{"id":"https://openalex.org/W2912368254","doi":"https://doi.org/10.3390/s19030539","title":"Real-Time Interferometric Refractive Index Change Measurement for the Direct Detection of Enzymatic Reactions and the Determination of Enzyme Kinetics","display_name":"Real-Time Interferometric Refractive Index Change Measurement for the Direct Detection of Enzymatic Reactions and the Determination of Enzyme Kinetics","publication_year":2019,"publication_date":"2019-01-28","ids":{"openalex":"https://openalex.org/W2912368254","doi":"https://doi.org/10.3390/s19030539","mag":"2912368254","pmid":"https://pubmed.ncbi.nlm.nih.gov/30696020"},"language":"en","primary_location":{"id":"doi:10.3390/s19030539","is_oa":true,"landing_page_url":"https://doi.org/10.3390/s19030539","pdf_url":"https://www.mdpi.com/1424-8220/19/3/539/pdf?version=1548665093","source":{"id":"https://openalex.org/S101949793","display_name":"Sensors","issn_l":"1424-8220","issn":["1424-8220"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sensors","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/1424-8220/19/3/539/pdf?version=1548665093","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110287897","display_name":"S\u00f8ren Terpager Jepsen","orcid":null},"institutions":[{"id":"https://openalex.org/I2799976261","display_name":"Aalborg University Hospital","ror":"https://ror.org/02jk5qe80","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2799976261"]},{"id":"https://openalex.org/I891191580","display_name":"Aalborg University","ror":"https://ror.org/04m5j1k67","country_code":"DK","type":"education","lineage":["https://openalex.org/I891191580"]}],"countries":["DK"],"is_corresponding":true,"raw_author_name":"S\u00f8ren T. Jepsen","raw_affiliation_strings":["Department of Clinical Biochemistry, Aalborg University Hospital, Sdr. Skovvej, DK-9000 Aalborg, Denmark","Department of Clinical Medicine, Aalborg University, Sdr. Skovvej, DK-9000 Aalborg, Denmark"],"affiliations":[{"raw_affiliation_string":"Department of Clinical Biochemistry, Aalborg University Hospital, Sdr. Skovvej, DK-9000 Aalborg, Denmark","institution_ids":["https://openalex.org/I2799976261"]},{"raw_affiliation_string":"Department of Clinical Medicine, Aalborg University, Sdr. Skovvej, DK-9000 Aalborg, Denmark","institution_ids":["https://openalex.org/I891191580"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064097618","display_name":"Thomas Martini J\u00f8rgensen","orcid":"https://orcid.org/0000-0003-2920-1343"},"institutions":[{"id":"https://openalex.org/I96673099","display_name":"Technical University of Denmark","ror":"https://ror.org/04qtj9h94","country_code":"DK","type":"education","lineage":["https://openalex.org/I96673099"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Thomas M. J\u00f8rgensen","raw_affiliation_strings":["Department of Applied Mathematics and Computer Science, Technical University of Denmark, DK-2800 Kongens Lyngby, Denmark"],"affiliations":[{"raw_affiliation_string":"Department of Applied Mathematics and Computer Science, Technical University of Denmark, DK-2800 Kongens Lyngby, Denmark","institution_ids":["https://openalex.org/I96673099"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102464608","display_name":"Henrik S. S\u00f8rensen","orcid":null},"institutions":[{"id":"https://openalex.org/I96673099","display_name":"Technical University of Denmark","ror":"https://ror.org/04qtj9h94","country_code":"DK","type":"education","lineage":["https://openalex.org/I96673099"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Henrik S. S\u00f8rensen","raw_affiliation_strings":["Department of Photonics Engineering, Technical University of Denmark, DK-2800 Kongens Lyngby, Denmark"],"affiliations":[{"raw_affiliation_string":"Department of Photonics Engineering, Technical University of Denmark, DK-2800 Kongens Lyngby, Denmark","institution_ids":["https://openalex.org/I96673099"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5075147644","display_name":"S\u00f8ren Risom Kristensen","orcid":"https://orcid.org/0000-0002-2649-506X"},"institutions":[{"id":"https://openalex.org/I2799976261","display_name":"Aalborg University Hospital","ror":"https://ror.org/02jk5qe80","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2799976261"]},{"id":"https://openalex.org/I891191580","display_name":"Aalborg