{"id":"https://openalex.org/W2794823324","doi":"https://doi.org/10.3390/g9020019","title":"Fractionated Follow-Up Chemotherapy Delays the Onset of Resistance in Bone Metastatic Prostate Cancer","display_name":"Fractionated Follow-Up Chemotherapy Delays the Onset of Resistance in Bone Metastatic Prostate Cancer","publication_year":2018,"publication_date":"2018-04-23","ids":{"openalex":"https://openalex.org/W2794823324","doi":"https://doi.org/10.3390/g9020019","mag":"2794823324","pmid":"https://pubmed.ncbi.nlm.nih.gov/33552562"},"language":"en","primary_location":{"id":"doi:10.3390/g9020019","is_oa":true,"landing_page_url":"https://doi.org/10.3390/g9020019","pdf_url":"https://www.mdpi.com/2073-4336/9/2/19/pdf?version=1525349560","source":{"id":"https://openalex.org/S6552842","display_name":"Games","issn_l":"2073-4336","issn":["2073-4336"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Games","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/2073-4336/9/2/19/pdf?version=1525349560","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5062961779","display_name":"Pranav Warman","orcid":"https://orcid.org/0000-0001-5199-2474"},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]},{"id":"https://openalex.org/I3019308854","display_name":"Moffitt Cancer Center","ror":"https://ror.org/01xf75524","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019308854"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Pranav I. Warman","raw_affiliation_strings":["Department of Cumputer Science, Duke University, Durham, NC 27708, USA","Integrated Mathematical Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA"],"raw_orcid":"https://orcid.org/0000-0001-5199-2474","affiliations":[{"raw_affiliation_string":"Department of Cumputer Science, Duke University, Durham, NC 27708, USA","institution_ids":["https://openalex.org/I170897317"]},{"raw_affiliation_string":"Integrated Mathematical Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA","institution_ids":["https://openalex.org/I3019308854"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056880989","display_name":"Artem Kaznatcheev","orcid":"https://orcid.org/0000-0001-8063-2187"},"institutions":[{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]},{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB","US"],"is_corresponding":false,"raw_author_name":"Artem Kaznatcheev","raw_affiliation_strings":["Department of Computer Science, University of Oxford, Oxford OX1 3QD, UK","Department of Translational Hematology & Oncology Research, Cleveland Clinic, Cleveland, OH 44195, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Computer Science, University of Oxford, Oxford OX1 3QD, UK","institution_ids":["https://openalex.org/I40120149"]},{"raw_affiliation_string":"Department of Translational Hematology & Oncology Research, Cleveland Clinic, Cleveland, OH 44195, USA","institution_ids":["https://openalex.org/I1316902750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009606518","display_name":"Arturo Araujo","orcid":"https://orcid.org/0000-0002-0269-2819"},"institutions":[{"id":"https://openalex.org/I3019308854","display_name":"Moffitt Cancer Center","ror":"https://ror.org/01xf75524","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019308854"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Arturo Araujo","raw_affiliation_strings":["Integrated Mathematical Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Integrated Mathematical Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA","institution_ids":["https://openalex.org/I3019308854"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005942374","display_name":"Conor C. Lynch","orcid":"https://orcid.org/0000-0002-4506-6244"},"institutions":[{"id":"https://openalex.org/I3019308854","display_name":"Moffitt Cancer Center","ror":"https://ror.org/01xf75524","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019308854"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Conor C. Lynch","raw_affiliation_strings":["Department of Tumor Biology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Tumor Biology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA","institution_ids":["https://openalex.org/I3019308854"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5003774553","display_name":"David Basanta","orcid":null},"institutions":[{"id":"https://openalex.org/I3019308854","display_name":"Moffitt Cancer Center","ror":"https://ror.org/01xf75524","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019308854"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"David Basanta","raw_affiliation_strings":["Integrated Mathematical Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Integrated