{"id":"https://openalex.org/W2105826358","doi":"https://doi.org/10.3390/s120709411","title":"Dynamics of Ras Complexes Observed in Living Cells","display_name":"Dynamics of Ras Complexes Observed in Living Cells","publication_year":2012,"publication_date":"2012-07-09","ids":{"openalex":"https://openalex.org/W2105826358","doi":"https://doi.org/10.3390/s120709411","mag":"2105826358","pmid":"https://pubmed.ncbi.nlm.nih.gov/23012550"},"language":"en","primary_location":{"id":"doi:10.3390/s120709411","is_oa":true,"landing_page_url":"https://doi.org/10.3390/s120709411","pdf_url":"https://www.mdpi.com/1424-8220/12/7/9411/pdf?version=1403317871","source":{"id":"https://openalex.org/S101949793","display_name":"Sensors","issn_l":"1424-8220","issn":["1424-8220"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sensors","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/1424-8220/12/7/9411/pdf?version=1403317871","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5057939990","display_name":"Xiangyong Li","orcid":"https://orcid.org/0000-0003-1131-5123"},"institutions":[{"id":"https://openalex.org/I4210138186","display_name":"Wuhan National Laboratory for Optoelectronics","ror":"https://ror.org/03c9ncn37","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210138186"]},{"id":"https://openalex.org/I47720641","display_name":"Huazhong University of Science and Technology","ror":"https://ror.org/00p991c53","country_code":"CN","type":"education","lineage":["https://openalex.org/I47720641"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiangyong Li","raw_affiliation_strings":["Britton Chance Center for Biomedical Photonics, Wuhan National Laboratory for Optoelectronics, Huazhong University of Science and Technology, Wuhan 430074, China","MoE Key Laboratory for Biomedical Photonics, Department of Biomedical Engineering, Huazhong University of Science and Technology, Wuhan 430074, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Britton Chance Center for Biomedical Photonics, Wuhan National Laboratory for Optoelectronics, Huazhong University of Science and Technology, Wuhan 430074, China","institution_ids":["https://openalex.org/I4210138186","https://openalex.org/I47720641"]},{"raw_affiliation_string":"MoE Key Laboratory for Biomedical Photonics, Department of Biomedical Engineering, Huazhong University of Science and Technology, Wuhan 430074, China","institution_ids":["https://openalex.org/I47720641"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037495777","display_name":"Zhiyong Cheng","orcid":"https://orcid.org/0000-0001-7615-9788"},"institutions":[{"id":"https://openalex.org/I4210100789","display_name":"Wuhan College","ror":"https://ror.org/01dashf18","country_code":"CN","type":"nonprofit","lineage":["https://openalex.org/I4210100789"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhiyong Cheng","raw_affiliation_strings":["Wuhan Mechanical Technology College, Wuhan 430075, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wuhan Mechanical Technology College, Wuhan 430075, China","institution_ids":["https://openalex.org/I4210100789"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5067551856","display_name":"Honglin Jin","orcid":"https://orcid.org/0000-0002-4398-9539"},"institutions":[{"id":"https://openalex.org/I4210138186","display_name":"Wuhan National Laboratory for Optoelectronics","ror":"https://ror.org/03c9ncn37","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210138186"]},{"id":"https://openalex.org/I47720641","display_name":"Huazhong University of Science and Technology","ror":"https://ror.org/00p991c53","country_code":"CN","type":"education","lineage":["https://openalex.org/I47720641"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Honglin Jin","raw_affiliation_strings":["Britton Chance Center for Biomedical Photonics, Wuhan National Laboratory for Optoelectronics, Huazhong University of Science and Technology, Wuhan 430074, China","MoE Key Laboratory for Biomedical Photonics, Department of Biomedical Engineering, Huazhong University of Science and Technology, Wuhan 430074, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Britton Chance Center for Biomedical Photonics, Wuhan National Laboratory for Optoelectronics, Huazhong University of Science and Technology, Wuhan 430074, China","institution_ids":["https://openalex.org/I4210138186","https://openalex.org/I47720641"]},{"raw_affiliation_string":"MoE Key Laboratory for Biomedical Photonics, Department of Biomedical Engineering, Huazhong University of Science and Technology, Wuhan 430074, China","institution_ids":["https://openalex.org/I47720641"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5067551856"],"corresponding_institution_ids":["https://openalex.org/I4210138186","https://openalex.org/I47720641"],"apc_list":{"value":2400,"currency":"CHF","value_usd":2673},"apc_paid":{"value":2400,"currency":"CHF","value_usd":2673},"fwci":0.0,"has_fulltext":false,"cited_by_count":11,"citation_normalized_percentile":{"value":0.10077419,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"12","issue":"7","first_page":"9411","last_page":"9422"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11533","display_name":"Melanoma