{"id":"https://openalex.org/W2912294247","doi":"https://doi.org/10.3390/jimaging5020022","title":"Understanding Vasomotion of Lung Microcirculation by In Vivo Imaging","display_name":"Understanding Vasomotion of Lung Microcirculation by In Vivo Imaging","publication_year":2019,"publication_date":"2019-01-22","ids":{"openalex":"https://openalex.org/W2912294247","doi":"https://doi.org/10.3390/jimaging5020022","mag":"2912294247","pmid":"https://pubmed.ncbi.nlm.nih.gov/34460470"},"language":"en","primary_location":{"id":"doi:10.3390/jimaging5020022","is_oa":true,"landing_page_url":"https://doi.org/10.3390/jimaging5020022","pdf_url":"https://www.mdpi.com/2313-433X/5/2/22/pdf?version=1548154461","source":{"id":"https://openalex.org/S2736465063","display_name":"Journal of Imaging","issn_l":"2313-433X","issn":["2313-433X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Imaging","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/2313-433X/5/2/22/pdf?version=1548154461","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5080763224","display_name":"Enrico Mazzuca","orcid":null},"institutions":[{"id":"https://openalex.org/I93860229","display_name":"Politecnico di Milano","ror":"https://ror.org/01nffqt88","country_code":"IT","type":"education","lineage":["https://openalex.org/I93860229"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Enrico Mazzuca","raw_affiliation_strings":["Department of Electronics, Information and Bioengineering, Politecnico di Milano, 20133 Milan, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Electronics, Information and Bioengineering, Politecnico di Milano, 20133 Milan, Italy","institution_ids":["https://openalex.org/I93860229"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085074218","display_name":"Andr\u00e9a Aliverti","orcid":"https://orcid.org/0000-0002-2950-0231"},"institutions":[{"id":"https://openalex.org/I93860229","display_name":"Politecnico di Milano","ror":"https://ror.org/01nffqt88","country_code":"IT","type":"education","lineage":["https://openalex.org/I93860229"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Andrea Aliverti","raw_affiliation_strings":["Department of Electronics, Information and Bioengineering, Politecnico di Milano, 20133 Milan, Italy"],"raw_orcid":"https://orcid.org/0000-0002-2950-0231","affiliations":[{"raw_affiliation_string":"Department of Electronics, Information and Bioengineering, Politecnico di Milano, 20133 Milan, Italy","institution_ids":["https://openalex.org/I93860229"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5079166399","display_name":"Giuseppe Miserocchi","orcid":"https://orcid.org/0000-0002-4474-8059"},"institutions":[{"id":"https://openalex.org/I66752286","display_name":"University of Milano-Bicocca","ror":"https://ror.org/01ynf4891","country_code":"IT","type":"education","lineage":["https://openalex.org/I66752286"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Giuseppe Miserocchi","raw_affiliation_strings":["Department of Experimental Medicine, Universit\u00e0 di Milano Bicocca, 20900 Milan, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Experimental Medicine, Universit\u00e0 di Milano Bicocca, 20900 Milan, Italy","institution_ids":["https://openalex.org/I66752286"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5079166399"],"corresponding_institution_ids":["https://openalex.org/I66752286"],"apc_list":{"value":1600,"currency":"CHF","value_usd":1732},"apc_paid":{"value":1600,"currency":"CHF","value_usd":1732},"fwci":1.4487,"has_fulltext":true,"cited_by_count":19,"citation_normalized_percentile":{"value":0.80245779,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"5","issue":"2","first_page":"22","last_page":"22"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11861","display_name":"Thermal Regulation in Medicine","score":0.9991999864578247,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11861","display_name":"Thermal Regulation in Medicine","score":0.9991999864578247,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10322","display_name":"Respiratory Support and Mechanisms","score":0.9968000054359436,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11109","display_name":"Thermoregulation and physiological responses","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/microcirculation","display_name":"Microcirculation","score":0.733242928981781},{"id":"https://openalex.org/keywords/lung","display_name":"Lung","score":0.6705418825149536},{"id":"https://openalex.org/keywords/blood-flow","display_name":"Blood