{"id":"https://openalex.org/W2156821455","doi":"https://doi.org/10.3390/s141222982","title":"Formation of DNA Adducts by Ellipticine and Its Micellar Form in Rats \u2014 A Comparative Study","display_name":"Formation of DNA Adducts by Ellipticine and Its Micellar Form in Rats \u2014 A Comparative Study","publication_year":2014,"publication_date":"2014-12-03","ids":{"openalex":"https://openalex.org/W2156821455","doi":"https://doi.org/10.3390/s141222982","mag":"2156821455","pmid":"https://pubmed.ncbi.nlm.nih.gov/25479328"},"language":"en","primary_location":{"id":"doi:10.3390/s141222982","is_oa":true,"landing_page_url":"https://doi.org/10.3390/s141222982","pdf_url":"https://www.mdpi.com/1424-8220/14/12/22982/pdf?version=1417604534","source":{"id":"https://openalex.org/S101949793","display_name":"Sensors","issn_l":"1424-8220","issn":["1424-8220"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sensors","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/1424-8220/14/12/22982/pdf?version=1417604534","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5009212415","display_name":"Marie Stiborov\u00e1","orcid":"https://orcid.org/0000-0001-5430-4403"},"institutions":[{"id":"https://openalex.org/I21250087","display_name":"Charles University","ror":"https://ror.org/024d6js02","country_code":"CZ","type":"education","lineage":["https://openalex.org/I21250087"]}],"countries":["CZ"],"is_corresponding":true,"raw_author_name":"Marie Stiborova","raw_affiliation_strings":["Department of Biochemistry, Faculty of Science, Charles University, Albertov 2030,  CZ-128-40 Prague 2, Czech Republic","Department of Biochemistry, Faculty of Science, Charles University, Albertov 2030, CZ-128-40 Prague 2, Czech Republic"],"raw_orcid":"https://orcid.org/0000-0001-5430-4403","affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Faculty of Science, Charles University, Albertov 2030,  CZ-128-40 Prague 2, Czech Republic","institution_ids":["https://openalex.org/I21250087"]},{"raw_affiliation_string":"Department of Biochemistry, Faculty of Science, Charles University, Albertov 2030, CZ-128-40 Prague 2, Czech Republic","institution_ids":["https://openalex.org/I21250087"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008258179","display_name":"Zuzana Manhartova","orcid":null},"institutions":[{"id":"https://openalex.org/I21250087","display_name":"Charles University","ror":"https://ror.org/024d6js02","country_code":"CZ","type":"education","lineage":["https://openalex.org/I21250087"]}],"countries":["CZ"],"is_corresponding":false,"raw_author_name":"Zuzana Manhartova","raw_affiliation_strings":["Department of Biochemistry, Faculty of Science, Charles University, Albertov 2030,  CZ-128-40 Prague 2, Czech Republic","Department of Biochemistry, Faculty of Science, Charles University, Albertov 2030, CZ-128-40 Prague 2, Czech Republic"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Faculty of Science, Charles University, Albertov 2030,  CZ-128-40 Prague 2, Czech Republic","institution_ids":["https://openalex.org/I21250087"]},{"raw_affiliation_string":"Department of Biochemistry, Faculty of Science, Charles University, Albertov 2030, CZ-128-40 Prague 2, Czech Republic","institution_ids":["https://openalex.org/I21250087"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025449624","display_name":"Petr Hodek","orcid":"https://orcid.org/0000-0003-3449-4697"},"institutions":[{"id":"https://openalex.org/I21250087","display_name":"Charles University","ror":"https://ror.org/024d6js02","country_code":"CZ","type":"education","lineage":["https://openalex.org/I21250087"]}],"countries":["CZ"],"is_corresponding":false,"raw_author_name":"Petr Hodek","raw_affiliation_strings":["Department of Biochemistry, Faculty of Science, Charles University, Albertov 2030,  CZ-128-40 Prague 2, Czech Republic","Department of Biochemistry, Faculty of Science, Charles University, Albertov 2030, CZ-128-40 Prague 2, Czech Republic"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Faculty of Science, Charles University, Albertov 2030,  CZ-128-40 Prague 2, Czech Republic","institution_ids":["https://openalex.org/I21250087"]},{"raw_affiliation_string":"Department of Biochemistry, Faculty of Science, Charles University, Albertov 2030, CZ-128-40 Prague 2, Czech Republic","institution_ids":["https://openalex.org/I21250087"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006376053","display_name":"Vojt\u011bch Adam","orcid":"https://orcid.org/0000-0002-8527-286X"},"institutions":[{"id":"https://openalex.org/I56081889","display_name":"Mendel