{"id":"https://openalex.org/W4381335284","doi":"https://doi.org/10.3390/jimaging9060124","title":"Predicting the Tumour Response to Radiation by Modelling the Five Rs of Radiotherapy Using PET Images","display_name":"Predicting the Tumour Response to Radiation by Modelling the Five Rs of Radiotherapy Using PET Images","publication_year":2023,"publication_date":"2023-06-20","ids":{"openalex":"https://openalex.org/W4381335284","doi":"https://doi.org/10.3390/jimaging9060124","pmid":"https://pubmed.ncbi.nlm.nih.gov/37367472"},"language":"en","primary_location":{"id":"doi:10.3390/jimaging9060124","is_oa":true,"landing_page_url":"https://doi.org/10.3390/jimaging9060124","pdf_url":"https://www.mdpi.com/2313-433X/9/6/124/pdf?version=1687235694","source":{"id":"https://openalex.org/S2736465063","display_name":"Journal of Imaging","issn_l":"2313-433X","issn":["2313-433X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Imaging","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/2313-433X/9/6/124/pdf?version=1687235694","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5092213875","display_name":"Rihab Hami","orcid":null},"institutions":[{"id":"https://openalex.org/I4210161065","display_name":"Laboratoire de Traitement de l'Information M\u00e9dicale","ror":"https://ror.org/05mqemx33","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I4210105774","https://openalex.org/I4210161065"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"funder","lineage":["https://openalex.org/I154526488"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"Rihab Hami","raw_affiliation_strings":["INSERM UMR 1101 \u201cLaTIM\u201d, CEDEX 3, 29238 Brest, France"],"affiliations":[{"raw_affiliation_string":"INSERM UMR 1101 \u201cLaTIM\u201d, CEDEX 3, 29238 Brest, France","institution_ids":["https://openalex.org/I4210161065","https://openalex.org/I154526488"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031829169","display_name":"Sena Apeke","orcid":"https://orcid.org/0000-0001-7492-6883"},"institutions":[{"id":"https://openalex.org/I180375564","display_name":"\u00c9cole nationale d'ing\u00e9nieurs de Brest","ror":"https://ror.org/02ypw0a72","country_code":"FR","type":"education","lineage":["https://openalex.org/I180375564"]},{"id":"https://openalex.org/I4210161065","display_name":"Laboratoire de Traitement de l'Information M\u00e9dicale","ror":"https://ror.org/05mqemx33","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I4210105774","https://openalex.org/I4210161065"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"funder","lineage":["https://openalex.org/I154526488"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Sena Apeke","raw_affiliation_strings":["CERV, European Center for Virtual Reality, ENIB, CEDEX 3, 29238 Brest, France","INSERM UMR 1101 \u201cLaTIM\u201d, CEDEX 3, 29238 Brest, France"],"affiliations":[{"raw_affiliation_string":"CERV, European Center for Virtual Reality, ENIB, CEDEX 3, 29238 Brest, France","institution_ids":["https://openalex.org/I180375564"]},{"raw_affiliation_string":"INSERM UMR 1101 \u201cLaTIM\u201d, CEDEX 3, 29238 Brest, France","institution_ids":["https://openalex.org/I4210161065","https://openalex.org/I154526488"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083334018","display_name":"Pascal Redou","orcid":null},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"funder","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210161065","display_name":"Laboratoire de Traitement de l'Information M\u00e9dicale","ror":"https://ror.org/05mqemx33","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I4210105774","https://openalex.org/I4210161065"]},{"id":"https://openalex.org/I180375564","display_name":"\u00c9cole nationale d'ing\u00e9nieurs de Brest","ror":"https://ror.org/02ypw0a72","country_code":"FR","type":"education","lineage":["https://openalex.org/I180375564"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Pascal Redou","raw_affiliation_strings":["CERV, European Center for Virtual Reality, ENIB, CEDEX 3, 29238 Brest, France","INSERM UMR 1101 \u201cLaTIM\u201d, CEDEX 3, 29238 