{"id":"https://openalex.org/W2047295783","doi":"https://doi.org/10.3390/s131216330","title":"Noninvasive High-Throughput Single-Cell Analysis of HIV Protease Activity Using Ratiometric Flow Cytometry","display_name":"Noninvasive High-Throughput Single-Cell Analysis of HIV Protease Activity Using Ratiometric Flow Cytometry","publication_year":2013,"publication_date":"2013-11-28","ids":{"openalex":"https://openalex.org/W2047295783","doi":"https://doi.org/10.3390/s131216330","mag":"2047295783","pmid":"https://pubmed.ncbi.nlm.nih.gov/24287545"},"language":"en","primary_location":{"id":"doi:10.3390/s131216330","is_oa":true,"landing_page_url":"https://doi.org/10.3390/s131216330","pdf_url":"https://www.mdpi.com/1424-8220/13/12/16330/pdf?version=1403339644","source":{"id":"https://openalex.org/S101949793","display_name":"Sensors","issn_l":"1424-8220","issn":["1424-8220"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sensors","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/1424-8220/13/12/16330/pdf?version=1403339644","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5001504611","display_name":"Rok Gaber","orcid":"https://orcid.org/0000-0003-2879-6322"},"institutions":[{"id":"https://openalex.org/I4210149465","display_name":"EN-FIST Centre of Excellence (Slovenia)","ror":"https://ror.org/04s1b0x88","country_code":"SI","type":"company","lineage":["https://openalex.org/I4210149465"]},{"id":"https://openalex.org/I4210152560","display_name":"National Institute of Chemistry","ror":"https://ror.org/050mac570","country_code":"SI","type":"facility","lineage":["https://openalex.org/I4210152560"]}],"countries":["SI"],"is_corresponding":false,"raw_author_name":"Rok Gaber","raw_affiliation_strings":["Center of Excellence EN-FIST, Ljubljana 1000, Slovenia","Laboratory of Biotechnology, National Institute of Chemistry, Ljubljana 1000, Slovenia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center of Excellence EN-FIST, Ljubljana 1000, Slovenia","institution_ids":["https://openalex.org/I4210149465"]},{"raw_affiliation_string":"Laboratory of Biotechnology, National Institute of Chemistry, Ljubljana 1000, Slovenia","institution_ids":["https://openalex.org/I4210152560"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014294173","display_name":"Andreja Majerle","orcid":"https://orcid.org/0000-0001-5884-2217"},"institutions":[{"id":"https://openalex.org/I4210149465","display_name":"EN-FIST Centre of Excellence (Slovenia)","ror":"https://ror.org/04s1b0x88","country_code":"SI","type":"company","lineage":["https://openalex.org/I4210149465"]},{"id":"https://openalex.org/I4210152560","display_name":"National Institute of Chemistry","ror":"https://ror.org/050mac570","country_code":"SI","type":"facility","lineage":["https://openalex.org/I4210152560"]}],"countries":["SI"],"is_corresponding":false,"raw_author_name":"Andreja Majerle","raw_affiliation_strings":["Center of Excellence EN-FIST, Ljubljana 1000, Slovenia","Laboratory of Biotechnology, National Institute of Chemistry, Ljubljana 1000, Slovenia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center of Excellence EN-FIST, Ljubljana 1000, Slovenia","institution_ids":["https://openalex.org/I4210149465"]},{"raw_affiliation_string":"Laboratory of Biotechnology, National Institute of Chemistry, Ljubljana 1000, Slovenia","institution_ids":["https://openalex.org/I4210152560"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055222513","display_name":"Roman Jerala","orcid":"https://orcid.org/0000-0002-6337-5251"},"institutions":[{"id":"https://openalex.org/I4210149465","display_name":"EN-FIST Centre of Excellence (Slovenia)","ror":"https://ror.org/04s1b0x88","country_code":"SI","type":"company","lineage":["https://openalex.org/I4210149465"]},{"id":"https://openalex.org/I4210152560","display_name":"National Institute of Chemistry","ror":"https://ror.org/050mac570","country_code":"SI","type":"facility","lineage":["https://openalex.org/I4210152560"]}],"countries":["SI"],"is_corresponding":false,"raw_author_name":"Roman Jerala","raw_affiliation_strings":["Center of Excellence EN-FIST, Ljubljana 1000, Slovenia","Laboratory of Biotechnology, National Institute of Chemistry, Ljubljana 1000, Slovenia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center of Excellence EN-FIST, Ljubljana 1000, Slovenia","institution_ids":["https://openalex.org/I4210149465"]},{"raw_affiliation_string":"Laboratory of Biotechnology, National Institute of