University in Brno","ror":"https://ror.org/058aeep47","country_code":"CZ","type":"education","lineage":["https://openalex.org/I56081889"]}],"countries":["CZ"],"is_corresponding":false,"raw_author_name":"Vojtech Adam","raw_affiliation_strings":["Department of Chemistry and Biochemistry, Faculty of Agronomy, Mendel University in Brno, Zemedelska 1, CZ-613-00 Brno, Czech Republic"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Biochemistry, Faculty of Agronomy, Mendel University in Brno, Zemedelska 1, CZ-613-00 Brno, Czech Republic","institution_ids":["https://openalex.org/I56081889"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009700689","display_name":"Ren\u00e9 Kizek","orcid":"https://orcid.org/0000-0002-0467-6169"},"institutions":[{"id":"https://openalex.org/I56081889","display_name":"Mendel University in Brno","ror":"https://ror.org/058aeep47","country_code":"CZ","type":"education","lineage":["https://openalex.org/I56081889"]}],"countries":["CZ"],"is_corresponding":false,"raw_author_name":"Rene Kizek","raw_affiliation_strings":["Department of Chemistry and Biochemistry, Faculty of Agronomy, Mendel University in Brno, Zemedelska 1, CZ-613-00 Brno, Czech Republic"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Biochemistry, Faculty of Agronomy, Mendel University in Brno, Zemedelska 1, CZ-613-00 Brno, Czech Republic","institution_ids":["https://openalex.org/I56081889"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5055879543","display_name":"Eva Frei","orcid":null},"institutions":[{"id":"https://openalex.org/I17937529","display_name":"German Cancer Research Center","ror":"https://ror.org/04cdgtt98","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I17937529"]},{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]},{"id":"https://openalex.org/I4210111460","display_name":"National Center for Tumor Diseases","ror":"https://ror.org/01txwsw02","country_code":"DE","type":"funder","lineage":["https://openalex.org/I4210111460"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Eva Frei","raw_affiliation_strings":["Division of Preventive Oncology, National Center for Tumor Diseases, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120 Heidelberg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Preventive Oncology, National Center for Tumor Diseases, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120 Heidelberg, Germany","institution_ids":["https://openalex.org/I4210111460","https://openalex.org/I17937529","https://openalex.org/I223822909"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5009212415"],"corresponding_institution_ids":["https://openalex.org/I21250087"],"apc_list":{"value":2400,"currency":"CHF","value_usd":2598},"apc_paid":{"value":2400,"currency":"CHF","value_usd":2598},"fwci":0.1423,"has_fulltext":false,"cited_by_count":7,"citation_normalized_percentile":{"value":0.55678827,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"14","issue":"12","first_page":"22982","last_page":"22997"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11845","display_name":"Cancer therapeutics and mechanisms","score":0.9973999857902527,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.996999979019165,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.8416564464569092},{"id":"https://openalex.org/keywords/adduct","display_name":"Adduct","score":0.7715463042259216},{"id":"https://openalex.org/keywords/dna","display_name":"DNA","score":0.6385634541511536},{"id":"https://openalex.org/keywords/covalent-bond","display_name":"Covalent bond","score":0.6376153826713562},{"id":"https://openalex.org/keywords/micelle","display_name":"Micelle","score":0.5927482843399048},{"id":"https://openalex.org/keywords/in-vivo","display_name":"In vivo","score":0.5335761904716492},{"id":"https://openalex.org/keywords/combinatorial-chemistry","display_name":"Combinatorial chemistry","score":0.5067511200904846},{"id":"https://openalex.org/keywords/dna-adduct","display_name":"DNA adduct","score":0.4635900855064392},{"id":"https://openalex.org/keywords/ethylene-oxide","display_name":"Ethylene oxide","score":0.4467249810695648},{"id":"https://openalex.org/keywords/biophysics","display_name":"Biophysics","score":0.37608280777931213},{"id":"https://openalex.org/keywords/copolymer","display_name":"Copolymer","score":0.25517216324806213},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.23799994587898254},{"id":"https://openalex.org/keywords/organic-chemistry","display_name":"Organic