{"id":"https://openalex.org/W2018844669","doi":"https://doi.org/10.3390/s140101195","title":"Topoisomerase I as a Biomarker: Detection of Activity at the Single Molecule Level","display_name":"Topoisomerase I as a Biomarker: Detection of Activity at the Single Molecule Level","publication_year":2014,"publication_date":"2014-01-10","ids":{"openalex":"https://openalex.org/W2018844669","doi":"https://doi.org/10.3390/s140101195","mag":"2018844669","pmid":"https://pubmed.ncbi.nlm.nih.gov/24434877"},"language":"en","primary_location":{"id":"doi:10.3390/s140101195","is_oa":true,"landing_page_url":"https://doi.org/10.3390/s140101195","pdf_url":"https://www.mdpi.com/1424-8220/14/1/1195/pdf?version=1403342861","source":{"id":"https://openalex.org/S101949793","display_name":"Sensors","issn_l":"1424-8220","issn":["1424-8220"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sensors","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/1424-8220/14/1/1195/pdf?version=1403342861","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5078646723","display_name":"Joanna Proszek","orcid":"https://orcid.org/0000-0003-4523-7901"},"institutions":[{"id":"https://openalex.org/I2802335433","display_name":"Aarhus University Hospital","ror":"https://ror.org/040r8fr65","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2802335433"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Joanna Proszek","raw_affiliation_strings":["Department of Pathology, Aarhus University Hospital, Aarhus C 8000, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Aarhus University Hospital, Aarhus C 8000, Denmark","institution_ids":["https://openalex.org/I2802335433"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064429093","display_name":"Amit Roy","orcid":"https://orcid.org/0000-0003-3237-3525"},"institutions":[{"id":"https://openalex.org/I204337017","display_name":"Aarhus University","ror":"https://ror.org/01aj84f44","country_code":"DK","type":"education","lineage":["https://openalex.org/I204337017"]},{"id":"https://openalex.org/I4210098333","display_name":"National Institute of Pharmaceutical Education and Research","ror":"https://ror.org/011npsm46","country_code":"IN","type":"education","lineage":["https://openalex.org/I4210098333"]}],"countries":["DK","IN"],"is_corresponding":false,"raw_author_name":"Amit Roy","raw_affiliation_strings":["Department of Biotechnology, National Institute of Pharmaceutical Education & Research (NIPER), Hajipur-844 101, Bihar, India","Department of Molecular Biology and Genetics, Aarhus University, Aarhus C 8000, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biotechnology, National Institute of Pharmaceutical Education & Research (NIPER), Hajipur-844 101, Bihar, India","institution_ids":["https://openalex.org/I4210098333"]},{"raw_affiliation_string":"Department of Molecular Biology and Genetics, Aarhus University, Aarhus C 8000, Denmark","institution_ids":["https://openalex.org/I204337017"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023557761","display_name":"Ann-Katrine Jakobsen","orcid":"https://orcid.org/0000-0001-9922-7819"},"institutions":[{"id":"https://openalex.org/I2802335433","display_name":"Aarhus University Hospital","ror":"https://ror.org/040r8fr65","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2802335433"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Ann-Katrine Jakobsen","raw_affiliation_strings":["Department of Pathology, Aarhus University Hospital, Aarhus C 8000, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Aarhus University Hospital, Aarhus C 8000, Denmark","institution_ids":["https://openalex.org/I2802335433"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072745158","display_name":"Rikke Fr\u00f8hlich","orcid":null},"institutions":[{"id":"https://openalex.org/I204337017","display_name":"Aarhus University","ror":"https://ror.org/01aj84f44","country_code":"DK","type":"education","lineage":["https://openalex.org/I204337017"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Rikke Fr\u00f8hlich","raw_affiliation_strings":["Department of Molecular Biology and Genetics, Aarhus University, Aarhus C 8000, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Biology and Genetics, Aarhus University, Aarhus C 8000, Denmark","institution_ids":["https://openalex.org/I204337017"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080879530","display_name":"Birgitta R. Knudsen","orcid":"https://orcid.org/0000-0002-3484-3802"},"institutions":[{"id":"https://openalex.org/I204337017","display_name":"Aarhus