{"id":"https://openalex.org/W2087168496","doi":"https://doi.org/10.3390/s110706685","title":"Label Free Inhibitor Screening of Hepatitis C Virus (HCV) NS5B Viral Protein Using RNA Oligonucleotide","display_name":"Label Free Inhibitor Screening of Hepatitis C Virus (HCV) NS5B Viral Protein Using RNA Oligonucleotide","publication_year":2011,"publication_date":"2011-06-27","ids":{"openalex":"https://openalex.org/W2087168496","doi":"https://doi.org/10.3390/s110706685","mag":"2087168496","pmid":"https://pubmed.ncbi.nlm.nih.gov/22163979"},"language":"en","primary_location":{"id":"doi:10.3390/s110706685","is_oa":true,"landing_page_url":"https://doi.org/10.3390/s110706685","pdf_url":"https://www.mdpi.com/1424-8220/11/7/6685/pdf?version=1403315466","source":{"id":"https://openalex.org/S101949793","display_name":"Sensors","issn_l":"1424-8220","issn":["1424-8220"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sensors","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/1424-8220/11/7/6685/pdf?version=1403315466","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5042309997","display_name":"Changhyun Roh","orcid":"https://orcid.org/0000-0002-0542-4828"},"institutions":[{"id":"https://openalex.org/I155671955","display_name":"Korea Atomic Energy Research Institute","ror":"https://ror.org/01xb4fs50","country_code":"KR","type":"facility","lineage":["https://openalex.org/I155671955","https://openalex.org/I27494661","https://openalex.org/I2801339556","https://openalex.org/I2801339556","https://openalex.org/I4210144908","https://openalex.org/I4387152098","https://openalex.org/I4387152098"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Changhyun Roh","raw_affiliation_strings":["Radiation Research Division for Biotechnology, Advanced Radiation Technology Institute (ARTI), Korea Atomic Energy Research Institute (KAERI), 1266 Shinjeong-dong, Jeongeup-si, Jeollabuk-do 580-185, Korea"],"affiliations":[{"raw_affiliation_string":"Radiation Research Division for Biotechnology, Advanced Radiation Technology Institute (ARTI), Korea Atomic Energy Research Institute (KAERI), 1266 Shinjeong-dong, Jeongeup-si, Jeollabuk-do 580-185, Korea","institution_ids":["https://openalex.org/I155671955"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101707931","display_name":"Sang Eun Kim","orcid":"https://orcid.org/0000-0003-1434-8369"},"institutions":[{"id":"https://openalex.org/I2803058125","display_name":"Seoul National University Bundang Hospital","ror":"https://ror.org/00cb3km46","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I139264467","https://openalex.org/I2802835388","https://openalex.org/I2803058125"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Sang Eun Kim","raw_affiliation_strings":["Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Seongnam 463-707, Korea"],"affiliations":[{"raw_affiliation_string":"Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Seongnam 463-707, Korea","institution_ids":["https://openalex.org/I2803058125"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5109980233","display_name":"Sung\u2010Kee Jo","orcid":null},"institutions":[{"id":"https://openalex.org/I155671955","display_name":"Korea Atomic Energy Research Institute","ror":"https://ror.org/01xb4fs50","country_code":"KR","type":"facility","lineage":["https://openalex.org/I155671955","https://openalex.org/I27494661","https://openalex.org/I2801339556","https://openalex.org/I2801339556","https://openalex.org/I4210144908","https://openalex.org/I4387152098","https://openalex.org/I4387152098"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Sung-Kee Jo","raw_affiliation_strings":["Radiation Research Division for Biotechnology, Advanced Radiation Technology Institute (ARTI), Korea Atomic Energy Research Institute (KAERI), 1266 Shinjeong-dong, Jeongeup-si, Jeollabuk-do 580-185, Korea"],"affiliations":[{"raw_affiliation_string":"Radiation Research Division for Biotechnology, Advanced Radiation Technology Institute (ARTI), Korea Atomic Energy Research Institute (KAERI), 1266 Shinjeong-dong, Jeongeup-si, Jeollabuk-do 580-185, Korea","institution_ids":["https://openalex.org/I155671955"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5042309997"],"corresponding_institution_ids":["https://openalex.org/I155671955"],"apc_list":{"value":2400,"currency":"CHF","value_usd":2598},"apc_paid":{"value":2400,"currency":"CHF","value_usd":2598},"fwci":0.2668,"has_fulltext":true,"cited_by_count":16,"citation_normalized_percentile":{"value":0.59138827,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"11","issue":"7","first_page":"6685","last_page":"6696"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10207","display_name":"Advanced biosensing and bioanalysis techniques","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10207","display_name":"Advanced biosensing and bioanalysis