{"id":"https://openalex.org/W2996891936","doi":"https://doi.org/10.3390/s20010196","title":"Immobilization of Allantoinase for the Development of an Optical Biosensor of Oxidative Stress States","display_name":"Immobilization of Allantoinase for the Development of an Optical Biosensor of Oxidative Stress States","publication_year":2019,"publication_date":"2019-12-29","ids":{"openalex":"https://openalex.org/W2996891936","doi":"https://doi.org/10.3390/s20010196","mag":"2996891936","pmid":"https://pubmed.ncbi.nlm.nih.gov/31905788"},"language":"en","primary_location":{"id":"doi:10.3390/s20010196","is_oa":true,"landing_page_url":"https://doi.org/10.3390/s20010196","pdf_url":"https://www.mdpi.com/1424-8220/20/1/196/pdf?version=1577784568","source":{"id":"https://openalex.org/S101949793","display_name":"Sensors","issn_l":"1424-8220","issn":["1424-8220"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sensors","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/1424-8220/20/1/196/pdf?version=1577784568","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5003923430","display_name":"Marialaura Marchetti","orcid":"https://orcid.org/0000-0002-4615-6786"},"institutions":[{"id":"https://openalex.org/I124601658","display_name":"University of Parma","ror":"https://ror.org/02k7wn190","country_code":"IT","type":"education","lineage":["https://openalex.org/I124601658"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Marialaura Marchetti","raw_affiliation_strings":["Centro Interdipartimentale Biopharmanet-TEC, Universit\u00e0 di Parma, Parco Area delle Scienze 27/A, 43124 Parma, Italy"],"raw_orcid":"https://orcid.org/0000-0002-4615-6786","affiliations":[{"raw_affiliation_string":"Centro Interdipartimentale Biopharmanet-TEC, Universit\u00e0 di Parma, Parco Area delle Scienze 27/A, 43124 Parma, Italy","institution_ids":["https://openalex.org/I124601658"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053290665","display_name":"Luca Ronda","orcid":"https://orcid.org/0000-0002-5389-2669"},"institutions":[{"id":"https://openalex.org/I124601658","display_name":"University of Parma","ror":"https://ror.org/02k7wn190","country_code":"IT","type":"education","lineage":["https://openalex.org/I124601658"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Luca Ronda","raw_affiliation_strings":["Centro Interdipartimentale Biopharmanet-TEC, Universit\u00e0 di Parma, Parco Area delle Scienze 27/A, 43124 Parma, Italy","Dipartimento di Medicina e Chirurgia, Universit\u00e0 di Parma, Via Gramsci 14, 43126 Parma, Italy"],"raw_orcid":"https://orcid.org/0000-0002-5389-2669","affiliations":[{"raw_affiliation_string":"Centro Interdipartimentale Biopharmanet-TEC, Universit\u00e0 di Parma, Parco Area delle Scienze 27/A, 43124 Parma, Italy","institution_ids":["https://openalex.org/I124601658"]},{"raw_affiliation_string":"Dipartimento di Medicina e Chirurgia, Universit\u00e0 di Parma, Via Gramsci 14, 43126 Parma, Italy","institution_ids":["https://openalex.org/I124601658"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091907746","display_name":"Riccardo Percudani","orcid":"https://orcid.org/0000-0001-8452-1062"},"institutions":[{"id":"https://openalex.org/I124601658","display_name":"University of Parma","ror":"https://ror.org/02k7wn190","country_code":"IT","type":"education","lineage":["https://openalex.org/I124601658"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Riccardo Percudani","raw_affiliation_strings":["Dipartimento di Scienze Chimiche, della Vita e della Sostenibilit\u00e0 Ambientale, Universit\u00e0 di Parma, Via Parco Area delle Scienze 11/A, 43124 Parma, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dipartimento di Scienze Chimiche, della Vita e della Sostenibilit\u00e0 Ambientale, Universit\u00e0 di Parma, Via Parco Area delle Scienze 11/A, 43124 Parma, Italy","institution_ids":["https://openalex.org/I124601658"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5066901937","display_name":"Stefano Bettati","orcid":"https://orcid.org/0000-0001-6787-0594"},"institutions":[{"id":"https://openalex.org/I124601658","display_name":"University of Parma","ror":"https://ror.org/02k7wn190","country_code":"IT","type":"education","lineage":["https://openalex.org/I124601658"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Stefano Bettati","raw_affiliation_strings":["Centro Interdipartimentale Biopharmanet-TEC, Universit\u00e0 di Parma, Parco Area delle Scienze 27/A, 43124 