{"id":"https://openalex.org/W2555966613","doi":"https://doi.org/10.3390/s16111916","title":"Optimized Detection of Plasmodium falciparum Topoisomerase I Enzyme Activity in a Complex Biological Sample by the Use of Molecular Beacons","display_name":"Optimized Detection of Plasmodium falciparum Topoisomerase I Enzyme Activity in a Complex Biological Sample by the Use of Molecular Beacons","publication_year":2016,"publication_date":"2016-11-15","ids":{"openalex":"https://openalex.org/W2555966613","doi":"https://doi.org/10.3390/s16111916","mag":"2555966613","pmid":"https://pubmed.ncbi.nlm.nih.gov/27854277"},"language":"en","primary_location":{"id":"doi:10.3390/s16111916","is_oa":true,"landing_page_url":"https://doi.org/10.3390/s16111916","pdf_url":"https://www.mdpi.com/1424-8220/16/11/1916/pdf?version=1479199761","source":{"id":"https://openalex.org/S101949793","display_name":"Sensors","issn_l":"1424-8220","issn":["1424-8220"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sensors","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/1424-8220/16/11/1916/pdf?version=1479199761","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5108109761","display_name":"Asger Givskov","orcid":null},"institutions":[{"id":"https://openalex.org/I204337017","display_name":"Aarhus University","ror":"https://ror.org/01aj84f44","country_code":"DK","type":"education","lineage":["https://openalex.org/I204337017"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Asger Givskov","raw_affiliation_strings":["Department of Molecular Biology and Genetics, Aarhus University, 8000 Aarhus C, Denmark"],"affiliations":[{"raw_affiliation_string":"Department of Molecular Biology and Genetics, Aarhus University, 8000 Aarhus C, Denmark","institution_ids":["https://openalex.org/I204337017"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011564713","display_name":"Emil L. Kristoffersen","orcid":"https://orcid.org/0000-0001-8965-8201"},"institutions":[{"id":"https://openalex.org/I204337017","display_name":"Aarhus University","ror":"https://ror.org/01aj84f44","country_code":"DK","type":"education","lineage":["https://openalex.org/I204337017"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Emil Kristoffersen","raw_affiliation_strings":["Department of Molecular Biology and Genetics, Aarhus University, 8000 Aarhus C, Denmark"],"affiliations":[{"raw_affiliation_string":"Department of Molecular Biology and Genetics, Aarhus University, 8000 Aarhus C, Denmark","institution_ids":["https://openalex.org/I204337017"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045586778","display_name":"Kamilla Vands\u00f8","orcid":null},"institutions":[{"id":"https://openalex.org/I204337017","display_name":"Aarhus University","ror":"https://ror.org/01aj84f44","country_code":"DK","type":"education","lineage":["https://openalex.org/I204337017"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Kamilla Vands\u00f8","raw_affiliation_strings":["Department of Molecular Biology and Genetics, Aarhus University, 8000 Aarhus C, Denmark"],"affiliations":[{"raw_affiliation_string":"Department of Molecular Biology and Genetics, Aarhus University, 8000 Aarhus C, Denmark","institution_ids":["https://openalex.org/I204337017"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026619357","display_name":"Yi\u2010Ping Ho","orcid":"https://orcid.org/0000-0002-2052-9724"},"institutions":[{"id":"https://openalex.org/I177725633","display_name":"Chinese University of Hong Kong","ror":"https://ror.org/00t33hh48","country_code":"HK","type":"education","lineage":["https://openalex.org/I177725633"]}],"countries":["HK"],"is_corresponding":false,"raw_author_name":"Yi-Ping Ho","raw_affiliation_strings":["Division of Biomedical Engineering, Department of Electronic Engineering, The Chinese University of Hong Kong, Shatin, New Territories 999077, Hong Kong, China"],"affiliations":[{"raw_affiliation_string":"Division of Biomedical Engineering, Department of Electronic Engineering, The Chinese University of Hong Kong, Shatin, New Territories 999077, Hong Kong, China","institution_ids":["https://openalex.org/I177725633"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030626300","display_name":"Magnus