{"id":"https://openalex.org/W4404702339","doi":"https://doi.org/10.3390/e26121012","title":"RNA World with Inhibitors","display_name":"RNA World with Inhibitors","publication_year":2024,"publication_date":"2024-11-23","ids":{"openalex":"https://openalex.org/W4404702339","doi":"https://doi.org/10.3390/e26121012","pmid":"https://pubmed.ncbi.nlm.nih.gov/39766641"},"language":"en","primary_location":{"id":"doi:10.3390/e26121012","is_oa":true,"landing_page_url":"https://doi.org/10.3390/e26121012","pdf_url":"https://www.mdpi.com/1099-4300/26/12/1012/pdf?version=1732352364","source":{"id":"https://openalex.org/S195231649","display_name":"Entropy","issn_l":"1099-4300","issn":["1099-4300"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Entropy","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/1099-4300/26/12/1012/pdf?version=1732352364","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5081914976","display_name":"Jaroslaw Synak","orcid":"https://orcid.org/0000-0002-9887-849X"},"institutions":[{"id":"https://openalex.org/I46597724","display_name":"Pozna\u0144 University of Technology","ror":"https://ror.org/00p7p3302","country_code":"PL","type":"education","lineage":["https://openalex.org/I46597724"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Jaroslaw Synak","raw_affiliation_strings":["European Center for Bioinformatics and Genomics, 60-965 Poznan, Poland","Institute of Computing Science, Poznan University of Technology, 60-965 Poznan, Poland"],"raw_orcid":"https://orcid.org/0000-0002-9887-849X","affiliations":[{"raw_affiliation_string":"European Center for Bioinformatics and Genomics, 60-965 Poznan, Poland","institution_ids":[]},{"raw_affiliation_string":"Institute of Computing Science, Poznan University of Technology, 60-965 Poznan, Poland","institution_ids":["https://openalex.org/I46597724"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027621077","display_name":"Agnieszka Rybarczyk","orcid":"https://orcid.org/0000-0003-4115-0737"},"institutions":[{"id":"https://openalex.org/I4210152414","display_name":"Institute of Bioorganic Chemistry, Polish Academy of Sciences","ror":"https://ror.org/04ejdtr48","country_code":"PL","type":"facility","lineage":["https://openalex.org/I4210152414","https://openalex.org/I99542240"]},{"id":"https://openalex.org/I46597724","display_name":"Pozna\u0144 University of Technology","ror":"https://ror.org/00p7p3302","country_code":"PL","type":"education","lineage":["https://openalex.org/I46597724"]}],"countries":["PL"],"is_corresponding":true,"raw_author_name":"Agnieszka Rybarczyk","raw_affiliation_strings":["European Center for Bioinformatics and Genomics, 60-965 Poznan, Poland","Institute of Bioorganic Chemistry, Polish Academy of Sciences, 61-704 Poznan, Poland","Institute of Computing Science, Poznan University of Technology, 60-965 Poznan, Poland"],"raw_orcid":"https://orcid.org/0000-0003-4115-0737","affiliations":[{"raw_affiliation_string":"European Center for Bioinformatics and Genomics, 60-965 Poznan, Poland","institution_ids":[]},{"raw_affiliation_string":"Institute of Bioorganic Chemistry, Polish Academy of Sciences, 61-704 Poznan, Poland","institution_ids":["https://openalex.org/I4210152414"]},{"raw_affiliation_string":"Institute of Computing Science, Poznan University of Technology, 60-965 Poznan, Poland","institution_ids":["https://openalex.org/I46597724"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036768913","display_name":"Marta Kasprzak","orcid":"https://orcid.org/0000-0002-9863-5412"},"institutions":[{"id":"https://openalex.org/I46597724","display_name":"Pozna\u0144 University of Technology","ror":"https://ror.org/00p7p3302","country_code":"PL","type":"education","lineage":["https://openalex.org/I46597724"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Marta Kasprzak","raw_affiliation_strings":["European Center for Bioinformatics and Genomics, 60-965 Poznan, Poland","Institute of Computing Science, Poznan University of Technology, 60-965 Poznan, Poland"],"raw_orcid":"https://orcid.org/0000-0002-9863-5412","affiliations":[{"raw_affiliation_string":"European Center for Bioinformatics and Genomics, 60-965 Poznan, Poland","institution_ids":[]},{"raw_affiliation_string":"Institute of Computing Science, Poznan University of Technology, 60-965 Poznan, Poland","institution_ids":["https://openalex.org/I46597724"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5024504556","display_name":"Jacek B\u0142a\u017cewicz","orcid":"https://orcid.org/0000-0001-8326-1094"},"institutions":[{"id":"https://openalex.org/I4210152414","display_name":"Institute of Bioorganic Chemistry, Polish Academy of Sciences","ror":"https://ror.org/04ejdtr48","country_code":"PL","type":"facility","lineage":["https://openalex.org/I4210152414","https://openalex.org/I99542240"]},{"id":"https://openalex.org/I46597724","display_name":"Pozna\u0144 University of Technology","ror":"https://ror.org/00p7p3302","country_code":"PL","type":"education","lineage":["https://openalex.org/I46597724"]}],"countries":["PL"],"is_corresponding":true,"raw_author_name":"Jacek