{"id":"https://openalex.org/W2915753902","doi":"https://doi.org/10.3390/s19040934","title":"Fluorescent Method for the Detection of Biothiols Using an Ag+-Mediated Conformational Switch","display_name":"Fluorescent Method for the Detection of Biothiols Using an Ag+-Mediated Conformational Switch","publication_year":2019,"publication_date":"2019-02-22","ids":{"openalex":"https://openalex.org/W2915753902","doi":"https://doi.org/10.3390/s19040934","mag":"2915753902","pmid":"https://pubmed.ncbi.nlm.nih.gov/30813324"},"language":"en","primary_location":{"id":"doi:10.3390/s19040934","is_oa":true,"landing_page_url":"https://doi.org/10.3390/s19040934","pdf_url":"https://www.mdpi.com/1424-8220/19/4/934/pdf?version=1551247949","source":{"id":"https://openalex.org/S101949793","display_name":"Sensors","issn_l":"1424-8220","issn":["1424-8220"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sensors","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/1424-8220/19/4/934/pdf?version=1551247949","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5018175501","display_name":"Han Zhao","orcid":"https://orcid.org/0000-0002-0490-3018"},"institutions":[{"id":"https://openalex.org/I139660479","display_name":"Central South University","ror":"https://ror.org/00f1zfq44","country_code":"CN","type":"education","lineage":["https://openalex.org/I139660479"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Han Zhao","raw_affiliation_strings":["School of Life Sciences, Central South University, Changsha 410083, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Life Sciences, Central South University, Changsha 410083, China","institution_ids":["https://openalex.org/I139660479"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101492065","display_name":"Mingjian Chen","orcid":"https://orcid.org/0000-0003-3484-9099"},"institutions":[{"id":"https://openalex.org/I139660479","display_name":"Central South University","ror":"https://ror.org/00f1zfq44","country_code":"CN","type":"education","lineage":["https://openalex.org/I139660479"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Mingjian Chen","raw_affiliation_strings":["School of Life Sciences, Central South University, Changsha 410083, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Life Sciences, Central South University, Changsha 410083, China","institution_ids":["https://openalex.org/I139660479"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5043917319","display_name":"Changbei Ma","orcid":"https://orcid.org/0000-0002-9973-0366"},"institutions":[{"id":"https://openalex.org/I139660479","display_name":"Central South University","ror":"https://ror.org/00f1zfq44","country_code":"CN","type":"education","lineage":["https://openalex.org/I139660479"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Changbei Ma","raw_affiliation_strings":["School of Life Sciences, Central South University, Changsha 410083, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Life Sciences, Central South University, Changsha 410083, China","institution_ids":["https://openalex.org/I139660479"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5043917319"],"corresponding_institution_ids":["https://openalex.org/I139660479"],"apc_list":{"value":2400,"currency":"CHF","value_usd":2673},"apc_paid":{"value":2400,"currency":"CHF","value_usd":2673},"fwci":0.3639,"has_fulltext":true,"cited_by_count":9,"citation_normalized_percentile":{"value":0.56451078,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"19","issue":"4","first_page":"934","last_page":"934"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11481","display_name":"Sulfur Compounds in Biology","score":0.9994000196456909,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11481","display_name":"Sulfur Compounds in Biology","score":0.9994000196456909,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10207","display_name":"Advanced biosensing and bioanalysis techniques","score":0.9973999857902527,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11346","display_name":"Mast cells and histamine","score":0.9787999987602234,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cysteine","display_name":"Cysteine","score":0.8332251310348511},{"id":"https://openalex.org/keywords/cytosine","display_name":"Cytosine","score":0.8022066950798035},{"id":"https://openalex.org/keywords/fluorescence","display_name":"Fluorescence","score":0.7920853495597839},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.7534253597259521},{"id":"https://openalex.org/keywords/glutathione","display_name":"Glutathione","score":0.7491913437843323},{"id":"https://openalex.org/keywords/detection-limit","display_name":"Detection limit","score":0.6752195954322815},{"id":"https://openalex.org/keywords/dna","display_name":"DNA","score":0.6366161108016968},{"id":"https://openalex.org/keywords/biophysics","display_name":"Biophysics","score":0.4698210060596466},{"id":"https://openalex.org/keywords/conformational-change","display_name":"Conformational