University","ror":"https://ror.org/01aj84f44","country_code":"DK","type":"education","lineage":["https://openalex.org/I204337017"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Birgitta Knudsen","raw_affiliation_strings":["Department of Molecular Biology and Genetics, Aarhus University, Aarhus C 8000, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Biology and Genetics, Aarhus University, Aarhus C 8000, Denmark","institution_ids":["https://openalex.org/I204337017"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5030626300","display_name":"Magnus Stougaard","orcid":"https://orcid.org/0000-0001-7456-902X"},"institutions":[{"id":"https://openalex.org/I2802335433","display_name":"Aarhus University Hospital","ror":"https://ror.org/040r8fr65","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2802335433"]}],"countries":["DK"],"is_corresponding":true,"raw_author_name":"Magnus Stougaard","raw_affiliation_strings":["Department of Pathology, Aarhus University Hospital, Aarhus C 8000, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Aarhus University Hospital, Aarhus C 8000, Denmark","institution_ids":["https://openalex.org/I2802335433"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5030626300"],"corresponding_institution_ids":["https://openalex.org/I2802335433"],"apc_list":{"value":2400,"currency":"CHF","value_usd":2598},"apc_paid":{"value":2400,"currency":"CHF","value_usd":2598},"fwci":1.5649,"has_fulltext":true,"cited_by_count":25,"citation_normalized_percentile":{"value":0.82222137,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"14","issue":"1","first_page":"1195","last_page":"1207"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11845","display_name":"Cancer therapeutics and mechanisms","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11845","display_name":"Cancer therapeutics and mechanisms","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12356","display_name":"Bioactive Compounds and Antitumor Agents","score":0.995199978351593,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12827","display_name":"Biochemical and Molecular Research","score":0.9926000237464905,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/biomarker","display_name":"Biomarker","score":0.6887623071670532},{"id":"https://openalex.org/keywords/topoisomerase","display_name":"Topoisomerase","score":0.5886891484260559},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.4273817837238312},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.3847719430923462},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.2610394060611725},{"id":"https://openalex.org/keywords/dna","display_name":"DNA","score":0.223186194896698},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.17645570635795593}],"concepts":[{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.6887623071670532},{"id":"https://openalex.org/C147897179","wikidata":"https://www.wikidata.org/wiki/Q407828","display_name":"Topoisomerase","level":3,"score":0.5886891484260559},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4273817837238312},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3847719430923462},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2610394060611725},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.223186194896698},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.17645570635795593}],"mesh":[{"descriptor_ui":"D002166","descriptor_name":"Camptothecin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002166","descriptor_name":"Camptothecin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002166","descriptor_name":"Camptothecin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004249","descriptor_name":"DNA Damage","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004249","descriptor_name":"DNA Damage","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004249","descriptor_name":"DNA Damage","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004249","descriptor_name":"DNA Damage","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004249","descriptor_name":"DNA Damage","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004249","descriptor_name":"DNA Damage","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004264","descriptor_name":"DNA Topoisomerases, Type I","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004264","descriptor_name":"DNA Topoisomerases, Type I","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004264","descriptor_name":"DNA Topoisomerases, Type I","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004264","descriptor_name":"DNA Topoisomerases, Type I","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004264","descriptor_name":"DNA