techniques","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.9986000061035156,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.9983999729156494,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/virology","display_name":"Virology","score":0.7044296264648438},{"id":"https://openalex.org/keywords/biotinylation","display_name":"Biotinylation","score":0.6706986427307129},{"id":"https://openalex.org/keywords/ns5b","display_name":"NS5B","score":0.6592860221862793},{"id":"https://openalex.org/keywords/hepatitis-c-virus","display_name":"Hepatitis C virus","score":0.6474826335906982},{"id":"https://openalex.org/keywords/oligonucleotide","display_name":"Oligonucleotide","score":0.5304398536682129},{"id":"https://openalex.org/keywords/rna","display_name":"RNA","score":0.5004651546478271},{"id":"https://openalex.org/keywords/aptamer","display_name":"Aptamer","score":0.49407389760017395},{"id":"https://openalex.org/keywords/ns3","display_name":"NS3","score":0.45685794949531555},{"id":"https://openalex.org/keywords/population","display_name":"Population","score":0.43968039751052856},{"id":"https://openalex.org/keywords/viral-hepatitis","display_name":"Viral hepatitis","score":0.43110066652297974},{"id":"https://openalex.org/keywords/viral-protein","display_name":"Viral protein","score":0.4284358620643616},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.4198463261127472},{"id":"https://openalex.org/keywords/virus","display_name":"Virus","score":0.36218565702438354},{"id":"https://openalex.org/keywords/molecular-biology","display_name":"Molecular biology","score":0.303927481174469},{"id":"https://openalex.org/keywords/hepacivirus","display_name":"Hepacivirus","score":0.2856137752532959},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.20555099844932556},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.14293283224105835},{"id":"https://openalex.org/keywords/dna","display_name":"DNA","score":0.11784231662750244},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.06823906302452087}],"concepts":[{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.7044296264648438},{"id":"https://openalex.org/C204628709","wikidata":"https://www.wikidata.org/wiki/Q864854","display_name":"Biotinylation","level":2,"score":0.6706986427307129},{"id":"https://openalex.org/C2781426373","wikidata":"https://www.wikidata.org/wiki/Q24766653","display_name":"NS5B","level":5,"score":0.6592860221862793},{"id":"https://openalex.org/C2776408679","wikidata":"https://www.wikidata.org/wiki/Q708693","display_name":"Hepatitis C virus","level":3,"score":0.6474826335906982},{"id":"https://openalex.org/C129312508","wikidata":"https://www.wikidata.org/wiki/Q133686","display_name":"Oligonucleotide","level":3,"score":0.5304398536682129},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.5004651546478271},{"id":"https://openalex.org/C128972844","wikidata":"https://www.wikidata.org/wiki/Q418722","display_name":"Aptamer","level":2,"score":0.49407389760017395},{"id":"https://openalex.org/C132379496","wikidata":"https://www.wikidata.org/wiki/Q83141645","display_name":"NS3","level":4,"score":0.45685794949531555},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.43968039751052856},{"id":"https://openalex.org/C2777072776","wikidata":"https://www.wikidata.org/wiki/Q1983841","display_name":"Viral hepatitis","level":2,"score":0.43110066652297974},{"id":"https://openalex.org/C2780879997","wikidata":"https://www.wikidata.org/wiki/Q952587","display_name":"Viral protein","level":3,"score":0.4284358620643616},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4198463261127472},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.36218565702438354},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.303927481174469},{"id":"https://openalex.org/C2781463415","wikidata":"https://www.wikidata.org/wiki/Q2082778","display_name":"Hepacivirus","level":4,"score":0.2856137752532959},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.20555099844932556},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.14293283224105835},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.11784231662750244},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.06823906302452087},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000998","descriptor_name":"Antiviral Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000998","descriptor_name":"Antiviral Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000998","descriptor_name":"Antiviral Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000998","descriptor_name":"Antiviral Agents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D000998","descriptor_name":"Antiviral Agents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D000998","descriptor_name":"Antiviral