Brest, France"],"affiliations":[{"raw_affiliation_string":"CERV, European Center for Virtual Reality, ENIB, CEDEX 3, 29238 Brest, France","institution_ids":["https://openalex.org/I180375564"]},{"raw_affiliation_string":"INSERM UMR 1101 \u201cLaTIM\u201d, CEDEX 3, 29238 Brest, France","institution_ids":["https://openalex.org/I4210161065","https://openalex.org/I154526488"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000146212","display_name":"Laurent Gaubert","orcid":"https://orcid.org/0000-0001-6808-2645"},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"funder","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I180375564","display_name":"\u00c9cole nationale d'ing\u00e9nieurs de Brest","ror":"https://ror.org/02ypw0a72","country_code":"FR","type":"education","lineage":["https://openalex.org/I180375564"]},{"id":"https://openalex.org/I4210161065","display_name":"Laboratoire de Traitement de l'Information M\u00e9dicale","ror":"https://ror.org/05mqemx33","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I4210105774","https://openalex.org/I4210161065"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Laurent Gaubert","raw_affiliation_strings":["CERV, European Center for Virtual Reality, ENIB, CEDEX 3, 29238 Brest, France","INSERM UMR 1101 \u201cLaTIM\u201d, CEDEX 3, 29238 Brest, France"],"affiliations":[{"raw_affiliation_string":"CERV, European Center for Virtual Reality, ENIB, CEDEX 3, 29238 Brest, France","institution_ids":["https://openalex.org/I180375564"]},{"raw_affiliation_string":"INSERM UMR 1101 \u201cLaTIM\u201d, CEDEX 3, 29238 Brest, France","institution_ids":["https://openalex.org/I4210161065","https://openalex.org/I154526488"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053143681","display_name":"Ludwig J. Dubois","orcid":"https://orcid.org/0000-0002-8887-4137"},"institutions":[{"id":"https://openalex.org/I34352273","display_name":"Maastricht University","ror":"https://ror.org/02jz4aj89","country_code":"NL","type":"education","lineage":["https://openalex.org/I34352273"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Ludwig J. Dubois","raw_affiliation_strings":["The D-Lab, Department of Precision Medicine, GROW-School for Oncology, Maastricht University, 6211 LK Maastricht, The Netherlands"],"affiliations":[{"raw_affiliation_string":"The D-Lab, Department of Precision Medicine, GROW-School for Oncology, Maastricht University, 6211 LK Maastricht, The Netherlands","institution_ids":["https://openalex.org/I34352273"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058987737","display_name":"Philippe Lambin","orcid":null},"institutions":[{"id":"https://openalex.org/I34352273","display_name":"Maastricht University","ror":"https://ror.org/02jz4aj89","country_code":"NL","type":"education","lineage":["https://openalex.org/I34352273"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Philippe Lambin","raw_affiliation_strings":["The D-Lab, Department of Precision Medicine, GROW-School for Oncology, Maastricht University, 6211 LK Maastricht, The Netherlands"],"affiliations":[{"raw_affiliation_string":"The D-Lab, Department of Precision Medicine, GROW-School for Oncology, Maastricht University, 6211 LK Maastricht, The Netherlands","institution_ids":["https://openalex.org/I34352273"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017138072","display_name":"Dimitris Visvikis","orcid":"https://orcid.org/0000-0003-0831-3637"},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"funder","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210132604","display_name":"Centre Hospitalier R\u00e9gional Universitaire de Brest","ror":"https://ror.org/03evbwn87","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I154526488","https://openalex.org/I4210105774","https://openalex.org/I4210132604","https://openalex.org/I4210161065"]},{"id":"https://openalex.org/I4210161065","display_name":"Laboratoire de Traitement de l'Information M\u00e9dicale","ror":"https://ror.org/05mqemx33","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I4210105774","https://openalex.org/I4210161065"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Dimitris