{"id":"https://openalex.org/W7161249356","doi":"https://doi.org/10.3390/jimaging12050210","title":"Beyond GLM: Inter-Subject Variability as a Complementary Approach to Detect Longitudinal Changes in Emotion Processing in Multiple Sclerosis","display_name":"Beyond GLM: Inter-Subject Variability as a Complementary Approach to Detect Longitudinal Changes in Emotion Processing in Multiple Sclerosis","publication_year":2026,"publication_date":"2026-05-15","ids":{"openalex":"https://openalex.org/W7161249356","doi":"https://doi.org/10.3390/jimaging12050210","pmid":"https://pubmed.ncbi.nlm.nih.gov/42188247"},"language":"en","primary_location":{"id":"doi:10.3390/jimaging12050210","is_oa":true,"landing_page_url":"https://doi.org/10.3390/jimaging12050210","pdf_url":null,"source":{"id":"https://openalex.org/S2736465063","display_name":"Journal of Imaging","issn_l":"2313-433X","issn":["2313-433X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Imaging","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.3390/jimaging12050210","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5032870006","display_name":"Alice Pirastru","orcid":"https://orcid.org/0000-0001-9474-2344"},"institutions":[{"id":"https://openalex.org/I4210116940","display_name":"Don Carlo Gnocchi Foundation","ror":"https://ror.org/02e3ssq97","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I4210116940"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Alice Pirastru","raw_affiliation_strings":["IRCCS Fondazione Don Carlo Gnocchi ETS, Via Capecelatro 66, 20148 Milan, Italy"],"raw_orcid":"https://orcid.org/0000-0001-9474-2344","affiliations":[{"raw_affiliation_string":"IRCCS Fondazione Don Carlo Gnocchi ETS, Via Capecelatro 66, 20148 Milan, Italy","institution_ids":["https://openalex.org/I4210116940"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007403206","display_name":"Valeria Blasi","orcid":"https://orcid.org/0000-0002-8395-0452"},"institutions":[{"id":"https://openalex.org/I4210116940","display_name":"Don Carlo Gnocchi Foundation","ror":"https://ror.org/02e3ssq97","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I4210116940"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Valeria Blasi","raw_affiliation_strings":["IRCCS Fondazione Don Carlo Gnocchi ETS, Via Capecelatro 66, 20148 Milan, Italy"],"raw_orcid":"https://orcid.org/0000-0002-8395-0452","affiliations":[{"raw_affiliation_string":"IRCCS Fondazione Don Carlo Gnocchi ETS, Via Capecelatro 66, 20148 Milan, Italy","institution_ids":["https://openalex.org/I4210116940"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5093427919","display_name":"Diego Michael Cacciatore","orcid":null},"institutions":[{"id":"https://openalex.org/I103320735","display_name":"Universit\u00e0 Cattolica del Sacro Cuore","ror":"https://ror.org/03h7r5v07","country_code":"IT","type":"education","lineage":["https://openalex.org/I103320735"]},{"id":"https://openalex.org/I4210116940","display_name":"Don Carlo Gnocchi Foundation","ror":"https://ror.org/02e3ssq97","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I4210116940"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Diego Michael Cacciatore","raw_affiliation_strings":["Department of Psychology, Universit\u00e0 Cattolica del Sacro Cuore, 20123 Milan, Italy","IRCCS Fondazione Don Carlo Gnocchi ETS, Via Capecelatro 66, 20148 Milan, Italy"],"raw_orcid":"https://orcid.org/0009-0009-7238-2427","affiliations":[{"raw_affiliation_string":"Department of Psychology, Universit\u00e0 Cattolica del Sacro Cuore, 20123 Milan, Italy","institution_ids":["https://openalex.org/I103320735"]},{"raw_affiliation_string":"IRCCS Fondazione Don Carlo Gnocchi ETS, Via Capecelatro 66, 20148 Milan, Italy","institution_ids":["https://openalex.org/I4210116940"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5136245587","display_name":"Marco Rovaris","orcid":"https://orcid.org/0000-0001-9691-1957"},"institutions":[{"id":"https://openalex.org/I4210116940","display_name":"Don Carlo Gnocchi Foundation","ror":"https://ror.org/02e3ssq97","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I4210116940"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Marco