{"id":"https://openalex.org/W4406149184","doi":"https://doi.org/10.3390/jimaging11010013","title":"Combined Input Deep Learning Pipeline for Embryo Selection for In Vitro Fertilization Using Light Microscopic Images and Additional Features","display_name":"Combined Input Deep Learning Pipeline for Embryo Selection for In Vitro Fertilization Using Light Microscopic Images and Additional Features","publication_year":2025,"publication_date":"2025-01-07","ids":{"openalex":"https://openalex.org/W4406149184","doi":"https://doi.org/10.3390/jimaging11010013","pmid":"https://pubmed.ncbi.nlm.nih.gov/39852326"},"language":"en","primary_location":{"id":"doi:10.3390/jimaging11010013","is_oa":true,"landing_page_url":"https://doi.org/10.3390/jimaging11010013","pdf_url":"https://www.mdpi.com/2313-433X/11/1/13/pdf?version=1736246083","source":{"id":"https://openalex.org/S2736465063","display_name":"Journal of Imaging","issn_l":"2313-433X","issn":["2313-433X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Imaging","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/2313-433X/11/1/13/pdf?version=1736246083","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5093468283","display_name":"Krittapat Onthuam","orcid":null},"institutions":[{"id":"https://openalex.org/I204778367","display_name":"Norwegian University of Science and Technology","ror":"https://ror.org/05xg72x27","country_code":"NO","type":"education","lineage":["https://openalex.org/I204778367"]},{"id":"https://openalex.org/I158708052","display_name":"Chulalongkorn University","ror":"https://ror.org/028wp3y58","country_code":"TH","type":"education","lineage":["https://openalex.org/I158708052"]}],"countries":["NO","TH"],"is_corresponding":false,"raw_author_name":"Krittapat Onthuam","raw_affiliation_strings":["Department of Marine Technology, Norwegian University of Science and Technology, 7491 Trondheim, Norway","International School of Engineering, Faculty of Engineering, Chulalongkorn University, Bangkok 10330, Thailand"],"affiliations":[{"raw_affiliation_string":"Department of Marine Technology, Norwegian University of Science and Technology, 7491 Trondheim, Norway","institution_ids":["https://openalex.org/I204778367"]},{"raw_affiliation_string":"International School of Engineering, Faculty of Engineering, Chulalongkorn University, Bangkok 10330, Thailand","institution_ids":["https://openalex.org/I158708052"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5093468281","display_name":"Norrawee Charnpinyo","orcid":null},"institutions":[{"id":"https://openalex.org/I158708052","display_name":"Chulalongkorn University","ror":"https://ror.org/028wp3y58","country_code":"TH","type":"education","lineage":["https://openalex.org/I158708052"]}],"countries":["TH"],"is_corresponding":false,"raw_author_name":"Norrawee Charnpinyo","raw_affiliation_strings":["International School of Engineering, Faculty of Engineering, Chulalongkorn University, Bangkok 10330, Thailand"],"affiliations":[{"raw_affiliation_string":"International School of Engineering, Faculty of Engineering, Chulalongkorn University, Bangkok 10330, Thailand","institution_ids":["https://openalex.org/I158708052"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5093468282","display_name":"Kornrapee Suthicharoenpanich","orcid":null},"institutions":[{"id":"https://openalex.org/I158708052","display_name":"Chulalongkorn University","ror":"https://ror.org/028wp3y58","country_code":"TH","type":"education","lineage":["https://openalex.org/I158708052"]}],"countries":["TH"],"is_corresponding":false,"raw_author_name":"Kornrapee Suthicharoenpanich","raw_affiliation_strings":["International School of Engineering, Faculty of Engineering, Chulalongkorn University, Bangkok 10330, Thailand"],"affiliations":[{"raw_affiliation_string":"International School of Engineering, Faculty of Engineering, Chulalongkorn University, Bangkok 10330, Thailand","institution_ids":["https://openalex.org/I158708052"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5093468284","display_name":"Supphaset Engphaiboon","orcid":null},"institutions":[{"id":"https://openalex.org/I158708052","display_name":"Chulalongkorn University","ror":"https://ror.org/028wp3y58","country_code":"TH","type":"education","lineage":["https://openalex.org/I158708052"]}],"countries":["TH"],"is_corresponding":false,"raw_author_name":"Supphaset