{"id":"https://openalex.org/W2041890736","doi":"https://doi.org/10.3390/s100908143","title":"The Structure of Ca2+ Sensor Case16 Reveals the Mechanism of Reaction to Low Ca2+ Concentrations","display_name":"The Structure of Ca2+ Sensor Case16 Reveals the Mechanism of Reaction to Low Ca2+ Concentrations","publication_year":2010,"publication_date":"2010-08-30","ids":{"openalex":"https://openalex.org/W2041890736","doi":"https://doi.org/10.3390/s100908143","mag":"2041890736","pmid":"https://pubmed.ncbi.nlm.nih.gov/22163646"},"language":"en","primary_location":{"id":"doi:10.3390/s100908143","is_oa":true,"landing_page_url":"https://doi.org/10.3390/s100908143","pdf_url":"https://www.mdpi.com/1424-8220/10/9/8143/pdf?version=1403312956","source":{"id":"https://openalex.org/S101949793","display_name":"Sensors","issn_l":"1424-8220","issn":["1424-8220"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sensors","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/1424-8220/10/9/8143/pdf?version=1403312956","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5029394023","display_name":"Lukas Leder","orcid":"https://orcid.org/0009-0002-4378-6739"},"institutions":[{"id":"https://openalex.org/I1283582996","display_name":"Novartis (Switzerland)","ror":"https://ror.org/02f9zrr09","country_code":"CH","type":"company","lineage":["https://openalex.org/I1283582996"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Lukas Leder","raw_affiliation_strings":["Novartis Pharma AG, NIBR/CPC/LFP, Lichtstrasse 35, CH-4002 Basel, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Novartis Pharma AG, NIBR/CPC/LFP, Lichtstrasse 35, CH-4002 Basel, Switzerland","institution_ids":["https://openalex.org/I1283582996"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025920791","display_name":"Wilhelm Stark","orcid":null},"institutions":[{"id":"https://openalex.org/I2972652528","display_name":"FHNW University of Applied Sciences and Arts","ror":"https://ror.org/04mq2g308","country_code":"CH","type":"education","lineage":["https://openalex.org/I2972652528"]},{"id":"https://openalex.org/I1283582996","display_name":"Novartis (Switzerland)","ror":"https://ror.org/02f9zrr09","country_code":"CH","type":"company","lineage":["https://openalex.org/I1283582996"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Wilhelm Stark","raw_affiliation_strings":["Fachhochschule Nordwestschweiz, Institute for Chemistry and Bioanalytics. Gruendenstrasse 40, CH-4132 Muttenz, Switzerland","Novartis Pharma AG, NIBR/CPC/LFP, Lichtstrasse 35, CH-4002 Basel, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fachhochschule Nordwestschweiz, Institute for Chemistry and Bioanalytics. Gruendenstrasse 40, CH-4132 Muttenz, Switzerland","institution_ids":["https://openalex.org/I2972652528"]},{"raw_affiliation_string":"Novartis Pharma AG, NIBR/CPC/LFP, Lichtstrasse 35, CH-4002 Basel, Switzerland","institution_ids":["https://openalex.org/I1283582996"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029681228","display_name":"Felix Freuler","orcid":null},"institutions":[{"id":"https://openalex.org/I1283582996","display_name":"Novartis (Switzerland)","ror":"https://ror.org/02f9zrr09","country_code":"CH","type":"company","lineage":["https://openalex.org/I1283582996"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Felix Freuler","raw_affiliation_strings":["Novartis Pharma AG, NIBR/CPC/LFP, Lichtstrasse 35, CH-4002 Basel, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Novartis Pharma AG, NIBR/CPC/LFP, Lichtstrasse 35, CH-4002 Basel, Switzerland","institution_ids":["https://openalex.org/I1283582996"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022874699","display_name":"M. Marsh","orcid":"https://orcid.org/0000-0002-3880-7438"},"institutions":[{"id":"https://openalex.org/I1283582996","display_name":"Novartis (Switzerland)","ror":"https://ror.org/02f9zrr09","country_code":"CH","type":"company","lineage":["https://openalex.org/I1283582996"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"May Marsh","raw_affiliation_strings":["Novartis Pharma AG, NIBR/CPC/LFP, Lichtstrasse 35, CH-4002 Basel, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Novartis Pharma AG, NIBR/CPC/LFP, Lichtstrasse 35, CH-4002 Basel, Switzerland","institution_ids":["https://openalex.org/I1283582996"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066811343","display_name":"Marco Meyerhofer","orcid":null},"institutions":[{"id":"https://openalex.org/I1283582996","display_name":"Novartis (Switzerland)","ror":"https://ror.org/02f9zrr09","country_code":"CH","type":"company","lineage":["https://openalex.org/I1283582996"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Marco Meyerhofer","raw_affiliation_strings":["Novartis Pharma AG, NIBR/CPC/LFP, Lichtstrasse 35, CH-4002 Basel, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Novartis Pharma AG, NIBR/CPC/LFP, Lichtstrasse 35, CH-4002 