{"id":"https://openalex.org/W3112356228","doi":"https://doi.org/10.3390/s20247244","title":"Simulation of Nanopore Sequencing Signals Based on BiGRU","display_name":"Simulation of Nanopore Sequencing Signals Based on BiGRU","publication_year":2020,"publication_date":"2020-12-17","ids":{"openalex":"https://openalex.org/W3112356228","doi":"https://doi.org/10.3390/s20247244","mag":"3112356228","pmid":"https://pubmed.ncbi.nlm.nih.gov/33348876"},"language":"en","primary_location":{"id":"doi:10.3390/s20247244","is_oa":true,"landing_page_url":"https://doi.org/10.3390/s20247244","pdf_url":"https://www.mdpi.com/1424-8220/20/24/7244/pdf?version=1608218067","source":{"id":"https://openalex.org/S101949793","display_name":"Sensors","issn_l":"1424-8220","issn":["1424-8220"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sensors","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/1424-8220/20/24/7244/pdf?version=1608218067","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5108067228","display_name":"Weigang Chen","orcid":"https://orcid.org/0000-0002-4880-8186"},"institutions":[{"id":"https://openalex.org/I162868743","display_name":"Tianjin University","ror":"https://ror.org/012tb2g32","country_code":"CN","type":"education","lineage":["https://openalex.org/I162868743"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Weigang Chen","raw_affiliation_strings":["Frontier Science Center for Synthetic Biology (Ministry of Education), Tianjin University, Tianjin 300072, China","School of Microelectronics, Tianjin University, Tianjin 300072, China"],"raw_orcid":"https://orcid.org/0000-0002-4880-8186","affiliations":[{"raw_affiliation_string":"Frontier Science Center for Synthetic Biology (Ministry of Education), Tianjin University, Tianjin 300072, China","institution_ids":["https://openalex.org/I162868743"]},{"raw_affiliation_string":"School of Microelectronics, Tianjin University, Tianjin 300072, China","institution_ids":["https://openalex.org/I162868743"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100364230","display_name":"Peng Zhang","orcid":"https://orcid.org/0000-0003-2228-3569"},"institutions":[{"id":"https://openalex.org/I162868743","display_name":"Tianjin University","ror":"https://ror.org/012tb2g32","country_code":"CN","type":"education","lineage":["https://openalex.org/I162868743"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Peng Zhang","raw_affiliation_strings":["School of Microelectronics, Tianjin University, Tianjin 300072, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Microelectronics, Tianjin University, Tianjin 300072, China","institution_ids":["https://openalex.org/I162868743"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057068738","display_name":"Lifu Song","orcid":"https://orcid.org/0000-0003-1092-4568"},"institutions":[{"id":"https://openalex.org/I162868743","display_name":"Tianjin University","ror":"https://ror.org/012tb2g32","country_code":"CN","type":"education","lineage":["https://openalex.org/I162868743"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lifu Song","raw_affiliation_strings":["Frontier Science Center for Synthetic Biology (Ministry of Education), Tianjin University, Tianjin 300072, China","School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Frontier Science Center for Synthetic Biology (Ministry of Education), Tianjin University, Tianjin 300072, China","institution_ids":["https://openalex.org/I162868743"]},{"raw_affiliation_string":"School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, China","institution_ids":["https://openalex.org/I162868743"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101681925","display_name":"Jinsheng Yang","orcid":"https://orcid.org/0000-0002-1780-6305"},"institutions":[{"id":"https://openalex.org/I162868743","display_name":"Tianjin University","ror":"https://ror.org/012tb2g32","country_code":"CN","type":"education","lineage":["https://openalex.org/I162868743"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jinsheng Yang","raw_affiliation_strings":["School of Microelectronics, Tianjin University, Tianjin 300072, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Microelectronics, Tianjin University, Tianjin 300072, China","institution_ids":["https://openalex.org/I162868743"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5080441313","display_name":"Changcai Han","orcid":"https://orcid.org/0000-0003-4879-1748"},"institutions":[{"id":"https://openalex.org/I162868743","display_name":"Tianjin University","ror":"https://ror.org/012tb2g32","country_code":"CN","type":"education","lineage":["https://openalex.org/I162868743"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Changcai Han","raw_affiliation_strings":["School of Microelectronics, Tianjin University, Tianjin 300072, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Microelectronics, Tianjin University, Tianjin 300072, China","institution_ids":["https://openalex.org/I162868743"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5080441313"],"corresponding_institution_ids":["https://openalex.org/I162868743"],"apc_list":{"value":2400,"currency":"CHF","value_usd":2598},"apc_paid":{"value":2400,"currency":"CHF","value_usd":2598},"fwci":0.5835,"has_fulltext":true,"cited_by_count":16,"citation_normalized_percentile":{"value":0.66187442,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":94,"max":99},"biblio":{"volume":"20","issue":"24","first_page":"7244","last_page":"7244"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10015","display_name":"Genomics