chemistry","score":0.2050156593322754},{"id":"https://openalex.org/keywords/aqueous-solution","display_name":"Aqueous solution","score":0.12241610884666443},{"id":"https://openalex.org/keywords/polymer","display_name":"Polymer","score":0.07023933529853821}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.8416564464569092},{"id":"https://openalex.org/C108204754","wikidata":"https://www.wikidata.org/wiki/Q353392","display_name":"Adduct","level":2,"score":0.7715463042259216},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.6385634541511536},{"id":"https://openalex.org/C180577832","wikidata":"https://www.wikidata.org/wiki/Q127920","display_name":"Covalent bond","level":2,"score":0.6376153826713562},{"id":"https://openalex.org/C11268172","wikidata":"https://www.wikidata.org/wiki/Q421110","display_name":"Micelle","level":3,"score":0.5927482843399048},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.5335761904716492},{"id":"https://openalex.org/C21951064","wikidata":"https://www.wikidata.org/wiki/Q899212","display_name":"Combinatorial chemistry","level":1,"score":0.5067511200904846},{"id":"https://openalex.org/C2781247443","wikidata":"https://www.wikidata.org/wiki/Q4153410","display_name":"DNA adduct","level":3,"score":0.4635900855064392},{"id":"https://openalex.org/C2777801237","wikidata":"https://www.wikidata.org/wiki/Q407473","display_name":"Ethylene oxide","level":4,"score":0.4467249810695648},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.37608280777931213},{"id":"https://openalex.org/C15920480","wikidata":"https://www.wikidata.org/wiki/Q421281","display_name":"Copolymer","level":3,"score":0.25517216324806213},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.23799994587898254},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.2050156593322754},{"id":"https://openalex.org/C184651966","wikidata":"https://www.wikidata.org/wiki/Q906356","display_name":"Aqueous solution","level":2,"score":0.12241610884666443},{"id":"https://openalex.org/C521977710","wikidata":"https://www.wikidata.org/wiki/Q81163","display_name":"Polymer","level":2,"score":0.07023933529853821},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D004339","descriptor_name":"Drug Compounding","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D004339","descriptor_name":"Drug Compounding","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D004339","descriptor_name":"Drug Compounding","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D004611","descriptor_name":"Ellipticines","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D004611","descriptor_name":"Ellipticines","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D004611","descriptor_name":"Ellipticines","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D004611","descriptor_name":"Ellipticines","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D004611","descriptor_name":"Ellipticines","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D004611","descriptor_name":"Ellipticines","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D004611","descriptor_name":"Ellipticines","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D004611","descriptor_name":"Ellipticines","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D004611","descriptor_name":"Ellipticines","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008657","descriptor_name":"Metabolic Clearance Rate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008657","descriptor_name":"Metabolic Clearance Rate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008657","descriptor_name":"Metabolic Clearance Rate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008823","descriptor_name":"Micelles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008823","descriptor_name":"Micelles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008823","descriptor_name":"Micelles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009928","descriptor_name":"Organ Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009928","descriptor_name":"Organ Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009928","descriptor_name":"Organ Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014018","descriptor_name":"Tissue Distribution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014018","descriptor_name":"Tissue Distribution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014018","descriptor_name":"Tissue