{"id":"https://openalex.org/W2509960233","doi":"https://doi.org/10.3390/mi7090162","title":"Microfluidic-Based Multi-Organ Platforms for Drug Discovery","display_name":"Microfluidic-Based Multi-Organ Platforms for Drug Discovery","publication_year":2016,"publication_date":"2016-09-08","ids":{"openalex":"https://openalex.org/W2509960233","doi":"https://doi.org/10.3390/mi7090162","mag":"2509960233","pmid":"https://pubmed.ncbi.nlm.nih.gov/30404334"},"language":"en","primary_location":{"id":"doi:10.3390/mi7090162","is_oa":true,"landing_page_url":"https://doi.org/10.3390/mi7090162","pdf_url":"https://www.mdpi.com/2072-666X/7/9/162/pdf?version=1473327411","source":{"id":"https://openalex.org/S96702057","display_name":"Micromachines","issn_l":"2072-666X","issn":["2072-666X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Micromachines","raw_type":"journal-article"},"type":"review","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/2072-666X/7/9/162/pdf?version=1473327411","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5078789861","display_name":"Ahmad Rezaei Kolahchi","orcid":null},"institutions":[{"id":"https://openalex.org/I168635309","display_name":"University of Calgary","ror":"https://ror.org/03yjb2x39","country_code":"CA","type":"education","lineage":["https://openalex.org/I168635309"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Ahmad Rezaei Kolahchi","raw_affiliation_strings":["BioMEMS and Bioinspired Microfluidic Laboratory, Department of Mechanical and Manufacturing Engineering, University of Calgary, 2500 University Drive NW, Calgary, AB T2N 1N4, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"BioMEMS and Bioinspired Microfluidic Laboratory, Department of Mechanical and Manufacturing Engineering, University of Calgary, 2500 University Drive NW, Calgary, AB T2N 1N4, Canada","institution_ids":["https://openalex.org/I168635309"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041825882","display_name":"Nima Khadem Mohtaram","orcid":null},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]},{"id":"https://openalex.org/I212119943","display_name":"University of Victoria","ror":"https://ror.org/04s5mat29","country_code":"CA","type":"education","lineage":["https://openalex.org/I212119943"]}],"countries":["CA","US"],"is_corresponding":false,"raw_author_name":"Nima Khadem Mohtaram","raw_affiliation_strings":["Department of Biomedical Engineering, University of Wisconsin-Madison, Madison, WI 53706, USA","Division of Medical Sciences, University of Victoria, Victoria, BC V8P 5C2, Canada","Laboratory for Innovations in MicroEngineering (LiME), Department of Mechanical Engineering, University of Victoria, Victoria, BC V8P 5C2, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, University of Wisconsin-Madison, Madison, WI 53706, USA","institution_ids":["https://openalex.org/I135310074"]},{"raw_affiliation_string":"Division of Medical Sciences, University of Victoria, Victoria, BC V8P 5C2, Canada","institution_ids":["https://openalex.org/I212119943"]},{"raw_affiliation_string":"Laboratory for Innovations in MicroEngineering (LiME), Department of Mechanical Engineering, University of Victoria, Victoria, BC V8P 5C2, Canada","institution_ids":["https://openalex.org/I212119943"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041293775","display_name":"Hassan Pezeshgi Modarres","orcid":null},"institutions":[{"id":"https://openalex.org/I168635309","display_name":"University of Calgary","ror":"https://ror.org/03yjb2x39","country_code":"CA","type":"education","lineage":["https://openalex.org/I168635309"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Hassan Pezeshgi Modarres","raw_affiliation_strings":["BioMEMS and Bioinspired Microfluidic Laboratory, Department of Mechanical and Manufacturing Engineering, University of Calgary, 2500 University Drive NW, Calgary, AB T2N 1N4, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"BioMEMS and Bioinspired Microfluidic Laboratory, Department of Mechanical and Manufacturing Engineering, University of Calgary, 2500 University Drive NW, Calgary, AB T2N 1N4, Canada","institution_ids":["https://openalex.org/I168635309"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100745061","display_name":"Mohammad Hossein Mohammadi","orcid":"https://orcid.org/0000-0003-0596-7539"},"institutions":[{"id":"https://openalex.org/I133529467","display_name":"Sharif University of