{"id":"https://openalex.org/W7134828522","doi":"https://doi.org/10.3390/jimaging12030118","title":"ClearScope: A Fully Integrated Light-Sheet Theta Microscope for Sub-Micron-Resolution Imaging Without Lateral Size Constraints","display_name":"ClearScope: A Fully Integrated Light-Sheet Theta Microscope for Sub-Micron-Resolution Imaging Without Lateral Size Constraints","publication_year":2026,"publication_date":"2026-03-10","ids":{"openalex":"https://openalex.org/W7134828522","doi":"https://doi.org/10.3390/jimaging12030118","pmid":"https://pubmed.ncbi.nlm.nih.gov/41892921"},"language":"en","primary_location":{"id":"doi:10.3390/jimaging12030118","is_oa":true,"landing_page_url":"https://doi.org/10.3390/jimaging12030118","pdf_url":null,"source":{"id":"https://openalex.org/S2736465063","display_name":"Journal of Imaging","issn_l":"2313-433X","issn":["2313-433X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Imaging","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.3390/jimaging12030118","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5128642253","display_name":"Matthew G. Fay","orcid":null},"institutions":[{"id":"https://openalex.org/I4210130942","display_name":"MBF Bioscience (United States)","ror":"https://ror.org/02zynam48","country_code":"US","type":"company","lineage":["https://openalex.org/I4210130942"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Matthew G. Fay","raw_affiliation_strings":["MBF Bioscience, Williston, VT 05495, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MBF Bioscience, Williston, VT 05495, USA","institution_ids":["https://openalex.org/I4210130942"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103091769","display_name":"Peter J. Lang","orcid":"https://orcid.org/0000-0001-5914-7478"},"institutions":[{"id":"https://openalex.org/I4210130942","display_name":"MBF Bioscience (United States)","ror":"https://ror.org/02zynam48","country_code":"US","type":"company","lineage":["https://openalex.org/I4210130942"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Peter J. Lang","raw_affiliation_strings":["MBF Bioscience, Williston, VT 05495, USA"],"raw_orcid":"https://orcid.org/0009-0007-1876-4104","affiliations":[{"raw_affiliation_string":"MBF Bioscience, Williston, VT 05495, USA","institution_ids":["https://openalex.org/I4210130942"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5106602376","display_name":"David S. Denu","orcid":null},"institutions":[{"id":"https://openalex.org/I4210130942","display_name":"MBF Bioscience (United States)","ror":"https://ror.org/02zynam48","country_code":"US","type":"company","lineage":["https://openalex.org/I4210130942"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David S. Denu","raw_affiliation_strings":["MBF Bioscience, Williston, VT 05495, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MBF Bioscience, Williston, VT 05495, USA","institution_ids":["https://openalex.org/I4210130942"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012287678","display_name":"Nathan O\u2019Connor","orcid":"https://orcid.org/0009-0000-5928-8692"},"institutions":[{"id":"https://openalex.org/I4210130942","display_name":"MBF Bioscience (United States)","ror":"https://ror.org/02zynam48","country_code":"US","type":"company","lineage":["https://openalex.org/I4210130942"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nathan J. O\u2019Connor","raw_affiliation_strings":["MBF Bioscience, Williston, VT 05495, USA"],"raw_orcid":"https://orcid.org/0009-0000-5928-8692","affiliations":[{"raw_affiliation_string":"MBF Bioscience, Williston, VT 05495, USA","institution_ids":["https://openalex.org/I4210130942"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5106602377","display_name":"Benjamin W. Haydock","orcid":null},"institutions":[{"id":"https://openalex.org/I4210130942","display_name":"MBF Bioscience (United States)","ror":"https://ror.org/02zynam48","country_code":"US","type":"company","lineage":["https://openalex.org/I4210130942"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Benjamin Haydock","raw_affiliation_strings":["MBF Bioscience, Williston, VT 05495, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MBF Bioscience, Williston, VT 05495, USA","institution_ids":["https://openalex.org/I4210130942"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5106058218","display_name":"Jeffrey