Visvikis","raw_affiliation_strings":["CHRU BREST, 29200 Brest, France","INSERM UMR 1101 \u201cLaTIM\u201d, CEDEX 3, 29238 Brest, France"],"affiliations":[{"raw_affiliation_string":"CHRU BREST, 29200 Brest, France","institution_ids":["https://openalex.org/I4210132604"]},{"raw_affiliation_string":"INSERM UMR 1101 \u201cLaTIM\u201d, CEDEX 3, 29238 Brest, France","institution_ids":["https://openalex.org/I4210161065","https://openalex.org/I154526488"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5048882427","display_name":"Nicolas Boussion","orcid":"https://orcid.org/0000-0003-2293-7753"},"institutions":[{"id":"https://openalex.org/I4210132604","display_name":"Centre Hospitalier R\u00e9gional Universitaire de Brest","ror":"https://ror.org/03evbwn87","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I154526488","https://openalex.org/I4210105774","https://openalex.org/I4210132604","https://openalex.org/I4210161065"]},{"id":"https://openalex.org/I4210161065","display_name":"Laboratoire de Traitement de l'Information M\u00e9dicale","ror":"https://ror.org/05mqemx33","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I4210105774","https://openalex.org/I4210161065"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"funder","lineage":["https://openalex.org/I154526488"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Nicolas Boussion","raw_affiliation_strings":["CHRU BREST, 29200 Brest, France","INSERM UMR 1101 \u201cLaTIM\u201d, CEDEX 3, 29238 Brest, France"],"affiliations":[{"raw_affiliation_string":"CHRU BREST, 29200 Brest, France","institution_ids":["https://openalex.org/I4210132604"]},{"raw_affiliation_string":"INSERM UMR 1101 \u201cLaTIM\u201d, CEDEX 3, 29238 Brest, France","institution_ids":["https://openalex.org/I4210161065","https://openalex.org/I154526488"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":8,"corresponding_author_ids":["https://openalex.org/A5092213875"],"corresponding_institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210161065"],"apc_list":{"value":1600,"currency":"CHF","value_usd":1732},"apc_paid":{"value":1482,"currency":"EUR","value_usd":1598},"fwci":0.9783,"has_fulltext":true,"cited_by_count":4,"citation_normalized_percentile":{"value":0.78671952,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":97},"biblio":{"volume":"9","issue":"6","first_page":"124","last_page":"124"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11176","display_name":"Radiation Therapy and Dosimetry","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.993399977684021,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/radiation-therapy","display_name":"Radiation therapy","score":0.7490178346633911},{"id":"https://openalex.org/keywords/radiosensitivity","display_name":"Radiosensitivity","score":0.6855162382125854},{"id":"https://openalex.org/keywords/radiation-sensitivity","display_name":"Radiation sensitivity","score":0.5302982330322266},{"id":"https://openalex.org/keywords/radiobiology","display_name":"Radiobiology","score":0.5271227955818176},{"id":"https://openalex.org/keywords/cell-cycle","display_name":"Cell cycle","score":0.5026319026947021},{"id":"https://openalex.org/keywords/repopulation","display_name":"Repopulation","score":0.441318154335022},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.42678162455558777},{"id":"https://openalex.org/keywords/cancer-research","display_name":"Cancer research","score":0.4260214567184448},{"id":"https://openalex.org/keywords/tumour-heterogeneity","display_name":"Tumour heterogeneity","score":0.41934558749198914},{"id":"https://openalex.org/keywords/dna-repair","display_name":"DNA repair","score":0.4182102680206299},{"id":"https://openalex.org/keywords/cell","display_name":"Cell","score":0.4172879457473755},{"id":"https://openalex.org/keywords/nuclear-medicine","display_name":"Nuclear