Rovaris","raw_affiliation_strings":["IRCCS Fondazione Don Carlo Gnocchi ETS, Via Capecelatro 66, 20148 Milan, Italy"],"raw_orcid":"https://orcid.org/0000-0001-9691-1957","affiliations":[{"raw_affiliation_string":"IRCCS Fondazione Don Carlo Gnocchi ETS, Via Capecelatro 66, 20148 Milan, Italy","institution_ids":["https://openalex.org/I4210116940"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047419126","display_name":"Elena Toselli","orcid":null},"institutions":[{"id":"https://openalex.org/I4210116940","display_name":"Don Carlo Gnocchi Foundation","ror":"https://ror.org/02e3ssq97","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I4210116940"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Elena Toselli","raw_affiliation_strings":["IRCCS Fondazione Don Carlo Gnocchi ETS, Via Capecelatro 66, 20148 Milan, Italy"],"raw_orcid":"https://orcid.org/0009-0004-2927-6657","affiliations":[{"raw_affiliation_string":"IRCCS Fondazione Don Carlo Gnocchi ETS, Via Capecelatro 66, 20148 Milan, Italy","institution_ids":["https://openalex.org/I4210116940"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025077360","display_name":"Francesco Pagnini","orcid":"https://orcid.org/0000-0003-1612-4211"},"institutions":[{"id":"https://openalex.org/I103320735","display_name":"Universit\u00e0 Cattolica del Sacro Cuore","ror":"https://ror.org/03h7r5v07","country_code":"IT","type":"education","lineage":["https://openalex.org/I103320735"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Francesco Pagnini","raw_affiliation_strings":["Department of Psychology, Universit\u00e0 Cattolica del Sacro Cuore, 20123 Milan, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychology, Universit\u00e0 Cattolica del Sacro Cuore, 20123 Milan, Italy","institution_ids":["https://openalex.org/I103320735"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5136239217","display_name":"Cesare Cavalera","orcid":null},"institutions":[{"id":"https://openalex.org/I103320735","display_name":"Universit\u00e0 Cattolica del Sacro Cuore","ror":"https://ror.org/03h7r5v07","country_code":"IT","type":"education","lineage":["https://openalex.org/I103320735"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Cesare Cavalera","raw_affiliation_strings":["Department of Psychology, Universit\u00e0 Cattolica del Sacro Cuore, 20123 Milan, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychology, Universit\u00e0 Cattolica del Sacro Cuore, 20123 Milan, Italy","institution_ids":["https://openalex.org/I103320735"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5136194220","display_name":"Fabrizio Esposito","orcid":"https://orcid.org/0000-0002-5099-9786"},"institutions":[{"id":"https://openalex.org/I197809005","display_name":"University of Campania \"Luigi Vanvitelli\"","ror":"https://ror.org/02kqnpp86","country_code":"IT","type":"education","lineage":["https://openalex.org/I197809005"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Fabrizio Esposito","raw_affiliation_strings":["Department of Advanced Medical and Surgical Sciences, University of Campania \u201cLuigi Vanvitelli\u201d, 80138 Naples, Italy"],"raw_orcid":"https://orcid.org/0000-0002-5099-9786","affiliations":[{"raw_affiliation_string":"Department of Advanced Medical and Surgical Sciences, University of Campania \u201cLuigi Vanvitelli\u201d, 80138 Naples, Italy","institution_ids":["https://openalex.org/I197809005"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012150223","display_name":"Giuseppe Baselli","orcid":"https://orcid.org/0000-0003-2978-1704"},"institutions":[{"id":"https://openalex.org/I93860229","display_name":"Politecnico di Milano","ror":"https://ror.org/01nffqt88","country_code":"IT","type":"education","lineage":["https://openalex.org/I93860229"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Giuseppe Baselli","raw_affiliation_strings":["Department of Electronics, Information, and Bioengineering, Politecnico di Milano, 20123 Milan, Italy"],"raw_orcid":"https://orcid.org/0000-0003-2978-1704","affiliations":[{"raw_affiliation_string":"Department of