{"id":"https://openalex.org/W2066485816","doi":"https://doi.org/10.3390/s120100347","title":"Single-Cell Chemical Lysis on Microfluidic Chips with Arrays of Microwells","display_name":"Single-Cell Chemical Lysis on Microfluidic Chips with Arrays of Microwells","publication_year":2011,"publication_date":"2011-12-30","ids":{"openalex":"https://openalex.org/W2066485816","doi":"https://doi.org/10.3390/s120100347","mag":"2066485816","pmid":"https://pubmed.ncbi.nlm.nih.gov/22368473"},"language":"en","primary_location":{"id":"doi:10.3390/s120100347","is_oa":true,"landing_page_url":"https://doi.org/10.3390/s120100347","pdf_url":"https://www.mdpi.com/1424-8220/12/1/347/pdf?version=1403316780","source":{"id":"https://openalex.org/S101949793","display_name":"Sensors","issn_l":"1424-8220","issn":["1424-8220"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sensors","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/1424-8220/12/1/347/pdf?version=1403316780","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5089823501","display_name":"Chun\u2010Ping Jen","orcid":"https://orcid.org/0000-0001-5558-5817"},"institutions":[{"id":"https://openalex.org/I148099254","display_name":"National Chung Cheng University","ror":"https://ror.org/0028v3876","country_code":"TW","type":"education","lineage":["https://openalex.org/I148099254"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Chun-Ping Jen","raw_affiliation_strings":["Department of Mechanical Engineering and Advanced Institute of Manufacturing with High-Tech Innovation, National Chung Cheng University, Chia Yi 62102, Taiwan"],"raw_orcid":"https://orcid.org/0000-0001-5558-5817","affiliations":[{"raw_affiliation_string":"Department of Mechanical Engineering and Advanced Institute of Manufacturing with High-Tech Innovation, National Chung Cheng University, Chia Yi 62102, Taiwan","institution_ids":["https://openalex.org/I148099254"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111797138","display_name":"Ju-Hsiu Hsiao","orcid":null},"institutions":[{"id":"https://openalex.org/I148099254","display_name":"National Chung Cheng University","ror":"https://ror.org/0028v3876","country_code":"TW","type":"education","lineage":["https://openalex.org/I148099254"]},{"id":"https://openalex.org/I188973947","display_name":"Novosibirsk State University","ror":"https://ror.org/04t2ss102","country_code":"RU","type":"education","lineage":["https://openalex.org/I188973947"]}],"countries":["RU","TW"],"is_corresponding":false,"raw_author_name":"Ju-Hsiu Hsiao","raw_affiliation_strings":["Department of Mechanical Engineering and Advanced Institute of Manufacturing with High-Tech Innovation, National Chung Cheng University, Chia Yi 62102, Taiwan","Novosibirsk state university"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Mechanical Engineering and Advanced Institute of Manufacturing with High-Tech Innovation, National Chung Cheng University, Chia Yi 62102, Taiwan","institution_ids":["https://openalex.org/I148099254"]},{"raw_affiliation_string":"Novosibirsk state university","institution_ids":["https://openalex.org/I188973947"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5026798237","display_name":"N. A. Maslov","orcid":"https://orcid.org/0000-0003-1979-1976"},"institutions":[{"id":"https://openalex.org/I148099254","display_name":"National Chung Cheng University","ror":"https://ror.org/0028v3876","country_code":"TW","type":"education","lineage":["https://openalex.org/I148099254"]},{"id":"https://openalex.org/I4210120969","display_name":"Institute of Theoretical and Applied Mechanics","ror":"https://ror.org/02azz6x90","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I1313323035","https://openalex.org/I4210120969","https://openalex.org/I4210127387","https://openalex.org/I4210164537"]}],"countries":["RU","TW"],"is_corresponding":false,"raw_author_name":"Nikolay A. Maslov","raw_affiliation_strings":["Khristianovich Institute of Theoretical and Applied Mechanics, Siberian Division, Russian Academy of Science, Novosibirsk 630090, Russia","Nat. Chung Cheng. Univ"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Khristianovich Institute of Theoretical and Applied Mechanics, Siberian Division, Russian Academy of Science, Novosibirsk 