Technology","ror":"https://ror.org/024c2fq17","country_code":"IR","type":"education","lineage":["https://openalex.org/I133529467"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Mohammad Mohammadi","raw_affiliation_strings":["Department of Chemical and Petroleum Engineering, Sharif University of Technology, Azadi Ave., Tehran 11155-9516, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical and Petroleum Engineering, Sharif University of Technology, Azadi Ave., Tehran 11155-9516, Iran","institution_ids":["https://openalex.org/I133529467"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022479717","display_name":"Armin Geraili","orcid":null},"institutions":[{"id":"https://openalex.org/I133529467","display_name":"Sharif University of Technology","ror":"https://ror.org/024c2fq17","country_code":"IR","type":"education","lineage":["https://openalex.org/I133529467"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Armin Geraili","raw_affiliation_strings":["Department of Chemical and Petroleum Engineering, Sharif University of Technology, Azadi Ave., Tehran 11155-9516, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical and Petroleum Engineering, Sharif University of Technology, Azadi Ave., Tehran 11155-9516, Iran","institution_ids":["https://openalex.org/I133529467"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079704650","display_name":"Parya Jafari","orcid":"https://orcid.org/0000-0003-2770-1627"},"institutions":[{"id":"https://openalex.org/I133529467","display_name":"Sharif University of Technology","ror":"https://ror.org/024c2fq17","country_code":"IR","type":"education","lineage":["https://openalex.org/I133529467"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Parya Jafari","raw_affiliation_strings":["Department of Electrical Engineering, Sharif University of Technology, Azadi Ave., Tehran 11155-9516, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Electrical Engineering, Sharif University of Technology, Azadi Ave., Tehran 11155-9516, Iran","institution_ids":["https://openalex.org/I133529467"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039506035","display_name":"Mohsen Akbari","orcid":"https://orcid.org/0000-0003-2902-6557"},"institutions":[{"id":"https://openalex.org/I212119943","display_name":"University of Victoria","ror":"https://ror.org/04s5mat29","country_code":"CA","type":"education","lineage":["https://openalex.org/I212119943"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Mohsen Akbari","raw_affiliation_strings":["Division of Medical Sciences, University of Victoria, Victoria, BC V8P 5C2, Canada","Laboratory for Innovations in MicroEngineering (LiME), Department of Mechanical Engineering, University of Victoria, Victoria, BC V8P 5C2, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Medical Sciences, University of Victoria, Victoria, BC V8P 5C2, Canada","institution_ids":["https://openalex.org/I212119943"]},{"raw_affiliation_string":"Laboratory for Innovations in MicroEngineering (LiME), Department of Mechanical Engineering, University of Victoria, Victoria, BC V8P 5C2, Canada","institution_ids":["https://openalex.org/I212119943"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5080888159","display_name":"Amir Sanati\u2010Nezhad","orcid":"https://orcid.org/0000-0002-2309-2388"},"institutions":[{"id":"https://openalex.org/I168635309","display_name":"University of Calgary","ror":"https://ror.org/03yjb2x39","country_code":"CA","type":"education","lineage":["https://openalex.org/I168635309"]}],"countries":["CA"],"is_corresponding":true,"raw_author_name":"Amir Sanati-Nezhad","raw_affiliation_strings":["BioMEMS and Bioinspired Microfluidic Laboratory, Department of Mechanical and Manufacturing Engineering, University of Calgary, 2500 University Drive NW, Calgary, AB T2N 1N4, Canada","Center for Bioengineering Research and Education, Biomedical Engineering Program, University of Calgary, 2500 University Drive NW, Calgary, AB T2N 1N4, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"BioMEMS and Bioinspired Microfluidic Laboratory, Department of Mechanical and Manufacturing Engineering, University of Calgary, 2500 University Drive NW, Calgary, AB T2N 1N4, Canada","institution_ids":["https://openalex.org/I168635309"]},{"raw_affiliation_string":"Center for Bioengineering Research and Education, Biomedical Engineering Program, University of Calgary, 2500 University Drive NW, Calgary, AB T2N 