Mathematical Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA","institution_ids":["https://openalex.org/I3019308854"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5003774553"],"corresponding_institution_ids":["https://openalex.org/I3019308854"],"apc_list":{"value":1400,"currency":"CHF","value_usd":1515},"apc_paid":{"value":1400,"currency":"CHF","value_usd":1515},"fwci":1.4675,"has_fulltext":true,"cited_by_count":14,"citation_normalized_percentile":{"value":0.82568097,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"9","issue":"2","first_page":"19","last_page":"19"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11395","display_name":"Radiopharmaceutical Chemistry and Applications","score":0.9962999820709229,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/prostate-cancer","display_name":"Prostate cancer","score":0.6732460260391235},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.5896711349487305},{"id":"https://openalex.org/keywords/oncology","display_name":"Oncology","score":0.5749814510345459},{"id":"https://openalex.org/keywords/chemotherapy","display_name":"Chemotherapy","score":0.5595883131027222},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.47436055541038513},{"id":"https://openalex.org/keywords/cancer","display_name":"Cancer","score":0.4696432948112488},{"id":"https://openalex.org/keywords/prostate","display_name":"Prostate","score":0.4379270374774933}],"concepts":[{"id":"https://openalex.org/C2780192828","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostate cancer","level":3,"score":0.6732460260391235},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5896711349487305},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.5749814510345459},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.5595883131027222},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.47436055541038513},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4696432948112488},{"id":"https://openalex.org/C2776235491","wikidata":"https://www.wikidata.org/wiki/Q9625","display_name":"Prostate","level":3,"score":0.4379270374774933}],"mesh":[],"locations_count":8,"locations":[{"id":"doi:10.3390/g9020019","is_oa":true,"landing_page_url":"https://doi.org/10.3390/g9020019","pdf_url":"https://www.mdpi.com/2073-4336/9/2/19/pdf?version=1525349560","source":{"id":"https://openalex.org/S6552842","display_name":"Games","issn_l":"2073-4336","issn":["2073-4336"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Games","raw_type":"journal-article"},{"id":"pmid:33552562","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33552562","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Games","raw_type":null},{"id":"pmh:oai:RePEc:gam:jgames:v:9:y:2018:i:2:p:19-:d:142707","is_oa":false,"landing_page_url":"https://www.mdpi.com/2073-4336/9/2/19/","pdf_url":null,"source":{"id":"https://openalex.org/S4306401271","display_name":"RePEc: Research Papers in Economics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I77793887","host_organization_name":"Federal Reserve Bank of St. Louis","host_organization_lineage":["https://openalex.org/I77793887"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"pmh:oai:doaj.org/article:31ca574d324d4999abcc9b53e5b351fe","is_oa":true,"landing_page_url":"https://doaj.org/article/31ca574d324d4999abcc9b53e5b351fe","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Games, Vol 9, Iss 2, p 19 (2018)","raw_type":"article"},{"id":"pmh:oai:econstor.eu:10419/179179","is_oa":true,"landing_page_url":"http://hdl.handle.net/10419/179179","pdf_url":null,"source":{"id":"https://openalex.org/S4306401696","display_name":"Econstor (Econstor)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"doc-type:article"},{"id":"pmh:oai:europepmc.org:6770870","is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC7864372","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:mdpi.com:/2073-4336/9/2/19/","is_oa":true,"landing_page_url":"https://dx.doi.org/10.3390/g9020019","pdf_url":null,"source":{"id":"https://openalex.org/S4306400947","display_name":"MDPI (MDPI AG)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210097602","host_organization_name":"Multidisciplinary Digital Publishing Institute (Switzerland)","host_organization_lineage":["https://openalex.org/I4210097602"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Games; Volume 9; Issue 2; Pages: 19","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:7864372","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7864372","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Games (Basel)","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.3390/g9020019","is_oa":true,"landing_page_url":"https://doi.org/10.3390/g9020019","pdf_url":"https://www.mdpi.com/2073-4336/9/2/19/pdf?version=1525349560","source":{"id":"https://openalex.org/S6552842","display_name":"Games","issn_l":"2073-4336","issn":["2073-4336"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Games","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/1","score":0.5899999737739563,"display_name":"No poverty"}],"awards":[{"id":"https://openalex.org/G2021782124","display_name":null,"funder_award_id":"U01CA202958","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G4119534169","display_name":null,"funder_award_id":"W81XWH","funder_id":"https://openalex.org/F4320306078","funder_display_name":"U.S. Department