{"id":"https://openalex.org/W3107555375","doi":"https://doi.org/10.3390/jimaging6120133","title":"3D Non-Local Neural Network: A Non-Invasive Biomarker for Immunotherapy Treatment Outcome Prediction. Case-Study: Metastatic Urothelial Carcinoma","display_name":"3D Non-Local Neural Network: A Non-Invasive Biomarker for Immunotherapy Treatment Outcome Prediction. Case-Study: Metastatic Urothelial Carcinoma","publication_year":2020,"publication_date":"2020-12-03","ids":{"openalex":"https://openalex.org/W3107555375","doi":"https://doi.org/10.3390/jimaging6120133","mag":"3107555375","pmid":"https://pubmed.ncbi.nlm.nih.gov/34460530"},"language":"en","primary_location":{"id":"doi:10.3390/jimaging6120133","is_oa":true,"landing_page_url":"https://doi.org/10.3390/jimaging6120133","pdf_url":"https://www.mdpi.com/2313-433X/6/12/133/pdf","source":{"id":"https://openalex.org/S2736465063","display_name":"Journal of Imaging","issn_l":"2313-433X","issn":["2313-433X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Imaging","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/2313-433X/6/12/133/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5036892535","display_name":"Francesco Rundo","orcid":"https://orcid.org/0000-0003-1766-3065"},"institutions":[{"id":"https://openalex.org/I4210154781","display_name":"STMicroelectronics (Italy)","ror":"https://ror.org/053bqv655","country_code":"IT","type":"company","lineage":["https://openalex.org/I131827901","https://openalex.org/I4210154781"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Francesco Rundo","raw_affiliation_strings":["STMicroelectronics\u2014ADG Central R&amp;D Division, 95125 Catania, Italy"],"raw_orcid":"https://orcid.org/0000-0003-1766-3065","affiliations":[{"raw_affiliation_string":"STMicroelectronics\u2014ADG Central R&amp;D Division, 95125 Catania, Italy","institution_ids":["https://openalex.org/I4210154781"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033351253","display_name":"Giuseppe Luigi Banna","orcid":"https://orcid.org/0000-0003-0764-3650"},"institutions":[{"id":"https://openalex.org/I2803040662","display_name":"United Lincolnshire Hospitals NHS Trust","ror":"https://ror.org/0377kyv52","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2803040662"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Giuseppe Luigi Banna","raw_affiliation_strings":["Medical Oncology Department, United Lincolnshire NHS Hospital Trust, Lincoln LN2, Lincolnshire, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Oncology Department, United Lincolnshire NHS Hospital Trust, Lincoln LN2, Lincolnshire, UK","institution_ids":["https://openalex.org/I2803040662"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059621984","display_name":"Luca Prezzavento","orcid":"https://orcid.org/0000-0002-0440-4921"},"institutions":[{"id":"https://openalex.org/I39063666","display_name":"University of Catania","ror":"https://ror.org/03a64bh57","country_code":"IT","type":"education","lineage":["https://openalex.org/I39063666"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Luca Prezzavento","raw_affiliation_strings":["DIEEI, University of Catania, 95125 Catania, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"DIEEI, University of Catania, 95125 Catania, Italy","institution_ids":["https://openalex.org/I39063666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066281190","display_name":"Francesca Trenta","orcid":"https://orcid.org/0000-0003-2524-3837"},"institutions":[{"id":"https://openalex.org/I39063666","display_name":"University of Catania","ror":"https://ror.org/03a64bh57","country_code":"IT","type":"education","lineage":["https://openalex.org/I39063666"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Francesca Trenta","raw_affiliation_strings":["IPLAB, University of Catania, 95125 Catania, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"IPLAB, University of Catania, 95125 Catania, Italy","institution_ids":["https://openalex.org/I39063666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005143396","display_name":"Sabrina Conoci","orcid":"https://orcid.org/0000-0002-5874-7284"},"institutions":[{"id":"https://openalex.org/I112862951","display_name":"University of Messina","ror":"https://ror.org/05ctdxz19","country_code":"IT","type":"education","lineage":["https://openalex.org/I112862951"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Sabrina Conoci","raw_affiliation_strings":["Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, 98100 Messina, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, 98100 Messina, Italy","institution_ids":["https://openalex.org/I112862951"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5042746008","display_name":"Sebastiano