Stougaard","orcid":"https://orcid.org/0000-0001-7456-902X"},"institutions":[{"id":"https://openalex.org/I2802335433","display_name":"Aarhus University Hospital","ror":"https://ror.org/040r8fr65","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2802335433"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Magnus Stougaard","raw_affiliation_strings":["Department of Pathology, Aarhus University Hospital, 8000 Aarhus C, Denmark"],"affiliations":[{"raw_affiliation_string":"Department of Pathology, Aarhus University Hospital, 8000 Aarhus C, Denmark","institution_ids":["https://openalex.org/I2802335433"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5080879530","display_name":"Birgitta R. Knudsen","orcid":"https://orcid.org/0000-0002-3484-3802"},"institutions":[{"id":"https://openalex.org/I204337017","display_name":"Aarhus University","ror":"https://ror.org/01aj84f44","country_code":"DK","type":"education","lineage":["https://openalex.org/I204337017"]}],"countries":["DK"],"is_corresponding":true,"raw_author_name":"Birgitta Knudsen","raw_affiliation_strings":["Department of Molecular Biology and Genetics, Aarhus University, 8000 Aarhus C, Denmark"],"affiliations":[{"raw_affiliation_string":"Department of Molecular Biology and Genetics, Aarhus University, 8000 Aarhus C, Denmark","institution_ids":["https://openalex.org/I204337017"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5080879530"],"corresponding_institution_ids":["https://openalex.org/I204337017"],"apc_list":{"value":2400,"currency":"CHF","value_usd":2598},"apc_paid":{"value":2400,"currency":"CHF","value_usd":2598},"fwci":1.0459,"has_fulltext":true,"cited_by_count":11,"citation_normalized_percentile":{"value":0.79319586,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":97},"biblio":{"volume":"16","issue":"11","first_page":"1916","last_page":"1916"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11845","display_name":"Cancer therapeutics and mechanisms","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11845","display_name":"Cancer therapeutics and mechanisms","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10207","display_name":"Advanced biosensing and bioanalysis techniques","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10432","display_name":"DNA and Nucleic Acid Chemistry","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/molecular-beacon","display_name":"Molecular beacon","score":0.9413645267486572},{"id":"https://openalex.org/keywords/rolling-circle-replication","display_name":"Rolling circle replication","score":0.7601872682571411},{"id":"https://openalex.org/keywords/plasmodium-falciparum","display_name":"Plasmodium falciparum","score":0.7242913246154785},{"id":"https://openalex.org/keywords/beacon","display_name":"Beacon","score":0.6539943218231201},{"id":"https://openalex.org/keywords/fluorescence","display_name":"Fluorescence","score":0.5288535356521606},{"id":"https://openalex.org/keywords/topoisomerase","display_name":"Topoisomerase","score":0.5191389918327332},{"id":"https://openalex.org/keywords/dna","display_name":"DNA","score":0.5139696002006531},{"id":"https://openalex.org/keywords/fluorometer","display_name":"Fluorometer","score":0.5011851787567139},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.4923008680343628},{"id":"https://openalex.org/keywords/hybridization-probe","display_name":"Hybridization probe","score":0.44186466932296753},{"id":"https://openalex.org/keywords/biological-system","display_name":"Biological system","score":0.42648884654045105},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.4180937707424164},{"id":"https://openalex.org/keywords/molecular-biology","display_name":"Molecular biology","score":0.34825563430786133},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.34203416109085083},{"id":"https://openalex.org/keywords/malaria","display_name":"Malaria","score":0.320826917886734},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.298458456993103},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.22621572017669678},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.22458416223526},{"id":"https://openalex.org/keywords/optics","display_name":"Optics","score":0.10671105980873108},{"id":"https://openalex.org/keywords/real-time-computing","display_name":"Real-time