flow","score":0.606533944606781},{"id":"https://openalex.org/keywords/anatomy","display_name":"Anatomy","score":0.5118805170059204},{"id":"https://openalex.org/keywords/in-vivo","display_name":"In vivo","score":0.4716433882713318},{"id":"https://openalex.org/keywords/lung-volumes","display_name":"Lung volumes","score":0.42495980858802795},{"id":"https://openalex.org/keywords/pathology","display_name":"Pathology","score":0.40627041459083557},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.40482521057128906},{"id":"https://openalex.org/keywords/biomedical-engineering","display_name":"Biomedical engineering","score":0.3268773555755615},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.2977376878261566},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.25065135955810547},{"id":"https://openalex.org/keywords/cardiology","display_name":"Cardiology","score":0.14519628882408142},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.13003793358802795}],"concepts":[{"id":"https://openalex.org/C12722491","wikidata":"https://www.wikidata.org/wiki/Q1632335","display_name":"Microcirculation","level":2,"score":0.733242928981781},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.6705418825149536},{"id":"https://openalex.org/C158846371","wikidata":"https://www.wikidata.org/wiki/Q1642137","display_name":"Blood flow","level":2,"score":0.606533944606781},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.5118805170059204},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.4716433882713318},{"id":"https://openalex.org/C27101514","wikidata":"https://www.wikidata.org/wiki/Q206120","display_name":"Lung volumes","level":3,"score":0.42495980858802795},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.40627041459083557},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.40482521057128906},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.3268773555755615},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2977376878261566},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.25065135955810547},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.14519628882408142},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.13003793358802795},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0}],"mesh":[],"locations_count":6,"locations":[{"id":"doi:10.3390/jimaging5020022","is_oa":true,"landing_page_url":"https://doi.org/10.3390/jimaging5020022","pdf_url":"https://www.mdpi.com/2313-433X/5/2/22/pdf?version=1548154461","source":{"id":"https://openalex.org/S2736465063","display_name":"Journal of Imaging","issn_l":"2313-433X","issn":["2313-433X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Imaging","raw_type":"journal-article"},{"id":"pmid:34460470","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34460470","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of imaging","raw_type":null},{"id":"pmh:oai:doaj.org/article:170f23fa71514a23bb2326903e6474db","is_oa":true,"landing_page_url":"https://doaj.org/article/170f23fa71514a23bb2326903e6474db","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Imaging, Vol 5, Iss 2, p 22 (2019)","raw_type":"article"},{"id":"pmh:oai:mdpi.com:/2313-433X/5/2/22/","is_oa":true,"landing_page_url":"http://doi.org/10.3390/jimaging5020022","pdf_url":null,"source":{"id":"https://openalex.org/S4306400947","display_name":"MDPI (MDPI AG)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210097602","host_organization_name":"Multidisciplinary Digital Publishing Institute (Switzerland)","host_organization_lineage":["https://openalex.org/I4210097602"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Imaging","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:8320900","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8320900","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"J Imaging","raw_type":"Text"},{"id":"pmh:oai:re.public.polimi.it:11311/1121229","is_oa":true,"landing_page_url":"http://hdl.handle.net/11311/1121229","pdf_url":null,"source":{"id":"https://openalex.org/S4306400312","display_name":"Virtual Community of Pathological Anatomy (University of Castilla La Mancha)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I79189158","host_organization_name":"University of Castilla-La Mancha","host_organization_lineage":["https://openalex.org/I79189158"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.3390/jimaging5020022","is_oa":true,"landing_page_url":"https://doi.org/10.3390/jimaging5020022","pdf_url":"https://www.mdpi.com/2313-433X/5/2/22/pdf?version=1548154461","source":{"id":"https://openalex.org/S2736465063","display_name":"Journal of