Parma, Italy","Dipartimento di Medicina e Chirurgia, Universit\u00e0 di Parma, Via Gramsci 14, 43126 Parma, Italy"],"raw_orcid":"https://orcid.org/0000-0001-6787-0594","affiliations":[{"raw_affiliation_string":"Centro Interdipartimentale Biopharmanet-TEC, Universit\u00e0 di Parma, Parco Area delle Scienze 27/A, 43124 Parma, Italy","institution_ids":["https://openalex.org/I124601658"]},{"raw_affiliation_string":"Dipartimento di Medicina e Chirurgia, Universit\u00e0 di Parma, Via Gramsci 14, 43126 Parma, Italy","institution_ids":["https://openalex.org/I124601658"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5053290665"],"corresponding_institution_ids":["https://openalex.org/I124601658"],"apc_list":{"value":2400,"currency":"CHF","value_usd":2598},"apc_paid":{"value":2400,"currency":"CHF","value_usd":2598},"fwci":0.3632,"has_fulltext":true,"cited_by_count":9,"citation_normalized_percentile":{"value":0.6311363,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"20","issue":"1","first_page":"196","last_page":"196"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10212","display_name":"Electrochemical sensors and biosensors","score":0.9987000226974487,"subfield":{"id":"https://openalex.org/subfields/2208","display_name":"Electrical and Electronic Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10212","display_name":"Electrochemical sensors and biosensors","score":0.9987000226974487,"subfield":{"id":"https://openalex.org/subfields/2208","display_name":"Electrical and Electronic Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T13127","display_name":"Biotin and Related Studies","score":0.9879000186920166,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10404","display_name":"Enzyme Catalysis and Immobilization","score":0.9836999773979187,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/allantoin","display_name":"Allantoin","score":0.9733439087867737},{"id":"https://openalex.org/keywords/biosensor","display_name":"Biosensor","score":0.706123948097229},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.6233354210853577},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.45381611585617065},{"id":"https://openalex.org/keywords/urate-oxidase","display_name":"Urate oxidase","score":0.4301506280899048},{"id":"https://openalex.org/keywords/enzyme","display_name":"Enzyme","score":0.36527690291404724},{"id":"https://openalex.org/keywords/chromatography","display_name":"Chromatography","score":0.3540728688240051}],"concepts":[{"id":"https://openalex.org/C2776073210","wikidata":"https://www.wikidata.org/wiki/Q409804","display_name":"Allantoin","level":2,"score":0.9733439087867737},{"id":"https://openalex.org/C160756335","wikidata":"https://www.wikidata.org/wiki/Q669391","display_name":"Biosensor","level":2,"score":0.706123948097229},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6233354210853577},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.45381611585617065},{"id":"https://openalex.org/C2776943133","wikidata":"https://www.wikidata.org/wiki/Q18057009","display_name":"Urate oxidase","level":3,"score":0.4301506280899048},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.36527690291404724},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.3540728688240051}],"mesh":[{"descriptor_ui":"D000581","descriptor_name":"Amidohydrolases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000581","descriptor_name":"Amidohydrolases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000581","descriptor_name":"Amidohydrolases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000581","descriptor_name":"Amidohydrolases","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D000581","descriptor_name":"Amidohydrolases","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D000581","descriptor_name":"Amidohydrolases","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D004800","descriptor_name":"Enzymes, Immobilized","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004800","descriptor_name":"Enzymes, Immobilized","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004800","descriptor_name":"Enzymes, Immobilized","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004800","descriptor_name":"Enzymes, Immobilized","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D004800","descriptor_name":"Enzymes, Immobilized","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D004800","descriptor_name":"Enzymes, Immobilized","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D005782","descriptor_name":"Gels","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D005782","descriptor_name":"Gels","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D005782","descriptor_name":"Gels","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012822","descriptor_name":"Silicon