pmid":"https://pubmed.ncbi.nlm.nih.gov/33450927"},"language":"en","primary_location":{"id":"doi:10.3390/s21020522","is_oa":true,"landing_page_url":"https://doi.org/10.3390/s21020522","pdf_url":"https://www.mdpi.com/1424-8220/21/2/522/pdf?version=1610530144","source":{"id":"https://openalex.org/S101949793","display_name":"Sensors","issn_l":"1424-8220","issn":["1424-8220"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sensors","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/1424-8220/21/2/522/pdf?version=1610530144","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5070022238","display_name":"Seohyun Lee","orcid":"https://orcid.org/0000-0002-0952-9547"},"institutions":[{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Seohyun Lee","raw_affiliation_strings":["Information Technology Center, Data Science Research Division, The University of Tokyo, Hongo 7-3-1, Bunkyo-ku, Tokyo 113-8656, Japan"],"raw_orcid":"https://orcid.org/0000-0002-0952-9547","affiliations":[{"raw_affiliation_string":"Information Technology Center, Data Science Research Division, The University of Tokyo, Hongo 7-3-1, Bunkyo-ku, Tokyo 113-8656, Japan","institution_ids":["https://openalex.org/I74801974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020336657","display_name":"Hyuno Kim","orcid":"https://orcid.org/0000-0003-0517-562X"},"institutions":[{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hyuno Kim","raw_affiliation_strings":["Information Technology Center, Data Science Research Division, The University of Tokyo, Hongo 7-3-1, Bunkyo-ku, Tokyo 113-8656, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Information Technology Center, Data Science Research Division, The University of Tokyo, Hongo 7-3-1, Bunkyo-ku, Tokyo 113-8656, Japan","institution_ids":["https://openalex.org/I74801974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054789190","display_name":"Hideo Higuchi","orcid":"https://orcid.org/0000-0002-6519-7348"},"institutions":[{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hideo Higuchi","raw_affiliation_strings":["Department of Physics, Graduate School of Science, The University of Tokyo, Hongo 7-3-1, Bunkyo-ku, Tokyo 113-0033, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physics, Graduate School of Science, The University of Tokyo, Hongo 7-3-1, Bunkyo-ku, Tokyo 113-0033, Japan","institution_ids":["https://openalex.org/I74801974"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5010897098","display_name":"Masatoshi Ishikawa","orcid":"https://orcid.org/0000-0002-6096-830X"},"institutions":[{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masatoshi Ishikawa","raw_affiliation_strings":["Information Technology Center, Data Science Research Division, The University of Tokyo, Hongo 7-3-1, Bunkyo-ku, Tokyo 113-8656, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Information Technology Center, Data Science Research Division, The University of Tokyo, Hongo 7-3-1, Bunkyo-ku, Tokyo 113-8656, Japan","institution_ids":["https://openalex.org/I74801974"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5070022238"],"corresponding_institution_ids":["https://openalex.org/I74801974"],"apc_list":{"value":2400,"currency":"CHF","value_usd":2598},"apc_paid":{"value":2400,"currency":"CHF","value_usd":2598},"fwci":1.5039,"has_fulltext":true,"cited_by_count":7,"citation_normalized_percentile":{"value":0.854422,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"21","issue":"2","first_page":"522","last_page":"522"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12859","display_name":"Cell Image Analysis Techniques","score":0.9986000061035156,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12859","display_name":"Cell Image Analysis Techniques","score":0.9986000061035156,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10540","display_name":"Advanced Fluorescence Microscopy Techniques","score":0.9957000017166138,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10531","display_name":"Advanced Vision and Imaging","score":0.9927999973297119,"subfield":{"id":"https://openalex.org/subfields/1707","display_name":"Computer Vision and Pattern Recognition"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/visualization","display_name":"Visualization","score":0.8182176351547241},{"id":"https://openalex.org/keywords/intracellular","display_name":"Intracellular","score":0.5920934081077576},{"id":"https://openalex.org/keywords/vesicle","display_name":"Vesicle","score":0.5915621519088745},{"id":"https://openalex.org/keywords/biological-system","display_name":"Biological system","score":0.5324023365974426},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5190978050231934},{"id":"https://openalex.org/keywords/intracellular-transport","display_name":"Intracellular