{"id":"https://openalex.org/W2065787152","doi":"https://doi.org/10.3390/s110908395","title":"Development of an Integrated Microfluidic Perfusion Cell Culture System for Real-Time Microscopic Observation of Biological Cells","display_name":"Development of an Integrated Microfluidic Perfusion Cell Culture System for Real-Time Microscopic Observation of Biological Cells","publication_year":2011,"publication_date":"2011-08-29","ids":{"openalex":"https://openalex.org/W2065787152","doi":"https://doi.org/10.3390/s110908395","mag":"2065787152","pmid":"https://pubmed.ncbi.nlm.nih.gov/22164082"},"language":"en","primary_location":{"id":"doi:10.3390/s110908395","is_oa":true,"landing_page_url":"https://doi.org/10.3390/s110908395","pdf_url":"https://www.mdpi.com/1424-8220/11/9/8395/pdf?version=1403316046","source":{"id":"https://openalex.org/S101949793","display_name":"Sensors","issn_l":"1424-8220","issn":["1424-8220"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sensors","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/1424-8220/11/9/8395/pdf?version=1403316046","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5064240374","display_name":"Jr-Lung Lin","orcid":null},"institutions":[{"id":"https://openalex.org/I98298690","display_name":"I-Shou University","ror":"https://ror.org/04d7e4m76","country_code":"TW","type":"education","lineage":["https://openalex.org/I98298690"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Jr-Lung Lin","raw_affiliation_strings":["Department of Mechanical and Automation Engineering, I-Shou University, Kaohsiung 82445, Taiwan"],"affiliations":[{"raw_affiliation_string":"Department of Mechanical and Automation Engineering, I-Shou University, Kaohsiung 82445, Taiwan","institution_ids":["https://openalex.org/I98298690"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100372339","display_name":"Bin Wang","orcid":"https://orcid.org/0000-0002-2371-2065"},"institutions":[{"id":"https://openalex.org/I173093425","display_name":"Chang Gung University","ror":"https://ror.org/00d80zx46","country_code":"TW","type":"education","lineage":["https://openalex.org/I173093425"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Shih-Siou Wang","raw_affiliation_strings":["Department of Chemical and Materials Engineering, Chang Gung University, Taoyuan 333, Taiwan"],"affiliations":[{"raw_affiliation_string":"Department of Chemical and Materials Engineering, Chang Gung University, Taoyuan 333, Taiwan","institution_ids":["https://openalex.org/I173093425"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054920568","display_name":"Min\u2010Hsien Wu","orcid":"https://orcid.org/0000-0002-3507-3512"},"institutions":[{"id":"https://openalex.org/I173093425","display_name":"Chang Gung University","ror":"https://ror.org/00d80zx46","country_code":"TW","type":"education","lineage":["https://openalex.org/I173093425"]}],"countries":["TW"],"is_corresponding":true,"raw_author_name":"Min-Hsien Wu","raw_affiliation_strings":["Graduate Institute of Biochemical and Biomedical Engineering, Chang Gung University, Taoyuan 333, Taiwan"],"affiliations":[{"raw_affiliation_string":"Graduate Institute of Biochemical and Biomedical Engineering, Chang Gung University, Taoyuan 333, Taiwan","institution_ids":["https://openalex.org/I173093425"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5088109421","display_name":"Chih-Chin Oh-Yang","orcid":null},"institutions":[{"id":"https://openalex.org/I98298690","display_name":"I-Shou University","ror":"https://ror.org/04d7e4m76","country_code":"TW","type":"education","lineage":["https://openalex.org/I98298690"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Chih-Chin Oh-Yang","raw_affiliation_strings":["Department of Mechanical and Automation Engineering, I-Shou University, Kaohsiung 82445, Taiwan"],"affiliations":[{"raw_affiliation_string":"Department of Mechanical and Automation Engineering, I-Shou University, Kaohsiung 