Electronics, Information, and Bioengineering, Politecnico di Milano, 20123 Milan, Italy","institution_ids":["https://openalex.org/I93860229"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5136235923","display_name":"Francesca Baglio","orcid":"https://orcid.org/0000-0002-6145-5274"},"institutions":[{"id":"https://openalex.org/I4210116940","display_name":"Don Carlo Gnocchi Foundation","ror":"https://ror.org/02e3ssq97","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I4210116940"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Francesca Baglio","raw_affiliation_strings":["IRCCS Fondazione Don Carlo Gnocchi ETS, Via Capecelatro 66, 20148 Milan, Italy"],"raw_orcid":"https://orcid.org/0000-0002-6145-5274","affiliations":[{"raw_affiliation_string":"IRCCS Fondazione Don Carlo Gnocchi ETS, Via Capecelatro 66, 20148 Milan, Italy","institution_ids":["https://openalex.org/I4210116940"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":1600,"currency":"CHF","value_usd":1782},"apc_paid":{"value":1600,"currency":"CHF","value_usd":1782},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.55695088,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"12","issue":"5","first_page":"210","last_page":"210"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10137","display_name":"Multiple Sclerosis Research Studies","score":0.9053000211715698,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10137","display_name":"Multiple Sclerosis Research Studies","score":0.9053000211715698,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10241","display_name":"Functional Brain Connectivity Studies","score":0.011900000274181366,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13283","display_name":"Mental Health Research Topics","score":0.0071000000461936,"subfield":{"id":"https://openalex.org/subfields/3205","display_name":"Experimental and Cognitive Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/neuroimaging","display_name":"Neuroimaging","score":0.6736999750137329},{"id":"https://openalex.org/keywords/neuroplasticity","display_name":"Neuroplasticity","score":0.5601999759674072},{"id":"https://openalex.org/keywords/multiple-sclerosis","display_name":"Multiple sclerosis","score":0.5090000033378601},{"id":"https://openalex.org/keywords/longitudinal-study","display_name":"Longitudinal study","score":0.42739999294281006},{"id":"https://openalex.org/keywords/depression","display_name":"Depression (economics)","score":0.35040000081062317},{"id":"https://openalex.org/keywords/longitudinal-data","display_name":"Longitudinal data","score":0.3449999988079071},{"id":"https://openalex.org/keywords/neurophysiology","display_name":"Neurophysiology","score":0.32850000262260437}],"concepts":[{"id":"https://openalex.org/C58693492","wikidata":"https://www.wikidata.org/wiki/Q551875","display_name":"Neuroimaging","level":2,"score":0.6736999750137329},{"id":"https://openalex.org/C47611674","wikidata":"https://www.wikidata.org/wiki/Q849491","display_name":"Neuroplasticity","level":2,"score":0.5601999759674072},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.5322999954223633},{"id":"https://openalex.org/C2780640218","wikidata":"https://www.wikidata.org/wiki/Q8277","display_name":"Multiple sclerosis","level":2,"score":0.5090000033378601},{"id":"https://openalex.org/C180747234","wikidata":"https://www.wikidata.org/wiki/Q23373","display_name":"Cognitive psychology","level":1,"score":0.4632999897003174},{"id":"https://openalex.org/C2777895361","wikidata":"https://www.wikidata.org/wiki/Q1758614","display_name":"Longitudinal study","level":2,"score":0.42739999294281006},{"id":"https://openalex.org/C70410870","wikidata":"https://www.wikidata.org/wiki/Q199906","display_name":"Clinical psychology","level":1,"score":0.3571999967098236},{"id":"https://openalex.org/C2776867660","wikidata":"https://www.wikidata.org/wiki/Q1814941","display_name":"Depression (economics)","level":2,"score":0.35040000081062317},{"id":"https://openalex.org/C3020672099","wikidata":"https://www.wikidata.org/wiki/Q857354","display_name":"Longitudinal