{"id":"https://openalex.org/W4220662885","doi":"https://doi.org/10.3390/jimaging8030071","title":"Multi-Modality Microscopy Image Style Augmentation for Nuclei Segmentation","display_name":"Multi-Modality Microscopy Image Style Augmentation for Nuclei Segmentation","publication_year":2022,"publication_date":"2022-03-11","ids":{"openalex":"https://openalex.org/W4220662885","doi":"https://doi.org/10.3390/jimaging8030071","pmid":"https://pubmed.ncbi.nlm.nih.gov/35324626"},"language":"en","primary_location":{"id":"doi:10.3390/jimaging8030071","is_oa":true,"landing_page_url":"https://doi.org/10.3390/jimaging8030071","pdf_url":"https://www.mdpi.com/2313-433X/8/3/71/pdf?version=1646979766","source":{"id":"https://openalex.org/S2736465063","display_name":"Journal of Imaging","issn_l":"2313-433X","issn":["2313-433X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Imaging","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/2313-433X/8/3/71/pdf?version=1646979766","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100346548","display_name":"Ye Liu","orcid":"https://orcid.org/0000-0002-2686-3002"},"institutions":[{"id":"https://openalex.org/I62916508","display_name":"Technical University of Munich","ror":"https://ror.org/02kkvpp62","country_code":"DE","type":"education","lineage":["https://openalex.org/I62916508"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Ye Liu","raw_affiliation_strings":["Department of Mathematics, Technical University Munich, 85748 Garching, Germany"],"affiliations":[{"raw_affiliation_string":"Department of Mathematics, Technical University Munich, 85748 Garching, Germany","institution_ids":["https://openalex.org/I62916508"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000341866","display_name":"Sophia J. Wagner","orcid":"https://orcid.org/0000-0003-3763-2282"},"institutions":[{"id":"https://openalex.org/I62916508","display_name":"Technical University of Munich","ror":"https://ror.org/02kkvpp62","country_code":"DE","type":"education","lineage":["https://openalex.org/I62916508"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Sophia J. Wagner","raw_affiliation_strings":["Department of Mathematics, Technical University Munich, 85748 Garching, Germany","Helmholtz AI, Helmholtz Munich, 85764 Neuherberg, Germany"],"affiliations":[{"raw_affiliation_string":"Department of Mathematics, Technical University Munich, 85748 Garching, Germany","institution_ids":["https://openalex.org/I62916508"]},{"raw_affiliation_string":"Helmholtz AI, Helmholtz Munich, 85764 Neuherberg, Germany","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5070636207","display_name":"Tingying Peng","orcid":"https://orcid.org/0000-0002-7881-1749"},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Tingying Peng","raw_affiliation_strings":["Helmholtz AI, Helmholtz Munich, 85764 Neuherberg, Germany"],"affiliations":[{"raw_affiliation_string":"Helmholtz AI, Helmholtz Munich, 85764 Neuherberg, Germany","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5070636207"],"corresponding_institution_ids":[],"apc_list":{"value":1600,"currency":"CHF","value_usd":1732},"apc_paid":{"value":1600,"currency":"CHF","value_usd":1732},"fwci":0.8157,"has_fulltext":false,"cited_by_count":8,"citation_normalized_percentile":{"value":0.72018265,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"8","issue":"3","first_page":"71","last_page":"71"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10775","display_name":"Generative Adversarial Networks and Image Synthesis","score":0.9993000030517578,"subfield":{"id":"https://openalex.org/subfields/1707","display_name":"Computer Vision and Pattern Recognition"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10775","display_name":"Generative Adversarial Networks and Image Synthesis","score":0.9993000030517578,"subfield":{"id":"https://openalex.org/subfields/1707","display_name":"Computer Vision and Pattern Recognition"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10862","display_name":"AI in cancer detection","score":0.9922999739646912,"subfield":{"id":"https://openalex.org/subfields/1702","display_name":"Artificial