Basel, Switzerland","institution_ids":["https://openalex.org/I1283582996"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015959047","display_name":"Thomas Stettler","orcid":null},"institutions":[{"id":"https://openalex.org/I1283582996","display_name":"Novartis (Switzerland)","ror":"https://ror.org/02f9zrr09","country_code":"CH","type":"company","lineage":["https://openalex.org/I1283582996"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Thomas Stettler","raw_affiliation_strings":["Novartis Pharma AG, NIBR/CPC/LFP, Lichtstrasse 35, CH-4002 Basel, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Novartis Pharma AG, NIBR/CPC/LFP, Lichtstrasse 35, CH-4002 Basel, Switzerland","institution_ids":["https://openalex.org/I1283582996"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051647746","display_name":"Lorenz M. Mayr","orcid":null},"institutions":[{"id":"https://openalex.org/I1283582996","display_name":"Novartis (Switzerland)","ror":"https://ror.org/02f9zrr09","country_code":"CH","type":"company","lineage":["https://openalex.org/I1283582996"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Lorenz M. Mayr","raw_affiliation_strings":["Novartis Pharma AG, NIBR/CPC/EPP, Lichtstrasse 35, CH-4002 Basel, Switzerland","Novartis Pharma AG, NIBR/CPC/LFP, Lichtstrasse 35, CH-4002 Basel, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Novartis Pharma AG, NIBR/CPC/EPP, Lichtstrasse 35, CH-4002 Basel, Switzerland","institution_ids":["https://openalex.org/I1283582996"]},{"raw_affiliation_string":"Novartis Pharma AG, NIBR/CPC/LFP, Lichtstrasse 35, CH-4002 Basel, Switzerland","institution_ids":["https://openalex.org/I1283582996"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018375058","display_name":"Olga V. Britanova","orcid":"https://orcid.org/0000-0002-6295-1392"},"institutions":[{"id":"https://openalex.org/I4210105571","display_name":"Institute of Bioorganic Chemistry","ror":"https://ror.org/01dg04253","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210105571","https://openalex.org/I4210129690"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Olga V. Britanova","raw_affiliation_strings":["Shemiakin-Ovchinnikov Institute of Bioorganic Chemistry, RAS, Miklukho-Maklaya str. 16/10, 117997, Moscow, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shemiakin-Ovchinnikov Institute of Bioorganic Chemistry, RAS, Miklukho-Maklaya str. 16/10, 117997, Moscow, Russia","institution_ids":["https://openalex.org/I4210105571"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027927527","display_name":"Lydia A. Strukova","orcid":null},"institutions":[{"id":"https://openalex.org/I4210105571","display_name":"Institute of Bioorganic Chemistry","ror":"https://ror.org/01dg04253","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210105571","https://openalex.org/I4210129690"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Lydia A. Strukova","raw_affiliation_strings":["Shemiakin-Ovchinnikov Institute of Bioorganic Chemistry, RAS, Miklukho-Maklaya str. 16/10, 117997, Moscow, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shemiakin-Ovchinnikov Institute of Bioorganic Chemistry, RAS, Miklukho-Maklaya str. 16/10, 117997, Moscow, Russia","institution_ids":["https://openalex.org/I4210105571"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060028352","display_name":"Dmitriy M. Chudakov","orcid":"https://orcid.org/0000-0003-0430-790X"},"institutions":[{"id":"https://openalex.org/I4210105571","display_name":"Institute of Bioorganic Chemistry","ror":"https://ror.org/01dg04253","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210105571","https://openalex.org/I4210129690"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Dmitriy M. Chudakov","raw_affiliation_strings":["Shemiakin-Ovchinnikov Institute of Bioorganic Chemistry, RAS, Miklukho-Maklaya str. 16/10, 117997, Moscow, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shemiakin-Ovchinnikov Institute of Bioorganic Chemistry, RAS, Miklukho-Maklaya str. 16/10, 117997, Moscow, Russia","institution_ids":["https://openalex.org/I4210105571"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5056346975","display_name":"Ekaterina A. Souslova","orcid":null},"institutions":[{"id":"https://openalex.org/I4210105571","display_name":"Institute of Bioorganic Chemistry","ror":"https://ror.org/01dg04253","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210105571","https://openalex.org/I4210129690"]}],"countries":["RU"],"is_corresponding":true,"raw_author_name":"Ekaterina A. Souslova","raw_affiliation_strings":["Shemiakin-Ovchinnikov Institute of Bioorganic Chemistry, RAS, Miklukho-Maklaya str. 16/10, 117997, Moscow, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shemiakin-Ovchinnikov Institute of Bioorganic Chemistry, RAS, Miklukho-Maklaya str. 16/10, 