medicine","score":0.4131987392902374},{"id":"https://openalex.org/keywords/pathology","display_name":"Pathology","score":0.35419854521751404},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.30505043268203735},{"id":"https://openalex.org/keywords/irradiation","display_name":"Irradiation","score":0.2762807607650757},{"id":"https://openalex.org/keywords/radiology","display_name":"Radiology","score":0.22314870357513428},{"id":"https://openalex.org/keywords/cancer","display_name":"Cancer","score":0.18933233618736267},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.1728363037109375},{"id":"https://openalex.org/keywords/stem-cell","display_name":"Stem cell","score":0.1620795726776123},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.1355258822441101},{"id":"https://openalex.org/keywords/dna","display_name":"DNA","score":0.10439231991767883},{"id":"https://openalex.org/keywords/cell-biology","display_name":"Cell biology","score":0.1024889349937439}],"concepts":[{"id":"https://openalex.org/C509974204","wikidata":"https://www.wikidata.org/wiki/Q180507","display_name":"Radiation therapy","level":2,"score":0.7490178346633911},{"id":"https://openalex.org/C206684579","wikidata":"https://www.wikidata.org/wiki/Q4387689","display_name":"Radiosensitivity","level":3,"score":0.6855162382125854},{"id":"https://openalex.org/C26114605","wikidata":"https://www.wikidata.org/wiki/Q7280368","display_name":"Radiation sensitivity","level":3,"score":0.5302982330322266},{"id":"https://openalex.org/C125118446","wikidata":"https://www.wikidata.org/wiki/Q690200","display_name":"Radiobiology","level":3,"score":0.5271227955818176},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.5026319026947021},{"id":"https://openalex.org/C2780918802","wikidata":"https://www.wikidata.org/wiki/Q25091543","display_name":"Repopulation","level":4,"score":0.441318154335022},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.42678162455558777},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4260214567184448},{"id":"https://openalex.org/C2777306565","wikidata":"https://www.wikidata.org/wiki/Q15917291","display_name":"Tumour heterogeneity","level":3,"score":0.41934558749198914},{"id":"https://openalex.org/C134935766","wikidata":"https://www.wikidata.org/wiki/Q210538","display_name":"DNA repair","level":3,"score":0.4182102680206299},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.4172879457473755},{"id":"https://openalex.org/C2989005","wikidata":"https://www.wikidata.org/wiki/Q214963","display_name":"Nuclear medicine","level":1,"score":0.4131987392902374},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.35419854521751404},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.30505043268203735},{"id":"https://openalex.org/C111337013","wikidata":"https://www.wikidata.org/wiki/Q2737837","display_name":"Irradiation","level":2,"score":0.2762807607650757},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.22314870357513428},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.18933233618736267},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.1728363037109375},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.1620795726776123},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.1355258822441101},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.10439231991767883},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.1024889349937439},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C185544564","wikidata":"https://www.wikidata.org/wiki/Q81197","display_name":"Nuclear physics","level":1,"score":0.0},{"id":"https://openalex.org/C109159458","wikidata":"https://www.wikidata.org/wiki/Q919283","display_name":"Haematopoiesis","level":3,"score":0.0}],"mesh":[],"locations_count":6,"locations":[{"id":"doi:10.3390/jimaging9060124","is_oa":true,"landing_page_url":"https://doi.org/10.3390/jimaging9060124","pdf_url":"https://www.mdpi.com/2313-433X/9/6/124/pdf?version=1687235694","source":{"id":"https://openalex.org/S2736465063","display_name":"Journal of Imaging","issn_l":"2313-433X","issn":["2313-433X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Imaging","raw_type":"journal-article"},{"id":"pmid:37367472","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37367472","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of