O. Blaisdell","orcid":null},"institutions":[{"id":"https://openalex.org/I4210130942","display_name":"MBF Bioscience (United States)","ror":"https://ror.org/02zynam48","country_code":"US","type":"company","lineage":["https://openalex.org/I4210130942"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jeffrey Blaisdell","raw_affiliation_strings":["MBF Bioscience, Williston, VT 05495, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MBF Bioscience, Williston, VT 05495, USA","institution_ids":["https://openalex.org/I4210130942"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5128670985","display_name":"Nicolas Roussel","orcid":null},"institutions":[{"id":"https://openalex.org/I4210130942","display_name":"MBF Bioscience (United States)","ror":"https://ror.org/02zynam48","country_code":"US","type":"company","lineage":["https://openalex.org/I4210130942"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nicolas Roussel","raw_affiliation_strings":["MBF Bioscience, Williston, VT 05495, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MBF Bioscience, Williston, VT 05495, USA","institution_ids":["https://openalex.org/I4210130942"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114210496","display_name":"Alissa L. Wilson","orcid":null},"institutions":[{"id":"https://openalex.org/I4210130942","display_name":"MBF Bioscience (United States)","ror":"https://ror.org/02zynam48","country_code":"US","type":"company","lineage":["https://openalex.org/I4210130942"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alissa Wilson","raw_affiliation_strings":["MBF Bioscience, Williston, VT 05495, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MBF Bioscience, Williston, VT 05495, USA","institution_ids":["https://openalex.org/I4210130942"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5106602379","display_name":"Sage R. Aronson","orcid":null},"institutions":[{"id":"https://openalex.org/I4210130942","display_name":"MBF Bioscience (United States)","ror":"https://ror.org/02zynam48","country_code":"US","type":"company","lineage":["https://openalex.org/I4210130942"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sage R. Aronson","raw_affiliation_strings":["MBF Bioscience, Williston, VT 05495, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MBF Bioscience, Williston, VT 05495, USA","institution_ids":["https://openalex.org/I4210130942"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062880253","display_name":"Veronica Pessino","orcid":"https://orcid.org/0000-0001-8625-4746"},"institutions":[{"id":"https://openalex.org/I4210130942","display_name":"MBF Bioscience (United States)","ror":"https://ror.org/02zynam48","country_code":"US","type":"company","lineage":["https://openalex.org/I4210130942"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Veronica Pessino","raw_affiliation_strings":["MBF Bioscience, Williston, VT 05495, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MBF Bioscience, Williston, VT 05495, USA","institution_ids":["https://openalex.org/I4210130942"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018138809","display_name":"Paul J. Angstman","orcid":null},"institutions":[{"id":"https://openalex.org/I4210130942","display_name":"MBF Bioscience (United States)","ror":"https://ror.org/02zynam48","country_code":"US","type":"company","lineage":["https://openalex.org/I4210130942"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Paul J. Angstman","raw_affiliation_strings":["MBF Bioscience, Williston, VT 05495, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MBF Bioscience, Williston, VT 05495, USA","institution_ids":["https://openalex.org/I4210130942"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Cheng Gong","orcid":"https://orcid.org/0000-0002-0026-2006"},"institutions":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Cheng Gong","raw_affiliation_strings":["Department of Biological Sciences, Columbia University, New York, NY 10027, USA","Department of Biomedical Engineering, Columbia University, New York, NY 10027, USA"],"raw_orcid":"https://orcid.org/0000-0002-0026-2006","affiliations":[{"raw_affiliation_string":"Department of Biological Sciences, Columbia University, New York, NY 10027, USA","institution_ids":["https://openalex.org/I78577930"]},{"raw_affiliation_string":"Department