Distribution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017208","descriptor_name":"Rats, Wistar","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017208","descriptor_name":"Rats, Wistar","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017208","descriptor_name":"Rats, Wistar","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018736","descriptor_name":"DNA Adducts","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018736","descriptor_name":"DNA Adducts","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018736","descriptor_name":"DNA Adducts","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018736","descriptor_name":"DNA Adducts","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D018736","descriptor_name":"DNA Adducts","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D018736","descriptor_name":"DNA Adducts","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":7,"locations":[{"id":"doi:10.3390/s141222982","is_oa":true,"landing_page_url":"https://doi.org/10.3390/s141222982","pdf_url":"https://www.mdpi.com/1424-8220/14/12/22982/pdf?version=1417604534","source":{"id":"https://openalex.org/S101949793","display_name":"Sensors","issn_l":"1424-8220","issn":["1424-8220"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sensors","raw_type":"journal-article"},{"id":"pmid:25479328","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25479328","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sensors (Basel, Switzerland)","raw_type":null},{"id":"pmh:oai:doaj.org/article:78223966f3a34148bf3df5347575f2ee","is_oa":true,"landing_page_url":"https://doaj.org/article/78223966f3a34148bf3df5347575f2ee","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Sensors, Vol 14, Iss 12, Pp 22982-22997 (2014)","raw_type":"article"},{"id":"pmh:oai:doaj.org/article:d3d6c1048cae48809caa14e4a95252a4","is_oa":false,"landing_page_url":"https://doaj.org/article/d3d6c1048cae48809caa14e4a95252a4","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Sensors, Vol 14, Iss 12, Pp 22982-22997 (2014)","raw_type":"article"},{"id":"pmh:oai:europepmc.org:3271630","is_oa":true,"landing_page_url":"http://europepmc.org/articles/PMC4299049","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:mdpi.com:/1424-8220/14/12/22982/","is_oa":true,"landing_page_url":"http://dx.doi.org/10.3390/s141222982","pdf_url":null,"source":{"id":"https://openalex.org/S4306400947","display_name":"MDPI (MDPI AG)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210097602","host_organization_name":"Multidisciplinary Digital Publishing Institute (Switzerland)","host_organization_lineage":["https://openalex.org/I4210097602"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Sensors","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:4299049","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4299049","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Sensors (Basel)","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.3390/s141222982","is_oa":true,"landing_page_url":"https://doi.org/10.3390/s141222982","pdf_url":"https://www.mdpi.com/1424-8220/14/12/22982/pdf?version=1417604534","source":{"id":"https://openalex.org/S101949793","display_name":"Sensors","issn_l":"1424-8220","issn":["1424-8220"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sensors","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8199999928474426}],"awards":[{"id":"https://openalex.org/G1822341119","display_name":null,"funder_award_id":"grant 14-18344S in panel P301","funder_id":"https://openalex.org/F4320321006","funder_display_name":"Grantov\u00e1 Agentura \u010cesk\u00e9 Republiky"},{"id":"https://openalex.org/G6728296349","display_name":null,"funder_award_id":"UNCE 204025/2012","funder_id":"https://openalex.org/F4320309755","funder_display_name":"Univerzita Karlova v Praze"}],"funders":[{"id":"https://openalex.org/F4320309755","display_name":"Univerzita Karlova v Praze","ror":"https://ror.org/024d6js02"},{"id":"https://openalex.org/F4320321006","display_name":"Grantov\u00e1 Agentura \u010cesk\u00e9 