Topoisomerases, Type I","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004264","descriptor_name":"DNA Topoisomerases, Type I","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010727","descriptor_name":"Phosphoric Diester Hydrolases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010727","descriptor_name":"Phosphoric Diester Hydrolases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010727","descriptor_name":"Phosphoric Diester Hydrolases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015153","descriptor_name":"Blotting, Western","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015153","descriptor_name":"Blotting, Western","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015153","descriptor_name":"Blotting, Western","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018628","descriptor_name":"Gene Dosage","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018628","descriptor_name":"Gene Dosage","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018628","descriptor_name":"Gene Dosage","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018938","descriptor_name":"Caco-2 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018938","descriptor_name":"Caco-2 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018938","descriptor_name":"Caco-2 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019073","descriptor_name":"HT29 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019073","descriptor_name":"HT29 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019073","descriptor_name":"HT29 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057075","descriptor_name":"Enzyme Assays","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D057075","descriptor_name":"Enzyme Assays","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D057075","descriptor_name":"Enzyme Assays","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":7,"locations":[{"id":"doi:10.3390/s140101195","is_oa":true,"landing_page_url":"https://doi.org/10.3390/s140101195","pdf_url":"https://www.mdpi.com/1424-8220/14/1/1195/pdf?version=1403342861","source":{"id":"https://openalex.org/S101949793","display_name":"Sensors","issn_l":"1424-8220","issn":["1424-8220"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sensors","raw_type":"journal-article"},{"id":"pmid:24434877","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24434877","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sensors (Basel, Switzerland)","raw_type":null},{"id":"pmh:oai:doaj.org/article:87374361d474416883c9c7ce1e73c2ce","is_oa":true,"landing_page_url":"https://doaj.org/article/87374361d474416883c9c7ce1e73c2ce","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Sensors, Vol 14, Iss 1, Pp 1195-1207 (2014)","raw_type":"article"},{"id":"pmh:oai:europepmc.org:2910366","is_oa":true,"landing_page_url":"http://europepmc.org/articles/PMC3926610","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:mdpi.com:/1424-8220/14/1/1195/","is_oa":true,"landing_page_url":"https://dx.doi.org/10.3390/s140101195","pdf_url":null,"source":{"id":"https://openalex.org/S4306400947","display_name":"MDPI (MDPI AG)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210097602","host_organization_name":"Multidisciplinary Digital Publishing Institute (Switzerland)","host_organization_lineage":["https://openalex.org/I4210097602"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Sensors","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3926610","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3926610","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Sensors (Basel)","raw_type":"Text"},{"id":"pmh:oai:pure.atira.dk:publications/c8134434-a395-450b-8708-d841ee7f40b5","is_oa":true,"landing_page_url":"http://www.mdpi.com/1424-8220/14/1/1195","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Proszek, J, Roy, A, Jakobsen, A-K, Hougaard, R F, Knudsen, B R & Stougaard, M 2014, 'Topoisomerase I as a Biomarker: Detection of Activity at the Single Molecule Level', Sensors, vol. 14, no. 1, pp. 1195-1207. https://doi.org/10.3390/s140101195","raw_type":"info:eu-repo/semantics/publishedVersion"}],"best_oa_location":{"id":"doi:10.3390/s140101195","is_oa":true,"landing_page_url":"https://doi.org/10.3390/s140101195","pdf_url":"https://www.mdpi.com/1424-8220/14/1/1195/pdf?version=1403342861","source":{"id":"https://openalex.org/S101949793","display_name":"Sensors","issn_l":"1424-8220","issn":["1424-8220"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sensors","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.7599999904632568}],"awards":[],"funders":[{"id":"https://openalex.org/F4320324994","display_name":"Kong