Agents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D001710","descriptor_name":"Biotin","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D001710","descriptor_name":"Biotin","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D001710","descriptor_name":"Biotin","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D002392","descriptor_name":"Catechin","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D002392","descriptor_name":"Catechin","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D002392","descriptor_name":"Catechin","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D002392","descriptor_name":"Catechin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002392","descriptor_name":"Catechin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002392","descriptor_name":"Catechin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002392","descriptor_name":"Catechin","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D002392","descriptor_name":"Catechin","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D002392","descriptor_name":"Catechin","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D003199","descriptor_name":"Computer Systems","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003199","descriptor_name":"Computer Systems","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003199","descriptor_name":"Computer Systems","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006526","descriptor_name":"Hepatitis C","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D006526","descriptor_name":"Hepatitis C","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D006526","descriptor_name":"Hepatitis C","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012324","descriptor_name":"RNA-Dependent RNA Polymerase","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016174","descriptor_name":"Hepacivirus","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D016174","descriptor_name":"Hepacivirus","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D016174","descriptor_name":"Hepacivirus","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D017361","descriptor_name":"Viral Nonstructural Proteins","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D017361","descriptor_name":"Viral Nonstructural Proteins","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D017361","descriptor_name":"Viral Nonstructural Proteins","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D017361","descriptor_name":"Viral Nonstructural Proteins","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D017361","descriptor_name":"Viral Nonstructural Proteins","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D017361","descriptor_name":"Viral Nonstructural Proteins","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D019809","descriptor_name":"Streptavidin","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D019809","descriptor_name":"Streptavidin","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D019809","descriptor_name":"Streptavidin","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D052157","descriptor_name":"Aptamers, Nucleotide","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D052157","descriptor_name":"Aptamers, Nucleotide","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D052157","descriptor_name":"Aptamers, Nucleotide","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.3390/s110706685","is_oa":true,"landing_page_url":"https://doi.org/10.3390/s110706685","pdf_url":"https://www.mdpi.com/1424-8220/11/7/6685/pdf?version=1403315466","source":{"id":"https://openalex.org/S101949793","display_name":"Sensors","issn_l":"1424-8220","issn":["1424-8220"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sensors","raw_type":"journal-article"},{"id":"pmid:22163979","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22163979","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sensors (Basel, Switzerland)","raw_type":null},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.286.9560","is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.286.9560","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/36/0f/Sensors_(Basel)_2011_Jun_27_11(7)_6685-6696.tar.gz","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:732c19ee2ec84e75bd923e5747e00edc","is_oa":true,"landing_page_url":"https://doaj.org/article/732c19ee2ec84e75bd923e5747e00edc","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Sensors, Vol 11, Iss 7, Pp 6685-6696 (2011)","raw_type":"article"},{"id":"pmh:oai:europepmc.org:2240781","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3231669","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"}],"best_oa_location":{"id":"doi:10.3390/s110706685","is_oa":true,"landing_page_url":"https://doi.org/10.3390/s110706685","pdf_url":"https://www.mdpi.com/1424-8220/11/7/6685/pdf?version=1403315466","source":{"id":"https://openalex.org/S101949793","display_name":"Sensors","issn_l":"1424-8220","issn":["1424-8220"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sensors","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.699999988079071}],"awards":[],"funders":[{"id":"https://openalex.org/F4320322109","display_name":"Korea