of Biomedical Engineering, Columbia University, New York, NY 10027, USA","institution_ids":["https://openalex.org/I78577930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000599932","display_name":"Tanvi Butola","orcid":"https://orcid.org/0000-0003-4350-0569"},"institutions":[{"id":"https://openalex.org/I4210086933","display_name":"NYU Langone Health","ror":"https://ror.org/005dvqh91","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210086933"]},{"id":"https://openalex.org/I57206974","display_name":"New York University","ror":"https://ror.org/0190ak572","country_code":"US","type":"education","lineage":["https://openalex.org/I57206974"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tanvi Butola","raw_affiliation_strings":["Comprehensive Epilepsy Center, Department of Neurology, New York University Grossman School of Medicine, New York, NY 10016, USA","Department of Neuroscience and Physiology, New York University Grossman School of Medicine, New York, NY 10016, USA","Neuroscience Institute, New York University Langone Health, New York, NY 10016, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Comprehensive Epilepsy Center, Department of Neurology, New York University Grossman School of Medicine, New York, NY 10016, USA","institution_ids":["https://openalex.org/I57206974"]},{"raw_affiliation_string":"Department of Neuroscience and Physiology, New York University Grossman School of Medicine, New York, NY 10016, USA","institution_ids":["https://openalex.org/I57206974"]},{"raw_affiliation_string":"Neuroscience Institute, New York University Langone Health, New York, NY 10016, USA","institution_ids":["https://openalex.org/I4210086933"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001041177","display_name":"Orrin Devinsky","orcid":"https://orcid.org/0000-0003-0044-4632"},"institutions":[{"id":"https://openalex.org/I57206974","display_name":"New York University","ror":"https://ror.org/0190ak572","country_code":"US","type":"education","lineage":["https://openalex.org/I57206974"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Orrin Devinsky","raw_affiliation_strings":["Comprehensive Epilepsy Center, Department of Neurology, New York University Grossman School of Medicine, New York, NY 10016, USA","Department of Neuroscience and Physiology, New York University Grossman School of Medicine, New York, NY 10016, USA","Department of Neurosurgery, New York University Grossman School of Medicine, New York, NY 10016, USA","Department of Psychiatry, New York University Grossman School of Medicine, New York, NY 10016, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Comprehensive Epilepsy Center, Department of Neurology, New York University Grossman School of Medicine, New York, NY 10016, USA","institution_ids":["https://openalex.org/I57206974"]},{"raw_affiliation_string":"Department of Neuroscience and Physiology, New York University Grossman School of Medicine, New York, NY 10016, USA","institution_ids":["https://openalex.org/I57206974"]},{"raw_affiliation_string":"Department of Neurosurgery, New York University Grossman School of Medicine, New York, NY 10016, USA","institution_ids":["https://openalex.org/I57206974"]},{"raw_affiliation_string":"Department of Psychiatry, New York University Grossman School of Medicine, New York, NY 10016, USA","institution_ids":["https://openalex.org/I57206974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001044140","display_name":"Jayeeta Basu","orcid":"https://orcid.org/0000-0002-7559-0936"},"institutions":[{"id":"https://openalex.org/I4210086933","display_name":"NYU Langone Health","ror":"https://ror.org/005dvqh91","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210086933"]},{"id":"https://openalex.org/I57206974","display_name":"New York University","ror":"https://ror.org/0190ak572","country_code":"US","type":"education","lineage":["https://openalex.org/I57206974"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jayeeta Basu","raw_affiliation_strings":["Center for Neural Science, New York University, New York, NY 10003, USA","Department of Neuroscience and Physiology, New York University Grossman School of Medicine, New York, NY 10016, USA","Neuroscience Institute, New York University Langone Health, New York, NY 10016, USA"],"raw_orcid":"https://orcid.org/0000-0002-7559-0936","affiliations":[{"raw_affiliation_string":"Center