Engphaiboon","raw_affiliation_strings":["International School of Engineering, Faculty of Engineering, Chulalongkorn University, Bangkok 10330, Thailand"],"affiliations":[{"raw_affiliation_string":"International School of Engineering, Faculty of Engineering, Chulalongkorn University, Bangkok 10330, Thailand","institution_ids":["https://openalex.org/I158708052"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007560512","display_name":"Punnarai Siricharoen","orcid":"https://orcid.org/0000-0001-7418-7427"},"institutions":[{"id":"https://openalex.org/I158708052","display_name":"Chulalongkorn University","ror":"https://ror.org/028wp3y58","country_code":"TH","type":"education","lineage":["https://openalex.org/I158708052"]}],"countries":["TH"],"is_corresponding":true,"raw_author_name":"Punnarai Siricharoen","raw_affiliation_strings":["Department of Computer Engineering, Faculty of Engineering, Chulalongkorn University, Bangkok 10330, Thailand"],"affiliations":[{"raw_affiliation_string":"Department of Computer Engineering, Faculty of Engineering, Chulalongkorn University, Bangkok 10330, Thailand","institution_ids":["https://openalex.org/I158708052"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038463793","display_name":"Ronnapee Chaichaowarat","orcid":"https://orcid.org/0000-0001-5002-7568"},"institutions":[{"id":"https://openalex.org/I158708052","display_name":"Chulalongkorn University","ror":"https://ror.org/028wp3y58","country_code":"TH","type":"education","lineage":["https://openalex.org/I158708052"]}],"countries":["TH"],"is_corresponding":false,"raw_author_name":"Ronnapee Chaichaowarat","raw_affiliation_strings":["International School of Engineering, Faculty of Engineering, Chulalongkorn University, Bangkok 10330, Thailand"],"affiliations":[{"raw_affiliation_string":"International School of Engineering, Faculty of Engineering, Chulalongkorn University, Bangkok 10330, Thailand","institution_ids":["https://openalex.org/I158708052"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5065873449","display_name":"Chanakarn Suebthawinkul","orcid":"https://orcid.org/0000-0002-4111-6427"},"institutions":[{"id":"https://openalex.org/I158708052","display_name":"Chulalongkorn University","ror":"https://ror.org/028wp3y58","country_code":"TH","type":"education","lineage":["https://openalex.org/I158708052"]}],"countries":["TH"],"is_corresponding":true,"raw_author_name":"Chanakarn Suebthawinkul","raw_affiliation_strings":["Department of Obstetrics and Gynecology, Faculty of Medicine, Chulalongkorn University, Bangkok 10330, Thailand"],"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, Faculty of Medicine, Chulalongkorn University, Bangkok 10330, Thailand","institution_ids":["https://openalex.org/I158708052"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5007560512","https://openalex.org/A5065873449"],"corresponding_institution_ids":["https://openalex.org/I158708052"],"apc_list":{"value":1600,"currency":"CHF","value_usd":1732},"apc_paid":{"value":1600,"currency":"CHF","value_usd":1732},"fwci":21.6144,"has_fulltext":true,"cited_by_count":11,"citation_normalized_percentile":{"value":0.99507893,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":100},"biblio":{"volume":"11","issue":"1","first_page":"13","last_page":"13"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10364","display_name":"Reproductive Biology and Fertility","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10364","display_name":"Reproductive Biology and Fertility","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pipeline","display_name":"Pipeline (software)","score":0.7370249032974243},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6449174880981445},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.6110025644302368},{"id":"https://openalex.org/keywords/selection","display_name":"Selection (genetic algorithm)","score":0.5909938216209412},{"id":"https://openalex.org/keywords/in-vitro-fertilisation","display_name":"In vitro fertilisation","score":0.5872777700424194},{"id":"https://openalex.org/keywords/embryo","display_name":"Embryo","score":0.5682143568992615},{"id":"https://openalex.org/keywords/human-fertilization","display_name":"Human fertilization","score":0.47438696026802063},{"id":"https://openalex.org/keywords/deep-learning","display_name":"Deep