Blazewicz","raw_affiliation_strings":["European Center for Bioinformatics and Genomics, 60-965 Poznan, Poland","Institute of Bioorganic Chemistry, Polish Academy of Sciences, 61-704 Poznan, Poland","Institute of Computing Science, Poznan University of Technology, 60-965 Poznan, Poland"],"raw_orcid":"https://orcid.org/0000-0001-8326-1094","affiliations":[{"raw_affiliation_string":"European Center for Bioinformatics and Genomics, 60-965 Poznan, Poland","institution_ids":[]},{"raw_affiliation_string":"Institute of Bioorganic Chemistry, Polish Academy of Sciences, 61-704 Poznan, Poland","institution_ids":["https://openalex.org/I4210152414"]},{"raw_affiliation_string":"Institute of Computing Science, Poznan University of Technology, 60-965 Poznan, Poland","institution_ids":["https://openalex.org/I46597724"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5024504556","https://openalex.org/A5027621077"],"corresponding_institution_ids":["https://openalex.org/I4210152414","https://openalex.org/I46597724"],"apc_list":{"value":2000,"currency":"CHF","value_usd":2227},"apc_paid":{"value":2000,"currency":"CHF","value_usd":2227},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.09843874,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"26","issue":"12","first_page":"1012","last_page":"1012"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11445","display_name":"Origins and Evolution of Life","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/3103","display_name":"Astronomy and Astrophysics"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11445","display_name":"Origins and Evolution of Life","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/3103","display_name":"Astronomy and Astrophysics"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.9639999866485596,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.9351999759674072,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/rna","display_name":"RNA","score":0.8209609985351562},{"id":"https://openalex.org/keywords/dna","display_name":"DNA","score":0.6208690404891968},{"id":"https://openalex.org/keywords/rna-world-hypothesis","display_name":"RNA world hypothesis","score":0.5516456961631775},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.5055568218231201},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.45509573817253113},{"id":"https://openalex.org/keywords/membrane","display_name":"Membrane","score":0.43232011795043945},{"id":"https://openalex.org/keywords/rna-editing","display_name":"RNA editing","score":0.4124811589717865},{"id":"https://openalex.org/keywords/function","display_name":"Function (biology)","score":0.41012099385261536},{"id":"https://openalex.org/keywords/cell-biology","display_name":"Cell biology","score":0.3833473026752472},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.3414195477962494},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.33855727314949036},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.33024758100509644},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.29985326528549194},{"id":"https://openalex.org/keywords/ribozyme","display_name":"Ribozyme","score":0.26082056760787964}],"concepts":[{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.8209609985351562},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.6208690404891968},{"id":"https://openalex.org/C155242204","wikidata":"https://www.wikidata.org/wiki/Q407525","display_name":"RNA world hypothesis","level":5,"score":0.5516456961631775},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5055568218231201},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.45509573817253113},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.43232011795043945},{"id":"https://openalex.org/C21786251","wikidata":"https://www.wikidata.org/wiki/Q14886350","display_name":"RNA editing","level":4,"score":0.4124811589717865},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.41012099385261536},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3833473026752472},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3414195477962494},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.33855727314949036},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.33024758100509644},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.29985326528549194},{"id":"https://openalex.org/C76346623","wikidata":"https://www.wikidata.org/wiki/Q205858","display_name":"Ribozyme","level":4,"score":0.26082056760787964}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3390/e26121012","is_oa":true,"landing_page_url":"https://doi.org/10.3390/e26121012","pdf_url":"https://www.mdpi.com/1099-4300/26/12/1012/pdf?version=1732352364","source":{"id":"https://openalex.org/S195231649","display_name":"Entropy","issn_l":"1099-4300","issn":["1099-4300"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Entropy","raw_type":"journal-article"},{"id":"pmid:39766641","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/39766641","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Entropy (Basel, Switzerland)","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:11726725","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11726725","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11726725/pdf/entropy-26-01012.