630090, Russia","institution_ids":["https://openalex.org/I4210120969"]},{"raw_affiliation_string":"Nat. Chung Cheng. Univ","institution_ids":["https://openalex.org/I148099254"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":2400,"currency":"CHF","value_usd":2673},"apc_paid":{"value":2400,"currency":"CHF","value_usd":2673},"fwci":2.3964,"has_fulltext":false,"cited_by_count":75,"citation_normalized_percentile":{"value":0.87753495,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":94,"max":99},"biblio":{"volume":"12","issue":"1","first_page":"347","last_page":"358"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11255","display_name":"Microfluidic and Bio-sensing Technologies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11255","display_name":"Microfluidic and Bio-sensing Technologies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10412","display_name":"Microfluidic and Capillary Electrophoresis Applications","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11190","display_name":"3D Printing in Biomedical Research","score":0.9991999864578247,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lysis","display_name":"Lysis","score":0.9656758308410645},{"id":"https://openalex.org/keywords/microfluidics","display_name":"Microfluidics","score":0.7875955700874329},{"id":"https://openalex.org/keywords/microfluidic-chip","display_name":"Microfluidic chip","score":0.6314655542373657},{"id":"https://openalex.org/keywords/lysis-buffer","display_name":"Lysis buffer","score":0.580436110496521},{"id":"https://openalex.org/keywords/cell","display_name":"Cell","score":0.557738721370697},{"id":"https://openalex.org/keywords/single-cell-analysis","display_name":"Single-cell analysis","score":0.5015504360198975},{"id":"https://openalex.org/keywords/population","display_name":"Population","score":0.4517502188682556},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.40054944157600403},{"id":"https://openalex.org/keywords/biophysics","display_name":"Biophysics","score":0.394795298576355},{"id":"https://openalex.org/keywords/nanotechnology","display_name":"Nanotechnology","score":0.3912837505340576},{"id":"https://openalex.org/keywords/materials-science","display_name":"Materials science","score":0.3829510509967804},{"id":"https://openalex.org/keywords/chromatography","display_name":"Chromatography","score":0.3296317160129547},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.2529361844062805},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.10399779677391052}],"concepts":[{"id":"https://openalex.org/C57409179","wikidata":"https://www.wikidata.org/wiki/Q1218293","display_name":"Lysis","level":2,"score":0.9656758308410645},{"id":"https://openalex.org/C8673954","wikidata":"https://www.wikidata.org/wiki/Q138845","display_name":"Microfluidics","level":2,"score":0.7875955700874329},{"id":"https://openalex.org/C2988198817","wikidata":"https://www.wikidata.org/wiki/Q633261","display_name":"Microfluidic chip","level":3,"score":0.6314655542373657},{"id":"https://openalex.org/C190431759","wikidata":"https://www.wikidata.org/wiki/Q6710242","display_name":"Lysis buffer","level":3,"score":0.580436110496521},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.557738721370697},{"id":"https://openalex.org/C2776950831","wikidata":"https://www.wikidata.org/wiki/Q15635432","display_name":"Single-cell analysis","level":3,"score":0.5015504360198975},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.4517502188682556},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.40054944157600403},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.394795298576355},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.3912837505340576},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.3829510509967804},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.3296317160129547},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2529361844062805},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.10399779677391052},{"id":"https://openalex.org/C144024400","wikidata":"https://www.wikidata.org/wiki/Q21201","display_name":"Sociology","level":0,"score":0.0},{"id":"https://openalex.org/C149923435","wikidata":"https://www.wikidata.org/wiki/Q37732","display_name":"Demography","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D005591","descriptor_name":"Chemical