and MAPK Pathways","score":0.996399998664856,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.9941999912261963,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bimolecular-fluorescence-complementation","display_name":"Bimolecular fluorescence complementation","score":0.8752870559692383},{"id":"https://openalex.org/keywords/cell-biology","display_name":"Cell biology","score":0.7095070481300354},{"id":"https://openalex.org/keywords/cytoplasm","display_name":"Cytoplasm","score":0.6583241820335388},{"id":"https://openalex.org/keywords/transfection","display_name":"Transfection","score":0.6102234721183777},{"id":"https://openalex.org/keywords/cytosol","display_name":"Cytosol","score":0.5107324123382568},{"id":"https://openalex.org/keywords/effector","display_name":"Effector","score":0.4871194362640381},{"id":"https://openalex.org/keywords/signal-transduction","display_name":"Signal transduction","score":0.45480889081954956},{"id":"https://openalex.org/keywords/fusion-protein","display_name":"Fusion protein","score":0.44563108682632446},{"id":"https://openalex.org/keywords/green-fluorescent-protein","display_name":"Green fluorescent protein","score":0.43665841221809387},{"id":"https://openalex.org/keywords/subcellular-localization","display_name":"Subcellular localization","score":0.43336382508277893},{"id":"https://openalex.org/keywords/cell-membrane","display_name":"Cell membrane","score":0.43269675970077515},{"id":"https://openalex.org/keywords/cell","display_name":"Cell","score":0.42447489500045776},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.42223894596099854},{"id":"https://openalex.org/keywords/anti-apoptotic-ras-signalling-cascade","display_name":"Anti-apoptotic Ras signalling cascade","score":0.4186098575592041},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.4090147018432617},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.24326390027999878},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.07817107439041138},{"id":"https://openalex.org/keywords/mapk/erk-pathway","display_name":"MAPK/ERK pathway","score":0.07668328285217285}],"concepts":[{"id":"https://openalex.org/C123243835","wikidata":"https://www.wikidata.org/wiki/Q863465","display_name":"Bimolecular fluorescence complementation","level":3,"score":0.8752870559692383},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.7095070481300354},{"id":"https://openalex.org/C190062978","wikidata":"https://www.wikidata.org/wiki/Q79899","display_name":"Cytoplasm","level":2,"score":0.6583241820335388},{"id":"https://openalex.org/C54009773","wikidata":"https://www.wikidata.org/wiki/Q1429031","display_name":"Transfection","level":3,"score":0.6102234721183777},{"id":"https://openalex.org/C98539663","wikidata":"https://www.wikidata.org/wiki/Q220599","display_name":"Cytosol","level":3,"score":0.5107324123382568},{"id":"https://openalex.org/C51785407","wikidata":"https://www.wikidata.org/wiki/Q2627568","display_name":"Effector","level":2,"score":0.4871194362640381},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.45480889081954956},{"id":"https://openalex.org/C123894998","wikidata":"https://www.wikidata.org/wiki/Q425158","display_name":"Fusion protein","level":4,"score":0.44563108682632446},{"id":"https://openalex.org/C142613039","wikidata":"https://www.wikidata.org/wiki/Q272983","display_name":"Green fluorescent protein","level":3,"score":0.43665841221809387},{"id":"https://openalex.org/C2776879804","wikidata":"https://www.wikidata.org/wiki/Q7630919","display_name":"Subcellular localization","level":3,"score":0.43336382508277893},{"id":"https://openalex.org/C2778106830","wikidata":"https://www.wikidata.org/wiki/Q29548","display_name":"Cell membrane","level":3,"score":0.43269675970077515},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.42447489500045776},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.42223894596099854},{"id":"https://openalex.org/C127812441","wikidata":"https://www.wikidata.org/wiki/Q4774319","display_name":"Anti-apoptotic Ras signalling cascade","level":4,"score":0.4186098575592041},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4090147018432617},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.24326390027999878},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.07817107439041138},{"id":"https://openalex.org/C57074206","wikidata":"https://www.wikidata.org/wiki/Q14197552","display_name":"MAPK/ERK pathway","level":3,"score":0.07668328285217285},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0},{"id":"https://openalex.org/C40767141","wikidata":"https://www.wikidata.org/wiki/Q285697","display_name":"Recombinant