1N4, Canada","institution_ids":["https://openalex.org/I168635309"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":8,"corresponding_author_ids":["https://openalex.org/A5080888159"],"corresponding_institution_ids":["https://openalex.org/I168635309"],"apc_list":{"value":2000,"currency":"CHF","value_usd":2165},"apc_paid":{"value":2000,"currency":"CHF","value_usd":2165},"fwci":2.9744,"has_fulltext":true,"cited_by_count":51,"citation_normalized_percentile":{"value":0.90841843,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":99},"biblio":{"volume":"7","issue":"9","first_page":"162","last_page":"162"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11190","display_name":"3D Printing in Biomedical Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11190","display_name":"3D Printing in Biomedical Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11407","display_name":"Innovative Microfluidic and Catalytic Techniques Innovation","score":0.9991000294685364,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10412","display_name":"Microfluidic and Capillary Electrophoresis Applications","score":0.9975000023841858,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/organ-on-a-chip","display_name":"Organ-on-a-chip","score":0.7920975685119629},{"id":"https://openalex.org/keywords/physiologically-based-pharmacokinetic-modelling","display_name":"Physiologically based pharmacokinetic modelling","score":0.6496899724006653},{"id":"https://openalex.org/keywords/in-silico","display_name":"In silico","score":0.569479763507843},{"id":"https://openalex.org/keywords/drug-discovery","display_name":"Drug discovery","score":0.5493199825286865},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5405051708221436},{"id":"https://openalex.org/keywords/microfluidics","display_name":"Microfluidics","score":0.4828127324581146},{"id":"https://openalex.org/keywords/preclinical-testing","display_name":"Preclinical testing","score":0.4611295759677887},{"id":"https://openalex.org/keywords/drug-development","display_name":"Drug development","score":0.44802364706993103},{"id":"https://openalex.org/keywords/drug","display_name":"Drug","score":0.4391687512397766},{"id":"https://openalex.org/keywords/clinical-trial","display_name":"Clinical trial","score":0.43588417768478394},{"id":"https://openalex.org/keywords/biochemical-engineering","display_name":"Biochemical engineering","score":0.41797754168510437},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.41257524490356445},{"id":"https://openalex.org/keywords/nanotechnology","display_name":"Nanotechnology","score":0.3740399479866028},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.29311513900756836},{"id":"https://openalex.org/keywords/pharmacology","display_name":"Pharmacology","score":0.2862721085548401},{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"Pharmacokinetics","score":0.2636305093765259},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.24613356590270996},{"id":"https://openalex.org/keywords/medical-physics","display_name":"Medical physics","score":0.1973775029182434},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.17446383833885193},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.15792042016983032},{"id":"https://openalex.org/keywords/engineering","display_name":"Engineering","score":0.15336567163467407},{"id":"https://openalex.org/keywords/materials-science","display_name":"Materials science","score":0.0869046151638031}],"concepts":[{"id":"https://openalex.org/C165932988","wikidata":"https://www.wikidata.org/wiki/Q7101746","display_name":"Organ-on-a-chip","level":3,"score":0.7920975685119629},{"id":"https://openalex.org/C185867374","wikidata":"https://www.wikidata.org/wiki/Q2562769","display_name":"Physiologically based pharmacokinetic modelling","level":3,"score":0.6496899724006653},{"id":"https://openalex.org/C2775905019","wikidata":"https://www.wikidata.org/wiki/Q192572","display_name":"In silico","level":3,"score":0.569479763507843},{"id":"https://openalex.org/C74187038","wikidata":"https://www.wikidata.org/wiki/Q1418791","display_name":"Drug discovery","level":2,"score":0.5493199825286865},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5405051708221436},{"id":"https://openalex.org/C8673954","wikidata":"https://www.wikidata.org/wiki/Q138845","display_name":"Microfluidics","level":2,"score":0.4828127324581146},{"id":"https://openalex.org/C2994543053","wikidata":"https://www.wikidata.org/wiki/Q7239206","display_name":"Preclinical