{"id":"https://openalex.org/W2972933757","doi":"https://doi.org/10.3390/s19183928","title":"Development of Fluorescent Reagent Based on Ligand Exchange Reaction for the Highly Sensitive and Selective Detection of Dopamine in the Serum","display_name":"Development of Fluorescent Reagent Based on Ligand Exchange Reaction for the Highly Sensitive and Selective Detection of Dopamine in the Serum","publication_year":2019,"publication_date":"2019-09-12","ids":{"openalex":"https://openalex.org/W2972933757","doi":"https://doi.org/10.3390/s19183928","mag":"2972933757","pmid":"https://pubmed.ncbi.nlm.nih.gov/31547244"},"language":"en","primary_location":{"id":"doi:10.3390/s19183928","is_oa":true,"landing_page_url":"https://doi.org/10.3390/s19183928","pdf_url":"https://www.mdpi.com/1424-8220/19/18/3928/pdf?version=1568272843","source":{"id":"https://openalex.org/S101949793","display_name":"Sensors","issn_l":"1424-8220","issn":["1424-8220"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sensors","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/1424-8220/19/18/3928/pdf?version=1568272843","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5043271179","display_name":"Yoshio Suzuki","orcid":"https://orcid.org/0000-0002-7305-1242"},"institutions":[{"id":"https://openalex.org/I73613424","display_name":"National Institute of Advanced Industrial Science and Technology","ror":"https://ror.org/01703db54","country_code":"JP","type":"government","lineage":["https://openalex.org/I73613424"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Yoshio Suzuki","raw_affiliation_strings":["Health Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), 1-1-1 Higashi, Tsukuba, Ibaraki 305-8566, Japan"],"affiliations":[{"raw_affiliation_string":"Health Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), 1-1-1 Higashi, Tsukuba, Ibaraki 305-8566, Japan","institution_ids":["https://openalex.org/I73613424"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5043271179"],"corresponding_institution_ids":["https://openalex.org/I73613424"],"apc_list":{"value":2400,"currency":"CHF","value_usd":2598},"apc_paid":{"value":2400,"currency":"CHF","value_usd":2598},"fwci":1.0046,"has_fulltext":true,"cited_by_count":15,"citation_normalized_percentile":{"value":0.73547148,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"19","issue":"18","first_page":"3928","last_page":"3928"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11240","display_name":"Luminescence and Fluorescent Materials","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11240","display_name":"Luminescence and Fluorescent Materials","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10532","display_name":"Molecular Sensors and Ion Detection","score":0.9994000196456909,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10212","display_name":"Electrochemical sensors and biosensors","score":0.996399998664856,"subfield":{"id":"https://openalex.org/subfields/2208","display_name":"Electrical and Electronic Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/fluorescence","display_name":"Fluorescence","score":0.8757691383361816},{"id":"https://openalex.org/keywords/dopamine","display_name":"Dopamine","score":0.8265206813812256},{"id":"https://openalex.org/keywords/fluorophore","display_name":"Fluorophore","score":0.7980268001556396},{"id":"https://openalex.org/keywords/reagent","display_name":"Reagent","score":0.7134736776351929},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.6551494598388672},{"id":"https://openalex.org/keywords/ligand","display_name":"Ligand (biochemistry)","score":0.5966126322746277},{"id":"https://openalex.org/keywords/detection-limit","display_name":"Detection limit","score":0.5948424935340881},{"id":"https://openalex.org/keywords/dopamine-transporter","display_name":"Dopamine transporter","score":0.5612096190452576},{"id":"https://openalex.org/keywords/photochemistry","display_name":"Photochemistry","score":0.3454709053039551},{"id":"https://openalex.org/keywords/analytical-chemistry","display_name":"Analytical Chemistry (journal)","score":0.3270878791809082},{"id":"https://openalex.org/keywords/chromatography","display_name":"Chromatography","score":0.23491820693016052},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.1675034761428833},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.11932012438774109},{"id":"https://openalex.org/keywords/physical-chemistry","display_name":"Physical