Research Council of Fundamental Science and Technology","ror":"https://ror.org/058rymf81"},{"id":"https://openalex.org/F4320322115","display_name":"Korea Atomic Energy Research Institute","ror":"https://ror.org/01xb4fs50"},{"id":"https://openalex.org/F4320322349","display_name":"Ministry of Education, Science and Technology","ror":"https://ror.org/01p262204"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2087168496.pdf","grobid_xml":"https://content.openalex.org/works/W2087168496.grobid-xml"},"referenced_works_count":32,"referenced_works":["https://openalex.org/W98584085","https://openalex.org/W185439575","https://openalex.org/W1488301483","https://openalex.org/W1527655614","https://openalex.org/W1763230925","https://openalex.org/W1964447884","https://openalex.org/W1965505230","https://openalex.org/W1965962980","https://openalex.org/W1970948296","https://openalex.org/W1972019991","https://openalex.org/W1982404148","https://openalex.org/W2016431195","https://openalex.org/W2018289835","https://openalex.org/W2023594790","https://openalex.org/W2059578315","https://openalex.org/W2071352029","https://openalex.org/W2073390559","https://openalex.org/W2078201528","https://openalex.org/W2079321730","https://openalex.org/W2086070404","https://openalex.org/W2096426963","https://openalex.org/W2100837269","https://openalex.org/W2108810815","https://openalex.org/W2124395350","https://openalex.org/W2128635872","https://openalex.org/W2148492588","https://openalex.org/W2409484057","https://openalex.org/W4236653785","https://openalex.org/W4293247451","https://openalex.org/W6604019212","https://openalex.org/W6637980809","https://openalex.org/W6714117836"],"related_works":["https://openalex.org/W2090326661","https://openalex.org/W2761831962","https://openalex.org/W2438953093","https://openalex.org/W2070001963","https://openalex.org/W188736300","https://openalex.org/W2541260794","https://openalex.org/W2765626208","https://openalex.org/W2039620306","https://openalex.org/W1545947145","https://openalex.org/W3036569604"],"abstract_inverted_index":{"Globally,":[0],"over":[1],"170":[2],"million":[3],"people":[4],"(ca.":[5],"3%":[6],"of":[7,42,53,58,115,119,145,170,211,224],"the":[8,14,36,40,51,81,113,132,183],"World's":[9],"population)":[10],"are":[11],"infected":[12],"with":[13,142],"hepatitis":[15],"C":[16],"virus":[17],"(HCV),":[18],"which":[19],"can":[20,138,164,201],"cause":[21],"serious":[22],"liver":[23],"diseases":[24],"such":[25],"as":[26,44,76,108],"chronic":[27],"hepatitis,":[28],"evolving":[29],"into":[30],"subsequent":[31],"health":[32],"problems.":[33],"Driven":[34],"by":[35],"need":[37],"to":[38,105,167,218,221],"detect":[39],"presence":[41],"HCV,":[43],"an":[45,77,101,109,155],"essential":[46],"factor":[47],"in":[48,61,72,112],"diagnostic":[49],"medicine,":[50],"monitoring":[52,206],"viral":[54,73,120,140,171,196,213],"protein":[55,74,141,172,214],"has":[56],"been":[57],"great":[59],"interest":[60],"developing":[62],"simple":[63],"and":[64,174,215],"reliable":[65],"HCV":[66,78,194,212],"detection":[67,75,89,118,143],"methods.":[68],"Despite":[69],"considerable":[70],"advances":[71],"disease":[79],"marker,":[80],"current":[82],"enzyme":[83],"linked":[84],"immunosorbent":[85],"assay":[86],"(ELISA)":[87],"based":[88],"methods":[90],"using":[91,149],"antibody":[92,110],"treatment":[93],"have":[94],"several":[95],"drawbacks.":[96],"To":[97],"overcome":[98],"this":[99,123,162],"bottleneck,":[100],"RNA":[102,133,152,179],"aptamer":[103,134],"become":[104],"be":[106,165,202,219],"emerged":[107],"substitute":[111],"application":[114],"biosensor":[116],"for":[117,208],"protein.":[121,197],"In":[122],"study,":[124],"we":[125,160],"demonstrated":[126],"a":[127,150,177,204],"streptavidin-biotin":[128],"conjugation":[129],"method,":[130],"namely,":[131],"sensor":[135],"system":[136],"that":[137],"quantify":[139],"level":[144],"700":[146],"pg":[147],"mL(-1)":[148],"biotinylated":[151,178],"oligonucleotide":[153,180],"on":[154,176,193],"Octet":[156],"optical":[157],"biosensor.":[158,181],"Also,":[159],"showed":[161,188],"method":[163,200,207],"used":[166],"screen":[168],"inhibitors":[169,184],"rapidly":[173],"simply":[175],"Among":[182],"screened,":[185],"(-)-Epigallocatechin":[186],"gallate":[187],"high":[189],"binding":[190],"inhibition":[191],"effect":[192],"NS5B":[195],"The":[198],"proposed":[199],"considered":[203],"real-time":[205],"inhibitor":[209],"screening":[210],"is":[216],"expected":[217],"applicable":[220],"other":[222],"types":[223],"diseases.":[225]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":4},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-04-04T16:13:02.066488","created_date":"2025-10-10T00:00:00"}