and Phylogenetic Studies","score":0.9882000088691711,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10015","display_name":"Genomics and Phylogenetic Studies","score":0.9882000088691711,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11582","display_name":"Nanopore and Nanochannel Transport Studies","score":0.9847999811172485,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11698","display_name":"Underwater Acoustics Research","score":0.9837999939918518,"subfield":{"id":"https://openalex.org/subfields/1910","display_name":"Oceanography"},"field":{"id":"https://openalex.org/fields/19","display_name":"Earth and Planetary Sciences"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nanopore","display_name":"Nanopore","score":0.8196331262588501},{"id":"https://openalex.org/keywords/nanopore-sequencing","display_name":"Nanopore sequencing","score":0.7732511758804321},{"id":"https://openalex.org/keywords/signal","display_name":"SIGNAL (programming language)","score":0.7476595044136047},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.4859817922115326},{"id":"https://openalex.org/keywords/signal-processing","display_name":"Signal processing","score":0.4463005065917969},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.43991607427597046},{"id":"https://openalex.org/keywords/dna-sequencing","display_name":"DNA sequencing","score":0.3834476172924042},{"id":"https://openalex.org/keywords/algorithm","display_name":"Algorithm","score":0.36563363671302795},{"id":"https://openalex.org/keywords/biological-system","display_name":"Biological system","score":0.3415612578392029},{"id":"https://openalex.org/keywords/materials-science","display_name":"Materials science","score":0.16294479370117188},{"id":"https://openalex.org/keywords/nanotechnology","display_name":"Nanotechnology","score":0.15459537506103516},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.12855100631713867},{"id":"https://openalex.org/keywords/telecommunications","display_name":"Telecommunications","score":0.11983448266983032},{"id":"https://openalex.org/keywords/dna","display_name":"DNA","score":0.11780309677124023},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.10521110892295837},{"id":"https://openalex.org/keywords/radar","display_name":"Radar","score":0.06847065687179565}],"concepts":[{"id":"https://openalex.org/C141795571","wikidata":"https://www.wikidata.org/wiki/Q580942","display_name":"Nanopore","level":2,"score":0.8196331262588501},{"id":"https://openalex.org/C126513998","wikidata":"https://www.wikidata.org/wiki/Q8973627","display_name":"Nanopore sequencing","level":4,"score":0.7732511758804321},{"id":"https://openalex.org/C2779843651","wikidata":"https://www.wikidata.org/wiki/Q7390335","display_name":"SIGNAL (programming language)","level":2,"score":0.7476595044136047},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4859817922115326},{"id":"https://openalex.org/C104267543","wikidata":"https://www.wikidata.org/wiki/Q208163","display_name":"Signal processing","level":3,"score":0.4463005065917969},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.43991607427597046},{"id":"https://openalex.org/C51679486","wikidata":"https://www.wikidata.org/wiki/Q380546","display_name":"DNA sequencing","level":3,"score":0.3834476172924042},{"id":"https://openalex.org/C11413529","wikidata":"https://www.wikidata.org/wiki/Q8366","display_name":"Algorithm","level":1,"score":0.36563363671302795},{"id":"https://openalex.org/C186060115","wikidata":"https://www.wikidata.org/wiki/Q30336093","display_name":"Biological system","level":1,"score":0.3415612578392029},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.16294479370117188},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.15459537506103516},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.12855100631713867},{"id":"https://openalex.org/C76155785","wikidata":"https://www.wikidata.org/wiki/Q418","display_name":"Telecommunications","level":1,"score":0.11983448266983032},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.11780309677124023},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.10521110892295837},{"id":"https://openalex.org/C554190296","wikidata":"https://www.wikidata.org/wiki/Q47528","display_name":"Radar","level":2,"score":0.06847065687179565},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.3390/s20247244","is_oa":true,"landing_page_url":"https://doi.org/10.3390/s20247244","pdf_url":"https://www.mdpi.com/1424-8220/20/24/7244/pdf?version=1608218067","source":{"id":"https://openalex.org/S101949793","display_name":"Sensors","issn_l":"1424-8220","issn":["1424-8220"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sensors","raw_type":"journal-article"},{"id":"pmid:33348876","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33348876","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sensors (Basel, Switzerland)","raw_type":null},{"id":"pmh:oai:doaj.org/article:06e7ca4304234796b9a5f56dfb873667","is_oa":true,"landing_page_url":"https://doaj.org/article/06e7ca4304234796b9a5f56dfb873667","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Sensors, Vol 