testing","level":2,"score":0.4611295759677887},{"id":"https://openalex.org/C64903051","wikidata":"https://www.wikidata.org/wiki/Q2198549","display_name":"Drug development","level":3,"score":0.44802364706993103},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.4391687512397766},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.43588417768478394},{"id":"https://openalex.org/C183696295","wikidata":"https://www.wikidata.org/wiki/Q2487696","display_name":"Biochemical engineering","level":1,"score":0.41797754168510437},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.41257524490356445},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.3740399479866028},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.29311513900756836},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.2862721085548401},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.2636305093765259},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.24613356590270996},{"id":"https://openalex.org/C19527891","wikidata":"https://www.wikidata.org/wiki/Q1120908","display_name":"Medical physics","level":1,"score":0.1973775029182434},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.17446383833885193},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.15792042016983032},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.15336567163467407},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.0869046151638031},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[],"locations_count":6,"locations":[{"id":"doi:10.3390/mi7090162","is_oa":true,"landing_page_url":"https://doi.org/10.3390/mi7090162","pdf_url":"https://www.mdpi.com/2072-666X/7/9/162/pdf?version=1473327411","source":{"id":"https://openalex.org/S96702057","display_name":"Micromachines","issn_l":"2072-666X","issn":["2072-666X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Micromachines","raw_type":"journal-article"},{"id":"pmid:30404334","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30404334","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Micromachines","raw_type":null},{"id":"pmh:oai:doaj.org/article:bb87150ab08e49a09ba3dbc016948f5a","is_oa":true,"landing_page_url":"https://doaj.org/article/bb87150ab08e49a09ba3dbc016948f5a","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Micromachines, Vol 7, Iss 9, p 162 (2016)","raw_type":"article"},{"id":"pmh:oai:dspace.library.uvic.ca:1828/10489","is_oa":false,"landing_page_url":"https://dspace.library.uvic.ca//handle/1828/10489","pdf_url":null,"source":{"id":"https://openalex.org/S4306401509","display_name":"UVic\u2019s Research and Learning Repository (University of Victoria)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I212119943","host_organization_name":"University of Victoria","host_organization_lineage":["https://openalex.org/I212119943"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article"},{"id":"pmh:oai:europepmc.org:5158153","is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC6189912","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:6189912","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6189912","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Micromachines (Basel)","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.3390/mi7090162","is_oa":true,"landing_page_url":"https://doi.org/10.3390/mi7090162","pdf_url":"https://www.mdpi.com/2072-666X/7/9/162/pdf?version=1473327411","source":{"id":"https://openalex.org/S96702057","display_name":"Micromachines","issn_l":"2072-666X","issn":["2072-666X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Micromachines","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.41999998688697815,"display_name":"Good health and well-being"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320325651","display_name":"Alberta Innovates","ror":null},{"id":"https://openalex.org/F4320334593","display_name":"Natural Sciences and Engineering Research Council of