data","level":2,"score":0.3449999988079071},{"id":"https://openalex.org/C99508421","wikidata":"https://www.wikidata.org/wiki/Q2678675","display_name":"Physical medicine and rehabilitation","level":1,"score":0.33880001306533813},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3285999894142151},{"id":"https://openalex.org/C152478114","wikidata":"https://www.wikidata.org/wiki/Q660910","display_name":"Neurophysiology","level":2,"score":0.32850000262260437},{"id":"https://openalex.org/C2778818304","wikidata":"https://www.wikidata.org/wiki/Q1819478","display_name":"Rehabilitation","level":2,"score":0.3276999890804291},{"id":"https://openalex.org/C138496976","wikidata":"https://www.wikidata.org/wiki/Q175002","display_name":"Developmental psychology","level":1,"score":0.32589998841285706},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.3257000148296356},{"id":"https://openalex.org/C169900460","wikidata":"https://www.wikidata.org/wiki/Q2200417","display_name":"Cognition","level":2,"score":0.301800012588501},{"id":"https://openalex.org/C548259974","wikidata":"https://www.wikidata.org/wiki/Q569965","display_name":"Audiology","level":1,"score":0.29739999771118164},{"id":"https://openalex.org/C52338299","wikidata":"https://www.wikidata.org/wiki/Q1004354","display_name":"Functional neuroimaging","level":3,"score":0.2946000099182129},{"id":"https://openalex.org/C129564537","wikidata":"https://www.wikidata.org/wiki/Q1460873","display_name":"Neural correlates of consciousness","level":3,"score":0.2944999933242798},{"id":"https://openalex.org/C2777438025","wikidata":"https://www.wikidata.org/wiki/Q1339090","display_name":"Emotion recognition","level":2,"score":0.29120001196861267},{"id":"https://openalex.org/C2779226451","wikidata":"https://www.wikidata.org/wiki/Q903809","display_name":"Functional magnetic resonance imaging","level":2,"score":0.2728999853134155},{"id":"https://openalex.org/C53059260","wikidata":"https://www.wikidata.org/wiki/Q374758","display_name":"Multilevel model","level":2,"score":0.2538999915122986},{"id":"https://openalex.org/C120843803","wikidata":"https://www.wikidata.org/wiki/Q4955807","display_name":"Brain activity and meditation","level":3,"score":0.2535000145435333}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.3390/jimaging12050210","is_oa":true,"landing_page_url":"https://doi.org/10.3390/jimaging12050210","pdf_url":null,"source":{"id":"https://openalex.org/S2736465063","display_name":"Journal of Imaging","issn_l":"2313-433X","issn":["2313-433X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Imaging","raw_type":"journal-article"},{"id":"pmid:42188247","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42188247","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of imaging","raw_type":null},{"id":"pmh:oai:doaj.org/article:22ffd4593f8f474d9cdac7956804d32a","is_oa":true,"landing_page_url":"https://doaj.org/article/22ffd4593f8f474d9cdac7956804d32a","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Imaging, Vol 12, Iss 5, p 210 (2026)","raw_type":"article"},{"id":"pmh:oai:publicatt.unicatt.it:10807/339537","is_oa":true,"landing_page_url":"https://hdl.handle.net/10807/339537","pdf_url":null,"source":{"id":"https://openalex.org/S4306400564","display_name":"PubliCatt (Universit\u00e0 Cattolica del Sacro Cuore)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13207876","is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13207876/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"J Imaging","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.3390/jimaging12050210","is_oa":true,"landing_page_url":"https://doi.org/10.3390/jimaging12050210","pdf_url":null,"source":{"id":"https://openalex.org/S2736465063","display_name":"Journal of