computing","score":0.09530773758888245}],"concepts":[{"id":"https://openalex.org/C119203544","wikidata":"https://www.wikidata.org/wiki/Q425891","display_name":"Molecular beacon","level":4,"score":0.9413645267486572},{"id":"https://openalex.org/C7452308","wikidata":"https://www.wikidata.org/wiki/Q3112822","display_name":"Rolling circle replication","level":4,"score":0.7601872682571411},{"id":"https://openalex.org/C2778371730","wikidata":"https://www.wikidata.org/wiki/Q311383","display_name":"Plasmodium falciparum","level":3,"score":0.7242913246154785},{"id":"https://openalex.org/C102168758","wikidata":"https://www.wikidata.org/wiki/Q7321258","display_name":"Beacon","level":2,"score":0.6539943218231201},{"id":"https://openalex.org/C91881484","wikidata":"https://www.wikidata.org/wiki/Q191807","display_name":"Fluorescence","level":2,"score":0.5288535356521606},{"id":"https://openalex.org/C147897179","wikidata":"https://www.wikidata.org/wiki/Q407828","display_name":"Topoisomerase","level":3,"score":0.5191389918327332},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.5139696002006531},{"id":"https://openalex.org/C202800777","wikidata":"https://www.wikidata.org/wiki/Q1781297","display_name":"Fluorometer","level":3,"score":0.5011851787567139},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4923008680343628},{"id":"https://openalex.org/C130197536","wikidata":"https://www.wikidata.org/wiki/Q418436","display_name":"Hybridization probe","level":3,"score":0.44186466932296753},{"id":"https://openalex.org/C186060115","wikidata":"https://www.wikidata.org/wiki/Q30336093","display_name":"Biological system","level":1,"score":0.42648884654045105},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4180937707424164},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.34825563430786133},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.34203416109085083},{"id":"https://openalex.org/C2778048844","wikidata":"https://www.wikidata.org/wiki/Q12156","display_name":"Malaria","level":2,"score":0.320826917886734},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.298458456993103},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.22621572017669678},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.22458416223526},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.10671105980873108},{"id":"https://openalex.org/C79403827","wikidata":"https://www.wikidata.org/wiki/Q3988","display_name":"Real-time computing","level":1,"score":0.09530773758888245},{"id":"https://openalex.org/C73573662","wikidata":"https://www.wikidata.org/wiki/Q130996","display_name":"DNA replication","level":3,"score":0.0},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.0},{"id":"https://openalex.org/C129312508","wikidata":"https://www.wikidata.org/wiki/Q133686","display_name":"Oligonucleotide","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D004264","descriptor_name":"DNA Topoisomerases, Type I","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004264","descriptor_name":"DNA Topoisomerases, Type I","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004264","descriptor_name":"DNA Topoisomerases, Type I","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004264","descriptor_name":"DNA Topoisomerases, Type I","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004264","descriptor_name":"DNA Topoisomerases, Type I","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004264","descriptor_name":"DNA Topoisomerases, Type I","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005470","descriptor_name":"Fluorometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005470","descriptor_name":"Fluorometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005470","descriptor_name":"Fluorometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008288","descriptor_name":"Malaria","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D008288","descriptor_name":"Malaria","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D008288","descriptor_name":"Malaria","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D010963","descriptor_name":"Plasmodium falciparum","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D010963","descriptor_name":"Plasmodium