Imaging","issn_l":"2313-433X","issn":["2313-433X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Imaging","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Clean water and sanitation","id":"https://metadata.un.org/sdg/6","score":0.7699999809265137}],"awards":[{"id":"https://openalex.org/G8693962778","display_name":null,"funder_award_id":"2012-0685","funder_id":"https://openalex.org/F4320321499","funder_display_name":"Fondazione Cariplo"}],"funders":[{"id":"https://openalex.org/F4320321499","display_name":"Fondazione Cariplo","ror":"https://ror.org/01gb56c55"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2912294247.pdf","grobid_xml":"https://content.openalex.org/works/W2912294247.grobid-xml"},"referenced_works_count":24,"referenced_works":["https://openalex.org/W2028781868","https://openalex.org/W2045110714","https://openalex.org/W2048448755","https://openalex.org/W2077112541","https://openalex.org/W2077335292","https://openalex.org/W2091055733","https://openalex.org/W2109316100","https://openalex.org/W2113419503","https://openalex.org/W2113566585","https://openalex.org/W2129145903","https://openalex.org/W2131364104","https://openalex.org/W2133409498","https://openalex.org/W2134240425","https://openalex.org/W2136596343","https://openalex.org/W2137135934","https://openalex.org/W2137137239","https://openalex.org/W2154054141","https://openalex.org/W2162139867","https://openalex.org/W2186097020","https://openalex.org/W2331102915","https://openalex.org/W2412607459","https://openalex.org/W2602136859","https://openalex.org/W2744158231","https://openalex.org/W4255576461"],"related_works":["https://openalex.org/W2358670732","https://openalex.org/W1485124972","https://openalex.org/W2385327185","https://openalex.org/W2740385447","https://openalex.org/W2363533425","https://openalex.org/W1556510108","https://openalex.org/W2370262970","https://openalex.org/W2129210307","https://openalex.org/W2258875363","https://openalex.org/W1968770722"],"abstract_inverted_index":{"The":[0,34],"balance":[1],"of":[2,10,36,51,61,97,100,109,128,188],"lung":[3,222],"extravascular":[4,46],"water":[5,47],"depends":[6],"upon":[7],"the":[8,14,26,30,49,52,58,62,83,105,189,202],"control":[9],"blood":[11,163,197],"flow":[12,164,198],"in":[13,24,45,80,107,126,150,162,205],"alveolar":[15,31,173,196],"distribution":[16,110,131],"vessels":[17,28,111,116,132,137,204],"that":[18,192],"feed":[19],"downstream":[20],"two":[21],"districts":[22],"placed":[23],"parallel,":[25],"corner":[27,115,136,203],"and":[29,77,114,135,156],"septal":[32],"network.":[33],"occurrence":[35],"an":[37,43,69],"edemagenic":[38,70],"condition":[39],"appears":[40],"critical":[41],"as":[42],"increase":[44],"endangers":[48],"thinness":[50],"air-blood":[53],"barrier,":[54],"thus":[55],"negatively":[56],"affecting":[57],"diffusive":[59],"capacity":[60],"lung.":[63],"We":[64,103],"exposed":[65],"anesthetized":[66],"rabbits":[67],"to":[68,201,212,220],"factor":[71],"(12%":[72],"hypoxia)":[73],"for":[74],"120":[75,144,194],"min":[76],"followed":[78],"by":[79,177],"vivo":[81],"imaging":[82],"micro-vascular":[84],"morphology":[85],"through":[86],"a":[87,91,95,123,214],"\"pleural":[88],"window\"":[89],"using":[90],"stereo":[92],"microscope":[93],"at":[94,140,193],"magnification":[96],"15\u00d7":[98],"(resolution":[99],"7.2":[101],"\u03bcm).":[102,118],"measured":[104],"change":[106],"diameter":[108,127],"(50-200":[112],"\u03bcm)":[113],"(<50":[117],"On":[119],"average,":[120],"hypoxia":[121],"caused":[122],"significant":[124],"decrease":[125],"both":[129],"smaller":[130],"(about":[133,138],"~50%)":[134],"~25%)":[139],"30":[141],"min.":[142],"After":[143],"min,":[145,195],"reperfusion":[146],"occurred.":[147],"Regional":[148],"differences":[149,161],"perivascular":[151],"interstitial":[152],"volume":[153],"were":[154,209],"observed":[155],"could":[157],"be":[158],"correlated":[159],"with":[160,184],"control.":[165],"To":[166],"understand":[167],"such":[168],"difference,":[169],"we":[170],"modelled":[171],"imaged":[172],"capillary":[174,185],"units,":[175],"obtained":[176],"Voronoi":[178],"method,":[179],"integrating":[180],"microvascular":[181],"pressure":[182],"parameters":[183],"filtration.":[186],"Results":[187],"analysis":[190],"suggested":[191],"was":[199],"diverted":[200],"larger":[206],"alveoli,":[207],"which":[208],"found":[210],"also":[211],"undergo":[213],"greater":[215,218],"filtration":[216],"indicating":[217],"proneness":[219],"develop":[221],"edema.":[223]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2}],"updated_date":"2026-05-21T09:19:25.381259","created_date":"2025-10-10T00:00:00"}