Battiato","orcid":"https://orcid.org/0000-0001-6127-2470"},"institutions":[{"id":"https://openalex.org/I39063666","display_name":"University of Catania","ror":"https://ror.org/03a64bh57","country_code":"IT","type":"education","lineage":["https://openalex.org/I39063666"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Sebastiano Battiato","raw_affiliation_strings":["IPLAB, University of Catania, 95125 Catania, Italy"],"raw_orcid":"https://orcid.org/0000-0001-6127-2470","affiliations":[{"raw_affiliation_string":"IPLAB, University of Catania, 95125 Catania, Italy","institution_ids":["https://openalex.org/I39063666"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5036892535"],"corresponding_institution_ids":["https://openalex.org/I4210154781"],"apc_list":{"value":1600,"currency":"CHF","value_usd":1782},"apc_paid":{"value":1600,"currency":"CHF","value_usd":1782},"fwci":2.5466,"has_fulltext":true,"cited_by_count":16,"citation_normalized_percentile":{"value":0.90475662,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":94,"max":98},"biblio":{"volume":"6","issue":"12","first_page":"133","last_page":"133"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10458","display_name":"Bladder and Urothelial Cancer Treatments","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10458","display_name":"Bladder and Urothelial Cancer Treatments","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12422","display_name":"Radiomics and Machine Learning in Medical Imaging","score":0.9987999796867371,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.9972000122070312,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/immunotherapy","display_name":"Immunotherapy","score":0.8505336046218872},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.6676764488220215},{"id":"https://openalex.org/keywords/biomarker","display_name":"Biomarker","score":0.6485722064971924},{"id":"https://openalex.org/keywords/oncology","display_name":"Oncology","score":0.5437245965003967},{"id":"https://openalex.org/keywords/pipeline","display_name":"Pipeline (software)","score":0.48802080750465393},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.3973459005355835},{"id":"https://openalex.org/keywords/cancer","display_name":"Cancer","score":0.390019953250885},{"id":"https://openalex.org/keywords/radiology","display_name":"Radiology","score":0.3375018239021301},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.2592772841453552}],"concepts":[{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.8505336046218872},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6676764488220215},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.6485722064971924},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.5437245965003967},{"id":"https://openalex.org/C43521106","wikidata":"https://www.wikidata.org/wiki/Q2165493","display_name":"Pipeline (software)","level":2,"score":0.48802080750465393},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3973459005355835},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.390019953250885},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.3375018239021301},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.2592772841453552},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.0},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3390/jimaging6120133","is_oa":true,"landing_page_url":"https://doi.org/10.3390/jimaging6120133","pdf_url":"https://www.mdpi.com/2313-433X/6/12/133/pdf","source":{"id":"https://openalex.org/S2736465063","display_name":"Journal of Imaging","issn_l":"2313-433X","issn":["2313-433X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Imaging","raw_type":"journal-article"},{"id":"pmid:34460530","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34460530","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of imaging","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:8321180","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8321180","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"J Imaging","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:9c7ace68bc034f5da9e184c11287e28b","is_oa":true,"landing_page_url":"https://doaj.org/article/9c7ace68bc034f5da9e184c11287e28b","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Imaging, Vol 6, Iss 12, p 133 (2020)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3390/jimaging6120133","is_oa":true,"landing_page_url":"https://doi.org/10.3390/jimaging6120133","pdf_url":"https://www.mdpi.com/2313-433X/6/12/133/pdf","source":{"id":"https://openalex.org/S2736465063","display_name":"Journal of Imaging","issn_l":"2313-433X","issn":["2313-433X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Imaging","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Reduced