82445, Taiwan","institution_ids":["https://openalex.org/I98298690"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5054920568"],"corresponding_institution_ids":["https://openalex.org/I173093425"],"apc_list":{"value":2400,"currency":"CHF","value_usd":2598},"apc_paid":{"value":2400,"currency":"CHF","value_usd":2598},"fwci":0.8627,"has_fulltext":true,"cited_by_count":28,"citation_normalized_percentile":{"value":0.74603819,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":98},"biblio":{"volume":"11","issue":"9","first_page":"8395","last_page":"8411"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11190","display_name":"3D Printing in Biomedical Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11190","display_name":"3D Printing in Biomedical Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10412","display_name":"Microfluidic and Capillary Electrophoresis Applications","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11407","display_name":"Innovative Microfluidic and Catalytic Techniques Innovation","score":0.9994000196456909,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/microheater","display_name":"Microheater","score":0.9854366779327393},{"id":"https://openalex.org/keywords/microfluidics","display_name":"Microfluidics","score":0.7477579116821289},{"id":"https://openalex.org/keywords/indium-tin-oxide","display_name":"Indium tin oxide","score":0.7005566358566284},{"id":"https://openalex.org/keywords/materials-science","display_name":"Materials science","score":0.6279803514480591},{"id":"https://openalex.org/keywords/nanotechnology","display_name":"Nanotechnology","score":0.44609150290489197},{"id":"https://openalex.org/keywords/thermal","display_name":"Thermal","score":0.4452459216117859},{"id":"https://openalex.org/keywords/cell-culture","display_name":"Cell culture","score":0.4388551712036133},{"id":"https://openalex.org/keywords/lab-on-a-chip","display_name":"Lab-on-a-chip","score":0.42499732971191406},{"id":"https://openalex.org/keywords/temperature-control","display_name":"Temperature control","score":0.4203258454799652},{"id":"https://openalex.org/keywords/biomedical-engineering","display_name":"Biomedical engineering","score":0.3622238039970398},{"id":"https://openalex.org/keywords/biological-system","display_name":"Biological system","score":0.34916573762893677},{"id":"https://openalex.org/keywords/fabrication","display_name":"Fabrication","score":0.12534603476524353},{"id":"https://openalex.org/keywords/mechanical-engineering","display_name":"Mechanical engineering","score":0.09692835807800293},{"id":"https://openalex.org/keywords/engineering","display_name":"Engineering","score":0.07367688417434692}],"concepts":[{"id":"https://openalex.org/C2779426163","wikidata":"https://www.wikidata.org/wiki/Q17123760","display_name":"Microheater","level":4,"score":0.9854366779327393},{"id":"https://openalex.org/C8673954","wikidata":"https://www.wikidata.org/wiki/Q138845","display_name":"Microfluidics","level":2,"score":0.7477579116821289},{"id":"https://openalex.org/C32737372","wikidata":"https://www.wikidata.org/wiki/Q417718","display_name":"Indium tin oxide","level":3,"score":0.7005566358566284},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.6279803514480591},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.44609150290489197},{"id":"https://openalex.org/C204530211","wikidata":"https://www.wikidata.org/wiki/Q752823","display_name":"Thermal","level":2,"score":0.4452459216117859},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.4388551712036133},{"id":"https://openalex.org/C138942068","wikidata":"https://www.wikidata.org/wiki/Q633261","display_name":"Lab-on-a-chip","level":3,"score":0.42499732971191406},{"id":"https://openalex.org/C536315585","wikidata":"https://www.wikidata.org/wiki/Q7698332","display_name":"Temperature control","level":2,"score":0.4203258454799652},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.3622238039970398},{"id":"https://openalex.org/C186060115","wikidata":"https://www.wikidata.org/wiki/Q30336093","display_name":"Biological