University","ror":"https://ror.org/04m5j1k67","country_code":"DK","type":"education","lineage":["https://openalex.org/I891191580"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"S\u00f8ren R. Kristensen","raw_affiliation_strings":["Department of Clinical Biochemistry, Aalborg University Hospital, Sdr. Skovvej, DK-9000 Aalborg, Denmark","Department of Clinical Medicine, Aalborg University, Sdr. Skovvej, DK-9000 Aalborg, Denmark"],"affiliations":[{"raw_affiliation_string":"Department of Clinical Biochemistry, Aalborg University Hospital, Sdr. Skovvej, DK-9000 Aalborg, Denmark","institution_ids":["https://openalex.org/I2799976261"]},{"raw_affiliation_string":"Department of Clinical Medicine, Aalborg University, Sdr. Skovvej, DK-9000 Aalborg, Denmark","institution_ids":["https://openalex.org/I891191580"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5110287897"],"corresponding_institution_ids":["https://openalex.org/I2799976261","https://openalex.org/I891191580"],"apc_list":{"value":2400,"currency":"CHF","value_usd":2598},"apc_paid":{"value":2400,"currency":"CHF","value_usd":2598},"fwci":0.3435,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":{"value":0.58322993,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"19","issue":"3","first_page":"539","last_page":"539"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12867","display_name":"Advanced Biosensing Techniques and Applications","score":0.9983000159263611,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12867","display_name":"Advanced Biosensing Techniques and Applications","score":0.9983000159263611,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10412","display_name":"Microfluidic and Capillary Electrophoresis Applications","score":0.9979000091552734,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11663","display_name":"Viral Infectious Diseases and Gene Expression in Insects","score":0.9976999759674072,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/apyrase","display_name":"Apyrase","score":0.9080034494400024},{"id":"https://openalex.org/keywords/refractive-index","display_name":"Refractive index","score":0.7044282555580139},{"id":"https://openalex.org/keywords/substrate","display_name":"Substrate (aquarium)","score":0.7036968469619751},{"id":"https://openalex.org/keywords/hexokinase","display_name":"Hexokinase","score":0.6894711852073669},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.6672381162643433},{"id":"https://openalex.org/keywords/kinetics","display_name":"Kinetics","score":0.5393145084381104},{"id":"https://openalex.org/keywords/enzyme-kinetics","display_name":"Enzyme kinetics","score":0.48641419410705566},{"id":"https://openalex.org/keywords/phosphate","display_name":"Phosphate","score":0.4176226258277893},{"id":"https://openalex.org/keywords/enzyme","display_name":"Enzyme","score":0.4033788740634918},{"id":"https://openalex.org/keywords/analytical-chemistry","display_name":"Analytical Chemistry (journal)","score":0.392521470785141},{"id":"https://openalex.org/keywords/chromatography","display_name":"Chromatography","score":0.3264041543006897},{"id":"https://openalex.org/keywords/materials-science","display_name":"Materials science","score":0.23823902010917664},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.22475188970565796},{"id":"https://openalex.org/keywords/optoelectronics","display_name":"Optoelectronics","score":0.09920701384544373},{"id":"https://openalex.org/keywords/active-site","display_name":"Active site","score":0.09461787343025208}],"concepts":[{"id":"https://openalex.org/C2779508331","wikidata":"https://www.wikidata.org/wiki/Q24770179","display_name":"Apyrase","level":3,"score":0.9080034494400024},{"id":"https://openalex.org/C42067758","wikidata":"https://www.wikidata.org/wiki/Q174102","display_name":"Refractive index","level":2,"score":0.7044282555580139},{"id":"https://openalex.org/C2777289219","wikidata":"https://www.wikidata.org/wiki/Q7632154","display_name":"Substrate (aquarium)","level":2,"score":0.7036968469619751},{"id":"https://openalex.org/C2779826832","wikidata":"https://www.wikidata.org/wiki/Q982914","display_name":"Hexokinase","level":4,"score":0.6894711852073669},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6672381162643433},{"id":"https://openalex.org/C148898269","wikidata":"https://www.wikidata.org/wiki/Q1108792","display_name":"Kinetics","level":2,"score":0.5393145084381104},{"id":"https://openalex.org/C56856141","wikidata":"https://www.wikidata.org/wiki/Q883112","display_name":"Enzyme kinetics","level":4,"score":0.48641419410705566},{"id":"https://openalex.org/C2777132085","wikidata":"https://www.wikidata.org/wiki/Q46220103","display_name":"Phosphate","level":2,"score":0.4176226258277893},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.4033788740634918},{"id":"https://openalex.org/C113196181","wikidata":"https://www.wikidata.org/wiki/Q485223","display_name":"Analytical Chemistry (journal)","level":2,"score":0.392521470785141},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.3264041543006897},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.23823902010917664},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.22475188970565796},{"id":"https://openalex.org/C49040817","wikidata":"https://www.wikidata.org/wiki/Q193091","display_name":"Optoelectronics","level":1,"score":0.09920701384544373},{"id":"https://openalex.org/C41183919","wikidata":"https://www.wikidata.org/wiki/Q423026","display_name":"Active site","level":3,"score":0.09461787343025208},{"id":"https://openalex.org/C111368507","wikidata":"https://www.wikidata.org/wiki/Q43518","display_name":"Oceanography","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0},{"id":"https://openalex.org/C20251656","wikidata":"https://www.wikidata.org/wiki/Q162643","display_name":"Glycolysis","level":3,"score":0.0},{"id":"https://openalex.org/C127313418","wikidata":"https://www.wikidata.org/wiki/Q1069","display_name":"Geology","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000255","descriptor_name":"Adenosine Triphosphate","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D000255","descriptor_name":"Adenosine Triphosphate","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D000255","descriptor_name":"Adenosine Triphosphate","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D002384","descriptor_name":"Catalysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002384","descriptor_name":"Catalysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002384","descriptor_name":"Catalysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005947","descriptor_name":"Glucose","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D005947","descriptor_name":"Glucose","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D005947","descriptor_name":"Glucose","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006593","descriptor_name":"Hexokinase","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006593","descriptor_name":"Hexokinase","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006593","descriptor_name":"Hexokinase","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D007368","descriptor_name":"Interferometry","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D007368","descriptor_name":"Interferometry","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D007368","descriptor_name":"Interferometry","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012031","descriptor_name":"Refractometry","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D012031","descriptor_name":"Refractometry","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D012031","descriptor_name":"Refractometry","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D012996","descriptor_name":"Solutions","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D012996","descriptor_name":"Solutions","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D012996","descriptor_name":"Solutions","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D019298","descriptor_name":"Glucose-6-Phosphate","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D019298","descriptor_name":"Glucose-6-Phosphate","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D019298","descriptor_name":"Glucose-6-Phosphate","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D044085","descriptor_name":"Microfluidics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