Intelligence"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11105","display_name":"Advanced Image Processing Techniques","score":0.9858999848365784,"subfield":{"id":"https://openalex.org/subfields/1707","display_name":"Computer Vision and Pattern Recognition"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/segmentation","display_name":"Segmentation","score":0.7548920512199402},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.7230582237243652},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.6379731893539429},{"id":"https://openalex.org/keywords/leverage","display_name":"Leverage (statistics)","score":0.5653690099716187},{"id":"https://openalex.org/keywords/image-segmentation","display_name":"Image segmentation","score":0.5130573511123657},{"id":"https://openalex.org/keywords/microscopy","display_name":"Microscopy","score":0.45506805181503296},{"id":"https://openalex.org/keywords/computer-vision","display_name":"Computer vision","score":0.4477095305919647},{"id":"https://openalex.org/keywords/modality","display_name":"Modality (human\u2013computer interaction)","score":0.43213945627212524},{"id":"https://openalex.org/keywords/pattern-recognition","display_name":"Pattern recognition (psychology)","score":0.39240437746047974},{"id":"https://openalex.org/keywords/pathology","display_name":"Pathology","score":0.08273479342460632}],"concepts":[{"id":"https://openalex.org/C89600930","wikidata":"https://www.wikidata.org/wiki/Q1423946","display_name":"Segmentation","level":2,"score":0.7548920512199402},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.7230582237243652},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.6379731893539429},{"id":"https://openalex.org/C153083717","wikidata":"https://www.wikidata.org/wiki/Q6535263","display_name":"Leverage (statistics)","level":2,"score":0.5653690099716187},{"id":"https://openalex.org/C124504099","wikidata":"https://www.wikidata.org/wiki/Q56933","display_name":"Image segmentation","level":3,"score":0.5130573511123657},{"id":"https://openalex.org/C147080431","wikidata":"https://www.wikidata.org/wiki/Q1074953","display_name":"Microscopy","level":2,"score":0.45506805181503296},{"id":"https://openalex.org/C31972630","wikidata":"https://www.wikidata.org/wiki/Q844240","display_name":"Computer vision","level":1,"score":0.4477095305919647},{"id":"https://openalex.org/C2780226545","wikidata":"https://www.wikidata.org/wiki/Q6888030","display_name":"Modality (human\u2013computer interaction)","level":2,"score":0.43213945627212524},{"id":"https://openalex.org/C153180895","wikidata":"https://www.wikidata.org/wiki/Q7148389","display_name":"Pattern recognition (psychology)","level":2,"score":0.39240437746047974},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.08273479342460632},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0}],"mesh":[],"locations_count":6,"locations":[{"id":"doi:10.3390/jimaging8030071","is_oa":true,"landing_page_url":"https://doi.org/10.3390/jimaging8030071","pdf_url":"https://www.mdpi.com/2313-433X/8/3/71/pdf?version=1646979766","source":{"id":"https://openalex.org/S2736465063","display_name":"Journal of Imaging","issn_l":"2313-433X","issn":["2313-433X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Imaging","raw_type":"journal-article"},{"id":"pmid:35324626","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35324626","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of imaging","raw_type":null},{"id":"pmh:oai:doaj.org/article:f7f3305dee834997b7295a2bdc89121f","is_oa":true,"landing_page_url":"https://doaj.org/article/f7f3305dee834997b7295a2bdc89121f","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Imaging, Vol 8, Iss 3, p 71 (2022)","raw_type":"article"},{"id":"pmh:oai:mediatum.ub.tum.de:node/1657622","is_oa":true,"landing_page_url":"https://mediatum.ub.tum.de/1657622","pdf_url":null,"source":{"id":"https://openalex.org/S4377196330","display_name":"mediaTUM  (Technical University of Munich)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I62916508","host_organization_name":"Technical University of