Dioxide","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D012822","descriptor_name":"Silicon Dioxide","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D012822","descriptor_name":"Silicon Dioxide","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D012965","descriptor_name":"Sodium Chloride","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D012965","descriptor_name":"Sodium Chloride","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D012965","descriptor_name":"Sodium Chloride","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015374","descriptor_name":"Biosensing Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015374","descriptor_name":"Biosensing Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015374","descriptor_name":"Biosensing Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018384","descriptor_name":"Oxidative Stress","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018384","descriptor_name":"Oxidative Stress","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018384","descriptor_name":"Oxidative Stress","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D055162","descriptor_name":"Biocatalysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055162","descriptor_name":"Biocatalysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055162","descriptor_name":"Biocatalysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055620","descriptor_name":"Optical Phenomena","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D055620","descriptor_name":"Optical Phenomena","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D055620","descriptor_name":"Optical Phenomena","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.3390/s20010196","is_oa":true,"landing_page_url":"https://doi.org/10.3390/s20010196","pdf_url":"https://www.mdpi.com/1424-8220/20/1/196/pdf?version=1577784568","source":{"id":"https://openalex.org/S101949793","display_name":"Sensors","issn_l":"1424-8220","issn":["1424-8220"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sensors","raw_type":"journal-article"},{"id":"pmid:31905788","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31905788","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sensors (Basel, Switzerland)","raw_type":null},{"id":"pmh:oai:doaj.org/article:4d52d6af37ce4ca59877fe32b5120da5","is_oa":true,"landing_page_url":"https://doaj.org/article/4d52d6af37ce4ca59877fe32b5120da5","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Sensors, Vol 20, Iss 1, p 196 (2019)","raw_type":"article"},{"id":"pmh:oai:mdpi.com:/1424-8220/20/1/196/","is_oa":true,"landing_page_url":"http://dx.doi.org/10.3390/s20010196","pdf_url":null,"source":{"id":"https://openalex.org/S4306400947","display_name":"MDPI (MDPI AG)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210097602","host_organization_name":"Multidisciplinary Digital Publishing Institute (Switzerland)","host_organization_lineage":["https://openalex.org/I4210097602"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Sensors","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:6983136","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6983136","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Sensors (Basel)","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.3390/s20010196","is_oa":true,"landing_page_url":"https://doi.org/10.3390/s20010196","pdf_url":"https://www.mdpi.com/1424-8220/20/1/196/pdf?version=1577784568","source":{"id":"https://openalex.org/S101949793","display_name":"Sensors","issn_l":"1424-8220","issn":["1424-8220"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sensors","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320322875","display_name":"Universit\u00e0 degli Studi di