117997, Moscow, Russia","institution_ids":["https://openalex.org/I4210105571"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":11,"corresponding_author_ids":["https://openalex.org/A5056346975"],"corresponding_institution_ids":["https://openalex.org/I4210105571"],"apc_list":{"value":2400,"currency":"CHF","value_usd":2598},"apc_paid":{"value":2400,"currency":"CHF","value_usd":2598},"fwci":0.8166,"has_fulltext":true,"cited_by_count":19,"citation_normalized_percentile":{"value":0.71601044,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"10","issue":"9","first_page":"8143","last_page":"8160"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10207","display_name":"Advanced biosensing and bioanalysis techniques","score":0.9991000294685364,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10207","display_name":"Advanced biosensing and bioanalysis techniques","score":0.9991000294685364,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10540","display_name":"Advanced Fluorescence Microscopy Techniques","score":0.9991000294685364,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.996999979019165,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/calmodulin","display_name":"Calmodulin","score":0.7535582184791565},{"id":"https://openalex.org/keywords/fluorescence","display_name":"Fluorescence","score":0.6986333131790161},{"id":"https://openalex.org/keywords/chromophore","display_name":"Chromophore","score":0.5935119390487671},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.5684162378311157},{"id":"https://openalex.org/keywords/peptide","display_name":"Peptide","score":0.5652122497558594},{"id":"https://openalex.org/keywords/biophysics","display_name":"Biophysics","score":0.5639582276344299},{"id":"https://openalex.org/keywords/molecule","display_name":"Molecule","score":0.5563762784004211},{"id":"https://openalex.org/keywords/intermolecular-force","display_name":"Intermolecular force","score":0.5304880738258362},{"id":"https://openalex.org/keywords/crystal-structure","display_name":"Crystal structure","score":0.48728764057159424},{"id":"https://openalex.org/keywords/crystallography","display_name":"Crystallography","score":0.4273183047771454},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.23158249258995056},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.19801980257034302},{"id":"https://openalex.org/keywords/photochemistry","display_name":"Photochemistry","score":0.18787437677383423},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.13536593317985535},{"id":"https://openalex.org/keywords/enzyme","display_name":"Enzyme","score":0.09433996677398682}],"concepts":[{"id":"https://openalex.org/C29688787","wikidata":"https://www.wikidata.org/wiki/Q409145","display_name":"Calmodulin","level":3,"score":0.7535582184791565},{"id":"https://openalex.org/C91881484","wikidata":"https://www.wikidata.org/wiki/Q191807","display_name":"Fluorescence","level":2,"score":0.6986333131790161},{"id":"https://openalex.org/C192468462","wikidata":"https://www.wikidata.org/wiki/Q533543","display_name":"Chromophore","level":2,"score":0.5935119390487671},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5684162378311157},{"id":"https://openalex.org/C2779281246","wikidata":"https://www.wikidata.org/wiki/Q172847","display_name":"Peptide","level":2,"score":0.5652122497558594},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.5639582276344299},{"id":"https://openalex.org/C32909587","wikidata":"https://www.wikidata.org/wiki/Q11369","display_name":"Molecule","level":2,"score":0.5563762784004211},{"id":"https://openalex.org/C166950319","wikidata":"https://www.wikidata.org/wiki/Q245031","display_name":"Intermolecular force","level":3,"score":0.5304880738258362},{"id":"https://openalex.org/C115624301","wikidata":"https://www.wikidata.org/wiki/Q895901","display_name":"Crystal structure","level":2,"score":0.48728764057159424},{"id":"https://openalex.org/C8010536","wikidata":"https://www.wikidata.org/wiki/Q160398","display_name":"Crystallography","level":1,"score":0.4273183047771454},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.23158249258995056},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.19801980257034302},{"id":"https://openalex.org/C75473681","wikidata":"https://www.wikidata.org/wiki/Q188651","display_name":"Photochemistry","level":1,"score":0.18787437677383423},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.13536593317985535},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.09433996677398682},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D002147","descriptor_name":"Calmodulin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002147","descriptor_name":"Calmodulin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002147","descriptor_name":"Calmodulin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002147","descriptor_name":"Calmodulin","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D002147","descriptor_name":"Calmodulin","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D002147","descriptor_name":"Calmodulin","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D003460","descriptor_name":"Crystallization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003460","descriptor_name":"Crystallization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003460","descriptor_name":"Crystallization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005456","descriptor_name":"Fluorescent