falciparum","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D010963","descriptor_name":"Plasmodium falciparum","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D015374","descriptor_name":"Biosensing Techniques","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D015374","descriptor_name":"Biosensing Techniques","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D015374","descriptor_name":"Biosensing Techniques","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D021141","descriptor_name":"Nucleic Acid Amplification Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D021141","descriptor_name":"Nucleic Acid Amplification Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D021141","descriptor_name":"Nucleic Acid Amplification Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.3390/s16111916","is_oa":true,"landing_page_url":"https://doi.org/10.3390/s16111916","pdf_url":"https://www.mdpi.com/1424-8220/16/11/1916/pdf?version=1479199761","source":{"id":"https://openalex.org/S101949793","display_name":"Sensors","issn_l":"1424-8220","issn":["1424-8220"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sensors","raw_type":"journal-article"},{"id":"pmid:27854277","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27854277","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sensors (Basel, Switzerland)","raw_type":null},{"id":"pmh:oai:pure.atira.dk:openaire/23cd32c1-c1ab-4ec9-8ef1-6686c9f9ad1c","is_oa":true,"landing_page_url":"https://pure.au.dk/portal/en/publications/23cd32c1-c1ab-4ec9-8ef1-6686c9f9ad1c","pdf_url":null,"source":null,"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J\u00f8rgensen, A G, Kristoffersen, E L, Petersen, K V, Ho, Y-P, Stougaard, M & Knudsen, B R 2016, 'Optimized Detection of Plasmodium falciparum Topoisomerase I Enzyme Activity in a Complex Biological Sample by the Use of Molecular Beacons', Sensors, vol. 16, no. 11, 1916. https://doi.org/10.3390/s16111916","raw_type":"info:eu-repo/semantics/publishedVersion"},{"id":"pmh:oai:doaj.org/article:50bf8340515f4ef89e977759c0f0a315","is_oa":true,"landing_page_url":"https://doaj.org/article/50bf8340515f4ef89e977759c0f0a315","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Sensors, Vol 16, Iss 11, p 1916 (2016)","raw_type":"article"},{"id":"pmh:oai:mdpi.com:/1424-8220/16/11/1916/","is_oa":true,"landing_page_url":"https://dx.doi.org/10.3390/s16111916","pdf_url":null,"source":{"id":"https://openalex.org/S4306400947","display_name":"MDPI (MDPI AG)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210097602","host_organization_name":"Multidisciplinary Digital Publishing Institute (Switzerland)","host_organization_lineage":["https://openalex.org/I4210097602"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Sensors; Volume 16; Issue 11; Pages: 1916","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:5134575","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5134575","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Sensors (Basel)","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.3390/s16111916","is_oa":true,"landing_page_url":"https://doi.org/10.3390/s16111916","pdf_url":"https://www.mdpi.com/1424-8220/16/11/1916/pdf?version=1479199761","source":{"id":"https://openalex.org/S101949793","display_name":"Sensors","issn_l":"1424-8220","issn":["1424-8220"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sensors","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.8199999928474426,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"awards":[{"id":"https://openalex.org/G6757166815","display_name":null,"funder_award_id":"start-up","funder_id":"https://openalex.org/F4320322942","funder_display_name":"Chinese University of Hong Kong"}],"funders":[{"id":"https://openalex.org/F4320309761","display_name":"Dagmar Marshalls Fond","ror":null},{"id":"https://openalex.org/F4320322314","display_name":"Karen Elise Jensens Fond","ror":"https://ror.org/00kaqnj29"},{"id":"https://openalex.org/F4320322942","display_name":"Chinese University of Hong Kong","ror":"https://ror.org/00t33hh48"},{"id":"https://openalex.org/F4320326368","display_name":"Familien Erichsens