learning","score":0.4371612071990967},{"id":"https://openalex.org/keywords/computer-vision","display_name":"Computer vision","score":0.41813531517982483},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.38644343614578247},{"id":"https://openalex.org/keywords/pattern-recognition","display_name":"Pattern recognition (psychology)","score":0.38368237018585205},{"id":"https://openalex.org/keywords/anatomy","display_name":"Anatomy","score":0.29412925243377686},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.25146761536598206},{"id":"https://openalex.org/keywords/cell-biology","display_name":"Cell biology","score":0.20537573099136353}],"concepts":[{"id":"https://openalex.org/C43521106","wikidata":"https://www.wikidata.org/wiki/Q2165493","display_name":"Pipeline (software)","level":2,"score":0.7370249032974243},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6449174880981445},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.6110025644302368},{"id":"https://openalex.org/C81917197","wikidata":"https://www.wikidata.org/wiki/Q628760","display_name":"Selection (genetic algorithm)","level":2,"score":0.5909938216209412},{"id":"https://openalex.org/C512716672","wikidata":"https://www.wikidata.org/wiki/Q200117","display_name":"In vitro fertilisation","level":3,"score":0.5872777700424194},{"id":"https://openalex.org/C196843134","wikidata":"https://www.wikidata.org/wiki/Q33196","display_name":"Embryo","level":2,"score":0.5682143568992615},{"id":"https://openalex.org/C88972607","wikidata":"https://www.wikidata.org/wiki/Q2666904","display_name":"Human fertilization","level":2,"score":0.47438696026802063},{"id":"https://openalex.org/C108583219","wikidata":"https://www.wikidata.org/wiki/Q197536","display_name":"Deep learning","level":2,"score":0.4371612071990967},{"id":"https://openalex.org/C31972630","wikidata":"https://www.wikidata.org/wiki/Q844240","display_name":"Computer vision","level":1,"score":0.41813531517982483},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.38644343614578247},{"id":"https://openalex.org/C153180895","wikidata":"https://www.wikidata.org/wiki/Q7148389","display_name":"Pattern recognition (psychology)","level":2,"score":0.38368237018585205},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.29412925243377686},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.25146761536598206},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.20537573099136353},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3390/jimaging11010013","is_oa":true,"landing_page_url":"https://doi.org/10.3390/jimaging11010013","pdf_url":"https://www.mdpi.com/2313-433X/11/1/13/pdf?version=1736246083","source":{"id":"https://openalex.org/S2736465063","display_name":"Journal of Imaging","issn_l":"2313-433X","issn":["2313-433X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Imaging","raw_type":"journal-article"},{"id":"pmid:39852326","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/39852326","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of imaging","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:11765875","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11765875","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11765875/pdf/jimaging-11-00013.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"J Imaging","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:85b32f57dcab46ffa63e39932504d7fe","is_oa":true,"landing_page_url":"https://doaj.org/article/85b32f57dcab46ffa63e39932504d7fe","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Imaging, Vol 11, Iss 1, p 13 (2025)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3390/jimaging11010013","is_oa":true,"landing_page_url":"https://doi.org/10.3390/jimaging11010013","pdf_url":"https://www.mdpi.com/2313-433X/11/1/13/pdf?version=1736246083","source":{"id":"https://openalex.org/S2736465063","display_name":"Journal of Imaging","issn_l":"2313-433X","issn":["2313-433X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Imaging","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320321557","display_name":"Chulalongkorn University","ror":"https://ror.org/028wp3y58"},{"id":"https://openalex.org/F4320329659","display_name":"Thailand Science Research and