of Defense"},{"id":"https://openalex.org/G4294856372","display_name":null,"funder_award_id":"W81XWH-15-1","funder_id":"https://openalex.org/F4320306078","funder_display_name":"U.S. Department of Defense"},{"id":"https://openalex.org/G7595236625","display_name":null,"funder_award_id":"U01CA202958-01","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320306078","display_name":"U.S. Department of Defense","ror":"https://ror.org/0447fe631"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320338485","display_name":"DOD Prostate Cancer Research Program","ror":null}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2794823324.pdf","grobid_xml":"https://content.openalex.org/works/W2794823324.grobid-xml"},"referenced_works_count":33,"referenced_works":["https://openalex.org/W1970517799","https://openalex.org/W1972741145","https://openalex.org/W1978239979","https://openalex.org/W1979199562","https://openalex.org/W1984654699","https://openalex.org/W1997175519","https://openalex.org/W2010375850","https://openalex.org/W2016009250","https://openalex.org/W2036374135","https://openalex.org/W2040389858","https://openalex.org/W2050199762","https://openalex.org/W2093419382","https://openalex.org/W2105933619","https://openalex.org/W2106572206","https://openalex.org/W2126504040","https://openalex.org/W2128666917","https://openalex.org/W2145903740","https://openalex.org/W2148851290","https://openalex.org/W2149218924","https://openalex.org/W2206457331","https://openalex.org/W2466315799","https://openalex.org/W2619430774","https://openalex.org/W2743125276","https://openalex.org/W2770572337","https://openalex.org/W2774281968","https://openalex.org/W2783235483","https://openalex.org/W2793726983","https://openalex.org/W2884246550","https://openalex.org/W2963622443","https://openalex.org/W3099532141","https://openalex.org/W3102557260","https://openalex.org/W4298032220","https://openalex.org/W6822120570"],"related_works":["https://openalex.org/W299695548","https://openalex.org/W4403381637","https://openalex.org/W2384122898","https://openalex.org/W151774199","https://openalex.org/W4281885123","https://openalex.org/W3015759778","https://openalex.org/W2088520467","https://openalex.org/W2075763133","https://openalex.org/W2376423713","https://openalex.org/W1583600832"],"abstract_inverted_index":{".":[0],"Understanding":[1],"how":[2,16],"tumor":[3,94,104,140],"cells":[4,105],"can":[5,203],"disrupt":[6],"bone":[7,48,108,144,210,222],"homeostasis":[8],"through":[9],"their":[10],"interactions":[11,101],"with":[12,106,216],"the":[13,25,46,61,77,81,86,90,100,107,123,139,142,148],"stroma":[14],"and":[15,50,96,110,129,141,176,179],"metastatic":[17,223],"tumors":[18],"respond":[19],"to":[20,24,136,147,205,214],"treatment":[21,111,128],"is":[22,164,183],"key":[23],"development":[26],"of":[27,44,80,89,102,151,201,208,219],"new":[28],"treatments":[29],"for":[30,221],"what":[31],"remains":[32],"an":[33,39],"incurable":[34],"disease.":[35],"Here":[36],"we":[37,154,195],"describe":[38],"evolutionary":[40,62],"game":[41,67],"theoretical":[42,68],"model":[43,58,84],"both":[45],"homeostatic":[47],"remodeling":[49],"its":[51],"co-option":[52],"by":[53,70,172],"prostate":[54,224],"cancer":[55,225],"metastases.":[56],"This":[57],"extends":[59],"past":[60],"aspects":[63],"typically":[64],"considered":[65],"in":[66,122,167],"models":[69],"also":[71,196],"including":[72],"ecological":[73],"factors":[74],"such":[75],"as":[76],"physical":[78],"microenvironment":[79,109],"bone.":[82],"Our":[83,113],"recapitulates":[85],"current":[87,149],"paradigm":[88],"\"vicious":[91],"cycle\"":[92],"driving":[93],"growth":[95],"sheds":[97],"light":[98],"on":[99],"heterogeneous":[103],"response.":[112],"results":[114],"show":[115,197],"that":[116,130,181,198,211],"resistant":[117],"populations":[118],"naturally":[119],"become":[120],"dominant":[121],"metastases":[124],"under":[125],"conventional":[126],"cytotoxic":[127],"novel":[131],"schedules":[132],"could":[133],"be":[134],"used":[135],"better":[137,184],"control":[138],"associated":[143],"disease":[145],"compared":[146],"standard":[150],"care.":[152],"Specifically,":[153],"introduce":[155],"fractionated":[156],"follow":[157],"up":[158],"therapy":[159],"-":[160,178],"chemotherapy":[161,202],"where":[162],"dosage":[163],"administered":[165],"initially":[166],"one":[168],"solid":[169],"block":[170],"followed":[171],"alternating":[173],"smaller":[174],"doeses":[175],"holidays":[177],"argue":[180],"it":[182],"than":[185],"either":[186],"a":[187,191],"continuous":[188],"application":[189],"or":[190],"periodic":[192],"one.":[193],"Furthermore,":[194],"different":[199,206],"regimens":[200],"lead":[204],"amounts":[207],"pathological":[209],"are":[212],"known":[213],"correlate":[215],"poor":[217],"quality":[218],"life":[220],"patients.":[226]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":6},{"year":2018,"cited_by_count":1}],"updated_date":"2026-05-06T08:25:59.206177","created_date":"2025-10-10T00:00:00"}