imaging","raw_type":null},{"id":"pmh:oai:cris.maastrichtuniversity.nl:openaire/c1240b2c-dbfd-4f44-9400-bd3134d9dc5d","is_oa":true,"landing_page_url":"https://cris.maastrichtuniversity.nl/en/publications/c1240b2c-dbfd-4f44-9400-bd3134d9dc5d","pdf_url":null,"source":{"id":"https://openalex.org/S4306402616","display_name":"Research Publications (Maastricht University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I34352273","host_organization_name":"Maastricht University","host_organization_lineage":["https://openalex.org/I34352273"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hami, R, Apeke, S, Redou, P, Gaubert, L, Dubois, L J, Lambin, P, Visvikis, D & Boussion, N 2023, 'Predicting the Tumour Response to Radiation by Modelling the Five Rs of Radiotherapy Using PET Images', Journal of Imaging, vol. 9, no. 6, 124. https://doi.org/10.3390/jimaging9060124","raw_type":"info:eu-repo/semantics/publishedVersion"},{"id":"pmh:oai:HAL:hal-05249365v1","is_oa":true,"landing_page_url":"https://hal.univ-brest.fr/hal-05249365","pdf_url":"https://hal.univ-brest.fr/hal-05249365/document","source":{"id":"https://openalex.org/S4406922466","display_name":"SPIRE - Sciences Po Institutional REpository","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Imaging, 2023, 9 (6), pp.124. &#x27E8;10.3390/jimaging9060124&#x27E9;","raw_type":"Journal articles"},{"id":"pmh:oai:pubmedcentral.nih.gov:10299216","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10299216","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10299216/pdf/jimaging-09-00124.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"J Imaging","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:432d5eb67ea043b1a19294fa5981dbe9","is_oa":true,"landing_page_url":"https://doaj.org/article/432d5eb67ea043b1a19294fa5981dbe9","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Imaging, Vol 9, Iss 6, p 124 (2023)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3390/jimaging9060124","is_oa":true,"landing_page_url":"https://doi.org/10.3390/jimaging9060124","pdf_url":"https://www.mdpi.com/2313-433X/9/6/124/pdf?version=1687235694","source":{"id":"https://openalex.org/S2736465063","display_name":"Journal of Imaging","issn_l":"2313-433X","issn":["2313-433X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Imaging","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.5,"id":"https://metadata.un.org/sdg/3"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4381335284.pdf"},"referenced_works_count":70,"referenced_works":["https://openalex.org/W21553284","https://openalex.org/W1529490909","https://openalex.org/W1605765845","https://openalex.org/W1691680131","https://openalex.org/W1965360179","https://openalex.org/W1965559692","https://openalex.org/W1970383924","https://openalex.org/W1976987057","https://openalex.org/W1978509389","https://openalex.org/W1982060476","https://openalex.org/W1987846933","https://openalex.org/W1995703832","https://openalex.org/W2002676538","https://openalex.org/W2004065286","https://openalex.org/W2008719853","https://openalex.org/W2030892741","https://openalex.org/W2031795384","https://openalex.org/W2032543826","https://openalex.org/W2039945538","https://openalex.org/W2049572042","https://openalex.org/W2054126150","https://openalex.org/W2058257534","https://openalex.org/W2059927830","https://openalex.org/W2060683289","https://openalex.org/W2061137918","https://openalex.org/W2064969226","https://openalex.org/W2065900444","https://openalex.org/W2077768973","https://openalex.org/W2080927611","https://openalex.org/W2083237530","https://openalex.org/W2091894720","https://openalex.org/W2093814864","https://openalex.org/W2094634315","https://openalex.org/W2128625986","https://openalex.org/W2130522035","https://openalex.org/W2140475905","https://openalex.org/W2146629016","https://openalex.org/W2168069373","https://openalex.org/W2170147411","https://openalex.org/W2214304471","https://openalex.org/W2236236168","https://openalex.org/W2282112002","https://openalex.org/W2296275884","https://openalex.org/W2302071074","https://openalex.org/W2321944794","https://openalex.org/W2428697703","https://openalex.org/W2518488580","https://openalex