DNA","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002522","descriptor_name":"Chlorocebus aethiops","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002522","descriptor_name":"Chlorocebus aethiops","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002522","descriptor_name":"Chlorocebus aethiops","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008164","descriptor_name":"Luminescent Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008164","descriptor_name":"Luminescent Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008164","descriptor_name":"Luminescent Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008164","descriptor_name":"Luminescent Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008164","descriptor_name":"Luminescent Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008164","descriptor_name":"Luminescent Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011993","descriptor_name":"Recombinant Fusion Proteins","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D011993","descriptor_name":"Recombinant Fusion Proteins","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D011993","descriptor_name":"Recombinant Fusion Proteins","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D011993","descriptor_name":"Recombinant Fusion Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011993","descriptor_name":"Recombinant Fusion Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011993","descriptor_name":"Recombinant Fusion Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011993","descriptor_name":"Recombinant Fusion Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011993","descriptor_name":"Recombinant Fusion Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011993","descriptor_name":"Recombinant Fusion Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018631","descriptor_name":"ras Proteins","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D018631","descriptor_name":"ras Proteins","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D018631","descriptor_name":"ras Proteins","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D018631","descriptor_name":"ras Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018631","descriptor_name":"ras Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018631","descriptor_name":"ras Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018631","descriptor_name":"ras Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018631","descriptor_name":"ras Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018631","descriptor_name":"ras Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019556","descriptor_name":"COS Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019556","descriptor_name":"COS Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019556","descriptor_name":"COS Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019908","descriptor_name":"Proto-Oncogene Proteins c-raf","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019908","descriptor_name":"Proto-Oncogene Proteins c-raf","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019908","descriptor_name":"Proto-Oncogene Proteins c-raf","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.3390/s120709411","is_oa":true,"landing_page_url":"https://doi.org/10.3390/s120709411","pdf_url":"https://www.mdpi.com/1424-8220/12/7/9411/pdf?version=1403317871","source":{"id":"https://openalex.org/S101949793","display_name":"Sensors","issn_l":"1424-8220","issn":["1424-8220"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sensors","raw_type":"journal-article"},{"id":"pmid:23012550","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23012550","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sensors (Basel, Switzerland)","raw_type":null},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.396.7419","is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.396.7419","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://www.mdpi.com/1424-8220/12/7/9411/pdf/","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:2b8c4ffada674c19b8cedc103e60ace8","is_oa":true,"landing_page_url":"https://doaj.org/article/2b8c4ffada674c19b8cedc103e60ace8","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Sensors, Vol 12, Iss 7, Pp 9411-9422 (2012)","raw_type":"article"},{"id":"pmh:oai:europepmc.org:2449909","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3444108","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:mdpi.com:/1424-8220/12/7/9411/","is_oa":true,"landing_page_url":"https://dx.doi.org/10.3390/s120709411","pdf_url":null,"source":{"id":"https://openalex.org/S4306400947","display_name":"MDPI (MDPI AG)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210097602","host_organization_name":"Multidisciplinary Digital Publishing Institute (Switzerland)","host_organization_lineage":["https://openalex.org/I4210097602"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Sensors; Volume 12; Issue 7; Pages: 