D044085","descriptor_name":"Microfluidics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D044085","descriptor_name":"Microfluidics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":8,"locations":[{"id":"doi:10.3390/s19030539","is_oa":true,"landing_page_url":"https://doi.org/10.3390/s19030539","pdf_url":"https://www.mdpi.com/1424-8220/19/3/539/pdf?version=1548665093","source":{"id":"https://openalex.org/S101949793","display_name":"Sensors","issn_l":"1424-8220","issn":["1424-8220"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sensors","raw_type":"journal-article"},{"id":"pmid:30696020","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30696020","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sensors (Basel, Switzerland)","raw_type":null},{"id":"pmh:oai:pure.atira.dk:openaire/7b0868b8-ff2d-43c1-a091-9559bb145db4","is_oa":true,"landing_page_url":"https://vbn.aau.dk/da/publications/7b0868b8-ff2d-43c1-a091-9559bb145db4","pdf_url":null,"source":{"id":"https://openalex.org/S4306401731","display_name":"VBN Forskningsportal (Aalborg Universitet)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I891191580","host_organization_name":"Aalborg University","host_organization_lineage":["https://openalex.org/I891191580"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Jepsen, S T, J\u00f8rgensen, T M, S\u00f8rensen, H S & Kristensen, S R 2019, 'Real-Time Interferometric Refractive Index Change Measurement for the Direct Detection of Enzymatic Reactions and the Determination of Enzyme Kinetics', Sensors, vol. 19, no. 3, 539. https://doi.org/10.3390/s19030539","raw_type":"info:eu-repo/semantics/publishedVersion"},{"id":"pmh:oai:doaj.org/article:b19e0a88c9224e128596400fe1917e01","is_oa":true,"landing_page_url":"https://doaj.org/article/b19e0a88c9224e128596400fe1917e01","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Sensors, Vol 19, Iss 3, p 539 (2019)","raw_type":"article"},{"id":"pmh:oai:europepmc.org:5385940","is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC6387378","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:mdpi.com:/1424-8220/19/3/539/","is_oa":true,"landing_page_url":"http://dx.doi.org/10.3390/s19030539","pdf_url":null,"source":{"id":"https://openalex.org/S4306400947","display_name":"MDPI (MDPI AG)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210097602","host_organization_name":"Multidisciplinary Digital Publishing Institute (Switzerland)","host_organization_lineage":["https://openalex.org/I4210097602"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Sensors","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:6387378","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6387378","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Sensors (Basel)","raw_type":"Text"},{"id":"pmh:oai:pure.atira.dk:publications/cc48765f-a035-49eb-85f7-1dd69a8a7c50","is_oa":true,"landing_page_url":"https://orbit.dtu.dk/en/publications/cc48765f-a035-49eb-85f7-1dd69a8a7c50","pdf_url":null,"source":{"id":"https://openalex.org/S4306400705","display_name":"Technical University of Denmark, DTU Orbit (Technical University of Denmark, DTU)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I96673099","host_organization_name":"Technical University of Denmark","host_organization_lineage":["https://openalex.org/I96673099"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Jepsen , S T , J\u00f8rgensen , T M , S\u00f8rensen , H S &amp; Kristensen , S R 2019 , ' Real-time interferometric refractive index change measurement for the direct detection of enzymatic reactions and the determination of enzyme kinetics ' , Sensors (Switzerland) , vol. 19 , no. 3 , 539 . https://doi.org/10.3390/s19030539","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3390/s19030539","is_oa":true,"landing_page_url":"https://doi.org/10.3390/s19030539","pdf_url":"https://www.mdpi.com/1424-8220/19/3/539/pdf?version=1548665093","source":{"id":"https://openalex.org/S101949793","display_name":"Sensors","issn_l":"1424-8220","issn":["1424-8220"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sensors","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.6299999952316284,"display_name":"Clean water and