Canada","ror":"https://ror.org/01h531d29"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2509960233.pdf","grobid_xml":"https://content.openalex.org/works/W2509960233.grobid-xml"},"referenced_works_count":320,"referenced_works":["https://openalex.org/W71660379","https://openalex.org/W72792975","https://openalex.org/W107985703","https://openalex.org/W110903188","https://openalex.org/W169855384","https://openalex.org/W190066829","https://openalex.org/W614733133","https://openalex.org/W656463618","https://openalex.org/W1425121398","https://openalex.org/W1485305032","https://openalex.org/W1489860951","https://openalex.org/W1512126150","https://openalex.org/W1547158290","https://openalex.org/W1557788839","https://openalex.org/W1561391636","https://openalex.org/W1563050877","https://openalex.org/W1572820526","https://openalex.org/W1608678137","https://openalex.org/W1847104216","https://openalex.org/W1848527143","https://openalex.org/W1894349587","https://openalex.org/W1928351941","https://openalex.org/W1963700571","https://openalex.org/W1966440946","https://openalex.org/W1967556762","https://openalex.org/W1967707196","https://openalex.org/W1967930109","https://openalex.org/W1968525684","https://openalex.org/W1969371715","https://openalex.org/W1977179045","https://openalex.org/W1977608305","https://openalex.org/W1977611420","https://openalex.org/W1979425216","https://openalex.org/W1979535562","https://openalex.org/W1979721854","https://openalex.org/W1980701768","https://openalex.org/W1980766303","https://openalex.org/W1981030985","https://openalex.org/W1981403460","https://openalex.org/W1982484840","https://openalex.org/W1983274250","https://openalex.org/W1984789788","https://openalex.org/W1985755631","https://openalex.org/W1988548218","https://openalex.org/W1989425919","https://openalex.org/W1989755866","https://openalex.org/W1990057599","https://openalex.org/W1990149568","https://openalex.org/W1990178988","https://openalex.org/W1990796754","https://openalex.org/W1991764064","https://openalex.org/W1992396382","https://openalex.org/W1992431000","https://openalex.org/W1994504773","https://openalex.org/W1994615618","https://openalex.org/W1994652953","https://openalex.org/W1994812037","https://openalex.org/W1995139987","https://openalex.org/W1995789501","https://openalex.org/W1996528078","https://openalex.org/W1997114875","https://openalex.org/W1997641556","https://openalex.org/W1997778378","https://openalex.org/W1998220531","https://openalex.org/W2000005040","https://openalex.org/W2000857913","https://openalex.org/W2000902592","https://openalex.org/W2001059760","https://openalex.org/W2001587260","https://openalex.org/W2002307302","https://openalex.org/W2002708055","https://openalex.org/W2002719464","https://openalex.org/W2003142831","https://openalex.org/W2004703030","https://openalex.org/W2005132453","https://openalex.org/W2005240239","https://openalex.org/W2010448327","https://openalex.org/W2010916968","https://openalex.org/W2011853932","https://openalex.org/W2012198831","https://openalex.org/W2012867417","https://openalex.org/W2013520568","https://openalex.org/W2013612087","https://openalex.org/W2014100786","https://openalex.org/W2014550978","https://openalex.org/W2017783406","https://openalex.org/W2018453465","https://openalex.org/W2018632954","https://openalex.org/W2019521100","https://openalex.org/W2020678155","https://openalex.org/W2020849195","https://openalex.org/W2022941161","https://openalex.org/W2023743275","https://openalex.org/W2024026781","https://openalex.org/W2024057623","https://openalex.org/W2024311391","https://openalex.org/W2025511593","https://openalex.org/W2027181368","https://openalex.org/W2027210766","https://openalex.org/W2029162014","https://openalex.org/W2030445837","https://openalex.org/W2031785809","https://openalex.org/W2032115883","https://openalex.org/W2032399582","https://openalex.org/W2032641845","https://openalex.org/W2034615268","https://openalex.org/W2034770584","https://openalex.org/W2035805239","https://openalex.org/W2038747334","https://openalex.org/W2038998535","https://openalex.org/W2041612826","https://openalex.org/W2043668209","https://openalex.org/W2044340941","https://openalex.org/W2046206115","https://openalex.org/W2047223066","https://openalex.org/W2048466758","https://openalex.org/W2049454057","https://openalex.org/W2049820772","https://openalex.org/W2050721997","https://openalex.org/W2051076903","https://openalex.org/W2052396986","https://openalex.org/W2053177949","https://openalex.org/W2054455698","https://openalex.org/W2055037481","https://openalex.org/W2055565290","https://openalex.org/W2055729674","https://openalex.org/W2056507429","https://openalex.org/W2058667011","https://openalex.org/W2059091110","https://openalex.org/W2060272389","https://openalex.org/W2061016350","https://openalex.org/W2061698013","https://openalex.org/W2062279417","https://openalex.org/W2062941476","https://openalex.org/W2063386795","https://openalex.org/W2065370993","https://openalex.org/W2065812