system","level":1,"score":0.34916573762893677},{"id":"https://openalex.org/C136525101","wikidata":"https://www.wikidata.org/wiki/Q5428139","display_name":"Fabrication","level":3,"score":0.12534603476524353},{"id":"https://openalex.org/C78519656","wikidata":"https://www.wikidata.org/wiki/Q101333","display_name":"Mechanical engineering","level":1,"score":0.09692835807800293},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.07367688417434692},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C2779227376","wikidata":"https://www.wikidata.org/wiki/Q6505497","display_name":"Layer (electronics)","level":2,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0},{"id":"https://openalex.org/C153294291","wikidata":"https://www.wikidata.org/wiki/Q25261","display_name":"Meteorology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D008853","descriptor_name":"Microscopy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D008853","descriptor_name":"Microscopy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D008853","descriptor_name":"Microscopy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D018929","descriptor_name":"Cell Culture Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018929","descriptor_name":"Cell Culture Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018929","descriptor_name":"Cell Culture Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D044085","descriptor_name":"Microfluidics","qualifier_ui":"Q000295","qualifier_name":"instrumentation","is_major_topic":false},{"descriptor_ui":"D044085","descriptor_name":"Microfluidics","qualifier_ui":"Q000295","qualifier_name":"instrumentation","is_major_topic":false},{"descriptor_ui":"D044085","descriptor_name":"Microfluidics","qualifier_ui":"Q000295","qualifier_name":"instrumentation","is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.3390/s110908395","is_oa":true,"landing_page_url":"https://doi.org/10.3390/s110908395","pdf_url":"https://www.mdpi.com/1424-8220/11/9/8395/pdf?version=1403316046","source":{"id":"https://openalex.org/S101949793","display_name":"Sensors","issn_l":"1424-8220","issn":["1424-8220"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sensors","raw_type":"journal-article"},{"id":"pmid:22164082","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22164082","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sensors (Basel, Switzerland)","raw_type":null},{"id":"pmh:oai:doaj.org/article:93bc3051ebfd4e2ca94b0e79cb79b668","is_oa":true,"landing_page_url":"https://doaj.org/article/93bc3051ebfd4e2ca94b0e79cb79b668","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Sensors, Vol 11, Iss 9, Pp 8395-8411 (2011)","raw_type":"article"},{"id":"pmh:oai:europepmc.org:2240656","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3231477","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:mdpi.com:/1424-8220/11/9/8395/","is_oa":true,"landing_page_url":"https://dx.doi.org/10.3390/s110908395","pdf_url":null,"source":{"id":"https://openalex.org/S4306400947","display_name":"MDPI (MDPI AG)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210097602","host_organization_name":"Multidisciplinary Digital Publishing Institute (Switzerland)","host_organization_lineage":["https://openalex.org/I4210097602"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Sensors; Volume 11; Issue 9; Pages: 8395-8411","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.3390/s110908395","is_oa":true,"landing_page_url":"https://doi.org/10.3390/s110908395","pdf_url":"https://www.mdpi.com/1424-8220/11/9/8395/pdf?version=1403316046","source":{"id":"https://openalex.org/S101949793","display_name":"Sensors","issn_l":"1424-8220","issn":["1424-8220"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sensors","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G8737284672","display_name":null,"funder_award_id":"NSC 99","funder_id":"https://openalex.org/F4320321040","funder_display_name":"National Science Council"}],"funders":[{"id":"https://openalex.org/F4320321040","display_name":"National Science Council","ror":"https://ror.org/02kv4zf79"},{"id":"https://openalex.org/F4320322201","display_name":"I-Shou