Munich","host_organization_lineage":["https://openalex.org/I62916508"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"article"},{"id":"pmh:oai:opus-zb.helmholtz-muenchen.de:64690","is_oa":true,"landing_page_url":"https://push-zb.helmholtz-muenchen.de/frontdoor.php?source_opus=64690","pdf_url":null,"source":{"id":"https://openalex.org/S4377196115","display_name":"Site cant be reached","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"J. Imaging 8:71 (2022)","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:8948875","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8948875","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"J Imaging","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.3390/jimaging8030071","is_oa":true,"landing_page_url":"https://doi.org/10.3390/jimaging8030071","pdf_url":"https://www.mdpi.com/2313-433X/8/3/71/pdf?version=1646979766","source":{"id":"https://openalex.org/S2736465063","display_name":"Journal of Imaging","issn_l":"2313-433X","issn":["2313-433X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Imaging","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4220662885.pdf","grobid_xml":"https://content.openalex.org/works/W4220662885.grobid-xml"},"referenced_works_count":17,"referenced_works":["https://openalex.org/W1901129140","https://openalex.org/W2093442488","https://openalex.org/W2103243046","https://openalex.org/W2565639579","https://openalex.org/W2891179298","https://openalex.org/W2946901414","https://openalex.org/W2962770929","https://openalex.org/W2962793481","https://openalex.org/W2963073614","https://openalex.org/W2963150697","https://openalex.org/W2980998394","https://openalex.org/W3003301247","https://openalex.org/W3012478585","https://openalex.org/W3022215132","https://openalex.org/W3159890710","https://openalex.org/W3204040591","https://openalex.org/W4226348722"],"related_works":["https://openalex.org/W2385859805","https://openalex.org/W2530972254","https://openalex.org/W2374013449","https://openalex.org/W73545470","https://openalex.org/W2364381299","https://openalex.org/W2374430585","https://openalex.org/W3144423903","https://openalex.org/W2377397762","https://openalex.org/W2793967660","https://openalex.org/W1522196789"],"abstract_inverted_index":{"Annotating":[0],"microscopy":[1],"images":[2],"for":[3,70],"nuclei":[4,124],"segmentation":[5,116,125],"by":[6],"medical":[7],"experts":[8],"is":[9],"laborious":[10],"and":[11,52,64,72,108,147],"time-consuming.":[12],"To":[13],"leverage":[14],"the":[15,77,80,95,115,119,128,137,143],"few":[16],"existing":[17],"annotations,":[18],"also":[19,56],"across":[20],"multiple":[21],"modalities,":[22,60],"we":[23,74],"propose":[24],"a":[25,32],"novel":[26],"microscopy-style":[27],"augmentation":[28,93,134],"technique":[29,135],"based":[30],"on":[31,94],"generative":[33],"adversarial":[34],"network":[35],"(GAN).":[36],"Unlike":[37],"other":[38],"style":[39,86,113],"transfer":[40],"methods,":[41],"it":[42],"can":[43,75],"not":[44],"only":[45],"deal":[46],"with":[47,57],"different":[48,58],"cell":[49,104],"assay":[50],"types":[51],"lighting":[53,106],"conditions,":[54,107],"but":[55],"imaging":[59,109],"such":[61],"as":[62],"bright-field":[63],"fluorescence":[65],"microscopy.":[66],"Using":[67],"disentangled":[68],"representations":[69],"content":[71],"style,":[73],"preserve":[76],"structure":[78],"of":[79,102,118,154],"original":[81],"image":[82],"while":[83],"altering":[84],"its":[85],"during":[87],"augmentation.":[88],"We":[89],"evaluate":[90],"our":[91,112,133],"data":[92,145],"2018":[96],"Data":[97],"Science":[98],"Bowl":[99],"dataset":[100],"consisting":[101],"various":[103],"assays,":[105],"modalities.":[110],"With":[111],"augmentation,":[114],"accuracy":[117],"two":[120],"top-ranked":[121],"Mask":[122],"R-CNN-based":[123],"algorithms":[126],"in":[127],"competition":[129],"increases":[130],"significantly.":[131],"Thus,":[132],"renders":[136],"downstream":[138],"task":[139],"more":[140],"robust":[141],"to":[142],"test":[144],"heterogeneity":[146],"helps":[148],"counteract":[149],"class":[150],"imbalance":[151],"without":[152],"resampling":[153],"minority":[155],"classes.":[156]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":1}],"updated_date":"2026-03-20T23:20:44.827607","created_date":"2025-10-10T00:00:00"}