{"id":"https://openalex.org/W2161788813","doi":"https://doi.org/10.3390/s100402731","title":"Oxidant Sensing by Protein Kinases A and G Enables Integration of Cell Redox State with Phosphoregulation","display_name":"Oxidant Sensing by Protein Kinases A and G Enables Integration of Cell Redox State with Phosphoregulation","publication_year":2010,"publication_date":"2010-03-26","ids":{"openalex":"https://openalex.org/W2161788813","doi":"https://doi.org/10.3390/s100402731","mag":"2161788813","pmid":"https://pubmed.ncbi.nlm.nih.gov/22319269"},"language":"en","primary_location":{"id":"doi:10.3390/s100402731","is_oa":true,"landing_page_url":"https://doi.org/10.3390/s100402731","pdf_url":"https://www.mdpi.com/1424-8220/10/4/2731/pdf?version=1403312307","source":{"id":"https://openalex.org/S101949793","display_name":"Sensors","issn_l":"1424-8220","issn":["1424-8220"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sensors","raw_type":"journal-article"},"type":"review","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/1424-8220/10/4/2731/pdf?version=1403312307","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5087970190","display_name":"Joseph R. Burgoyne","orcid":"https://orcid.org/0000-0001-7325-7382"},"institutions":[{"id":"https://openalex.org/I1324925910","display_name":"St Thomas' Hospital","ror":"https://ror.org/054gk2851","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1324925910","https://openalex.org/I200166805","https://openalex.org/I4210111135"]},{"id":"https://openalex.org/I183935753","display_name":"King's College London","ror":"https://ror.org/0220mzb33","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I183935753"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Joseph R. Burgoyne","raw_affiliation_strings":["Department of Cardiology, The Rayne Institute, King\u2019s College London, St. Thomas\u2019 Hospital, London, SE1 7EH, UK","Department of Cardiology, The Rayne Institute, King's College London, St. Thomas' Hospital, London, SE1 7EH, UK"],"affiliations":[{"raw_affiliation_string":"Department of Cardiology, The Rayne Institute, King\u2019s College London, St. Thomas\u2019 Hospital, London, SE1 7EH, UK","institution_ids":["https://openalex.org/I1324925910"]},{"raw_affiliation_string":"Department of Cardiology, The Rayne Institute, King's College London, St. Thomas' Hospital, London, SE1 7EH, UK","institution_ids":["https://openalex.org/I1324925910","https://openalex.org/I183935753"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5023426107","display_name":"Philip Eaton","orcid":"https://orcid.org/0000-0003-0748-2367"},"institutions":[{"id":"https://openalex.org/I183935753","display_name":"King's College London","ror":"https://ror.org/0220mzb33","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I183935753"]},{"id":"https://openalex.org/I1324925910","display_name":"St Thomas' Hospital","ror":"https://ror.org/054gk2851","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1324925910","https://openalex.org/I200166805","https://openalex.org/I4210111135"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Philip Eaton","raw_affiliation_strings":["Department of Cardiology, The Rayne Institute, King\u2019s College London, St. Thomas\u2019 Hospital, London, SE1 7EH, UK","Department of Cardiology, The Rayne Institute, King's College London, St. Thomas' Hospital, London, SE1 7EH, UK"],"affiliations":[{"raw_affiliation_string":"Department of Cardiology, The Rayne Institute, King\u2019s College London, St. Thomas\u2019 Hospital, London, SE1 7EH, UK","institution_ids":["https://openalex.org/I1324925910"]},{"raw_affiliation_string":"Department of Cardiology, The Rayne Institute, King's College London, St. Thomas' Hospital, London, SE1 7EH, UK","institution_ids":["https://openalex.org/I1324925910","https://openalex.org/I183935753"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5023426107"],"corresponding_institution_ids":["https://openalex.org/I1324925910","https://openalex.org/I183935753"],"apc_list":{"value":2400,"currency":"CHF","value_usd":2598},"apc_paid":{"value":2400,"currency":"CHF","value_usd":2598},"fwci":0.5144,"has_fulltext":true,"cited_by_count":21,"citation_normalized_percentile":{"value":0.68696668,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":98},"biblio":{"volume":"10","issue":"4","first_page":"2731","last_page":"2751"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.9993000030517578,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.9993000030517578,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11884","display_name":"Redox biology and oxidative stress","score":0.9980999827384949,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.9957000017166138,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/kinase","display_name":"Kinase","score":0.7833033800125122},{"id":"https://openalex.org/keywords/second-messenger-system","display_name":"Second messenger system","score":0.6264538764953613},{"id":"https://openalex.org/keywords/cell-biology","display_name":"Cell