sanitation","id":"https://metadata.un.org/sdg/6"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2912368254.pdf","grobid_xml":"https://content.openalex.org/works/W2912368254.grobid-xml"},"referenced_works_count":31,"referenced_works":["https://openalex.org/W1588519390","https://openalex.org/W1971017691","https://openalex.org/W1976192602","https://openalex.org/W1980108396","https://openalex.org/W1981962823","https://openalex.org/W1988888049","https://openalex.org/W2003507219","https://openalex.org/W2003656403","https://openalex.org/W2011243939","https://openalex.org/W2013714550","https://openalex.org/W2022966906","https://openalex.org/W2025122052","https://openalex.org/W2043026524","https://openalex.org/W2068406956","https://openalex.org/W2075229839","https://openalex.org/W2080367104","https://openalex.org/W2090364676","https://openalex.org/W2141431753","https://openalex.org/W2143943504","https://openalex.org/W2147818124","https://openalex.org/W2153919739","https://openalex.org/W2194794763","https://openalex.org/W2293539868","https://openalex.org/W2418993214","https://openalex.org/W2477077008","https://openalex.org/W2487064210","https://openalex.org/W2489572555","https://openalex.org/W2804174780","https://openalex.org/W6651168253","https://openalex.org/W6696795888","https://openalex.org/W6721009369"],"related_works":["https://openalex.org/W2035423234","https://openalex.org/W2032416620","https://openalex.org/W2151666053","https://openalex.org/W2092798307","https://openalex.org/W2312981770","https://openalex.org/W2049739512","https://openalex.org/W2005390874","https://openalex.org/W4210412909","https://openalex.org/W3084294408","https://openalex.org/W2006639977"],"abstract_inverted_index":{"Back":[0],"scatter":[1],"interferometry":[2],"(BSI)":[3],"is":[4,60],"a":[5,17,20,56,140],"sensitive":[6],"method":[7],"for":[8,37,204],"detecting":[9],"changes":[10,82,196],"in":[11,19,47,71,197],"the":[12,38,63,66,78,84,91,101,125,135,145,149,169,175,198,205],"bulk":[13],"refractive":[14,74,80,137,170,199],"index":[15,75,81,138,171,200],"of":[16,93,103,177,208],"solution":[18],"microfluidic":[21],"system.":[22],"Here":[23],"we":[24],"demonstrate":[25],"that":[26,77,168,180,194],"BSI":[27],"can":[28,127,201],"be":[29,128,157,182,202],"used":[30,203],"to":[31,54,95,105,120,144,156],"directly":[32,129],"detect":[33],"enzymatic":[34,85],"reactions":[35],"and,":[36],"first":[39],"time,":[40],"derive":[41],"kinetic":[42],"parameters.":[43],"While":[44],"many":[45],"methods":[46],"biomedical":[48],"assays":[49],"rely":[50],"on":[51,174],"detectable":[52],"biproducts":[53],"produce":[55],"signal,":[57],"direct":[58,206],"detection":[59],"possible":[61],"if":[62],"substrate":[64,209],"or":[65],"product":[67],"exert":[68],"distinct":[69],"differences":[70],"their":[72],"specific":[73],"so":[76],"total":[79],"during":[83],"reaction.":[86],"In":[87],"this":[88,188],"study,":[89],"both":[90],"conversion":[92,102,126],"glucose":[94,121],"glucose-6-phosphate,":[96],"catalyzed":[97,110],"by":[98,111,115,131],"hexokinase,":[99],"and":[100,108,139,211],"adenosine-triphosphate":[104],"adenosine":[106],"di-phosphate":[107],"mono-phosphate,":[109],"apyrase,":[112],"were":[113],"monitored":[114],"BSI.":[116],"When":[117],"adding":[118],"hexokinase":[119],"solutions":[122],"containing":[123],"adenosine-triphosphate,":[124],"followed":[130],"BSI,":[132],"which":[133],"shows":[134],"increasing":[136],"final":[141],"plateau":[142],"corresponding":[143],"particular":[146],"concentration.":[147],"From":[148],"initial":[150],"reaction":[151],"velocities,":[152],"<i>K<sub>M</sub></i>":[153],"was":[154],"found":[155],"0.33":[158],"mM":[159],"using":[160,187],"Michaelis\u207bMenten":[161],"kinetics.":[162,213],"The":[163],"experiments":[164],"with":[165],"apyrase":[166],"indicate":[167],"also":[172],"depends":[173],"presence":[176],"various":[178],"ions":[179],"must":[181],"taken":[183],"into":[184],"account":[185],"when":[186],"technique.":[189],"This":[190],"study":[191],"clearly":[192],"demonstrates":[193],"measuring":[195],"determination":[207],"concentrations":[210],"enzyme":[212]},"counts_by_year":[{"year":2022,"cited_by_count":3},{"year":2020,"cited_by_count":1}],"updated_date":"2026-04-04T16:13:02.066488","created_date":"2025-10-10T00:00:00"}