Christian den Tiendes Fond","ror":null},{"id":"https://openalex.org/F4320326367","display_name":"Fabrikant Einar Willumsens Mindelegat","ror":null},{"id":"https://openalex.org/F4320326368","display_name":"Familien Erichsens Mindefond","ror":null}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2018844669.pdf","grobid_xml":"https://content.openalex.org/works/W2018844669.grobid-xml"},"referenced_works_count":42,"referenced_works":["https://openalex.org/W33370272","https://openalex.org/W1595184397","https://openalex.org/W1705636341","https://openalex.org/W1871475547","https://openalex.org/W1908304664","https://openalex.org/W1964753741","https://openalex.org/W1968646546","https://openalex.org/W1971256828","https://openalex.org/W1974404201","https://openalex.org/W1975426967","https://openalex.org/W1982294356","https://openalex.org/W1986566498","https://openalex.org/W1987644182","https://openalex.org/W1988516897","https://openalex.org/W1993287563","https://openalex.org/W2004257622","https://openalex.org/W2006122393","https://openalex.org/W2018321661","https://openalex.org/W2019502079","https://openalex.org/W2023041614","https://openalex.org/W2026554582","https://openalex.org/W2031315000","https://openalex.org/W2038544276","https://openalex.org/W2042794520","https://openalex.org/W2048399045","https://openalex.org/W2049584440","https://openalex.org/W2050240034","https://openalex.org/W2056843446","https://openalex.org/W2059224614","https://openalex.org/W2062954993","https://openalex.org/W2074144195","https://openalex.org/W2076333033","https://openalex.org/W2090604606","https://openalex.org/W2103152356","https://openalex.org/W2104359749","https://openalex.org/W2132600317","https://openalex.org/W2157769714","https://openalex.org/W2160696559","https://openalex.org/W2168026882","https://openalex.org/W2314927739","https://openalex.org/W6601296348","https://openalex.org/W6639949037"],"related_works":["https://openalex.org/W4387497383","https://openalex.org/W2948807893","https://openalex.org/W2899084033","https://openalex.org/W2778153218","https://openalex.org/W2748952813","https://openalex.org/W1531601525","https://openalex.org/W4391375266","https://openalex.org/W2078814861","https://openalex.org/W2527526854","https://openalex.org/W1976181487"],"abstract_inverted_index":{"Human":[0],"topoisomerase":[1],"I":[2],"(hTopI)":[3],"is":[4,11,19,34,157],"an":[5],"essential":[6],"cellular":[7,74,171],"enzyme.":[8],"The":[9],"enzyme":[10,65,152],"often":[12],"upregulated":[13],"in":[14,41,45,52,73,137,146,159,186],"cancer":[15],"cells,":[16],"and":[17,39,43,64,127,183],"it":[18],"a":[20,177],"target":[21],"for":[22,195],"chemotherapeutic":[23],"drugs":[24],"of":[25,90,117,135,140,149,161,180,188],"the":[26,95,133,138,147,150,192],"camptothecin":[27],"(CPT)":[28],"family.":[29],"Response":[30],"to":[31,50,70,76,102],"CPT-based":[32],"treatment":[33],"dependent":[35],"on":[36],"hTopI":[37,46,91,118,136,184],"activity,":[38,42],"reduction":[40],"mutations":[44],"have":[47,67],"been":[48,68],"reported":[49],"result":[51],"CPT":[53,108,172,189,196],"resistance.":[54],"Therefore,":[55],"hTOPI":[56],"gene":[57,119],"copy":[58,120],"number,":[59,121],"mRNA":[60,122],"level,":[61,98],"protein":[62,125],"amount,":[63,123,126],"activity":[66,93,134,148,168,182,185],"studied":[69],"explain":[71],"differences":[72,106,111,145],"response":[75],"CPT.":[77,141],"We":[78],"show":[79],"that":[80,176],"Rolling":[81],"Circle":[82],"Enhanced":[83],"Enzyme":[84],"Activity":[85],"Detection":[86],"(REEAD),":[87],"allowing":[88],"measurement":[89,179],"cleavage-religation":[92],"at":[94],"single":[96],"molecule":[97],"may":[99],"be":[100,113,191],"used":[101],"detect":[103],"posttranslational":[104],"enzymatic":[105],"influencing":[107],"response.":[109,197],"These":[110],"cannot":[112],"detected":[114,144],"by":[115],"analysis":[116],"or":[124],"only":[128],"become":[129],"apparent":[130],"upon":[131],"measuring":[132],"presence":[139,187],"Furthermore,":[142],"we":[143,174],"repair":[151,160],"tyrosyl-DNA":[153],"phosphodiesterase":[154],"1,":[155],"which":[156],"involved":[158],"hTopI-induced":[162],"DNA":[163],"damage.":[164],"Since":[165],"increased":[166],"TDP1":[167,181],"can":[169],"reduce":[170],"sensitivity":[173],"suggest":[175],"combined":[178],"will":[190],"best":[193],"determinant":[194]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":3},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":2}],"updated_date":"2026-05-21T06:26:12.895304","created_date":"2025-10-10T00:00:00"}