Imaging","issn_l":"2313-433X","issn":["2313-433X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Imaging","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.4626461863517761}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":43,"referenced_works":["https://openalex.org/W1854715682","https://openalex.org/W1904565533","https://openalex.org/W1993560519","https://openalex.org/W2020776370","https://openalex.org/W2025605722","https://openalex.org/W2039860386","https://openalex.org/W2048132832","https://openalex.org/W2048707777","https://openalex.org/W2053983047","https://openalex.org/W2063085086","https://openalex.org/W2071881327","https://openalex.org/W2091004044","https://openalex.org/W2108459864","https://openalex.org/W2111720749","https://openalex.org/W2116649573","https://openalex.org/W2117340355","https://openalex.org/W2117981173","https://openalex.org/W2136485397","https://openalex.org/W2142869478","https://openalex.org/W2156284662","https://openalex.org/W2160992167","https://openalex.org/W2168778334","https://openalex.org/W2178080901","https://openalex.org/W2269717697","https://openalex.org/W2342495668","https://openalex.org/W2460529817","https://openalex.org/W2619132938","https://openalex.org/W2769396987","https://openalex.org/W2777074421","https://openalex.org/W2795122830","https://openalex.org/W2795667189","https://openalex.org/W2885644971","https://openalex.org/W2911135784","https://openalex.org/W2919008424","https://openalex.org/W2973007151","https://openalex.org/W3032707732","https://openalex.org/W3041669821","https://openalex.org/W3135449444","https://openalex.org/W4233350830","https://openalex.org/W4388234101","https://openalex.org/W4388706412","https://openalex.org/W4390079002","https://openalex.org/W4391945963"],"related_works":[],"abstract_inverted_index":{"Understanding":[0],"how":[1],"to":[2,43,181],"reliably":[3],"capture":[4,102],"neural":[5,83,104],"changes":[6],"induced":[7],"by":[8],"treatments":[9],"in":[10,23,28,77,91,158,189],"neurological":[11,190],"patients":[12],"remains":[13],"a":[14,36,110,178],"major":[15],"methodological":[16],"challenge.":[17],"This":[18,94],"issue":[19],"is":[20],"particularly":[21],"evident":[22],"the":[24,172],"emotional":[25,143],"domain\u2014frequently":[26],"impaired":[27],"conditions":[29],"such":[30],"as":[31,67,109,177],"multiple":[32],"sclerosis":[33],"(MS)":[34],"and":[35,62,88,131],"key":[37],"target":[38],"of":[39,174],"rehabilitation\u2014yet":[40],"not":[41],"limited":[42],"it.":[44],"Longitudinal":[45],"neuroimaging":[46],"studies":[47],"predominantly":[48],"rely":[49],"on":[50],"group-level":[51],"analyses":[52,184],"(e.g.,":[53],"General":[54],"Linear":[55],"Model,":[56],"GLM),":[57],"which":[58,121],"assume":[59],"inter-subject":[60,64],"homogeneity":[61],"treat":[63],"variability":[65,157],"(ISV)":[66],"noise.":[68],"Such":[69],"assumptions":[70],"may":[71],"obscure":[72],"treatment-related":[73,103,187],"neuroplastic":[74],"changes,":[75,105],"especially":[76],"domains":[78],"like":[79],"emotion":[80],"processing,":[81],"where":[82],"responses":[84],"are":[85],"intrinsically":[86],"variable":[87],"highly":[89],"individualized":[90],"clinical":[92],"populations.":[93,191],"study":[95],"investigates":[96],"whether":[97],"modeling":[98],"ISV":[99],"can":[100],"better":[101],"using":[106],"emotion-focused":[107],"rehabilitation":[108],"representative":[111],"case.":[112],"We":[113],"compared":[114],"GLM":[115,148,183],"with":[116,134],"threshold-weighted":[117],"overlap":[118],"maps":[119],"(OMth\u2212w),":[120],"quantify":[122],"spatial":[123],"consistency":[124],"across":[125],"individuals.":[126],"Thirty":[127],"healthy":[128],"controls":[129],"(HCs)":[130],"thirteen":[132],"people":[133],"MS":[135],"(pwMS)":[136],"undergoing":[137],"EMDR":[138],"for":[139,185],"depression":[140],"performed":[141],"an":[142],"fMRI":[144],"task":[145],"(pwMS":[146],"pre/post-treatment).":[147],"revealed":[149],"no":[150],"longitudinal":[151],"effects,":[152],"whereas":[153],"OMth\u2212w":[154],"showed":[155],"reduced":[156],"pwMS":[159],"after":[160],"treatment,":[161],"alongside":[162],"decreased":[163],"depressive":[164],"symptoms":[165],"(p":[166],"<":[167],"0.001).":[168],"These":[169],"findings":[170],"highlight":[171],"value":[173],"variability-based":[175],"approaches":[176],"complementary":[179],"framework":[180],"conventional":[182],"detecting":[186],"neuroplasticity":[188]},"counts_by_year":[],"updated_date":"2026-07-22T07:51:19.307946","created_date":"2026-05-16T00:00:00"}