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Entropy (Basel)","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:6cb493db3bb84943966c6bb612afcf18","is_oa":false,"landing_page_url":"https://doaj.org/article/6cb493db3bb84943966c6bb612afcf18","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Entropy, Vol 26, Iss 12, p 1012 (2024)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3390/e26121012","is_oa":true,"landing_page_url":"https://doi.org/10.3390/e26121012","pdf_url":"https://www.mdpi.com/1099-4300/26/12/1012/pdf?version=1732352364","source":{"id":"https://openalex.org/S195231649","display_name":"Entropy","issn_l":"1099-4300","issn":["1099-4300"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Entropy","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4404702339.pdf","grobid_xml":"https://content.openalex.org/works/W4404702339.grobid-xml"},"referenced_works_count":57,"referenced_works":["https://openalex.org/W1989893690","https://openalex.org/W1993748480","https://openalex.org/W1995143868","https://openalex.org/W2003825614","https://openalex.org/W2007951194","https://openalex.org/W2010762045","https://openalex.org/W2017454755","https://openalex.org/W2031583483","https://openalex.org/W2046538112","https://openalex.org/W2049534291","https://openalex.org/W2050110866","https://openalex.org/W2061091972","https://openalex.org/W2066582149","https://openalex.org/W2085954575","https://openalex.org/W2087895317","https://openalex.org/W2089370618","https://openalex.org/W2089644153","https://openalex.org/W2098021908","https://openalex.org/W2098725272","https://openalex.org/W2105284342","https://openalex.org/W2126901778","https://openalex.org/W2132920850","https://openalex.org/W2144840613","https://openalex.org/W2153339171","https://openalex.org/W2168528449","https://openalex.org/W2300752742","https://openalex.org/W2320164531","https://openalex.org/W2560750880","https://openalex.org/W2562163731","https://openalex.org/W2593220981","https://openalex.org/W2735322110","https://openalex.org/W2736063617","https://openalex.org/W2803705642","https://openalex.org/W2892140782","https://openalex.org/W2918005410","https://openalex.org/W2943510327","https://openalex.org/W2954236142","https://openalex.org/W3000068290","https://openalex.org/W3030343346","https://openalex.org/W3082564993","https://openalex.org/W3130279262","https://openalex.org/W3135511916","https://openalex.org/W3139088209","https://openalex.org/W3157030426","https://openalex.org/W3192987284","https://openalex.org/W3197736901","https://openalex.org/W3213568287","https://openalex.org/W4205522891","https://openalex.org/W4206749235","https://openalex.org/W4210280173","https://openalex.org/W4212847374","https://openalex.org/W4220826434","https://openalex.org/W4223519683","https://openalex.org/W4255996317","https://openalex.org/W4310493711","https://openalex.org/W4391167818","https://openalex.org/W4392383343"],"related_works":["https://openalex.org/W2145660312","https://openalex.org/W1929212941","https://openalex.org/W4390006932","https://openalex.org/W2034409080","https://openalex.org/W4245682324","https://openalex.org/W2117819109","https://openalex.org/W2001190945","https://openalex.org/W2150698842","https://openalex.org/W2944808730","https://openalex.org/W4387579936"],"abstract_inverted_index":{"During":[0],"the":[1,4,27,62,77],"evolution":[2],"of":[3,11,29,50,59,79],"RNA":[5,43,110],"World,":[6],"compartments,":[7,35],"which":[8,112],"were":[9],"fragments":[10],"space":[12],"surrounded":[13],"by":[14,127],"a":[15,47,57,96],"primitive":[16],"lipid":[17],"membrane,":[18],"had":[19,38],"to":[20,26,39,44,64,67],"have":[21,84,102,114],"emerged.":[22],"These":[23],"led":[24],"eventually":[25],"formation":[28],"modern":[30,90],"cellular":[31,91],"membranes.":[32],"Inside":[33],"these":[34],"another":[36],"process":[37],"take":[40],"place-switching":[41],"from":[42],"DNA":[45,63],"as":[46],"primary":[48],"storage":[49],"genetic":[51],"information.":[52],"The":[53,93,117],"latter":[54],"part":[55],"needed":[56],"handful":[58],"enzymes":[60],"for":[61],"be":[65],"able":[66],"perform":[68],"its":[69],"function.":[70],"A":[71],"natural":[72],"question":[73],"arises,":[74],"i.e.,":[75],"how":[76,99],"concentration":[78],"all":[80],"vital":[81],"molecules":[82],"could":[83,101,113],"been":[85],"kept":[86],"in":[87],"check":[88],"without":[89],"mechanisms.":[92],"authors":[94],"propose":[95],"theory":[97],"on":[98],"it":[100],"worked":[103],"during":[104],"early":[105],"stages,":[106],"using":[107,128],"only":[108],"short":[109],"molecules,":[111],"emerged":[115],"spontaneously.":[116],"hypothesis":[118],"was":[119],"analysed":[120],"mathematically":[121],"and":[122],"tested":[123],"against":[124],"different":[125],"scenarios":[126],"computer":[129],"simulations.":[130]},"counts_by_year":[],"updated_date":"2026-08-18T07:49:30.821534","created_date":"2025-10-10T00:00:00"}