Chemistry, Ljubljana 1000, Slovenia","institution_ids":["https://openalex.org/I4210152560"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5031628712","display_name":"Mojca Ben\u010dina","orcid":"https://orcid.org/0000-0002-3644-9948"},"institutions":[{"id":"https://openalex.org/I4210149465","display_name":"EN-FIST Centre of Excellence (Slovenia)","ror":"https://ror.org/04s1b0x88","country_code":"SI","type":"company","lineage":["https://openalex.org/I4210149465"]},{"id":"https://openalex.org/I4210152560","display_name":"National Institute of Chemistry","ror":"https://ror.org/050mac570","country_code":"SI","type":"facility","lineage":["https://openalex.org/I4210152560"]}],"countries":["SI"],"is_corresponding":true,"raw_author_name":"Mojca Ben\u010dina","raw_affiliation_strings":["Center of Excellence EN-FIST, Ljubljana 1000, Slovenia","Laboratory of Biotechnology, National Institute of Chemistry, Ljubljana 1000, Slovenia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center of Excellence EN-FIST, Ljubljana 1000, Slovenia","institution_ids":["https://openalex.org/I4210149465"]},{"raw_affiliation_string":"Laboratory of Biotechnology, National Institute of Chemistry, Ljubljana 1000, Slovenia","institution_ids":["https://openalex.org/I4210152560"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5031628712"],"corresponding_institution_ids":["https://openalex.org/I4210149465","https://openalex.org/I4210152560"],"apc_list":{"value":2600,"currency":"CHF","value_usd":3137},"apc_paid":{"value":2600,"currency":"CHF","value_usd":3137},"fwci":0.2561,"has_fulltext":true,"cited_by_count":10,"citation_normalized_percentile":{"value":0.54430605,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"13","issue":"12","first_page":"16330","last_page":"16346"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10526","display_name":"HIV/AIDS drug development and treatment","score":0.9977999925613403,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10207","display_name":"Advanced biosensing and bioanalysis techniques","score":0.9955000281333923,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/f\u00f6rster-resonance-energy-transfer","display_name":"F\u00f6rster resonance energy transfer","score":0.9106948375701904},{"id":"https://openalex.org/keywords/protease","display_name":"Protease","score":0.8491833806037903},{"id":"https://openalex.org/keywords/flow-cytometry","display_name":"Flow cytometry","score":0.824508011341095},{"id":"https://openalex.org/keywords/intracellular","display_name":"Intracellular","score":0.6716127395629883},{"id":"https://openalex.org/keywords/hiv-1-protease","display_name":"HIV-1 protease","score":0.5529994368553162},{"id":"https://openalex.org/keywords/in-vitro","display_name":"In vitro","score":0.547702431678772},{"id":"https://openalex.org/keywords/high-throughput-screening","display_name":"High-throughput screening","score":0.5230606198310852},{"id":"https://openalex.org/keywords/human-immunodeficiency-virus","display_name":"Human immunodeficiency virus (HIV)","score":0.5182945132255554},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.503706157207489},{"id":"https://openalex.org/keywords/cell-biology","display_name":"Cell biology","score":0.45047011971473694},{"id":"https://openalex.org/keywords/single-cell-analysis","display_name":"Single-cell analysis","score":0.43902266025543213},{"id":"https://openalex.org/keywords/plate-reader","display_name":"Plate reader","score":0.43271946907043457},{"id":"https://openalex.org/keywords/cytometry","display_name":"Cytometry","score":0.4238867163658142},{"id":"https://openalex.org/keywords/cell","display_name":"Cell","score":0.38032734394073486},{"id":"https://openalex.org/keywords/virology","display_name":"Virology","score":0.3758648633956909},{"id":"https://openalex.org/keywords/biophysics","display_name":"Biophysics","score":0.326840877532959},{"id":"https://openalex.org/keywords/fluorescence","display_name":"Fluorescence","score":0.3239368796348572},{"id":"https://openalex.org/keywords/molecular-biology","display_name":"Molecular biology","score":0.2306261956691742},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.225913405418396},{"id":"https://openalex.org/keywords/enzyme","display_name":"Enzyme","score":0.15842631459236145}],"concepts":[{"id":"https://openalex.org/C96305047","wikidata":"https://www.wikidata.org/wiki/Q367473","display_name":"F\u00f6rster resonance energy