Dyes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005456","descriptor_name":"Fluorescent Dyes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005456","descriptor_name":"Fluorescent Dyes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005456","descriptor_name":"Fluorescent Dyes","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D005456","descriptor_name":"Fluorescent Dyes","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D005456","descriptor_name":"Fluorescent Dyes","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009219","descriptor_name":"Myosin-Light-Chain Kinase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009219","descriptor_name":"Myosin-Light-Chain Kinase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009219","descriptor_name":"Myosin-Light-Chain Kinase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009219","descriptor_name":"Myosin-Light-Chain Kinase","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D009219","descriptor_name":"Myosin-Light-Chain Kinase","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D009219","descriptor_name":"Myosin-Light-Chain Kinase","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D010446","descriptor_name":"Peptide Fragments","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010446","descriptor_name":"Peptide Fragments","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010446","descriptor_name":"Peptide Fragments","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010446","descriptor_name":"Peptide Fragments","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D010446","descriptor_name":"Peptide Fragments","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D010446","descriptor_name":"Peptide Fragments","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015374","descriptor_name":"Biosensing Techniques","qualifier_ui":"Q000295","qualifier_name":"instrumentation","is_major_topic":false},{"descriptor_ui":"D015374","descriptor_name":"Biosensing Techniques","qualifier_ui":"Q000295","qualifier_name":"instrumentation","is_major_topic":false},{"descriptor_ui":"D015374","descriptor_name":"Biosensing Techniques","qualifier_ui":"Q000295","qualifier_name":"instrumentation","is_major_topic":false},{"descriptor_ui":"D015374","descriptor_name":"Biosensing Techniques","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D015374","descriptor_name":"Biosensing Techniques","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D015374","descriptor_name":"Biosensing Techniques","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D049452","descriptor_name":"Green Fluorescent Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D049452","descriptor_name":"Green Fluorescent Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D049452","descriptor_name":"Green Fluorescent Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D049452","descriptor_name":"Green Fluorescent Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D049452","descriptor_name":"Green Fluorescent Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D049452","descriptor_name":"Green Fluorescent Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.3390/s100908143","is_oa":true,"landing_page_url":"https://doi.org/10.3390/s100908143","pdf_url":"https://www.mdpi.com/1424-8220/10/9/8143/pdf?version=1403312956","source":{"id":"https://openalex.org/S101949793","display_name":"Sensors","issn_l":"1424-8220","issn":["1424-8220"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sensors","raw_type":"journal-article"},{"id":"pmid:22163646","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22163646","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sensors (Basel, Switzerland)","raw_type":null},{"id":"pmh:oai:doaj.org/article:52b012813ad240e49e7016e54c7cfe43","is_oa":true,"landing_page_url":"https://doaj.org/article/52b012813ad240e49e7016e54c7cfe43","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Sensors, Vol 10, Iss 9, Pp 8143-8160 (2010)","raw_type":"article"},{"id":"pmh:oai:dora:psi_15027","is_oa":false,"landing_page_url":"https://www.dora.lib4ri.ch/psi/islandora/object/psi%3A15027","pdf_url":null,"source":{"id":"https://openalex.org/S4306402574","display_name":"DORA PSI (Paul Scherrer Institute)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I2802229908","host_organization_name":"Paul Scherrer Institute","host_organization_lineage":["https://openalex.org/I2802229908"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:europepmc.org:2240417","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3231237","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:mdpi.com:/1424-8220/10/9/8143/","is_oa":true,"landing_page_url":"https://dx.doi.org/10.3390/s100908143","pdf_url":null,"source":{"id":"https://openalex.org/S4306400947","display_name":"MDPI (MDPI AG)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210097602","host_organization_name":"Multidisciplinary Digital Publishing Institute (Switzerland)","host_organization_lineage":["https://openalex.org/I4210097602"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Sensors; Volume 10; Issue 9; Pages: 8143-8160","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.3390/s100908143","is_oa":true,"landing_page_url":"https://doi.org/10.3390/s100908143","pdf_url":"https://www.mdpi.com/1424-8220/10/9/8143/pdf?version=1403312956","source":{"id":"https://openalex.org/S101949793","display_name":"Sensors","issn_l":"1424-8220","issn":["1424-8220"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sensors","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Life in Land","score":0.44999998807907104,"id":"https://metadata.un.org/sdg/15"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320321079","display_name":"Russian Foundation for Basic Research","ror":"https://ror.org/02mh1ke95"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2041890736.pdf","grobid_xml":"https://content.openalex.org/works/W2041890736.grobid-xml"},"referenced_works_count":30,"referenced_works":["https://openalex.org/W113855239","https://openalex.org/W178619301","https://openalex.org/W1486466859","https://openalex.org/W1542263802","https://openalex.org/W1565248232","https://openalex.org/W1571164133","https://openalex.org/W1967642375","https://openalex.org/W1969369977","https://openalex.org/W1980087697","https://openalex.org/W1980726951","https://openalex.org/W1986450417","https://openalex.org/W1987159249","https://openalex.org/W1988326309","https://openalex.org/W1997529300","https://openalex.org/W2010002568","https://openalex.org/W2010694064","https://openalex.org/W2021692017","https://openalex.org/W2033098008","https://openalex.org/W2038840577","https://openalex.org/W2055772538","https://openalex.org/W2074698051","https://openalex.org/W2088864569","https://openalex.org/W2097493124","https://openalex.org/W2109234881","https://openalex.org/W2121406336","https://openalex.org/W2133844804","https://openalex.org/W2144081223","https://openalex.org/W2153535707","https://openalex.org/W2157199084","https://openalex.org/W2159209971"],"related_works":["https://openalex.org/W2118668532","https://openalex.org/W2088314087","https://openalex.org/W2008627400","https://openalex.org/W2079436230","https://openalex.org/W2296931932","https://openalex.org/W2026289228","https://openalex.org/W1970032998","https://openalex.org/W2012600810","https://openalex.org/W2950157573","https://openalex.org/W1955500350"],"abstract_inverted_index":{"Here":[0],"we":[1,99],"report":[2,81],"the":[3,22,32,35,40,44,82,86,110,119,122,142,146,150,155],"first":[4,41],"crystal":[5,83],"structure":[6,30,84],"of":[7,24,34,43,51,55,85,112,121,132,135,149,168,171],"a":[8,25,65],"high-contrast":[9],"genetically":[10],"encoded":[11],"circularly":[12],"permuted":[13],"green":[14],"fluorescent":[15,147],"protein":[16],"(cpGFP)-based":[17],"Ca(2+)":[18,27,61,88,93,103,172],"sensor,":[19],"Case16,":[20],"in":[21,174],"presence":[23],"low":[26],"concentration.":[28,94],"The":[29],"reveals":[31,140],"positioning":[33],"chromophore":[36],"within":[37],"Case16":[38,69,128],"at":[39,91],"stage":[42],"Ca(2+)-dependent":[45],"response":[46,148],"when":[47],"only":[48],"two":[49],"out":[50],"four":[52],"Ca(2+)-binding":[53],"pockets":[54],"calmodulin":[56],"(CaM)":[57],"are":[58],"occupied":[59],"with":[60,159],"ions.":[62],"In":[63],"such":[64],"\"half":[66],"Ca(2+)-bound":[67],"state\",":[68],"is":[70],"characterized":[71],"by":[72],"an":[73],"incomplete":[74],"interaction":[75,158],"between":[76],"its":[77],"CaM-/M13-domains.":[78],"We":[79,152],"also":[80],"related":[87],"sensor":[89,114,124],"Case12":[90,126],"saturating":[92],"Based":[95],"on":[96],"this":[97,169],"structure,":[98],"postulate":[100],"that":[101,141,154],"cpGFP-based":[102],"sensors":[104,173],"can":[105,164],"form":[106],"non-functional":[107],"homodimers":[108],"where":[109],"CaM-domain":[111],"one":[113],"molecule":[115],"binds":[116],"symmetrically":[117],"to":[118],"M13-peptide":[120,139],"partner":[123],"molecule.":[125],"and":[127,162],"behavior":[129],"upon":[130],"addition":[131],"high":[133],"concentrations":[134],"free":[136],"CaM":[137],"or":[138],"latter":[143],"effectively":[144],"blocks":[145],"sensor.":[151],"speculate":[153],"demonstrated":[156],"intermolecular":[157],"endogenous":[160],"substrates":[161],"homodimerization":[163],"impede":[165],"proper":[166],"functioning":[167],"type":[170],"living":[175],"cells.":[176]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":1}],"updated_date":"2026-05-06T08:25:59.206177","created_date":"2025-10-10T00:00:00"}