inequalities","score":0.7300000190734863,"id":"https://metadata.un.org/sdg/10"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3107555375.pdf","grobid_xml":"https://content.openalex.org/works/W3107555375.grobid-xml"},"referenced_works_count":55,"referenced_works":["https://openalex.org/W1500037179","https://openalex.org/W1757407923","https://openalex.org/W1861122615","https://openalex.org/W2019607817","https://openalex.org/W2026027774","https://openalex.org/W2071358970","https://openalex.org/W2128739912","https://openalex.org/W2148562299","https://openalex.org/W2307535535","https://openalex.org/W2395714980","https://openalex.org/W2414977199","https://openalex.org/W2487949013","https://openalex.org/W2546607321","https://openalex.org/W2559804019","https://openalex.org/W2588916311","https://openalex.org/W2593949124","https://openalex.org/W2604441970","https://openalex.org/W2618530766","https://openalex.org/W2626778328","https://openalex.org/W2742317286","https://openalex.org/W2746549795","https://openalex.org/W2747016053","https://openalex.org/W2760661635","https://openalex.org/W2767280760","https://openalex.org/W2770201307","https://openalex.org/W2777192533","https://openalex.org/W2886408322","https://openalex.org/W2889691772","https://openalex.org/W2891732223","https://openalex.org/W2905307056","https://openalex.org/W2907029474","https://openalex.org/W2909784248","https://openalex.org/W2917274988","https://openalex.org/W2920830615","https://openalex.org/W2938240210","https://openalex.org/W2938353934","https://openalex.org/W2943798021","https://openalex.org/W2944218525","https://openalex.org/W2944314174","https://openalex.org/W2945472816","https://openalex.org/W2947219786","https://openalex.org/W2957964427","https://openalex.org/W2962858109","https://openalex.org/W2963091558","https://openalex.org/W2965056773","https://openalex.org/W2974120146","https://openalex.org/W2980263953","https://openalex.org/W2981731882","https://openalex.org/W2996516316","https://openalex.org/W2998648213","https://openalex.org/W3000716014","https://openalex.org/W3001499986","https://openalex.org/W6729016426","https://openalex.org/W6762562549","https://openalex.org/W6762627229"],"related_works":["https://openalex.org/W2155887765","https://openalex.org/W141524600","https://openalex.org/W1841185769","https://openalex.org/W2072926321","https://openalex.org/W2049214470","https://openalex.org/W2418638721","https://openalex.org/W2902148150","https://openalex.org/W4301368631","https://openalex.org/W4206284710","https://openalex.org/W2937519691"],"abstract_inverted_index":{"Immunotherapy":[0],"is":[1,60],"regarded":[2],"as":[3,76,161],"one":[4],"of":[5,18,65,78,93,110,143,157],"the":[6,23,37,63,86,118,132,144,155,158],"most":[7],"significant":[8],"breakthroughs":[9],"in":[10,82,128],"cancer":[11],"treatment.":[12,24,42,70],"Unfortunately,":[13],"only":[14],"a":[15,66,79,90],"small":[16],"percentage":[17],"patients":[19,38,94,106],"respond":[20],"properly":[21],"to":[22,26,34,45,68,104,130,152],"Moreover,":[25],"date,":[27],"there":[28],"are":[29],"no":[30],"efficient":[31],"bio-markers":[32],"able":[33],"early":[35],"discriminate":[36,105],"eligible":[39],"for":[40,62],"this":[41],"In":[43],"order":[44,129],"help":[46],"overcome":[47],"these":[48],"limitations,":[49],"an":[50,162],"innovative":[51],"non-invasive":[52],"deep":[53],"pipeline,":[54],"integrating":[55,125],"Computed":[56],"Tomography":[57],"(CT)":[58],"imaging,":[59],"investigated":[61],"prediction":[64],"response":[67,111,135,165],"immunotherapy":[69,133,163],"We":[71],"report":[72],"preliminary":[73],"results":[74],"collected":[75],"part":[77],"case":[80],"study":[81],"which":[83],"we":[84],"validated":[85],"implemented":[87],"method":[88],"on":[89],"clinical":[91],"dataset":[92],"affected":[95],"by":[96],"Metastatic":[97],"Urothelial":[98],"Carcinoma.":[99],"The":[100,146],"proposed":[101,159],"pipeline":[102],"aims":[103],"with":[107,114],"high":[108],"chances":[109],"from":[112,136],"those":[113],"disease":[115],"progression.":[116],"Specifically,":[117],"authors":[119],"propose":[120],"ad-hoc":[121],"3D":[122],"Deep":[123],"Networks":[124],"Self-Attention":[126],"mechanisms":[127],"estimate":[131],"treatment":[134,164],"CT-scan":[137],"images":[138],"and":[139],"such":[140],"hemato-chemical":[141],"data":[142],"patients.":[145],"performance":[147],"evaluation":[148],"(average":[149],"accuracy":[150],"close":[151],"92%)":[153],"confirms":[154],"effectiveness":[156],"approach":[160],"biomarker.":[166]},"counts_by_year":[{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":7}],"updated_date":"2026-08-11T07:18:39.950985","created_date":"2025-10-10T00:00:00"}