transfer","level":3,"score":0.9106948375701904},{"id":"https://openalex.org/C2776714187","wikidata":"https://www.wikidata.org/wiki/Q212410","display_name":"Protease","level":3,"score":0.8491833806037903},{"id":"https://openalex.org/C553184892","wikidata":"https://www.wikidata.org/wiki/Q1141429","display_name":"Flow cytometry","level":2,"score":0.824508011341095},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.6716127395629883},{"id":"https://openalex.org/C2777583353","wikidata":"https://www.wikidata.org/wiki/Q410261","display_name":"HIV-1 protease","level":4,"score":0.5529994368553162},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.547702431678772},{"id":"https://openalex.org/C51323132","wikidata":"https://www.wikidata.org/wiki/Q626251","display_name":"High-throughput screening","level":2,"score":0.5230606198310852},{"id":"https://openalex.org/C3013748606","wikidata":"https://www.wikidata.org/wiki/Q15787","display_name":"Human immunodeficiency virus (HIV)","level":2,"score":0.5182945132255554},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.503706157207489},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.45047011971473694},{"id":"https://openalex.org/C2776950831","wikidata":"https://www.wikidata.org/wiki/Q15635432","display_name":"Single-cell analysis","level":3,"score":0.43902266025543213},{"id":"https://openalex.org/C2778861558","wikidata":"https://www.wikidata.org/wiki/Q3101245","display_name":"Plate reader","level":3,"score":0.43271946907043457},{"id":"https://openalex.org/C2780339063","wikidata":"https://www.wikidata.org/wiki/Q5201367","display_name":"Cytometry","level":3,"score":0.4238867163658142},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.38032734394073486},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.3758648633956909},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.326840877532959},{"id":"https://openalex.org/C91881484","wikidata":"https://www.wikidata.org/wiki/Q191807","display_name":"Fluorescence","level":2,"score":0.3239368796348572},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.2306261956691742},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.225913405418396},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.15842631459236145},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005434","descriptor_name":"Flow Cytometry","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D005434","descriptor_name":"Flow Cytometry","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D005434","descriptor_name":"Flow Cytometry","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D016333","descriptor_name":"HIV Protease","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016333","descriptor_name":"HIV Protease","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016333","descriptor_name":"HIV Protease","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D057166","descriptor_name":"High-Throughput Screening Assays","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D057166","descriptor_name":"High-Throughput Screening Assays","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D057166","descriptor_name":"High-Throughput Screening Assays","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D059010","descriptor_name":"Single-Cell Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D059010","descriptor_name":"Single-Cell Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D059010","descriptor_name":"Single-Cell Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.3390/s131216330","is_oa":true,"landing_page_url":"https://doi.org/10.3390/s131216330","pdf_url":"https://www.mdpi.com/1424-8220/13/12/16330/pdf?version=1403339644","source":{"id":"https://openalex.org/S101949793","display_name":"Sensors","issn_l":"1424-8220","issn":["1424-8220"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sensors","raw_type":"journal-article"},{"id":"pmid:24287545","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24287545","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sensors (Basel, Switzerland)","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:2881274","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3892856","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:4323bef6851647b28755479129fe3123","is_oa":false,"landing_page_url":"https://doaj.org/article/4323bef6851647b28755479129fe3123","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Sensors, Vol 13, Iss 12, Pp 16330-16346 (2013)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3390/s131216330","is_oa":true,"landing_page_url":"https://doi.org/10.3390/s131216330","pdf_url":"https://www.mdpi.com/1424-8220/13/12/16330/pdf?version=1403339644","source":{"id":"https://openalex.org/S101949793","display_name":"Sensors","issn_l":"1424-8220","issn":["1424-8220"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sensors","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8700000047683716}],"awards":[{"id":"https://openalex.org/G1412571906","display_name":null,"funder_award_id":"pNL4-3","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G6511232711","display_name":null,"funder_award_id":"pNL4-3","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320322554","display_name":"Javna Agencija za Raziskovalno Dejavnost RS","ror":"https://ror.org/059bp8k51"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2047295783.pdf","grobid_xml":"https://content.openalex.org/works/W2047295783.grobid-xml"},"referenced_works_count":21,"referenced_works":["https://openalex.org/W1635485592","https://openalex.org/W1925504181","https://openalex.org/W1978206433","https://openalex.org/W1982829412","https://openalex.org/W1988255276","https://openalex.org/W1997994170","https://openalex.org/W2035095394","https://openalex.org/W2040693047","https://openalex.org/W2049080258","https://openalex.org/W2053468663","https://openalex.org/W2058714484","https://openalex.org/W2072901265","https://openalex.org/W2077316978","https://openalex.org/W2097919816","https://openalex.org/W2101370555","https://openalex.org/W2109591894","https://openalex.org/W2113983551","https://openalex.org/W2143094150","https://openalex.org/W2152989668","https://openalex.org/W2160005499","https://openalex.org/W2164909857"],"related_works":["https://openalex.org/W2281981908","https://openalex.org/W3049153735","https://openalex.org/W1965524375","https://openalex.org/W946894882","https://openalex.org/W2049562205","https://openalex.org/W4283833723","https://openalex.org/W3043693625","https://openalex.org/W2023869314","https://openalex.org/W2346364295","https://openalex.org/W2040211505"],"abstract_inverted_index":{"To":[0],"effectively":[1],"fight":[2],"against":[3],"the":[4,71,86,133,178,181],"human":[5],"immunodeficiency":[6,10],"virus":[7],"infection/":[8],"acquired":[9],"syndrome":[11],"(HIV/AIDS)":[12],"epidemic,":[13],"ongoing":[14],"development":[15],"of":[16,34,54,93,129,141,157,180,187],"novel":[17],"HIV":[18,48,78,94,158,189],"protease":[19,79,95,159,190],"inhibitors":[20],"is":[21],"required.":[22],"Inexpensive":[23],"high-throughput":[24,117],"screening":[25,80],"assays":[26],"are":[27],"needed":[28],"to":[29,161,176],"quickly":[30],"scan":[31],"large":[32,127],"sets":[33],"chemicals":[35],"for":[36,89,125,184],"potential":[37],"inhibitors.":[38],"We":[39,113],"have":[40,84,114,167],"developed":[41,115],"a":[42,52,55,116,121,169],"F\u00f6rster":[43],"resonance":[44],"energy":[45],"transfer":[46],"(FRET)-based,":[47],"protease-sensitive":[49],"sensor":[50,73,88,183],"using":[51],"combination":[53],"fluorescent":[56],"protein":[57],"pair,":[58],"namely":[59],"mCerulean":[60],"and":[61,147,149],"mCitrine.":[62],"Through":[63],"extensive":[64],"in":[65,77,97,110],"vitro":[66,111],"characterization,":[67],"we":[68,83,166],"show":[69],"that":[70,119,131],"FRET-HIV":[72,87,134,182],"can":[74],"be":[75,151,162],"used":[76,85,152,168],"assays.":[81],"Furthermore,":[82],"intracellular":[90,155,188],"quantitative":[91],"detection":[92,186],"activity":[96,156],"living":[98],"cells,":[99],"which":[100],"more":[101],"closely":[102],"resembles":[103],"an":[104,109],"actual":[105],"viral":[106],"infection":[107],"than":[108],"assay.":[112],"method":[118,137],"employs":[120],"ratiometric":[122],"flow":[123],"cytometry":[124],"analyzing":[126],"populations":[128],"cells":[130,143],"express":[132],"sensor.":[135],"The":[136],"enables":[138],"FRET":[139,174],"measurement":[140],"single":[142],"with":[144],"high":[145],"sensitivity":[146],"speed":[148],"should":[150],"when":[153],"subpopulation-specific":[154],"needs":[160],"estimated.":[163],"In":[164],"addition,":[165],"confocal":[170],"microscopy":[171],"sensitized":[172],"emission":[173],"technique":[175],"evaluate":[177],"usefulness":[179],"spatiotemporal":[185],"activity.":[191]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2014,"cited_by_count":2}],"updated_date":"2026-08-27T14:10:00.468798","created_date":"2025-10-10T00:00:00"}