Republiky","ror":"https://ror.org/01pv73b02"}],"has_content":{"grobid_xml":false,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2156821455.pdf"},"referenced_works_count":56,"referenced_works":["https://openalex.org/W98801929","https://openalex.org/W100972702","https://openalex.org/W170867664","https://openalex.org/W1495785845","https://openalex.org/W1599208660","https://openalex.org/W1947884488","https://openalex.org/W1963847519","https://openalex.org/W1965147058","https://openalex.org/W1971849282","https://openalex.org/W1972190934","https://openalex.org/W1979086948","https://openalex.org/W1988209640","https://openalex.org/W1988514232","https://openalex.org/W1998966320","https://openalex.org/W2000702241","https://openalex.org/W2002182083","https://openalex.org/W2007996033","https://openalex.org/W2014330039","https://openalex.org/W2014443673","https://openalex.org/W2016521087","https://openalex.org/W2017139362","https://openalex.org/W2017479001","https://openalex.org/W2020236755","https://openalex.org/W2020389331","https://openalex.org/W2021208131","https://openalex.org/W2031291993","https://openalex.org/W2034171802","https://openalex.org/W2034607919","https://openalex.org/W2039920192","https://openalex.org/W2068285316","https://openalex.org/W2069161814","https://openalex.org/W2070838947","https://openalex.org/W2072013588","https://openalex.org/W2077301074","https://openalex.org/W2079799830","https://openalex.org/W2081127284","https://openalex.org/W2086218743","https://openalex.org/W2088961696","https://openalex.org/W2092666165","https://openalex.org/W2093135599","https://openalex.org/W2094354352","https://openalex.org/W2101372104","https://openalex.org/W2106180240","https://openalex.org/W2106360230","https://openalex.org/W2129337898","https://openalex.org/W2159170347","https://openalex.org/W2165829036","https://openalex.org/W2312770056","https://openalex.org/W2419609395","https://openalex.org/W2468345930","https://openalex.org/W4382140905","https://openalex.org/W6604049313","https://openalex.org/W6604066556","https://openalex.org/W6606983666","https://openalex.org/W6717699498","https://openalex.org/W7073670608"],"related_works":["https://openalex.org/W2996656052","https://openalex.org/W2584558183","https://openalex.org/W2186989045","https://openalex.org/W3025989039","https://openalex.org/W1974483066","https://openalex.org/W1148664835","https://openalex.org/W2032051056","https://openalex.org/W2340192401","https://openalex.org/W4250801280","https://openalex.org/W1976891699"],"abstract_inverted_index":{"The":[0,112],"requirements":[1],"for":[2,22,163],"early":[3],"diagnostics":[4],"as":[5,7,26,28,117],"well":[6,27],"effective":[8],"treatment":[9,32,168],"of":[10,19,30,35,51,67,77,82,134,169,178,190,204],"cancer":[11],"diseases":[12],"have":[13],"increased":[14],"the":[15,31,36,41,48,78,132,164,198],"pressure":[16],"on":[17],"development":[18],"efficient":[20,58],"methods":[21],"targeted":[23],"drug":[24,42],"delivery":[25,43,207],"imaging":[29,120],"success.":[33],"One":[34],"most":[37,79],"recent":[38],"approaches":[39],"covering":[40],"aspects":[44],"is":[45,75],"benefitting":[46],"from":[47,96,192],"unique":[49],"properties":[50],"nanomaterials.":[52],"Ellipticine":[53],"and":[54,124,137,184,201],"its":[55,83,97,138,193],"derivatives":[56],"are":[57],"anticancer":[59],"compounds":[60],"that":[61,167,186],"function":[62],"through":[63],"multiple":[64],"mechanisms.":[65],"Formation":[66],"covalent":[68,103,126],"DNA":[69,128,180],"adducts":[70,104,155,181],"after":[71],"ellipticine":[72,92,136,172,191],"enzymatic":[73],"activation":[74],"one":[76],"important":[80],"mechanisms":[81],"pharmacological":[84],"action.":[85],"In":[86],"this":[87,205],"study,":[88],"we":[89,161],"investigated":[90],"whether":[91],"might":[93,196],"be":[94],"released":[95],"micellar":[98,139,194],"(encapsulated)":[99],"form":[100,140,153,195],"to":[101,106,122,152],"generate":[102],"analogous":[105],"those":[107],"formed":[108],"by":[109],"free":[110,135],"ellipticine.":[111],"(32)P-postlabeling":[113],"technique":[114],"was":[115],"used":[116],"a":[118,187],"useful":[119],"method":[121],"detect":[123],"quantify":[125],"ellipticine-derived":[127,179],"adducts.":[129],"We":[130],"compared":[131],"efficiencies":[133],"(the":[141],"poly(ethylene":[142],"oxide)-block-poly(allyl":[143],"glycidyl":[144],"ether)":[145],"(PAGE-PEO)":[146],"block":[147],"copolymer,":[148],"P":[149],"119":[150],"nanoparticles)":[151],"ellipticine-DNA":[154],"in":[156,158,173,176,182],"rats":[157,170],"vivo.":[159],"Here,":[160],"demonstrate":[162],"first":[165],"time":[166],"with":[171],"micelles":[174],"resulted":[175],"formation":[177],"vivo":[183],"suggest":[185],"gradual":[188],"release":[189],"produce":[197],"enhanced":[199],"permeation":[200],"retention":[202],"effect":[203],"ellipticine-micellar":[206],"system.":[208]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":1},{"year":2015,"cited_by_count":1}],"updated_date":"2026-05-22T06:13:13.366637","created_date":"2025-10-10T00:00:00"}