University","ror":"https://ror.org/04d7e4m76"},{"id":"https://openalex.org/F4320322767","display_name":"Chang Gung Medical Foundation","ror":"https://ror.org/02verss31"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2065787152.pdf","grobid_xml":"https://content.openalex.org/works/W2065787152.grobid-xml"},"referenced_works_count":28,"referenced_works":["https://openalex.org/W1982788326","https://openalex.org/W1984417171","https://openalex.org/W1992644383","https://openalex.org/W1995376647","https://openalex.org/W1995891480","https://openalex.org/W2009915078","https://openalex.org/W2016211113","https://openalex.org/W2017656225","https://openalex.org/W2025859541","https://openalex.org/W2026938213","https://openalex.org/W2036564583","https://openalex.org/W2040848333","https://openalex.org/W2041077836","https://openalex.org/W2041612826","https://openalex.org/W2046755374","https://openalex.org/W2048974962","https://openalex.org/W2055759462","https://openalex.org/W2059852491","https://openalex.org/W2066239691","https://openalex.org/W2071311642","https://openalex.org/W2072741204","https://openalex.org/W2078206345","https://openalex.org/W2090253188","https://openalex.org/W2094576343","https://openalex.org/W2138807887","https://openalex.org/W2161734444","https://openalex.org/W2163232083","https://openalex.org/W2211464868"],"related_works":["https://openalex.org/W2079928829","https://openalex.org/W1969711776","https://openalex.org/W3088675879","https://openalex.org/W2899132461","https://openalex.org/W2095605164","https://openalex.org/W2053673665","https://openalex.org/W2021085378","https://openalex.org/W2121310445","https://openalex.org/W1916814302","https://openalex.org/W2733260917"],"abstract_inverted_index":{"This":[0],"study":[1],"reports":[2],"an":[3,18,177],"integrated":[4],"microfluidic":[5,13],"perfusion":[6,28,136],"cell":[7,14,29,137,150,172],"culture":[8,15,138,173],"system":[9,37,174],"consisting":[10],"of":[11,66,116,131,152,186],"a":[12,51,56,118,128,135,168,190],"chip,":[16],"and":[17,31,43,49,55,71,102,123,193],"indium":[19],"tin":[20],"oxide":[21],"(ITO)":[22],"glass-based":[23],"microheater":[24,75,113],"chip":[25],"for":[26],"micro-scale":[27],"culture,":[30],"its":[32],"real-time":[33,183],"microscopic":[34,184],"observation.":[35],"The":[36],"features":[38],"in":[39,189],"maintaining":[40],"both":[41],"uniform,":[42],"stable":[44],"chemical":[45],"or":[46],"thermal":[47,58,121],"environments,":[48],"providing":[50,117],"backflow-free":[52],"medium":[53,68,83],"pumping,":[54],"precise":[57,124],"control":[59,126],"functions.":[60],"In":[61,98,156],"this":[62],"work,":[63],"the":[64,67,72,82,110,143,157,159,170],"performance":[65],"pumping":[69,90],"scheme,":[70],"ITO":[73,111],"glass":[74,112],"were":[76,105,146],"experimentally":[77],"evaluated.":[78],"Results":[79],"show":[80],"that":[81,109],"delivery":[84],"mechanism":[85],"was":[86,114,139],"able":[87],"to":[88,95,107,180],"provide":[89],"rates":[91],"ranging":[92],"from":[93],"15.4":[94],"120.0":[96],"\u03bcL\u00b7min(-1).":[97],"addition,":[99],"numerical":[100],"simulation":[101],"experimental":[103],"evaluation":[104],"conducted":[106],"verify":[108],"capable":[115],"spatially":[119],"uniform":[120],"environment,":[122],"temperature":[125],"with":[127],"mild":[129],"variation":[130],"\u00b10.3":[132],"\u00b0C.":[133],"Furthermore,":[134],"successfully":[140],"demonstrated,":[141],"showing":[142],"cultured":[144,160],"cells":[145,188],"kept":[147],"at":[148],"high":[149],"viability":[151],"95":[153],"\u00b1":[154],"2%.":[155],"process,":[158],"chondrocytes":[161],"can":[162],"be":[163],"clearly":[164],"visualized":[165],"microscopically.":[166],"As":[167],"whole,":[169],"proposed":[171],"has":[175],"paved":[176],"alternative":[178],"route":[179],"carry":[181],"out":[182],"observation":[185],"biological":[187],"simple,":[191],"user-friendly,":[192],"low":[194],"cost":[195],"manner.":[196]},"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":2},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-04-10T15:06:20.359241","created_date":"2016-06-24T00:00:00"}