.org/W2580449060","https://openalex.org/W2617182253","https://openalex.org/W2746897413","https://openalex.org/W2754569863","https://openalex.org/W2767638961","https://openalex.org/W2781525129","https://openalex.org/W2812160382","https://openalex.org/W2889949934","https://openalex.org/W2898680980","https://openalex.org/W2925103866","https://openalex.org/W2947494439","https://openalex.org/W2950835872","https://openalex.org/W2951432721","https://openalex.org/W2952051913","https://openalex.org/W2987338943","https://openalex.org/W2997696500","https://openalex.org/W3009918684","https://openalex.org/W3026366501","https://openalex.org/W3118279708","https://openalex.org/W3125696078","https://openalex.org/W4205356079","https://openalex.org/W4302886507","https://openalex.org/W6636340995"],"related_works":["https://openalex.org/W2027669728","https://openalex.org/W2123423958","https://openalex.org/W2070641071","https://openalex.org/W1977747302","https://openalex.org/W1942446571","https://openalex.org/W2021000205","https://openalex.org/W2021945482","https://openalex.org/W2123136808","https://openalex.org/W2807590345","https://openalex.org/W2413095015"],"abstract_inverted_index":{"Despite":[0],"the":[1,19,34,43,58,88,95,105,119,128,139,174,197,207,233,240],"intensive":[2],"use":[3],"of":[4,33,91,97,121,141,148,183,199],"radiotherapy":[5,116],"in":[6,110,127,133,206,214,226],"clinical":[7,246],"practice,":[8],"its":[9],"effectiveness":[10],"depends":[11],"on":[12,99,124],"several":[13],"factors.":[14],"Several":[15],"studies":[16],"showed":[17,196],"that":[18,222],"tumour":[20,35,44,100,153,188,234],"response":[21,32,235],"to":[22,28,93,236],"radiation":[23,98,151,211,237],"differs":[24],"from":[25],"one":[26],"patient":[27],"another.":[29],"The":[30,194,204,229],"non-uniform":[31],"is":[36],"mainly":[37],"caused":[38],"by":[39,143],"multiple":[40],"interactions":[41],"between":[42],"microenvironment":[45],"and":[46,75,113,154,167,201,217,238],"healthy":[47],"cells.":[48,156,203],"To":[49],"understand":[50],"these":[51],"interactions,":[52],"five":[53,89],"major":[54],"biologic":[55],"concepts":[56,64],"called":[57],"\"5":[59],"Rs\"":[60],"have":[61],"emerged.":[62],"These":[63],"include":[65],"reoxygenation,":[66],"DNA":[67],"damage":[68],"repair,":[69],"cell":[70,129,208],"cycle":[71,130],"redistribution,":[72],"cellular":[73,76],"radiosensitivity":[74],"repopulation.":[77],"In":[78,102,186],"this":[79,103,227],"study,":[80],"we":[81,158],"used":[82,165],"a":[83,145,243],"multi-scale":[84],"model,":[85,104],"which":[86,220],"included":[87,225],"Rs":[90],"radiotherapy,":[92],"predict":[94],"effects":[96],"growth.":[101],"oxygen":[106],"level":[107],"was":[108,117,131,212,224],"varied":[109],"both":[111,215],"time":[112],"space.":[114],"When":[115],"given,":[118],"sensitivity":[120],"cells":[122,142],"depending":[123],"their":[125],"location":[126],"taken":[132],"account.":[134],"This":[135],"model":[136,231],"also":[137],"considered":[138],"repair":[140],"giving":[144],"different":[146],"probability":[147,190],"survival":[149],"after":[150,210],"for":[152,242],"normal":[155,202,216],"Here,":[157],"developed":[159],"four":[160],"fractionation":[161],"protocol":[162],"schemes.":[163],"We":[164],"simulated":[166],"positron":[168],"emission":[169],"tomography":[170],"(PET)":[171],"imaging":[172],"with":[173],"hypoxia":[175],"tracer":[176],"18F-flortanidazole":[177],"(18F-HX4)":[178],"images":[179],"as":[180],"input":[181],"data":[182,251],"our":[184],"model.":[185,228],"addition,":[187],"control":[189],"curves":[191],"were":[192],"simulated.":[193],"result":[195],"evolution":[198],"tumours":[200],"increase":[205],"number":[209],"seen":[213],"malignant":[218],"cells,":[219],"proves":[221],"repopulation":[223],"proposed":[230],"predicts":[232],"forms":[239],"basis":[241],"more":[244],"patient-specific":[245],"tool":[247],"where":[248],"related":[249],"biological":[250],"will":[252],"be":[253],"included.":[254]},"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":1}],"updated_date":"2026-03-11T14:59:36.786465","created_date":"2025-10-10T00:00:00"}