change","score":0.42940229177474976},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.3105736970901489},{"id":"https://openalex.org/keywords/chromatography","display_name":"Chromatography","score":0.12319973111152649},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.0939280092716217},{"id":"https://openalex.org/keywords/enzyme","display_name":"Enzyme","score":0.07192468643188477}],"concepts":[{"id":"https://openalex.org/C2779201268","wikidata":"https://www.wikidata.org/wiki/Q186474","display_name":"Cysteine","level":3,"score":0.8332251310348511},{"id":"https://openalex.org/C2776023528","wikidata":"https://www.wikidata.org/wiki/Q178425","display_name":"Cytosine","level":3,"score":0.8022066950798035},{"id":"https://openalex.org/C91881484","wikidata":"https://www.wikidata.org/wiki/Q191807","display_name":"Fluorescence","level":2,"score":0.7920853495597839},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7534253597259521},{"id":"https://openalex.org/C538909803","wikidata":"https://www.wikidata.org/wiki/Q116907","display_name":"Glutathione","level":3,"score":0.7491913437843323},{"id":"https://openalex.org/C119128265","wikidata":"https://www.wikidata.org/wiki/Q900165","display_name":"Detection limit","level":2,"score":0.6752195954322815},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.6366161108016968},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.4698210060596466},{"id":"https://openalex.org/C2777339483","wikidata":"https://www.wikidata.org/wiki/Q647203","display_name":"Conformational change","level":2,"score":0.42940229177474976},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3105736970901489},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.12319973111152649},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0939280092716217},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.07192468643188477},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D003545","descriptor_name":"Cysteine","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D003545","descriptor_name":"Cysteine","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D003545","descriptor_name":"Cysteine","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D005978","descriptor_name":"Glutathione","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D005978","descriptor_name":"Glutathione","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D005978","descriptor_name":"Glutathione","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012834","descriptor_name":"Silver","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D012834","descriptor_name":"Silver","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D012834","descriptor_name":"Silver","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D015075","descriptor_name":"2-Aminopurine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015075","descriptor_name":"2-Aminopurine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015075","descriptor_name":"2-Aminopurine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.3390/s19040934","is_oa":true,"landing_page_url":"https://doi.org/10.3390/s19040934","pdf_url":"https://www.mdpi.com/1424-8220/19/4/934/pdf?version=1551247949","source":{"id":"https://openalex.org/S101949793","display_name":"Sensors","issn_l":"1424-8220","issn":["1424-8220"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sensors","raw_type":"journal-article"},{"id":"pmid:30813324","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30813324","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sensors (Basel, Switzerland)","raw_type":null},{"id":"pmh:oai:doaj.org/article:4c800f7bc8bd4fac9ee4eccd52df6cbc","is_oa":true,"landing_page_url":"https://doaj.org/article/4c800f7bc8bd4fac9ee4eccd52df6cbc","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Sensors, Vol 19, Iss 4, p 934 (2019)","raw_type":"article"},{"id":"pmh:oai:europepmc.org:5431297","is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC6412505","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:mdpi.com:/1424-8220/19/4/934/","is_oa":true,"landing_page_url":"http://dx.doi.org/10.3390/s19040934","pdf_url":null,"source":{"id":"https://openalex.org/S4306400947","display_name":"MDPI (MDPI AG)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210097602","host_organization_name":"Multidisciplinary Digital Publishing Institute (Switzerland)","host_organization_lineage":["https://openalex.org/I4210097602"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Sensors","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:6412505","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6412505","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Sensors (Basel)","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.3390/s19040934","is_oa":true,"landing_page_url":"https://doi.org/10.3390/s19040934","pdf_url":"https://www.mdpi.com/1424-8220/19/4/934/pdf?version=1551247949","source":{"id":"https://openalex.org/S101949793","display_name":"Sensors","issn_l":"1424-8220","issn":["1424-8220"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sensors","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Clean