chemistry","score":0.09963220357894897},{"id":"https://openalex.org/keywords/receptor","display_name":"Receptor","score":0.08379516005516052}],"concepts":[{"id":"https://openalex.org/C91881484","wikidata":"https://www.wikidata.org/wiki/Q191807","display_name":"Fluorescence","level":2,"score":0.8757691383361816},{"id":"https://openalex.org/C513476851","wikidata":"https://www.wikidata.org/wiki/Q170304","display_name":"Dopamine","level":2,"score":0.8265206813812256},{"id":"https://openalex.org/C2778617687","wikidata":"https://www.wikidata.org/wiki/Q2448456","display_name":"Fluorophore","level":3,"score":0.7980268001556396},{"id":"https://openalex.org/C40875361","wikidata":"https://www.wikidata.org/wiki/Q2356542","display_name":"Reagent","level":2,"score":0.7134736776351929},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6551494598388672},{"id":"https://openalex.org/C116569031","wikidata":"https://www.wikidata.org/wiki/Q899107","display_name":"Ligand (biochemistry)","level":3,"score":0.5966126322746277},{"id":"https://openalex.org/C119128265","wikidata":"https://www.wikidata.org/wiki/Q900165","display_name":"Detection limit","level":2,"score":0.5948424935340881},{"id":"https://openalex.org/C2776755682","wikidata":"https://www.wikidata.org/wiki/Q2271947","display_name":"Dopamine transporter","level":4,"score":0.5612096190452576},{"id":"https://openalex.org/C75473681","wikidata":"https://www.wikidata.org/wiki/Q188651","display_name":"Photochemistry","level":1,"score":0.3454709053039551},{"id":"https://openalex.org/C113196181","wikidata":"https://www.wikidata.org/wiki/Q485223","display_name":"Analytical Chemistry (journal)","level":2,"score":0.3270878791809082},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.23491820693016052},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1675034761428833},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.11932012438774109},{"id":"https://openalex.org/C147789679","wikidata":"https://www.wikidata.org/wiki/Q11372","display_name":"Physical chemistry","level":1,"score":0.09963220357894897},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.08379516005516052},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0},{"id":"https://openalex.org/C137183658","wikidata":"https://www.wikidata.org/wiki/Q461076","display_name":"Dopaminergic","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D001896","descriptor_name":"Boron Compounds","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D001896","descriptor_name":"Boron Compounds","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D001896","descriptor_name":"Boron Compounds","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D004298","descriptor_name":"Dopamine","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D004298","descriptor_name":"Dopamine","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D004298","descriptor_name":"Dopamine","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D005456","descriptor_name":"Fluorescent Dyes","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D005456","descriptor_name":"Fluorescent Dyes","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D005456","descriptor_name":"Fluorescent Dyes","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006863","descriptor_name":"Hydrogen-Ion Concentration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006863","descriptor_name":"Hydrogen-Ion Concentration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006863","descriptor_name":"Hydrogen-Ion Concentration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007501","descriptor_name":"Iron","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D007501","descriptor_name":"Iron","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D007501","descriptor_name":"Iron","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008670","descriptor_name":"Metals","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008670","descriptor_name":"Metals","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008670","descriptor_name":"Metals","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D013050","descriptor_name":"Spectrometry, Fluorescence","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D013050","descriptor_name":"Spectrometry, Fluorescence","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D013050","descriptor_name":"Spectrometry, Fluorescence","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D057230","descriptor_name":"Limit of Detection","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057230","descriptor_name":"Limit of Detection","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057230","descriptor_name":"Limit of Detection","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.3390/s19183928","is_oa":true,"landing_page_url":"https://doi.org/10.3390/s19183928","pdf_url":"https://www.mdpi.com/1424-8220/19/18/3928/pdf?version=1568272843","source":{"id":"https://openalex.org/S101949793","display_name":"Sensors","issn_l":"1424-8220","issn":["1424-8220"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sensors","raw_type":"journal-article"},{"id":"pmid:31547244","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31547244","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sensors (Basel, Switzerland)","raw_type":null},{"id":"pmh:oai:doaj.org/article:d2f63f9ebc0840c6b39a13754750c51a","is_oa":true,"landing_page_url":"https://doaj.org/article/d2f63f9ebc0840c6b39a13754750c51a","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Sensors, Vol 19, Iss 18, p 3928 (2019)","raw_type":"article"},{"id":"pmh:oai:mdpi.com:/1424-8220/19/18/3928/","is_oa":true,"landing_page_url":"http://dx.doi.org/10.3390/s19183928","pdf_url":null,"source":{"id":"https://openalex.org/S4306400947","display_name":"MDPI (MDPI AG)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210097602","host_organization_name":"Multidisciplinary Digital Publishing Institute (Switzerland)","host_organization_lineage":["https://openalex.org/I4210097602"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Sensors","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:6766910","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6766910","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Sensors (Basel)","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.3390/s19183928","is_oa":true,"landing_page_url":"https://doi.org/10.3390/s19183928","pdf_url":"https://www.mdpi.com/1424-8220/19/18/3928/pdf?version=1568272843","source":{"id":"https://openalex.org/S101949793","display_name":"Sensors","issn_l":"1424-8220","issn":["1424-8220"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sensors","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2972933757.pdf","grobid_xml":"https://content.openalex.org/works/W2972933757.grobid-xml"},"referenced_works_count":25,"referenced_works":["https://openalex.org/W423395282","https://openalex.org/W1990080074","https://openalex.org/W1991428014","https://openalex.org/W2016940513","https://openalex.org/W2028828446","https://openalex.org/W2039252107","https://openalex.org/W2039524327","https://openalex.org/W2053228281","https://openalex.org/W2054029703","https://openalex.org/W2063719902","https://openalex.org/W2068683693","https://openalex.org/W2083695818","https://openalex.org/W2086946929","https://openalex.org/W2097744565","https://openalex.org/W2112492496","https://openalex.org/W2113981935","https://openalex.org/W2133348055","https://openalex.org/W2335240697","https://openalex.org/W2469802286","https://openalex.org/W2508796889","https://openalex.org/W2517151712","https://openalex.org/W2587305512","https://openalex.org/W2599633465","https://openalex.org/W2734864958","https://openalex.org/W2888536071"],"related_works":["https://openalex.org/W1973576252","https://openalex.org/W1997975262","https://openalex.org/W2030104137","https://openalex.org/W2004875175","https://openalex.org/W2019484765","https://openalex.org/W2468271471","https://openalex.org/W1987455074","https://openalex.org/W2023536292","https://openalex.org/W2479013781","https://openalex.org/W1966148872"],"abstract_inverted_index":{"A":[0],"new":[1],"fluorescent":[2,146],"probe":[3,148],"(<b>BDP-Fe<sup>2+</sup></b>)":[4],"was":[5,68,75,91,111],"developed":[6],"for":[7,149],"targeting":[8],"dopamine,":[9],"with":[10,46,109],"a":[11,19,71,95,144],"boron-dipyrromethenyl":[12],"(BDP)":[13],"group":[14],"as":[15,22],"the":[16,23,50,57,78,115,121,128,139,150],"fluorophore":[17],"and":[18,70,81,154],"Fe<sup>2+</sup>":[20,53,60],"complex":[21],"ligand":[24],"exchange":[25],"site.":[26],"The":[27,63,84,105,132],"free":[28],"form":[29],"of":[30,52,59,87,101,107,117,125,134,152],"<b>BDP-Fe<sup>2+</sup></b>":[31,90,108,142],"in":[32,65,127,159],"solution":[33],"displayed":[34],"weak":[35],"fluorescence":[36,42,66,79],"emission,":[37],"while":[38],"it":[39],"showed":[40],"strong":[41],"emission":[43],"after":[44],"interaction":[45],"dopamine":[47,82,88,110,126,153],"due":[48],"to":[49,61],"release":[51],"from":[54],"<b>BDP-Fe<sup>2+</sup></b>,":[55],"confirming":[56],"binding":[58],"dopamine.":[62],"increase":[64],"intensity":[67,80],"concentration-dependent,":[69],"good":[72],"linear":[73],"relationship":[74],"observed":[76],"between":[77],"concentration.":[83],"detection":[85,124,151],"limit":[86],"by":[89,114],"1.1":[92],"nM,":[93],"indicating":[94],"20-fold":[96],"higher":[97],"sensitivity":[98],"than":[99],"that":[100,138],"previously":[102],"reported":[103],"compounds.":[104],"reaction":[106],"not":[112],"affected":[113],"presence":[116],"foreign":[118],"substances,":[119],"allowing":[120],"highly":[122],"selective":[123],"human":[129],"serum":[130],"sample.":[131],"results":[133],"this":[135],"study":[136],"indicate":[137],"novel":[140],"compound":[141],"is":[143],"reliable":[145],"molecular":[147],"can":[155],"be":[156],"widely":[157],"employed":[158],"diverse":[160],"scientific":[161],"areas.":[162]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":3}],"updated_date":"2026-03-20T23:20:44.827607","created_date":"2025-10-10T00:00:00"}