biology","score":0.6080762147903442},{"id":"https://openalex.org/keywords/intracellular","display_name":"Intracellular","score":0.5255452394485474},{"id":"https://openalex.org/keywords/phosphorylation","display_name":"Phosphorylation","score":0.5053415894508362},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.4987945556640625},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.4583756923675537},{"id":"https://openalex.org/keywords/protein-kinase-a","display_name":"Protein kinase A","score":0.4470316767692566},{"id":"https://openalex.org/keywords/mitogen-activated-protein-kinase","display_name":"Mitogen-activated protein kinase","score":0.43469610810279846},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.3667607307434082}],"concepts":[{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.7833033800125122},{"id":"https://openalex.org/C163235415","wikidata":"https://www.wikidata.org/wiki/Q899814","display_name":"Second messenger system","level":3,"score":0.6264538764953613},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6080762147903442},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.5255452394485474},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.5053415894508362},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4987945556640625},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4583756923675537},{"id":"https://openalex.org/C97029542","wikidata":"https://www.wikidata.org/wiki/Q281417","display_name":"Protein kinase A","level":3,"score":0.4470316767692566},{"id":"https://openalex.org/C132149769","wikidata":"https://www.wikidata.org/wiki/Q899651","display_name":"Mitogen-activated protein kinase","level":3,"score":0.43469610810279846},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3667607307434082}],"mesh":[{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009119","descriptor_name":"Muscle Contraction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D009119","descriptor_name":"Muscle Contraction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D009119","descriptor_name":"Muscle Contraction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D009119","descriptor_name":"Muscle Contraction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D009131","descriptor_name":"Muscle, Smooth, Vascular","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009131","descriptor_name":"Muscle, Smooth, Vascular","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009131","descriptor_name":"Muscle, Smooth, Vascular","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009131","descriptor_name":"Muscle, Smooth, Vascular","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010084","descriptor_name":"Oxidation-Reduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010084","descriptor_name":"Oxidation-Reduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010084","descriptor_name":"Oxidation-Reduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010084","descriptor_name":"Oxidation-Reduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011499","descriptor_name":"Protein Processing, Post-Translational","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011499","descriptor_name":"Protein Processing, Post-Translational","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011499","descriptor_name":"Protein Processing, Post-Translational","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011499","descriptor_name":"Protein Processing, Post-Translational","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014661","descriptor_name":"Vasoconstriction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014661","descriptor_name":"Vasoconstriction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014661","descriptor_name":"Vasoconstriction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014661","descriptor_name":"Vasoconstriction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015374","descriptor_name":"Biosensing Techniques","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D015374","descriptor_name":"Biosensing Techniques","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D015374","descriptor_name":"Biosensing Techniques","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D015374","descriptor_name":"Biosensing Techniques","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D016877","descriptor_name":"Oxidants","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016877","descriptor_name":"Oxidants","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016877","descriptor_name":"Oxidants","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016877","descriptor_name":"Oxidants","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017868","descriptor_name":"Cyclic AMP-Dependent Protein Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017868","descriptor_name":"Cyclic AMP-Dependent Protein Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017868","descriptor_name":"Cyclic AMP-Dependent Protein Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017868","descriptor_name":"Cyclic AMP-Dependent Protein Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017869","descriptor_name":"Cyclic GMP-Dependent Protein Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017869","descriptor_name":"Cyclic GMP-Dependent Protein Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017869","descriptor_name":"Cyclic