Innovation","ror":null}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4406149184.pdf","grobid_xml":"https://content.openalex.org/works/W4406149184.grobid-xml"},"referenced_works_count":34,"referenced_works":["https://openalex.org/W2009614010","https://openalex.org/W2124656409","https://openalex.org/W2138276947","https://openalex.org/W2194775991","https://openalex.org/W2531409750","https://openalex.org/W2935410449","https://openalex.org/W2946948417","https://openalex.org/W2949676527","https://openalex.org/W2949941775","https://openalex.org/W2967209289","https://openalex.org/W2973140050","https://openalex.org/W2980847177","https://openalex.org/W3005680577","https://openalex.org/W3015106848","https://openalex.org/W3039893618","https://openalex.org/W3088783181","https://openalex.org/W3091320226","https://openalex.org/W3096831136","https://openalex.org/W3132659982","https://openalex.org/W3136138984","https://openalex.org/W3136418969","https://openalex.org/W3171087525","https://openalex.org/W3181451688","https://openalex.org/W3213394397","https://openalex.org/W4284990211","https://openalex.org/W4321469928","https://openalex.org/W4362520980","https://openalex.org/W4367056781","https://openalex.org/W4384520053","https://openalex.org/W4389577180","https://openalex.org/W4405491957","https://openalex.org/W6796931752","https://openalex.org/W6803376173","https://openalex.org/W6839161322"],"related_works":["https://openalex.org/W2298426203","https://openalex.org/W2352666574","https://openalex.org/W2055856425","https://openalex.org/W2358572045","https://openalex.org/W2388900877","https://openalex.org/W2374690712","https://openalex.org/W2320619678","https://openalex.org/W2347392021","https://openalex.org/W2352650956","https://openalex.org/W2058473156"],"abstract_inverted_index":{"The":[0,134,165],"current":[1],"process":[2],"of":[3,37,45,61,120,162],"embryo":[4,68],"selection":[5],"in":[6,7,124,190],"vitro":[8],"fertilization":[9],"is":[10],"based":[11],"on":[12],"morphological":[13],"criteria;":[14],"embryos":[15,38,46],"are":[16],"manually":[17],"evaluated":[18],"by":[19,65,156],"embryologists":[20],"under":[21,174],"subjective":[22],"assessment.":[23],"In":[24,100],"this":[25],"study,":[26],"a":[27,58,102,108,193],"deep":[28],"learning-based":[29],"pipeline":[30],"was":[31,105,137],"developed":[32,55,138],"to":[33,158],"classify":[34],"the":[35,67,114,140,160,163,199],"viability":[36,76],"using":[39,107,129,143,150],"combined":[40,146],"inputs,":[41],"including":[42,57],"microscopic":[43],"images":[44,128,145],"and":[47,54,73,89,93,154,172,181,192],"additional":[48],"features,":[49],"such":[50],"as":[51,113],"patient":[52],"age":[53],"pseudo-features,":[56],"continuous":[59],"interpretation":[60],"Istanbul":[62],"grading":[63],"scores":[64],"predicting":[66],"stage,":[69],"inner":[70],"cell":[71],"mass,":[72],"trophectoderm.":[74],"For":[75],"prediction,":[77],"convolution-based":[78],"transferred":[79],"learning":[80,110],"models":[81,86],"were":[82,87,98,177],"employed,":[83],"multiple":[84],"pretrained":[85],"compared,":[88],"image":[90],"preprocessing":[91],"techniques":[92],"hyperparameter":[94],"optimization":[95],"via":[96],"Optuna":[97,157],"utilized.":[99],"addition,":[101],"custom":[103],"weight":[104],"trained":[106],"self-supervised":[109],"framework":[111],"known":[112],"Simple":[115],"Framework":[116],"for":[117],"Contrastive":[118],"Learning":[119],"Visual":[121],"Representations":[122],"(SimCLR)":[123],"cooperation":[125],"with":[126,147,198],"generated":[127,149],"generative":[130],"adversarial":[131],"networks":[132],"(GANs).":[133],"best":[135],"model":[136,142],"from":[139],"EfficientNet-B0":[141,152],"preprocessed":[144],"pseudo-features":[148],"separate":[151],"models,":[153],"optimized":[155],"tune":[159],"hyperparameters":[161],"models.":[164],"designed":[166],"model's":[167],"F1":[168],"score,":[169],"accuracy,":[170],"sensitivity,":[171],"area":[173],"curve":[175],"(AUC)":[176],"65.02%,":[178],"69.04%,":[179],"56.76%,":[180],"66.98%,":[182],"respectively.":[183],"This":[184],"study":[185],"also":[186],"showed":[187],"an":[188],"advantage":[189],"accuracy":[191],"similar":[194],"AUC":[195],"when":[196],"compared":[197],"recent":[200],"ensemble":[201],"method.":[202]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":6}],"updated_date":"2026-03-20T23:20:44.827607","created_date":"2025-10-10T00:00:00"}