for Neural Science, New York University, New York, NY 10003, USA","institution_ids":["https://openalex.org/I57206974"]},{"raw_affiliation_string":"Department of Neuroscience and Physiology, New York University Grossman School of Medicine, New York, NY 10016, USA","institution_ids":["https://openalex.org/I57206974"]},{"raw_affiliation_string":"Neuroscience Institute, New York University Langone Health, New York, NY 10016, USA","institution_ids":["https://openalex.org/I4210086933"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085712951","display_name":"Raju Tomer","orcid":"https://orcid.org/0000-0002-4229-2860"},"institutions":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Raju Tomer","raw_affiliation_strings":["Department of Biological Sciences, Columbia University, New York, NY 10027, USA","Department of Biomedical Engineering, Columbia University, New York, NY 10027, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Sciences, Columbia University, New York, NY 10027, USA","institution_ids":["https://openalex.org/I78577930"]},{"raw_affiliation_string":"Department of Biomedical Engineering, Columbia University, New York, NY 10027, USA","institution_ids":["https://openalex.org/I78577930"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5066141902","display_name":"Jacob R. Glaser","orcid":"https://orcid.org/0000-0003-4463-207X"},"institutions":[{"id":"https://openalex.org/I4210130942","display_name":"MBF Bioscience (United States)","ror":"https://ror.org/02zynam48","country_code":"US","type":"company","lineage":["https://openalex.org/I4210130942"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jacob R. Glaser","raw_affiliation_strings":["MBF Bioscience, Williston, VT 05495, USA"],"raw_orcid":"https://orcid.org/0000-0003-4463-207X","affiliations":[{"raw_affiliation_string":"MBF Bioscience, Williston, VT 05495, USA","institution_ids":["https://openalex.org/I4210130942"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":17,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":1600,"currency":"CHF","value_usd":1732},"apc_paid":{"value":1600,"currency":"CHF","value_usd":1732},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.3668114,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"12","issue":"3","first_page":"118","last_page":"118"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10540","display_name":"Advanced Fluorescence Microscopy Techniques","score":0.8453999757766724,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10540","display_name":"Advanced Fluorescence Microscopy Techniques","score":0.8453999757766724,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12859","display_name":"Cell Image Analysis Techniques","score":0.06520000100135803,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11897","display_name":"Digital Holography and Microscopy","score":0.027499999850988388,"subfield":{"id":"https://openalex.org/subfields/3107","display_name":"Atomic and Molecular Physics, and Optics"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/clearance","display_name":"Clearance","score":0.7560999989509583},{"id":"https://openalex.org/keywords/human-brain","display_name":"Human brain","score":0.6014000177383423},{"id":"https://openalex.org/keywords/microscopy","display_name":"Microscopy","score":0.5519999861717224},{"id":"https://openalex.org/keywords/brain-tissue","display_name":"Brain tissue","score":0.4569999873638153},{"id":"https://openalex.org/keywords/microscope","display_name":"Microscope","score":0.45579999685287476},{"id":"https://openalex.org/keywords/confocal-laser-scanning-microscopy","display_name":"Confocal laser scanning microscopy","score":0.40450000762939453},{"id":"https://openalex.org/keywords/resolution","display_name":"Resolution (logic)","score":0.39480000734329224},{"id":"https://openalex.org/keywords/confocal","display_name":"Confocal","score":0.3815999925136566},{"id":"https://openalex.org/keywords/laser-microscopy","display_name":"Laser Microscopy","score":0.3767000138759613}],"concepts":[{"id":"https://openalex.org/C138944611","wikidata":"https://www.wikidata.org/wiki/Q1163287","display_name":"Clearance","level":2,"score":0.7560999989509583},{"id":"https://openalex.org/C2777670902","wikidata":"https://www.wikidata.org/wiki/Q492038","display_name":"Human