Fractionation","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D005591","descriptor_name":"Chemical Fractionation","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D005591","descriptor_name":"Chemical Fractionation","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D006367","descriptor_name":"HeLa Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006367","descriptor_name":"HeLa Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006367","descriptor_name":"HeLa Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008856","descriptor_name":"Microscopy, Fluorescence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008856","descriptor_name":"Microscopy, Fluorescence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008856","descriptor_name":"Microscopy, Fluorescence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D046210","descriptor_name":"Microfluidic Analytical Techniques","qualifier_ui":"Q000295","qualifier_name":"instrumentation","is_major_topic":false},{"descriptor_ui":"D046210","descriptor_name":"Microfluidic Analytical Techniques","qualifier_ui":"Q000295","qualifier_name":"instrumentation","is_major_topic":false},{"descriptor_ui":"D046210","descriptor_name":"Microfluidic Analytical Techniques","qualifier_ui":"Q000295","qualifier_name":"instrumentation","is_major_topic":false},{"descriptor_ui":"D046210","descriptor_name":"Microfluidic Analytical Techniques","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D046210","descriptor_name":"Microfluidic Analytical Techniques","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D046210","descriptor_name":"Microfluidic Analytical Techniques","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D059010","descriptor_name":"Single-Cell Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D059010","descriptor_name":"Single-Cell Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D059010","descriptor_name":"Single-Cell Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.3390/s120100347","is_oa":true,"landing_page_url":"https://doi.org/10.3390/s120100347","pdf_url":"https://www.mdpi.com/1424-8220/12/1/347/pdf?version=1403316780","source":{"id":"https://openalex.org/S101949793","display_name":"Sensors","issn_l":"1424-8220","issn":["1424-8220"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sensors","raw_type":"journal-article"},{"id":"pmid:22368473","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22368473","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sensors (Basel, Switzerland)","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:3279217","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3279217","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Sensors (Basel)","raw_type":"Text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.271.2865","is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.271.2865","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/4f/51/Sensors_(Basel)_2011_Dec_30_12(1)_347-358.tar.gz","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:f7609d49dcac4045bac9c3959ff9f5aa","is_oa":true,"landing_page_url":"https://doaj.org/article/f7609d49dcac4045bac9c3959ff9f5aa","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Sensors, Vol 12, Iss 1, Pp 347-358 (2011)","raw_type":"article"},{"id":"pmh:oai:mdpi.com:/1424-8220/12/1/347/","is_oa":true,"landing_page_url":"https://dx.doi.org/10.3390/s120100347","pdf_url":null,"source":{"id":"https://openalex.org/S4306400947","display_name":"MDPI (MDPI AG)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210097602","host_organization_name":"Multidisciplinary Digital Publishing Institute (Switzerland)","host_organization_lineage":["https://openalex.org/I4210097602"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Sensors; Volume 12; Issue 1; Pages: 347-358","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.3390/s120100347","is_oa":true,"landing_page_url":"https://doi.org/10.3390/s120100347","pdf_url":"https://www.mdpi.com/1424-8220/12/1/347/pdf?version=1403316780","source":{"id":"https://openalex.org/S101949793","display_name":"Sensors","issn_l":"1424-8220","issn":["1424-8220"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sensors","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.4300000071525574,"display_name":"Clean