641","https://openalex.org/W2067189227","https://openalex.org/W2068096393","https://openalex.org/W2070163108","https://openalex.org/W2071425128","https://openalex.org/W2071872829","https://openalex.org/W2071898789","https://openalex.org/W2072076138","https://openalex.org/W2072715165","https://openalex.org/W2073830577","https://openalex.org/W2074103138","https://openalex.org/W2074175525","https://openalex.org/W2074192927","https://openalex.org/W2075262732","https://openalex.org/W2075379134","https://openalex.org/W2075387868","https://openalex.org/W2075908701","https://openalex.org/W2076922024","https://openalex.org/W2077331674","https://openalex.org/W2079364523","https://openalex.org/W2079761432","https://openalex.org/W2080070718","https://openalex.org/W2081269531","https://openalex.org/W2082445922","https://openalex.org/W2082460536","https://openalex.org/W2082748862","https://openalex.org/W2083147890","https://openalex.org/W2084641827","https://openalex.org/W2085292179","https://openalex.org/W2085681304","https://openalex.org/W2086452068","https://openalex.org/W2087315598","https://openalex.org/W2088190768","https://openalex.org/W2088261937","https://openalex.org/W2088920577","https://openalex.org/W2089264904","https://openalex.org/W2089704822","https://openalex.org/W2090136117","https://openalex.org/W2090922187","https://openalex.org/W2091262011","https://openalex.org/W2091306254","https://openalex.org/W2091564445","https://openalex.org/W2091680093","https://openalex.org/W2093082279","https://openalex.org/W2094791588","https://openalex.org/W2098301610","https://openalex.org/W2098999080","https://openalex.org/W2099582861","https://openalex.org/W2100454719","https://openalex.org/W2100657340","https://openalex.org/W2103895990","https://openalex.org/W2106330541","https://openalex.org/W2107919217","https://openalex.org/W2108155748","https://openalex.org/W2108481138","https://openalex.org/W2110183864","https://openalex.org/W2110637491","https://openalex.org/W2112719889","https://openalex.org/W2112791462","https://openalex.org/W2113588951","https://openalex.org/W2113738161","https://openalex.org/W2114732687","https://openalex.org/W2115848859","https://openalex.org/W2116911631","https://openalex.org/W2117184765","https://openalex.org/W2117397508","https://openalex.org/W2117724115","https://openalex.org/W2119698183","https://openalex.org/W2119708685","https://openalex.org/W2120057418","https://openalex.org/W2121604817","https://openalex.org/W2122726632","https://openalex.org/W2122927773","https://openalex.org/W2123046057","https://openalex.org/W2123155732","https://openalex.org/W2124612875","https://openalex.org/W2124838743","https://openalex.org/W2125062201","https://openalex.org/W2125936195","https://openalex.org/W2126324493","https://openalex.org/W2126924184","https://openalex.org/W2128797730","https://openalex.org/W2129916980","https://openalex.org/W2130410032","https://openalex.org/W2131725992","https://openalex.org/W2132192652","https://openalex.org/W2133257763","https://openalex.org/W2134377528","https://openalex.org/W2134652644","https://openalex.org/W2136203762","https://openalex.org/W2136735215","https://openalex.org/W2136863166","https://openalex.org/W2137330513","https://openalex.org/W2137478711","https://openalex.org/W2137507165","https://openalex.org/W2138512826","https://openalex.org/W2140442813","https://openalex.org/W2140595402","https://openalex.org/W2140723257","https://openalex.org/W2140981422","https://openalex.org/W2143727927","https://openalex.org/W2144523724","https://openalex.org/W2144869738","https://openalex.org/W2144901653","https://openalex.org/W2147281741","https://openalex.org/W2147695654","https://openalex.org/W2148476676","https://openalex.org/W2148669551","https://openalex.org/W2149720473","https://openalex.org/W2150065588","https://openalex.org/W2152987538","https://openalex.org/W2154033946","https://openalex.org/W2154896031","https://openalex.org/W2155157373","https://openalex.org/W2155681477","https://openalex.org/W2159583324","https://openalex.org/W2159982080","https://openalex.org/W2160751320","https://openalex.org/W2160757004","https://openalex.org/W2161723120","https://openalex.org/W2161817427","https://openalex.org/W2162011385","https://openalex.org/W2163307683","https://openalex.org/W2163907848","https://openalex.org/W2164548118","https://openalex.org/W2165022280","https://openalex.org/W2165232124","https://openalex.org/W2166997364","