{"id":"https://openalex.org/W2902948188","doi":"https://doi.org/10.3390/s18124248","title":"Suppression Technique of HeLa Cell Proliferation Using Ultrasonic Power Amplifiers Integrated with a Series-Diode Linearizer","display_name":"Suppression Technique of HeLa Cell Proliferation Using Ultrasonic Power Amplifiers Integrated with a Series-Diode Linearizer","publication_year":2018,"publication_date":"2018-12-03","ids":{"openalex":"https://openalex.org/W2902948188","doi":"https://doi.org/10.3390/s18124248","mag":"2902948188","pmid":"https://pubmed.ncbi.nlm.nih.gov/30513959"},"language":"en","primary_location":{"id":"doi:10.3390/s18124248","is_oa":true,"landing_page_url":"https://doi.org/10.3390/s18124248","pdf_url":null,"source":{"id":"https://openalex.org/S101949793","display_name":"Sensors","issn_l":"1424-8220","issn":["1424-8220"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sensors","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.3390/s18124248","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5025292160","display_name":"Se\u2010woon Choe","orcid":"https://orcid.org/0000-0002-7298-4147"},"institutions":[{"id":"https://openalex.org/I113409471","display_name":"Kumoh National Institute of Technology","ror":"https://ror.org/05dkjfz60","country_code":"KR","type":"education","lineage":["https://openalex.org/I113409471"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Se-woon Choe","raw_affiliation_strings":["Department of Medical IT Convergence Engineering, Kumoh National Institute of Technology, Gumi-Daero 350-27, Gumi 39253, Korea"],"raw_orcid":"https://orcid.org/0000-0002-7298-4147","affiliations":[{"raw_affiliation_string":"Department of Medical IT Convergence Engineering, Kumoh National Institute of Technology, Gumi-Daero 350-27, Gumi 39253, Korea","institution_ids":["https://openalex.org/I113409471"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101887930","display_name":"Hojong Choi","orcid":"https://orcid.org/0000-0003-1955-7696"},"institutions":[{"id":"https://openalex.org/I113409471","display_name":"Kumoh National Institute of Technology","ror":"https://ror.org/05dkjfz60","country_code":"KR","type":"education","lineage":["https://openalex.org/I113409471"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Hojong Choi","raw_affiliation_strings":["Department of Medical IT Convergence Engineering, Kumoh National Institute of Technology, Gumi-Daero 350-27, Gumi 39253, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical IT Convergence Engineering, Kumoh National Institute of Technology, Gumi-Daero 350-27, Gumi 39253, Korea","institution_ids":["https://openalex.org/I113409471"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5101887930"],"corresponding_institution_ids":["https://openalex.org/I113409471"],"apc_list":{"value":2400,"currency":"CHF","value_usd":2598},"apc_paid":{"value":2400,"currency":"CHF","value_usd":2598},"fwci":1.5601,"has_fulltext":false,"cited_by_count":22,"citation_normalized_percentile":{"value":0.82384998,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":99},"biblio":{"volume":"18","issue":"12","first_page":"4248","last_page":"4248"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10958","display_name":"Ultrasound and Hyperthermia Applications","score":0.9976999759674072,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10958","display_name":"Ultrasound and Hyperthermia Applications","score":0.9976999759674072,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11842","display_name":"Ultrasound and Cavitation Phenomena","score":0.9940000176429749,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10727","display_name":"Ultrasound Imaging and Elastography","score":0.9914000034332275,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/linearizer","display_name":"Linearizer","score":0.9804553985595703},{"id":"https://openalex.org/keywords/ultrasonic-sensor","display_name":"Ultrasonic sensor","score":0.7688969373703003},{"id":"https://openalex.org/keywords/amplifier","display_name":"Amplifier","score":0.7426213622093201},{"id":"https://openalex.org/keywords/materials-science","display_name":"Materials science","score":0.47598472237586975},{"id":"https://openalex.org/keywords/current-sense-amplifier","display_name":"Current sense amplifier","score":0.41982704401016235},{"id":"https://openalex.org/keywords/electrical-engineering","display_name":"Electrical engineering","score":0.3439573645591736},{"id":"https://openalex.org/keywords/electronic-engineering","display_name":"Electronic engineering","score":0.3217076063156128},{"id":"https://openalex.org/keywords/engineering","display_name":"Engineering","score":0.279636949300766},{"id":"https://openalex.org/keywords/optoelectronics","display_name":"Optoelectronics","score":0.2741868197917938},{"id":"https://openalex.org/keywords/acoustics","display_name":"Acoustics","score":0.2194693386554718},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.17143771052360535},{"id":"https://openalex.org/keywords/operational-amplifier","display_name":"Operational