transport","score":0.5073100924491882},{"id":"https://openalex.org/keywords/cell","display_name":"Cell","score":0.501894474029541},{"id":"https://openalex.org/keywords/vesicular-transport-protein","display_name":"Vesicular transport protein","score":0.4893435835838318},{"id":"https://openalex.org/keywords/tracking","display_name":"Tracking (education)","score":0.48027563095092773},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.35238370299339294},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.3451393246650696},{"id":"https://openalex.org/keywords/cell-biology","display_name":"Cell biology","score":0.32228559255599976},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.3205753266811371},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.2306729257106781},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.09829548001289368}],"concepts":[{"id":"https://openalex.org/C36464697","wikidata":"https://www.wikidata.org/wiki/Q451553","display_name":"Visualization","level":2,"score":0.8182176351547241},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.5920934081077576},{"id":"https://openalex.org/C130316041","wikidata":"https://www.wikidata.org/wiki/Q189206","display_name":"Vesicle","level":3,"score":0.5915621519088745},{"id":"https://openalex.org/C186060115","wikidata":"https://www.wikidata.org/wiki/Q30336093","display_name":"Biological system","level":1,"score":0.5324023365974426},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5190978050231934},{"id":"https://openalex.org/C2780212709","wikidata":"https://www.wikidata.org/wiki/Q14890439","display_name":"Intracellular transport","level":3,"score":0.5073100924491882},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.501894474029541},{"id":"https://openalex.org/C167019083","wikidata":"https://www.wikidata.org/wiki/Q4082043","display_name":"Vesicular transport protein","level":4,"score":0.4893435835838318},{"id":"https://openalex.org/C2775936607","wikidata":"https://www.wikidata.org/wiki/Q466845","display_name":"Tracking (education)","level":2,"score":0.48027563095092773},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.35238370299339294},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.3451393246650696},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.32228559255599976},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3205753266811371},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2306729257106781},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.09829548001289368},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.0},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.0},{"id":"https://openalex.org/C19417346","wikidata":"https://www.wikidata.org/wiki/Q7922","display_name":"Pedagogy","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D007091","descriptor_name":"Image Processing, Computer-Assisted","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007091","descriptor_name":"Image Processing, Computer-Assisted","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007091","descriptor_name":"Image Processing, Computer-Assisted","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057849","descriptor_name":"Optic Flow","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D057849","descriptor_name":"Optic Flow","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D057849","descriptor_name":"Optic Flow","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":6,"locations":[{"id":"doi:10.3390/s21020522","is_oa":true,"landing_page_url":"https://doi.org/10.3390/s21020522","pdf_url":"https://www.mdpi.com/1424-8220/21/2/522/pdf?version=1610530144","source":{"id":"https://openalex.org/S101949793","display_name":"Sensors","issn_l":"1424-8220","issn":["1424-8220"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sensors","raw_type":"journal-article"},{"id":"pmid:33450927","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33450927","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sensors (Basel, Switzerland)","raw_type":null},{"id":"pmh:oai:doaj.org/article:0ffc19ce1f6c4dfbb29576ee3ae5fdbe","is_oa":true,"landing_page_url":"https://doaj.org/article/0ffc19ce1f6c4dfbb29576ee3ae5fdbe","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Sensors, Vol 21, Iss 2, p 522 (2021)","raw_type":"article"},{"id":"pmh:oai:europepmc.org:6734371","is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC7828387","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:mdpi.com:/1424-8220/21/2/522/","is_oa":true,"landing_page_url":"https://dx.doi.org/10.3390/s21020522","pdf_url":null,"source":{"id":"https://openalex.org/S4306400947","display_name":"MDPI (MDPI AG)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210097602","host_organization_name":"Multidisciplinary Digital Publishing Institute (Switzerland)","host_organization_lineage":["https://openalex.org/I4210097602"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Sensors; Volume 21; Issue 