brain","level":2,"score":0.6014000177383423},{"id":"https://openalex.org/C147080431","wikidata":"https://www.wikidata.org/wiki/Q1074953","display_name":"Microscopy","level":2,"score":0.5519999861717224},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.5152999758720398},{"id":"https://openalex.org/C2986936838","wikidata":"https://www.wikidata.org/wiki/Q492038","display_name":"Brain tissue","level":2,"score":0.4569999873638153},{"id":"https://openalex.org/C67649825","wikidata":"https://www.wikidata.org/wiki/Q196538","display_name":"Microscope","level":2,"score":0.45579999685287476},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4271000027656555},{"id":"https://openalex.org/C88412794","wikidata":"https://www.wikidata.org/wiki/Q902045","display_name":"Confocal laser scanning microscopy","level":2,"score":0.40450000762939453},{"id":"https://openalex.org/C138268822","wikidata":"https://www.wikidata.org/wiki/Q1051925","display_name":"Resolution (logic)","level":2,"score":0.39480000734329224},{"id":"https://openalex.org/C31972630","wikidata":"https://www.wikidata.org/wiki/Q844240","display_name":"Computer vision","level":1,"score":0.39250001311302185},{"id":"https://openalex.org/C136009344","wikidata":"https://www.wikidata.org/wiki/Q336201","display_name":"Confocal","level":2,"score":0.3815999925136566},{"id":"https://openalex.org/C2909230309","wikidata":"https://www.wikidata.org/wiki/Q1074953","display_name":"Laser Microscopy","level":3,"score":0.3767000138759613},{"id":"https://openalex.org/C205372480","wikidata":"https://www.wikidata.org/wiki/Q210521","display_name":"Image resolution","level":2,"score":0.3765999972820282},{"id":"https://openalex.org/C58693492","wikidata":"https://www.wikidata.org/wiki/Q551875","display_name":"Neuroimaging","level":2,"score":0.3750999867916107},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.37070000171661377},{"id":"https://openalex.org/C64389972","wikidata":"https://www.wikidata.org/wiki/Q2075980","display_name":"Biological specimen","level":2,"score":0.36910000443458557},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.3666999936103821},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.36390000581741333},{"id":"https://openalex.org/C3020199158","wikidata":"https://www.wikidata.org/wiki/Q210521","display_name":"High resolution","level":2,"score":0.33899998664855957},{"id":"https://openalex.org/C177212765","wikidata":"https://www.wikidata.org/wiki/Q627335","display_name":"Workflow","level":2,"score":0.3346000015735626},{"id":"https://openalex.org/C2779178360","wikidata":"https://www.wikidata.org/wiki/Q902045","display_name":"Confocal microscopy","level":2,"score":0.325300008058548},{"id":"https://openalex.org/C9417928","wikidata":"https://www.wikidata.org/wiki/Q1070689","display_name":"Image processing","level":3,"score":0.3246999979019165},{"id":"https://openalex.org/C136339569","wikidata":"https://www.wikidata.org/wiki/Q1142297","display_name":"Molecular imaging","level":3,"score":0.32339999079704285},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.3181000053882599},{"id":"https://openalex.org/C3020205268","wikidata":"https://www.wikidata.org/wiki/Q1038886","display_name":"Imaging technique","level":2,"score":0.3109000027179718},{"id":"https://openalex.org/C141379421","wikidata":"https://www.wikidata.org/wiki/Q6094427","display_name":"Iterative reconstruction","level":2,"score":0.2890999913215637},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2833000123500824},{"id":"https://openalex.org/C3020794687","wikidata":"https://www.wikidata.org/wiki/Q7380","display_name":"Non human primate","level":2,"score":0.2825999855995178},{"id":"https://openalex.org/C160697094","wikidata":"https://www.wikidata.org/wiki/Q1233197","display_name":"Oblique case","level":2,"score":0.27630001306533813},{"id":"https://openalex.org/C29331040","wikidata":"https://www.wikidata.org/wiki/Q7239554","display_name":"Preclinical imaging","level":3,"score":0.2644999921321869},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.2639999985694885},{"id":"https://openalex.org/C31601959","wikidata":"https://www.wikidata.org/wiki/Q931309","display_name":"Medical imaging","level":2,"score":0.2590000033378601},{"id":"https://openalex.org/C92630104","wikidata":"https://www.wikidata.org/wiki/Q4115103","display_name":"Optical