amplifier","score":0.16794145107269287},{"id":"https://openalex.org/keywords/predistortion","display_name":"Predistortion","score":0.10171562433242798}],"concepts":[{"id":"https://openalex.org/C2776193875","wikidata":"https://www.wikidata.org/wiki/Q17010244","display_name":"Linearizer","level":5,"score":0.9804553985595703},{"id":"https://openalex.org/C81288441","wikidata":"https://www.wikidata.org/wiki/Q20736125","display_name":"Ultrasonic sensor","level":2,"score":0.7688969373703003},{"id":"https://openalex.org/C194257627","wikidata":"https://www.wikidata.org/wiki/Q211554","display_name":"Amplifier","level":3,"score":0.7426213622093201},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.47598472237586975},{"id":"https://openalex.org/C182442803","wikidata":"https://www.wikidata.org/wiki/Q5195113","display_name":"Current sense amplifier","level":5,"score":0.41982704401016235},{"id":"https://openalex.org/C119599485","wikidata":"https://www.wikidata.org/wiki/Q43035","display_name":"Electrical engineering","level":1,"score":0.3439573645591736},{"id":"https://openalex.org/C24326235","wikidata":"https://www.wikidata.org/wiki/Q126095","display_name":"Electronic engineering","level":1,"score":0.3217076063156128},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.279636949300766},{"id":"https://openalex.org/C49040817","wikidata":"https://www.wikidata.org/wiki/Q193091","display_name":"Optoelectronics","level":1,"score":0.2741868197917938},{"id":"https://openalex.org/C24890656","wikidata":"https://www.wikidata.org/wiki/Q82811","display_name":"Acoustics","level":1,"score":0.2194693386554718},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.17143771052360535},{"id":"https://openalex.org/C145366948","wikidata":"https://www.wikidata.org/wiki/Q178947","display_name":"Operational amplifier","level":4,"score":0.16794145107269287},{"id":"https://openalex.org/C2778587875","wikidata":"https://www.wikidata.org/wiki/Q7239686","display_name":"Predistortion","level":4,"score":0.10171562433242798},{"id":"https://openalex.org/C46362747","wikidata":"https://www.wikidata.org/wiki/Q173431","display_name":"CMOS","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000669","descriptor_name":"Amplifiers, Electronic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000669","descriptor_name":"Amplifiers, Electronic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000669","descriptor_name":"Amplifiers, Electronic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002452","descriptor_name":"Cell Count","qualifier_ui":"Q000295","qualifier_name":"instrumentation","is_major_topic":false},{"descriptor_ui":"D002452","descriptor_name":"Cell Count","qualifier_ui":"Q000295","qualifier_name":"instrumentation","is_major_topic":false},{"descriptor_ui":"D002452","descriptor_name":"Cell Count","qualifier_ui":"Q000295","qualifier_name":"instrumentation","is_major_topic":false},{"descriptor_ui":"D006367","descriptor_name":"HeLa Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006367","descriptor_name":"HeLa Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006367","descriptor_name":"HeLa Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012815","descriptor_name":"Signal Processing, Computer-Assisted","qualifier_ui":"Q000295","qualifier_name":"instrumentation","is_major_topic":false},{"descriptor_ui":"D012815","descriptor_name":"Signal Processing, Computer-Assisted","qualifier_ui":"Q000295","qualifier_name":"instrumentation","is_major_topic":false},{"descriptor_ui":"D012815","descriptor_name":"Signal Processing, Computer-Assisted","qualifier_ui":"Q000295","qualifier_name":"instrumentation","is_major_topic":false},{"descriptor_ui":"D014465","descriptor_name":"Ultrasonics","qualifier_ui":"Q000295","qualifier_name":"instrumentation","is_major_topic":false},{"descriptor_ui":"D014465","descriptor_name":"Ultrasonics","qualifier_ui":"Q000295","qualifier_name":"instrumentation","is_major_topic":false},{"descriptor_ui":"D014465","descriptor_name":"Ultrasonics","qualifier_ui":"Q000295","qualifier_name":"instrumentation","is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.3390/s18124248","is_oa":true,"landing_page_url":"https://doi.org/10.3390/s18124248","pdf_url":null,"source":{"id":"https://openalex.org/S101949793","display_name":"Sensors","issn_l":"1424-8220","issn":["1424-8220"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sensors","raw_type":"journal-article"},{"id":"pmid:30513959","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30513959","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sensors (Basel, Switzerland)","raw_type":null},{"id":"pmh:oai:doaj.org/article:b4ff3051d8004bf8aea88c801d52f93f","is_oa":true,"landing_page_url":"https://doaj.org/article/b4ff3051d8004bf8aea88c801d52f93f","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Sensors, Vol 18, Iss 12, p 4248 (2018)","raw_type":"article"},{"id":"pmh:oai:europepmc.org:5291946","is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC6308487","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:mdpi.com:/1424-8220/18/12/4248/","is_oa":true,"landing_page_url":"http://dx.doi.org/10.3390/s18124248","pdf_url":null,"source":{"id":"https://openalex.org/S4306400947","display_name":"MDPI (MDPI AG)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210097602","host_organization_name":"Multidisciplinary Digital Publishing Institute (Switzerland)","host_organization_lineage":["https://openalex.org/I4210097602"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Sensors","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:6308487","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6308487","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Sensors (Basel)","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.3390/s18124248","is_oa":true,"landing_page_url":"https://doi.org/10.3390/s18124248","pdf_url":null,"source":{"id":"https://openalex.org/S101949793","display_name":"Sensors","issn_l":"1424-8220","issn":["1424-8220"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sensors","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/7","score":0.5400000214576721,"display_name":"Affordable and clean energy"}],"awards":[{"id":"https://openalex.org/G1587643404","display_name":null,"funder_award_id":"2017R1C1B1003606","funder_id":"https://openalex.org/F4320322120","funder_display_name":"National Research Foundation of Korea"},{"id":"https://openalex.org/G1948346738","display_name":null,"funder_award_id":"2016R1D1A1B03934950","funder_id":"https://openalex.org/F4320322120","funder_display_name":"National Research Foundation of Korea"}],"funders":[{"id":"https://openalex.org/F4320322120","display_name":"National Research Foundation of Korea","ror":"https://ror.org/013aysd81"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":17,"referenced_works":["https://openalex.org/W1260083798","https://openalex.org/W1530233944","https://openalex.org/W1967632378","https://openalex.org/W1987104507","https://openalex.org/W2023923048","https://openalex.org/W2029276624","https://openalex.org/W2048557326","https://openalex.org/W2100044517","https://openalex.org/W2110155791","https://openalex.org/W2119575462","https://openalex.org/W2406101030","https://openalex.org/W2410786902","https://openalex.org/W2532061108","https://openalex.org/W2552703134","https://openalex.org/W2752033959","https://openalex.org/W2766403853","https://openalex.org/W6744132644"],"related_works":["https://openalex.org/W2775167734","https://openalex.org/W2148583833","https://openalex.org/W3137445666","https://openalex.org/W2102454024","https://openalex.org/W2536229131","https://openalex.org/W994323718","https://openalex.org/W2354047607","https://openalex.org/W200089558","https://openalex.org/W2022738546","https://openalex.org/W2100482915"],"abstract_inverted_index":{"A":[0],"series-diode":[1],"linearizer":[2,25,113,186,197],"scheme":[3],"is":[4],"developed,":[5],"which":[6,43],"can":[7,44,55],"possibly":[8],"generate":[9],"higher":[10],"voltage":[11],"signals.":[12],"To":[13],"verify":[14],"our":[15],"proposed":[16],"concept,":[17],"ultrasonic":[18,36,75,103,107,133,179,190],"power":[19,104,108,134,175,180,191],"amplifiers":[20,109],"with":[21,111,182,193],"and":[22,48,106,117,142,189],"without":[23],"the":[24,39,81,96,112,148,158,163,171],"were":[26],"tested":[27],"for":[28],"HeLa":[29],"cells":[30,70],"proliferation":[31,149],"in":[32],"vitro.":[33],"In":[34],"general,":[35],"stimulus":[37],"initiates":[38],"process":[40],"of":[41,50,59,67,80,95,152,162],"cavitation":[42,54],"cause":[45],"cell":[46,51,78,93,159],"lysis":[47],"disruption":[49],"attachment.":[52],"The":[53,77],"also":[56],"induce":[57],"formation":[58],"free":[60],"radicals":[61],"so":[62],"that":[63,129,157],"a":[64],"rigid":[65],"membrane":[66],"malignant":[68],"cancer":[69],"have":[71],"increased":[72,84],"sensitivity":[73],"to":[74,86,170],"stimulus.":[76],"density":[79,160],"control":[82,172],"group":[83,98,155,173],"up":[85],"almost":[87],"100%":[88],"on":[89],"Day":[90],"3.":[91],"However,":[92],"densities":[94],"experimental":[97,154,164],"when":[99,130],"using":[100,131],"an":[101,132],"isolated":[102],"amplifier,":[105],"integrated":[110],"at":[114],"1":[115,183],"V":[116,119,184,195],"5":[118,194],"DC":[120],"(direct":[121],"current)":[122],"bias":[123],"could":[124],"be":[125],"suppressed":[126],"more":[127],"than":[128],"amplifier":[135,176,181,192],"(90.7":[136],"\u00b1":[137,140,144],"1.2%,":[138],"75.8":[139],"3.5%,":[141],"68.1":[143],"1.1%,":[145],"respectively).":[146],"Additionally,":[147],"suppressing":[150],"ratios":[151],"each":[153],"confirmed":[156],"decrements":[161],"groups":[165],"exhibited":[166],"statistical":[167],"significance":[168],"compared":[169],"(ultrasonic":[174],"=":[177,187,198],"8.87%,":[178],"biased":[185,196],"23.87%,":[188],"31.56%).":[199]},"counts_by_year":[{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":6}],"updated_date":"2026-05-06T08:25:59.206177","created_date":"2025-10-10T00:00:00"}