2; Pages: 522","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:7828387","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7828387","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Sensors (Basel)","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.3390/s21020522","is_oa":true,"landing_page_url":"https://doi.org/10.3390/s21020522","pdf_url":"https://www.mdpi.com/1424-8220/21/2/522/pdf?version=1610530144","source":{"id":"https://openalex.org/S101949793","display_name":"Sensors","issn_l":"1424-8220","issn":["1424-8220"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sensors","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.6800000071525574,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"awards":[{"id":"https://openalex.org/G713756128","display_name":null,"funder_award_id":"19K23717","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G715651512","display_name":null,"funder_award_id":"20K15753","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"}],"funders":[{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3119423008.pdf","grobid_xml":"https://content.openalex.org/works/W3119423008.grobid-xml"},"referenced_works_count":52,"referenced_works":["https://openalex.org/W1755205674","https://openalex.org/W1982003147","https://openalex.org/W2001270910","https://openalex.org/W2012279551","https://openalex.org/W2014901738","https://openalex.org/W2035379092","https://openalex.org/W2048718074","https://openalex.org/W2052829593","https://openalex.org/W2054543531","https://openalex.org/W2058092532","https://openalex.org/W2059612594","https://openalex.org/W2060012365","https://openalex.org/W2062142305","https://openalex.org/W2064833530","https://openalex.org/W2067005574","https://openalex.org/W2079981758","https://openalex.org/W2081771890","https://openalex.org/W2084729729","https://openalex.org/W2092463269","https://openalex.org/W2093057809","https://openalex.org/W2094152798","https://openalex.org/W2096054643","https://openalex.org/W2100553187","https://openalex.org/W2104095591","https://openalex.org/W2104716153","https://openalex.org/W2118877769","https://openalex.org/W2120135262","https://openalex.org/W2129140439","https://openalex.org/W2138825607","https://openalex.org/W2147353977","https://openalex.org/W2149806687","https://openalex.org/W2411207881","https://openalex.org/W2591660462","https://openalex.org/W2607489189","https://openalex.org/W2701107559","https://openalex.org/W2751023760","https://openalex.org/W2753635270","https://openalex.org/W2757376791","https://openalex.org/W2757978713","https://openalex.org/W2794406436","https://openalex.org/W2796625735","https://openalex.org/W2808247466","https://openalex.org/W2923579218","https://openalex.org/W2989869971","https://openalex.org/W2990949920","https://openalex.org/W3003662786","https://openalex.org/W3006930655","https://openalex.org/W3035092993","https://openalex.org/W3083851805","https://openalex.org/W3093599382","https://openalex.org/W4211233966","https://openalex.org/W6774485392"],"related_works":["https://openalex.org/W1998020191","https://openalex.org/W2074333462","https://openalex.org/W2423361515","https://openalex.org/W1965869657","https://openalex.org/W3021716504","https://openalex.org/W2625665063","https://openalex.org/W2551364262","https://openalex.org/W125114485","https://openalex.org/W2061267512","https://openalex.org/W2134827549"],"abstract_inverted_index":{"Elucidation":[0],"of":[1,32,66],"cell-level":[2,40],"transport":[3,42,68,95],"mediated":[4],"by":[5],"vesicles":[6],"within":[7],"a":[8,52,63,87],"living":[9],"cell":[10,75,109],"provides":[11],"key":[12],"information":[13,36],"regarding":[14,37],"viral":[15],"infection":[16],"processes":[17],"and":[18,78],"also":[19],"drug":[20],"delivery":[21],"mechanisms.":[22],"Although":[23],"the":[24,38,48,83,93,97],"single-particle":[25],"tracking":[26],"method":[27,65,90,99],"has":[28],"enabled":[29],"clear":[30],"analysis":[31],"individual":[33],"vesicle":[34,67],"trajectories,":[35],"entire":[39],"intracellular":[41,94],"is":[43,100],"hardly":[44],"obtainable,":[45],"due":[46],"to":[47,102],"difficulty":[49],"in":[50,106],"collecting":[51],"large":[53],"dataset":[54],"with":[55],"current":[56],"methods.":[57],"In":[58],"this":[59],"paper,":[60],"we":[61],"propose":[62],"visualization":[64,89],"using":[69],"optical":[70],"flow,":[71],"based":[72],"on":[73],"geometric":[74],"center":[76],"estimation":[77],"vector":[79],"analysis,":[80],"for":[81,91],"measuring":[82],"trafficking":[84],"directions.":[85],"As":[86],"quantitative":[88],"determining":[92],"status,":[96],"proposed":[98],"expected":[101],"be":[103],"universally":[104],"exploited":[105],"various":[107],"biomedical":[108],"image":[110],"analyses.":[111]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":1}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}