imaging","level":2,"score":0.257999986410141},{"id":"https://openalex.org/C113976765","wikidata":"https://www.wikidata.org/wiki/Q1823502","display_name":"Light sheet fluorescence microscopy","level":4,"score":0.2554999887943268}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3390/jimaging12030118","is_oa":true,"landing_page_url":"https://doi.org/10.3390/jimaging12030118","pdf_url":null,"source":{"id":"https://openalex.org/S2736465063","display_name":"Journal of Imaging","issn_l":"2313-433X","issn":["2313-433X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Imaging","raw_type":"journal-article"},{"id":"pmid:41892921","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41892921","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of imaging","raw_type":null},{"id":"pmh:oai:doaj.org/article:28247eb091bf4137a7cbbd1e97b80184","is_oa":true,"landing_page_url":"https://doaj.org/article/28247eb091bf4137a7cbbd1e97b80184","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Imaging, Vol 12, Iss 3, p 118 (2026)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13027753","is_oa":true,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41892921/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"J Imaging","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.3390/jimaging12030118","is_oa":true,"landing_page_url":"https://doi.org/10.3390/jimaging12030118","pdf_url":null,"source":{"id":"https://openalex.org/S2736465063","display_name":"Journal of Imaging","issn_l":"2313-433X","issn":["2313-433X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Imaging","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":[],"abstract_inverted_index":{"Three-dimensional":[0],"(3D)":[1],"ex":[2],"vivo":[3],"imaging":[4,48,106,150],"of":[5,49,60,93,115,151,184],"cleared":[6,51],"tissue":[7],"from":[8,11],"intact":[9,152],"brains":[10,154],"animal":[12],"models,":[13],"human":[14,21,156],"brain":[15,25,157],"surgical":[16],"specimens,":[17],"and":[18,22,34,39,62,98,138,141,155,170,176,186],"large":[19,119,191],"postmortem":[20],"non-human":[23],"primate":[24],"specimens":[26,120],"is":[27,54,145],"essential":[28],"for":[29],"understanding":[30],"physiological":[31],"neural":[32],"connectivity":[33],"pathological":[35],"alterations":[36],"underlying":[37],"neurological":[38],"neuropsychiatric":[40],"disorders.":[41],"Contemporary":[42],"light-sheet":[43],"microscopy":[44,71],"enables":[45,103,180],"rapid,":[46],"high-resolution":[47,148],"large,":[50],"samples":[52],"but":[53],"limited":[55],"by":[56,76,111,147],"the":[57,91,112,116],"orthogonal":[58],"arrangement":[59],"illumination":[61,80],"detection":[63,86],"optics,":[64],"which":[65],"constrains":[66],"specimen":[67],"size.":[68],"Light-sheet":[69],"theta":[70],"(LSTM)":[72],"overcomes":[73],"this":[74],"limitation":[75],"employing":[77],"two":[78],"oblique":[79],"paths":[81],"while":[82],"maintaining":[83],"a":[84,94,129],"perpendicular":[85],"geometry.":[87],"Here,":[88],"we":[89],"report":[90],"development":[92],"next-generation,":[95],"fully":[96],"integrated":[97],"user-friendly":[99],"LSTM":[100,178],"system":[101,127],"that":[102],"uniform":[104],"subcellular-resolution":[105],"(with":[107],"subcellular":[108],"resolution":[109],"determined":[110],"lateral":[113,123],"performance":[114],"system)":[117],"throughout":[118],"without":[121],"constraining":[122],"(XY)":[124],"dimensions.":[125],"The":[126],"provides":[128],"seamless":[130],"workflow":[131],"encompassing":[132],"image":[133],"acquisition,":[134],"data":[135],"storage,":[136],"pre-":[137],"post-processing,":[139],"enhancement":[140],"quantitative":[142,182],"analysis.":[143,173],"Performance":[144],"demonstrated":[146],"3D":[149],"mouse":[153],"samples,":[158],"including":[159],"complete":[160],"downstream":[161],"analyses":[162],"such":[163],"as":[164],"digital":[165],"neuron":[166],"tracing,":[167],"vascular":[168],"reconstruction":[169],"design-based":[171],"stereological":[172],"This":[174],"enhanced":[175],"accessible":[177],"implementation":[179],"rapid":[181],"mapping":[183],"molecular":[185],"cellular":[187],"features":[188],"in":[189],"very":[190],"biological":[192],"specimens.":[193]},"counts_by_year":[],"updated_date":"2026-06-11T09:08:48.828518","created_date":"2026-03-11T00:00:00"}