20, Iss 24, p 7244 (2020)","raw_type":"article"},{"id":"pmh:oai:mdpi.com:/1424-8220/20/24/7244/","is_oa":true,"landing_page_url":"https://dx.doi.org/10.3390/s20247244","pdf_url":null,"source":{"id":"https://openalex.org/S4306400947","display_name":"MDPI (MDPI AG)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210097602","host_organization_name":"Multidisciplinary Digital Publishing Institute (Switzerland)","host_organization_lineage":["https://openalex.org/I4210097602"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Sensors; Volume 20; Issue 24; Pages: 7244","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:7766754","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7766754","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Sensors (Basel)","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.3390/s20247244","is_oa":true,"landing_page_url":"https://doi.org/10.3390/s20247244","pdf_url":"https://www.mdpi.com/1424-8220/20/24/7244/pdf?version=1608218067","source":{"id":"https://openalex.org/S101949793","display_name":"Sensors","issn_l":"1424-8220","issn":["1424-8220"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sensors","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G1842293871","display_name":null,"funder_award_id":"2020XY-0062","funder_id":"https://openalex.org/F4320336365","funder_display_name":"Seed Foundation of Tianjin University"}],"funders":[{"id":"https://openalex.org/F4320322701","display_name":"Tianjin University","ror":"https://ror.org/012tb2g32"},{"id":"https://openalex.org/F4320336365","display_name":"Seed Foundation of Tianjin University","ror":null}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3112356228.pdf","grobid_xml":"https://content.openalex.org/works/W3112356228.grobid-xml"},"referenced_works_count":32,"referenced_works":["https://openalex.org/W1519765314","https://openalex.org/W2126450798","https://openalex.org/W2144994235","https://openalex.org/W2194172909","https://openalex.org/W2194187530","https://openalex.org/W2317495605","https://openalex.org/W2346680365","https://openalex.org/W2467325308","https://openalex.org/W2514454343","https://openalex.org/W2517617279","https://openalex.org/W2526857311","https://openalex.org/W2550586733","https://openalex.org/W2591367881","https://openalex.org/W2737928538","https://openalex.org/W2789843538","https://openalex.org/W2795321802","https://openalex.org/W2883511460","https://openalex.org/W2891691532","https://openalex.org/W2896399231","https://openalex.org/W2901438556","https://openalex.org/W2903402350","https://openalex.org/W2911416569","https://openalex.org/W2915583118","https://openalex.org/W2949279762","https://openalex.org/W2950266744","https://openalex.org/W2950609999","https://openalex.org/W2950993016","https://openalex.org/W2953020124","https://openalex.org/W2953174564","https://openalex.org/W2969871939","https://openalex.org/W2999719567","https://openalex.org/W3006545642"],"related_works":["https://openalex.org/W2774675543","https://openalex.org/W2119052929","https://openalex.org/W2326282944","https://openalex.org/W2330402197","https://openalex.org/W3197006535","https://openalex.org/W3201371206","https://openalex.org/W2420153309","https://openalex.org/W2096970964","https://openalex.org/W3175842380","https://openalex.org/W2107323267"],"abstract_inverted_index":{"Oxford":[0],"Nanopore":[1],"sequencing":[2,6,38,47,99,129,133,163],"is":[3,23,39,78,104,158],"an":[4],"important":[5],"technology,":[7],"which":[8],"reads":[9],"the":[10,15,51,71,82,88,93,108,113,122,140,144,149,154,161,166,172],"nucleotide":[11,95],"sequence":[12,96],"by":[13,92],"detecting":[14],"electrical":[16],"current":[17],"signal":[18,34,58,72,90,110,126,130,156,164],"changes":[19],"when":[20],"DNA":[21],"molecule":[22],"forced":[24],"to":[25,80,86,107,111,160],"pass":[26],"through":[27,131],"a":[28,56],"biological":[29],"nanopore.":[30],"The":[31,135],"research":[32],"on":[33,62,76],"simulation":[35,52,59,136,174],"of":[36,45,148],"nanopore":[37,46,98],"highly":[40],"desirable":[41],"for":[42],"method":[43,60,118,142],"developments":[44],"applications.":[48],"To":[49],"improve":[50],"accuracy,":[53],"we":[54],"propose":[55],"novel":[57],"based":[61,75],"Bi-directional":[63],"Gated":[64],"Recurrent":[65],"Units":[66],"(BiGRU).":[67],"In":[68],"this":[69],"method,":[70],"processing":[73],"model":[74,121],"BiGRU":[77],"built":[79],"replace":[81],"traditional":[83],"low-pass":[84],"filter":[85],"post-process":[87],"ground-truth":[89,125],"calculated":[91],"input":[94],"and":[97,127,168],"pore":[100],"model.":[101],"Gaussian":[102],"noise":[103],"then":[105],"added":[106],"filtered":[109],"generate":[112,153],"final":[114],"simulated":[115,155],"signal.":[116],"This":[117],"can":[119,152],"accurately":[120],"relation":[123],"between":[124],"real-world":[128,162],"experimental":[132],"data.":[134],"results":[137],"reveal":[138],"that":[139,157],"proposed":[141],"utilizing":[143],"powerful":[145],"learning":[146],"ability":[147],"neural":[150],"network":[151],"closer":[159],"in":[165],"time":[167],"frequency":[169],"domains":[170],"than":[171],"existing":[173],"method.":[175]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":2}],"updated_date":"2026-05-21T06:26:12.895304","created_date":"2025-10-10T00:00:00"}