Parma","ror":"https://ror.org/02k7wn190"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2996891936.pdf","grobid_xml":"https://content.openalex.org/works/W2996891936.grobid-xml"},"referenced_works_count":58,"referenced_works":["https://openalex.org/W141907434","https://openalex.org/W1500203282","https://openalex.org/W1899691127","https://openalex.org/W1905838994","https://openalex.org/W1966239973","https://openalex.org/W1971372982","https://openalex.org/W1971727064","https://openalex.org/W1974263330","https://openalex.org/W1976535675","https://openalex.org/W1977486634","https://openalex.org/W1980273143","https://openalex.org/W1982129164","https://openalex.org/W1987768340","https://openalex.org/W1989162521","https://openalex.org/W1991428500","https://openalex.org/W1998973832","https://openalex.org/W1999408921","https://openalex.org/W2000721848","https://openalex.org/W2006848737","https://openalex.org/W2008645916","https://openalex.org/W2018137694","https://openalex.org/W2018930134","https://openalex.org/W2021372975","https://openalex.org/W2025372788","https://openalex.org/W2045432481","https://openalex.org/W2057293867","https://openalex.org/W2065730495","https://openalex.org/W2067217950","https://openalex.org/W2067520366","https://openalex.org/W2068130092","https://openalex.org/W2070207957","https://openalex.org/W2078040293","https://openalex.org/W2078874434","https://openalex.org/W2082871367","https://openalex.org/W2084210410","https://openalex.org/W2104950518","https://openalex.org/W2115488145","https://openalex.org/W2124019798","https://openalex.org/W2143862620","https://openalex.org/W2150695940","https://openalex.org/W2152425447","https://openalex.org/W2152833660","https://openalex.org/W2253434930","https://openalex.org/W2293332446","https://openalex.org/W2469266261","https://openalex.org/W2491458126","https://openalex.org/W2543731306","https://openalex.org/W2613068733","https://openalex.org/W2735543581","https://openalex.org/W2741660153","https://openalex.org/W2758501968","https://openalex.org/W2758805513","https://openalex.org/W2938209869","https://openalex.org/W4286855734","https://openalex.org/W6630036395","https://openalex.org/W6645096440","https://openalex.org/W6671255647","https://openalex.org/W6719817232"],"related_works":["https://openalex.org/W2350894681","https://openalex.org/W2010833780","https://openalex.org/W2019695253","https://openalex.org/W2228050271","https://openalex.org/W2111984389","https://openalex.org/W2162975723","https://openalex.org/W2118359290","https://openalex.org/W2154519754","https://openalex.org/W1802306473","https://openalex.org/W2777088676"],"abstract_inverted_index":{"Allantoin,":[0],"the":[1,14,21,36,70,113,123,126,151,155,161,168],"natural":[2],"end":[3],"product":[4],"of":[5,16,23,27,38,47,72,129,154,170],"purine":[6],"catabolism":[7],"in":[8,29,51,65,87,118],"mammals,":[9],"is":[10],"non-enzymatically":[11],"produced":[12],"from":[13],"scavenging":[15],"reactive":[17],"oxygen":[18],"species":[19],"through":[20,103],"degradation":[22],"uric":[24],"acid.":[25],"Levels":[26],"allantoin":[28,63,81,172],"biological":[30],"fluids":[31],"are":[32],"sensitively":[33],"influenced":[34],"by":[35],"presence":[37],"free":[39],"radicals,":[40],"making":[41],"this":[42,55],"molecule":[43],"a":[44,73,76,88,164],"candidate":[45,166],"marker":[46],"acute":[48],"oxidative":[49],"stress":[50],"clinical":[52],"analyses.":[53],"With":[54],"aim,":[56],"we":[57],"exploited":[58],"allantoinase-the":[59],"enzyme":[60],"responsible":[61],"for":[62,80,140,167],"hydrolization":[64],"plants":[66],"and":[67,94,99,106,110,125,138,158],"lower":[68],"organisms-for":[69],"development":[71,169],"biosensor":[74],"exploiting":[75],"fast":[77],"enzymatic-chemical":[78],"assay":[79],"quantification.":[82],"Recombinant":[83],"allantoinase":[84,163],"was":[85],"entrapped":[86,130],"wet":[89],"nanoporous":[90],"silica":[91,119],"gel":[92,120],"matrix":[93],"its":[95],"structural":[96],"properties,":[97],"function,":[98],"stability":[100],"were":[101],"characterized":[102],"fluorescence":[104],"spectroscopy":[105],"circular":[107],"dichroism":[108],"measurements,":[109],"compared":[111],"to":[112],"soluble":[114],"enzyme.":[115],"Physical":[116],"immobilization":[117],"minimally":[121],"influences":[122],"structure":[124],"catalytic":[127],"efficiency":[128],"allantoinase,":[131],"which":[132],"can":[133],"be":[134],"reused":[135],"several":[136,141],"times":[137],"stored":[139],"months":[142],"with":[143,150],"good":[144,165],"activity":[145],"retention.":[146],"These":[147],"results,":[148],"together":[149],"relative":[152],"ease":[153],"sol-gel":[156],"preparation":[157],"handling,":[159],"make":[160],"encapsulated":[162],"an":[171],"biosensor.":[173]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1}],"updated_date":"2026-05-21T09:19:25.381259","created_date":"2025-10-10T00:00:00"}