water and sanitation","score":0.5299999713897705,"id":"https://metadata.un.org/sdg/6"}],"awards":[{"id":"https://openalex.org/G1589705463","display_name":null,"funder_award_id":"2018zzts384","funder_id":"https://openalex.org/F4320321514","funder_display_name":"Central South University"},{"id":"https://openalex.org/G5632898110","display_name":null,"funder_award_id":"2017006","funder_id":"https://openalex.org/F4320326871","funder_display_name":"State Key Laboratory of Chemo/Biosensing and Chemometrics"},{"id":"https://openalex.org/G6918049205","display_name":null,"funder_award_id":"2018zzts399","funder_id":"https://openalex.org/F4320321514","funder_display_name":"Central South University"},{"id":"https://openalex.org/G815006141","display_name":null,"funder_award_id":"2017006","funder_id":"https://openalex.org/F4320322191","funder_display_name":"Hunan University"}],"funders":[{"id":"https://openalex.org/F4320321514","display_name":"Central South University","ror":"https://ror.org/00f1zfq44"},{"id":"https://openalex.org/F4320322191","display_name":"Hunan University","ror":"https://ror.org/05htk5m33"},{"id":"https://openalex.org/F4320326871","display_name":"State Key Laboratory of Chemo/Biosensing and Chemometrics","ror":null}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2915753902.pdf","grobid_xml":"https://content.openalex.org/works/W2915753902.grobid-xml"},"referenced_works_count":35,"referenced_works":["https://openalex.org/W1971228028","https://openalex.org/W1981375350","https://openalex.org/W1987670153","https://openalex.org/W1995057696","https://openalex.org/W2000914047","https://openalex.org/W2011034028","https://openalex.org/W2012520671","https://openalex.org/W2014238404","https://openalex.org/W2016542211","https://openalex.org/W2028997445","https://openalex.org/W2052199071","https://openalex.org/W2055589505","https://openalex.org/W2056041326","https://openalex.org/W2063865037","https://openalex.org/W2075151456","https://openalex.org/W2088696081","https://openalex.org/W2100622640","https://openalex.org/W2119817499","https://openalex.org/W2159540321","https://openalex.org/W2159964063","https://openalex.org/W2166337262","https://openalex.org/W2185282830","https://openalex.org/W2327730472","https://openalex.org/W2463787286","https://openalex.org/W2507242974","https://openalex.org/W2622410335","https://openalex.org/W2737525513","https://openalex.org/W2791362717","https://openalex.org/W2801131481","https://openalex.org/W2810825256","https://openalex.org/W2894497105","https://openalex.org/W2899340280","https://openalex.org/W2910662760","https://openalex.org/W2911788112","https://openalex.org/W2912460142"],"related_works":["https://openalex.org/W1788024602","https://openalex.org/W1566944420","https://openalex.org/W1985451517","https://openalex.org/W2103964183","https://openalex.org/W2018628774","https://openalex.org/W2167807668","https://openalex.org/W1968537115","https://openalex.org/W2038358489","https://openalex.org/W2346287228","https://openalex.org/W2089441615"],"abstract_inverted_index":{"In":[0,47],"this":[1],"work,":[2],"a":[3,22,58,85,96,138,145],"novel,":[4],"simple,":[5],"and":[6,16,67,93,107,119,124],"time-saving":[7],"fluorescence":[8,35,53,109],"approach":[9],"for":[10,117,141],"the":[11,43,48,52,61,68,79,88,98,108,129,142],"detection":[12,115],"of":[13,45,50,60,63,70,74,81,87,131],"biothiols":[14,92,132],"(glutathione":[15],"cysteine)":[17],"was":[18,57,83,111,121],"developed":[19],"by":[20],"employing":[21],"DNA":[23,100],"probe":[24,101,143],"labeled":[25],"with":[26],"2-aminopurine.":[27,71],"As":[28,95],"an":[29],"adenine":[30],"analogue,":[31],"2-aminopurine":[32],"exhibits":[33],"high":[34],"intensity":[36],"that":[37],"can":[38],"be":[39],"rapidly":[40],"quenched":[41,112],"in":[42,133,148],"presence":[44,49],"DNA.":[46],"Ag\u207a,":[51],"increased":[54],"significantly,":[55],"which":[56],"result":[59],"formation":[62],"cytosine\u207bAg\u207a\u207bcytosine":[64,82],"base":[65],"pairs":[66],"release":[69],"Upon":[72],"addition":[73],"either":[75],"glutathione":[76,118],"or":[77],"cysteine,":[78],"structure":[80],"disrupted,":[84],"product":[86],"stronger":[89],"affinity":[90],"between":[91],"Ag\u207a.":[94],"result,":[97],"2-aminopurine-labeled":[99],"returned":[102],"to":[103],"its":[104],"former":[105],"structure,":[106],"signal":[110],"accordingly.":[113],"The":[114],"limit":[116],"cysteine":[120],"3":[122],"nM":[123],"5":[125],"nM,":[126],"respectively.":[127],"Furthermore,":[128],"determination":[130],"human":[134],"blood":[135],"serum":[136],"provided":[137],"potential":[139],"application":[140],"as":[144],"diagnostic":[146],"tool":[147],"clinical":[149],"practice.":[150]},"counts_by_year":[{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1}],"updated_date":"2026-07-22T07:51:19.307946","created_date":"2025-10-10T00:00:00"}