GMP-Dependent Protein Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017869","descriptor_name":"Cyclic GMP-Dependent Protein Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D032342","descriptor_name":"Muscle Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D032342","descriptor_name":"Muscle Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D032342","descriptor_name":"Muscle Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D032342","descriptor_name":"Muscle Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.3390/s100402731","is_oa":true,"landing_page_url":"https://doi.org/10.3390/s100402731","pdf_url":"https://www.mdpi.com/1424-8220/10/4/2731/pdf?version=1403312307","source":{"id":"https://openalex.org/S101949793","display_name":"Sensors","issn_l":"1424-8220","issn":["1424-8220"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sensors","raw_type":"journal-article"},{"id":"pmid:22319269","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22319269","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sensors (Basel, Switzerland)","raw_type":null},{"id":"pmh:oai:doaj.org/article:cfa730bebecf4b7abcf4bd07c53e0f71","is_oa":true,"landing_page_url":"https://doaj.org/article/cfa730bebecf4b7abcf4bd07c53e0f71","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Sensors, Vol 10, Iss 4, Pp 2731-2751 (2010)","raw_type":"article"},{"id":"pmh:oai:kclpure.kcl.ac.uk:publications/7373e2ea-bffa-4cac-9a67-6ec457f79762","is_oa":false,"landing_page_url":"https://kclpure.kcl.ac.uk/portal/en/publications/7373e2ea-bffa-4cac-9a67-6ec457f79762","pdf_url":null,"source":{"id":"https://openalex.org/S4306400216","display_name":"Research Portal (King's College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I183935753","host_organization_name":"King's College London","host_organization_lineage":["https://openalex.org/I183935753"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Burgoyne, J R & Eaton, P 2010, 'Oxidant Sensing by Protein Kinases A and G Enables Integration of Cell Redox State with Phosphoregulation', SENSORS, vol. 10, no. 4, pp. 2731 - 2751. https://doi.org/10.3390/s100402731","raw_type":"info:eu-repo/semantics/publishedVersion"},{"id":"pmh:oai:mdpi.com:/1424-8220/10/4/2731/","is_oa":true,"landing_page_url":"https://dx.doi.org/10.3390/s100402731","pdf_url":null,"source":{"id":"https://openalex.org/S4306400947","display_name":"MDPI (MDPI AG)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210097602","host_organization_name":"Multidisciplinary Digital Publishing Institute (Switzerland)","host_organization_lineage":["https://openalex.org/I4210097602"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Sensors; Volume 10; Issue 4; Pages: 2731-2751","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3274199","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3274199","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Sensors (Basel)","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.3390/s100402731","is_oa":true,"landing_page_url":"https://doi.org/10.3390/s100402731","pdf_url":"https://www.mdpi.com/1424-8220/10/4/2731/pdf?version=1403312307","source":{"id":"https://openalex.org/S101949793","display_name":"Sensors","issn_l":"1424-8220","issn":["1424-8220"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sensors","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/15","score":0.6100000143051147,"display_name":"Life in Land"}],"awards":[{"id":"https://openalex.org/G7407982985","display_name":null,"funder_award_id":"Fellowship","funder_id":"https://openalex.org/F4320334626","funder_display_name":"Medical Research Council"}],"funders":[{"id":"https://openalex.org/F4320311904","display_name":"Wellcome Trust","ror":"https://ror.org/029chgv08"},{"id":"https://openalex.org/F4320334626","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2161788813.pdf","grobid_xml":"https://content.openalex.org/works/W2161788813.grobid-xml"},"referenced_works_count":121,"referenced_works":["https://openalex.org/W157644240","https://openalex.org/W184935174","https://openalex.org/W1490236928","https://openalex.org/W1490821933","https://openalex.org/W1523578038","https://openalex.org/W1537911503","https://openalex.org/W1593764722","https://openalex.org/W1654031744","https://openalex.org/W1921519961","https://openalex.org/W1922087192","https://openalex.org/W1963716438","https://openalex.org/W1968720947","https://openalex.org/W1972310474","https://openalex.org/W1973780824","https://openalex.org/W1975841469","https://openalex.org/W1981706848","https://openalex.org/W1985696843","https://openalex.org/W1992267770","https://openalex.org/W1992993460","https://openalex.org/W1994717724","https://openalex.org/W1995320987","https://openalex.org/W1995797923","https://openalex.org/W1997778815","https://openalex.org/W2001348079","https://openalex.org/W2002587019","https://openalex.org/W2005678263","https://openalex.org/W2007453374","https://openalex.org/W2009552875","https://openalex.org/W2009765916","https://openalex.org/W2010637373","https://openalex.org/W2012185701","https://openalex.org/W2012931405","https://openalex.org/W2013173288","https://openalex.org/W2016449014","https://openalex.org/