https://openalex.org/W2168253538","https://openalex.org/W2168752825","https://openalex.org/W2170188107","https://openalex.org/W2170517330","https://openalex.org/W2171780488","https://openalex.org/W2172053176","https://openalex.org/W2175949414","https://openalex.org/W2192571848","https://openalex.org/W2215816474","https://openalex.org/W2225235469","https://openalex.org/W2235700348","https://openalex.org/W2255555283","https://openalex.org/W2268580286","https://openalex.org/W2283705062","https://openalex.org/W2283883132","https://openalex.org/W2284497447","https://openalex.org/W2292693662","https://openalex.org/W2312529381","https://openalex.org/W2314336289","https://openalex.org/W2317397001","https://openalex.org/W2318407122","https://openalex.org/W2319156699","https://openalex.org/W2322203152","https://openalex.org/W2323238642","https://openalex.org/W2323575477","https://openalex.org/W2326560155","https://openalex.org/W2330454176","https://openalex.org/W2331001184","https://openalex.org/W2332136925","https://openalex.org/W2334966290","https://openalex.org/W2337513243","https://openalex.org/W2339636180","https://openalex.org/W2343330756","https://openalex.org/W2345750707","https://openalex.org/W2396397062","https://openalex.org/W2411615760","https://openalex.org/W2417144235","https://openalex.org/W2418269173","https://openalex.org/W2419225477","https://openalex.org/W2439733355","https://openalex.org/W2466156521","https://openalex.org/W2508094018","https://openalex.org/W2593030081","https://openalex.org/W2798579143","https://openalex.org/W2798958841","https://openalex.org/W3021092633","https://openalex.org/W3188714199","https://openalex.org/W4235212583","https://openalex.org/W4236877766","https://openalex.org/W6602995268","https://openalex.org/W6604353192","https://openalex.org/W6645320524","https://openalex.org/W6651354305","https://openalex.org/W6657021095","https://openalex.org/W6674648170","https://openalex.org/W6689858234"],"related_works":["https://openalex.org/W4297964896","https://openalex.org/W2766249071","https://openalex.org/W4285204701","https://openalex.org/W4223926210","https://openalex.org/W4395695856","https://openalex.org/W4376570109","https://openalex.org/W2991137874","https://openalex.org/W2744720587","https://openalex.org/W2901737871","https://openalex.org/W1933076568"],"abstract_inverted_index":{"Development":[0],"of":[1,20,42,74,86,89,110,137,145],"predictive":[2,103,122],"multi-organ":[3,70,104],"models":[4,93,105],"before":[5],"implementing":[6],"costly":[7],"clinical":[8,40],"trials":[9],"is":[10,45],"central":[11],"for":[12,72,94,106,141],"screening":[13],"the":[14,39,87,108,116,128,132,138,143],"toxicity,":[15],"efficacy,":[16],"and":[17,55,60,62,69,78,97,135],"side":[18],"effects":[19],"new":[21,75],"therapeutic":[22],"agents.":[23],"Despite":[24],"significant":[25],"efforts":[26],"that":[27],"have":[28,66],"been":[29],"recently":[30],"made":[31],"to":[32],"develop":[33],"biomimetic":[34],"in":[35,52,63,101],"vitro":[36],"tissue":[37],"models,":[38],"application":[41],"such":[43,126],"platforms":[44,71],"still":[46],"far":[47],"from":[48],"reality.":[49],"Recent":[50],"advances":[51],"physiologically-based":[53],"pharmacokinetic":[54],"pharmacodynamic":[56],"(PBPK-PD)":[57],"modeling,":[58],"micro-":[59],"nanotechnology,":[61],"silico":[64],"modeling":[65],"enabled":[67],"single-":[68],"investigation":[73],"chemical":[76],"agents":[77],"tissue-tissue":[79],"interactions.":[80],"This":[81],"review":[82],"provides":[83],"an":[84],"overview":[85],"principles":[88,136],"designing":[90],"microfluidic-based":[91],"organ-on-chip":[92],"drug":[95],"testing":[96],"highlights":[98],"current":[99],"state-of-the-art":[100],"developing":[102],"studying":[107],"cross-talk":[109],"interconnected":[111],"organs.":[112],"We":[113],"further":[114],"discuss":[115],"challenges":[117],"associated":[118],"with":[119,147],"establishing":[120],"a":[121],"body-on-chip":[123],"(BOC)":[124],"model":[125],"as":[127],"scaling,":[129],"cell":[130],"types,":[131],"common":[133],"medium,":[134],"study":[139],"design":[140],"characterizing":[142],"interaction":[144],"drugs":[146],"multiple":[148],"targets.":[149]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":8},{"year":2020,"cited_by_count":9},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":6},{"year":2017,"cited_by_count":5}],"updated_date":"2026-05-21T06:26:12.895304","created_date":"2025-10-10T00:00:00"}