9411-9422","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.3390/s120709411","is_oa":true,"landing_page_url":"https://doi.org/10.3390/s120709411","pdf_url":"https://www.mdpi.com/1424-8220/12/7/9411/pdf?version=1403317871","source":{"id":"https://openalex.org/S101949793","display_name":"Sensors","issn_l":"1424-8220","issn":["1424-8220"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sensors","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/15","display_name":"Life in Land","score":0.4300000071525574}],"awards":[],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337346","display_name":"National Institute of Mental Health","ror":"https://ror.org/04xeg9z08"}],"has_content":{"pdf":true,"grobid_xml":false},"content_urls":{"pdf":"https://content.openalex.org/works/W2105826358.pdf"},"referenced_works_count":34,"referenced_works":["https://openalex.org/W192451759","https://openalex.org/W198944900","https://openalex.org/W1590871522","https://openalex.org/W1965169361","https://openalex.org/W1965684839","https://openalex.org/W1978478230","https://openalex.org/W1986242330","https://openalex.org/W1986812906","https://openalex.org/W1987195331","https://openalex.org/W1990065094","https://openalex.org/W1991760443","https://openalex.org/W1996962669","https://openalex.org/W2004109773","https://openalex.org/W2010207338","https://openalex.org/W2018258118","https://openalex.org/W2021563552","https://openalex.org/W2035726898","https://openalex.org/W2036312188","https://openalex.org/W2037483496","https://openalex.org/W2043409309","https://openalex.org/W2043450412","https://openalex.org/W2052371969","https://openalex.org/W2060438880","https://openalex.org/W2063445224","https://openalex.org/W2070210483","https://openalex.org/W2093965961","https://openalex.org/W2104666395","https://openalex.org/W2116234410","https://openalex.org/W2117669008","https://openalex.org/W2121243961","https://openalex.org/W2126577131","https://openalex.org/W2162658068","https://openalex.org/W2176744910","https://openalex.org/W6647786800"],"related_works":["https://openalex.org/W1970346242","https://openalex.org/W3089702875","https://openalex.org/W4200245575","https://openalex.org/W2156628706","https://openalex.org/W2125112783","https://openalex.org/W2018494620","https://openalex.org/W1984529171","https://openalex.org/W3033096450","https://openalex.org/W2583256514","https://openalex.org/W2991586723"],"abstract_inverted_index":{"K-Ras":[0,26,63,122,177,192,205],"works":[1],"as":[2,171],"a":[3,55,85,121,182,197],"switch":[4],"in":[5,15,100,111,132,145],"many":[6],"important":[7,13],"intracellular":[8],"signaling":[9],"pathways":[10],"and":[11,20,62,84,119,150,166,178,193,195,206],"plays":[12],"roles":[14],"cell":[16,47,102,134,211],"growth,":[17],"proliferation,":[18],"differentiation":[19],"carcinogenesis.":[21],"For":[22],"signal":[23],"transduction":[24],"from":[25,42],"to":[27,45,73,130,200,209],"Raf1,":[28],"the":[29,34,43,46,91,94,101,105,112,115,133,154,172,189,202,210],"best-characterized":[30],"effector":[31],"of":[32,57,77,117,157],"K-Ras,":[33,165],"general":[35],"view":[36],"is":[37,160],"that":[38,153,167],"Ras":[39],"recruits":[40],"Raf1":[41,61,106,118,179,194,207],"cytoplasm":[44],"membrane.":[48,135,212],"To":[49],"elucidate":[50,201],"this":[51],"process,":[52],"we":[53],"constructed":[54],"series":[56],"fusion":[58],"proteins":[59,68],"(including":[60],"fused":[64],"with":[65,148],"either":[66],"fluorescent":[67,70],"or":[69],"protein":[71],"fragments)":[72],"compare":[74],"subcellular":[75],"localizations":[76],"these":[78],"proteins.":[79],"Bimolecular":[80],"fluorescence":[81],"complementation":[82],"(BiFC)":[83],"co-transfection":[86],"system":[87],"were":[88,97,127],"used.":[89],"In":[90,136],"BiFC":[92],"system,":[93],"K-Ras/Raf1":[95,158],"complexes":[96,116,159],"mainly":[98],"located":[99],"membrane,":[103],"while":[104],"control":[107],"was":[108,143],"uniformly":[109],"distributed":[110],"cytoplasm.":[113],"However,":[114],"K-RasC185S,":[120],"mutant":[123],"which":[124],"loses":[125],"membrane-localization,":[126],"also":[128],"able":[129],"accumulate":[131],"contrast,":[137],"an":[138],"apparent":[139],"cytosolic":[140],"distribution":[141],"pattern":[142],"observed":[144],"cells":[146],"co-transfected":[147],"mcerulean-Raf1":[149],"EGFP-K-RasC185S,":[151],"suggesting":[152],"membrane":[155],"localization":[156],"not":[161],"entirely":[162],"dependent":[163],"on":[164,188],"other":[168],"factors,":[169],"such":[170],"irreversible":[173],"conformation":[174],"formed":[175],"between":[176,191],"may":[180],"play":[181],"role.":[183],"This":[184],"study":[185],"sheds":[186],"light":[187],"interaction":[190],"provides":[196],"practical":[198],"method":[199],"mechanism":[203],"underlying":[204],"binding":[208]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":4},{"year":2017,"cited_by_count":1}],"updated_date":"2026-07-22T07:51:19.307946","created_date":"2025-10-10T00:00:00"}