water and sanitation","id":"https://metadata.un.org/sdg/6"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320321040","display_name":"National Science Council","ror":"https://ror.org/02kv4zf79"}],"has_content":{"grobid_xml":false,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2066485816.pdf"},"referenced_works_count":38,"referenced_works":["https://openalex.org/W1965621981","https://openalex.org/W1966291881","https://openalex.org/W1968421448","https://openalex.org/W1971018355","https://openalex.org/W1974511084","https://openalex.org/W1975872110","https://openalex.org/W1979038838","https://openalex.org/W1980688685","https://openalex.org/W1993390786","https://openalex.org/W2005464082","https://openalex.org/W2005887917","https://openalex.org/W2008764190","https://openalex.org/W2011292082","https://openalex.org/W2019976157","https://openalex.org/W2028008883","https://openalex.org/W2032344057","https://openalex.org/W2032884095","https://openalex.org/W2045145170","https://openalex.org/W2046166714","https://openalex.org/W2046926752","https://openalex.org/W2057859026","https://openalex.org/W2067445353","https://openalex.org/W2067456238","https://openalex.org/W2070418129","https://openalex.org/W2071624306","https://openalex.org/W2087631258","https://openalex.org/W2103333529","https://openalex.org/W2104672342","https://openalex.org/W2113891751","https://openalex.org/W2119339939","https://openalex.org/W2134896855","https://openalex.org/W2139074780","https://openalex.org/W2141093691","https://openalex.org/W2148438834","https://openalex.org/W2150739149","https://openalex.org/W2157765551","https://openalex.org/W2164406135","https://openalex.org/W2164527416"],"related_works":["https://openalex.org/W2775294347","https://openalex.org/W3186580930","https://openalex.org/W7382634","https://openalex.org/W2382095280","https://openalex.org/W586114392","https://openalex.org/W2372017743","https://openalex.org/W3148992845","https://openalex.org/W4306742332","https://openalex.org/W2509355859","https://openalex.org/W163326304"],"abstract_inverted_index":{"Many":[0],"conventional":[1],"biochemical":[2],"assays":[3],"are":[4],"performed":[5],"using":[6],"populations":[7],"of":[8,58,90,95,105],"cells":[9],"to":[10],"determine":[11],"their":[12],"quantitative":[13],"biomolecular":[14],"profiles.":[15],"However,":[16,93],"population":[17],"averages":[18],"do":[19],"not":[20],"reflect":[21],"actual":[22],"physiological":[23],"processes":[24],"in":[25,66,73,81,138],"individual":[26,101],"cells,":[27],"which":[28,143],"occur":[29],"either":[30],"on":[31],"short":[32],"time":[33],"scales":[34],"or":[35],"nonsynchronously.":[36],"Therefore,":[37],"accurate":[38],"analysis":[39],"at":[40,85,109],"the":[41,67,96,110,121,139],"single-cell":[42,63,111],"level":[43,112],"has":[44],"become":[45],"a":[46],"highly":[47],"attractive":[48],"tool":[49],"for":[50,62,146],"investigating":[51],"cellular":[52,71],"content.":[53],"Microfluidic":[54],"chips":[55],"with":[56],"arrays":[57],"microwells":[59,75,83,99],"were":[60,117,127],"developed":[61],"chemical":[64,106,134],"lysis":[65,107,122,135],"present":[68],"study.":[69],"The":[70,103],"occupancy":[72],"30-\u03bcm-diameter":[74],"(91.45%)":[76],"was":[77,124,136],"higher":[78],"than":[79],"that":[80,114],"20-\u03bcm-diameter":[82,98],"(83.19%)":[84],"an":[86],"injection":[87],"flow":[88],"rate":[89],"2.8":[91],"\u03bcL/min.":[92],"most":[94],"occupied":[97],"contained":[100],"cells.":[102],"results":[104],"experiments":[108],"indicate":[113],"cell":[115,148],"membranes":[116],"gradually":[118],"lysed":[119,129],"as":[120],"buffer":[123],"injected;":[125],"they":[126],"fully":[128],"after":[130],"12":[131],"s.":[132],"Single-cell":[133],"demonstrated":[137],"proposed":[140],"microfluidic":[141],"chip,":[142],"is":[144],"suitable":[145],"high-throughput":[147],"lysis.":[149]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":7},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":7},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":10},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":7},{"year":2014,"cited_by_count":6},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":3}],"updated_date":"2026-08-11T07:18:39.950985","created_date":"2025-10-10T00:00:00"}