Mindefond","ror":null}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2555966613.pdf","grobid_xml":"https://content.openalex.org/works/W2555966613.grobid-xml"},"referenced_works_count":46,"referenced_works":["https://openalex.org/W1520883967","https://openalex.org/W1575228817","https://openalex.org/W1608352093","https://openalex.org/W1764637697","https://openalex.org/W1970514767","https://openalex.org/W1971256828","https://openalex.org/W1981952398","https://openalex.org/W1983060533","https://openalex.org/W1989799325","https://openalex.org/W1996458190","https://openalex.org/W2004377350","https://openalex.org/W2004412500","https://openalex.org/W2010974451","https://openalex.org/W2018806650","https://openalex.org/W2018844669","https://openalex.org/W2023041614","https://openalex.org/W2026710381","https://openalex.org/W2027001273","https://openalex.org/W2034671935","https://openalex.org/W2038311101","https://openalex.org/W2042273260","https://openalex.org/W2049825818","https://openalex.org/W2050833116","https://openalex.org/W2056813411","https://openalex.org/W2076333033","https://openalex.org/W2078234460","https://openalex.org/W2079271073","https://openalex.org/W2081325029","https://openalex.org/W2085696271","https://openalex.org/W2103793558","https://openalex.org/W2113646543","https://openalex.org/W2114938026","https://openalex.org/W2131060469","https://openalex.org/W2131629478","https://openalex.org/W2132600317","https://openalex.org/W2139614344","https://openalex.org/W2146274229","https://openalex.org/W2148312059","https://openalex.org/W2154892443","https://openalex.org/W2160696559","https://openalex.org/W2161953634","https://openalex.org/W2166996651","https://openalex.org/W2422608197","https://openalex.org/W2486444003","https://openalex.org/W2521258978","https://openalex.org/W6636466646"],"related_works":["https://openalex.org/W4230883443","https://openalex.org/W2030863896","https://openalex.org/W3119520818","https://openalex.org/W2887331731","https://openalex.org/W3167158237","https://openalex.org/W2010974451","https://openalex.org/W2171758033","https://openalex.org/W3016254390","https://openalex.org/W302496292","https://openalex.org/W2199273067"],"abstract_inverted_index":{"The":[0,41,144],"so-called":[1],"Rolling":[2,54,84,179],"Circle":[3,55,85,180],"Amplification":[4,56,86,181],"allows":[5],"for":[6,111,157,174],"amplification":[7,39],"of":[8,29,43,74,98,106,116,119,133,152,177],"circular":[9],"DNA":[10,31],"structures":[11],"in":[12,19,48,62,91,130],"a":[13,49,63,149],"manner":[14],"that":[15,25],"can":[16,59],"be":[17,60,170],"detected":[18],"real-time":[20,175],"using":[21,75],"nucleotide-based":[22],"molecular":[23,45,78],"beacons":[24,46,79],"unfold":[26],"upon":[27],"recognition":[28],"the":[30,38,44,53,66,72,92,104,117,120,125,131,138,153,167],"product,":[32],"which":[33],"is":[34],"being":[35],"produced":[36],"during":[37],"process.":[40],"unfolding":[42],"results":[47,146],"fluorescence":[50,99],"increase":[51],"as":[52],"proceeds.":[57],"This":[58],"measured":[61],"fluorometer.":[64],"In":[65,164],"current":[67],"study,":[68],"we":[69],"have":[70],"investigated":[71],"possibility":[73],"two":[76,82],"different":[77],"to":[80],"detect":[81],"distinct":[83],"reactions":[87],"proceeding":[88],"simultaneously":[89],"and":[90,113],"same":[93],"reaction":[94],"tube":[95],"by":[96],"measurement":[97],"over":[100],"time.":[101],"We":[102],"demonstrate":[103],"application":[105],"this":[107],"fluorometric":[108],"readout":[109],"method,":[110],"automated":[112],"specific":[114],"detection":[115],"activity":[118],"type":[121],"IB":[122],"topoisomerase":[123,140],"from":[124,142],"malaria":[126,158],"parasite":[127],"<i>Plasmodium":[128],"falciparum</i>":[129],"presence":[132],"human":[134],"cell":[135],"extract":[136],"containing":[137],"related":[139],"I":[141],"humans.":[143],"obtained":[145],"point":[147],"towards":[148],"future":[150],"use":[151],"presented":[154],"assay":[155],"setup":[156],"diagnostics":[159],"or":[160],"drug":[161],"screening":[162],"purposes.":[163],"longer":[165],"terms":[166],"method":[168],"may":[169],"applied":[171],"more":[172],"broadly":[173],"sensing":[176],"various":[178],"reactions.":[182]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":3}],"updated_date":"2026-04-10T15:06:20.359241","created_date":"2025-10-10T00:00:00"}