W2018234159","https://openalex.org/W2019753129","https://openalex.org/W2019822857","https://openalex.org/W2020592084","https://openalex.org/W2023395394","https://openalex.org/W2028117464","https://openalex.org/W2030508354","https://openalex.org/W2031196559","https://openalex.org/W2035341518","https://openalex.org/W2035348154","https://openalex.org/W2041516978","https://openalex.org/W2045141838","https://openalex.org/W2046351270","https://openalex.org/W2050182741","https://openalex.org/W2050824263","https://openalex.org/W2051740739","https://openalex.org/W2052606608","https://openalex.org/W2054165134","https://openalex.org/W2054455749","https://openalex.org/W2054939291","https://openalex.org/W2060375326","https://openalex.org/W2060499407","https://openalex.org/W2060959023","https://openalex.org/W2063780889","https://openalex.org/W2064061284","https://openalex.org/W2065630380","https://openalex.org/W2067093972","https://openalex.org/W2069650298","https://openalex.org/W2070840730","https://openalex.org/W2072862372","https://openalex.org/W2073574276","https://openalex.org/W2077601534","https://openalex.org/W2077916251","https://openalex.org/W2079310705","https://openalex.org/W2084158921","https://openalex.org/W2085253569","https://openalex.org/W2091973604","https://openalex.org/W2092166571","https://openalex.org/W2095252036","https://openalex.org/W2096445692","https://openalex.org/W2101822309","https://openalex.org/W2105445824","https://openalex.org/W2108872949","https://openalex.org/W2109384903","https://openalex.org/W2118103351","https://openalex.org/W2118272405","https://openalex.org/W2118709256","https://openalex.org/W2119355019","https://openalex.org/W2121452261","https://openalex.org/W2121486402","https://openalex.org/W2125590987","https://openalex.org/W2125644036","https://openalex.org/W2126712564","https://openalex.org/W2126920991","https://openalex.org/W2129236855","https://openalex.org/W2132073262","https://openalex.org/W2135554123","https://openalex.org/W2136196985","https://openalex.org/W2137377367","https://openalex.org/W2140313980","https://openalex.org/W2140577781","https://openalex.org/W2141307759","https://openalex.org/W2144799645","https://openalex.org/W2144804934","https://openalex.org/W2146056013","https://openalex.org/W2149421053","https://openalex.org/W2156835140","https://openalex.org/W2160416495","https://openalex.org/W2165485467","https://openalex.org/W2168010680","https://openalex.org/W2169632610","https://openalex.org/W2169653175","https://openalex.org/W2194472783","https://openalex.org/W2214291492","https://openalex.org/W2317399755","https://openalex.org/W2333347653","https://openalex.org/W2335815721","https://openalex.org/W2404108595","https://openalex.org/W2407741878","https://openalex.org/W2483097012","https://openalex.org/W2764603309","https://openalex.org/W2792980560","https://openalex.org/W4229512269","https://openalex.org/W4253431854","https://openalex.org/W6650863752","https://openalex.org/W6713745582","https://openalex.org/W6713957447"],"related_works":["https://openalex.org/W2051108283","https://openalex.org/W1964515703","https://openalex.org/W1973807900","https://openalex.org/W4362623556","https://openalex.org/W4362610326","https://openalex.org/W1978425204","https://openalex.org/W3175522830","https://openalex.org/W4232974937","https://openalex.org/W4239892895","https://openalex.org/W2014668380"],"abstract_inverted_index":{"The":[0,66],"control":[1],"of":[2,9,22,71,102,125,130],"vascular":[3],"smooth":[4],"muscle":[5],"contractility":[6],"enables":[7],"regulation":[8,124],"blood":[10,24,37],"pressure,":[11],"which":[12,57],"is":[13,26,44,128],"paramount":[14],"in":[15],"physiological":[16,131],"adaptation":[17],"to":[18,40],"environmental":[19],"challenges.":[20],"Maintenance":[21],"stable":[23],"pressure":[25],"crucial":[27],"for":[28,69],"health":[29],"as":[30],"deregulation":[31],"(caused":[32],"by":[33,47,84],"high":[34],"or":[35],"low":[36],"pressure)":[38],"leads":[39],"disease":[41],"progression.":[42],"Vasotone":[43],"principally":[45],"controlled":[46],"the":[48,80,111,137],"cyclic":[49,86,105],"nucleotide":[50,87],"dependent":[51],"protein":[52,63],"kinases":[53,74,112,127],"A":[54],"and":[55,61,78,82,96,133],"G,":[56],"regulate":[58],"intracellular":[59],"calcium":[60,64],"contractile":[62],"sensitivity.":[65],"classical":[67,138],"pathways":[68],"activation":[70,83],"these":[72,126],"two":[73],"are":[75],"well":[76],"established":[77],"involve":[79],"formation":[81],"specific":[85],"second":[88],"messengers.":[89],"Recently":[90],"we":[91],"reported":[92],"that":[93],"both":[94],"PKA":[95],"PKG":[97],"can":[98],"be":[99],"regulated":[100],"independently":[101],"their":[103],"respective":[104],"nucleotides":[106],"via":[107],"a":[108],"mechanism":[109],"whereby":[110],"sense":[113],"cellular":[114],"oxidant":[115],"production":[116],"using":[117],"redox":[118,123],"active":[119],"thiols.":[120],"This":[121],"novel":[122],"potentially":[129],"importance,":[132],"may":[134],"synergise":[135],"with":[136],"regulatory":[139],"mechanisms.":[140]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-04-10T15:06:20.359241","created_date":"2025-10-10T00:00:00"}