{"id":"https://openalex.org/W4280601714","doi":"https://doi.org/10.3390/e24050693","title":"Inference of Molecular Regulatory Systems Using Statistical Path-Consistency Algorithm","display_name":"Inference of Molecular Regulatory Systems Using Statistical Path-Consistency Algorithm","publication_year":2022,"publication_date":"2022-05-13","ids":{"openalex":"https://openalex.org/W4280601714","doi":"https://doi.org/10.3390/e24050693","pmid":"https://pubmed.ncbi.nlm.nih.gov/35626576"},"language":"en","primary_location":{"id":"doi:10.3390/e24050693","is_oa":true,"landing_page_url":"https://doi.org/10.3390/e24050693","pdf_url":"https://www.mdpi.com/1099-4300/24/5/693/pdf?version=1652688426","source":{"id":"https://openalex.org/S195231649","display_name":"Entropy","issn_l":"1099-4300","issn":["1099-4300"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Entropy","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/1099-4300/24/5/693/pdf?version=1652688426","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5020787845","display_name":"Yan Yan","orcid":"https://orcid.org/0000-0002-5833-4607"},"institutions":[{"id":"https://openalex.org/I91125648","display_name":"Wuhan Institute of Technology","ror":"https://ror.org/04jcykh16","country_code":"CN","type":"education","lineage":["https://openalex.org/I91125648"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yan Yan","raw_affiliation_strings":["School of Mathematics and Physics, Wuhan Institute of Technology, Wuhan 430205, China"],"raw_orcid":"https://orcid.org/0000-0002-5833-4607","affiliations":[{"raw_affiliation_string":"School of Mathematics and Physics, Wuhan Institute of Technology, Wuhan 430205, China","institution_ids":["https://openalex.org/I91125648"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100767952","display_name":"Feng Jiang","orcid":"https://orcid.org/0000-0002-4219-6510"},"institutions":[{"id":"https://openalex.org/I158934434","display_name":"Zhongnan University of Economics and Law","ror":"https://ror.org/04yqxxq63","country_code":"CN","type":"education","lineage":["https://openalex.org/I158934434"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Feng Jiang","raw_affiliation_strings":["School of Statistics and Mathematics, Zhongnan University of Economics and Law, Wuhan 430073, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Statistics and Mathematics, Zhongnan University of Economics and Law, Wuhan 430073, China","institution_ids":["https://openalex.org/I158934434"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058742858","display_name":"Xinan Zhang","orcid":"https://orcid.org/0000-0001-8614-7975"},"institutions":[{"id":"https://openalex.org/I40963666","display_name":"Central China Normal University","ror":"https://ror.org/03x1jna21","country_code":"CN","type":"education","lineage":["https://openalex.org/I40963666"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Xinan Zhang","raw_affiliation_strings":["School of Mathematics and Statistics, Central China Normal University, Wuhan 430079, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Mathematics and Statistics, Central China Normal University, Wuhan 430079, China","institution_ids":["https://openalex.org/I40963666"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5039097797","display_name":"Tianhai Tian","orcid":"https://orcid.org/0000-0001-6191-0209"},"institutions":[{"id":"https://openalex.org/I56590836","display_name":"Monash University","ror":"https://ror.org/02bfwt286","country_code":"AU","type":"education","lineage":["https://openalex.org/I56590836"]}],"countries":["AU"],"is_corresponding":true,"raw_author_name":"Tianhai Tian","raw_affiliation_strings":["School of Mathematics, Monash University, Melbourne 3800, Australia"],"raw_orcid":"https://orcid.org/0000-0001-6191-0209","affiliations":[{"raw_affiliation_string":"School of Mathematics, Monash University, Melbourne 3800, Australia","institution_ids":["https://openalex.org/I56590836"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5039097797","https://openalex.org/A5058742858"],"corresponding_institution_ids":["https://openalex.org/I40963666","https://openalex.org/I56590836"],"apc_list":{"value":2000,"currency":"CHF","value_usd":2165},"apc_paid":{"value":2000,"currency":"CHF","value_usd":2165},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.04574854,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"24","issue":"5","first_page":"693","last_page":"693"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9994000196456909,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.9973000288009644,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/benchmark","display_name":"Benchmark (surveying)","score":0.6945098638534546},{"id":"https://openalex.org/keywords/inference","display_name":"Inference","score":0.6812554001808167},{"id":"https://openalex.org/keywords/consistency","display_name":"Consistency (knowledge bases)","score":0.6704378128051758},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6251111626625061},{"id":"https://openalex.org/keywords/enhanced-data-rates-for-gsm-evolution","display_name":"Enhanced Data Rates for GSM Evolution","score":0.5621325969696045},{"id":"https://openalex.org/keywords/variable","display_name":"Variable (mathematics)","score":0.5504136085510254},{"id":"https://openalex.org/keywords/path","display_name":"Path (computing)","score":0.5304944515228271},{"id":"https://openalex.org/keywords/gene-regulatory-network","display_name":"Gene regulatory network","score":0.45673298835754395},{"id":"https://openalex.org/keywords/algorithm","display_name":"Algorithm","score":0.4343523383140564},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.43203508853912354},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.2730062007904053},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.23724302649497986},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.23031938076019287},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.222804993391037},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.08918792009353638},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.08845019340515137}],"concepts":[{"id":"https://openalex.org/C185798385","wikidata":"https://www.wikidata.org/wiki/Q1161707","display_name":"Benchmark (surveying)","level":2,"score":0.6945098638534546},{"id":"https://openalex.org/C2776214188","wikidata":"https://www.wikidata.org/wiki/Q408386","display_name":"Inference","level":2,"score":0.6812554001808167},{"id":"https://openalex.org/C2776436953","wikidata":"https://www.wikidata.org/wiki/Q5163215","display_name":"Consistency (knowledge bases)","level":2,"score":0.6704378128051758},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6251111626625061},{"id":"https://openalex.org/C162307627","wikidata":"https://www.wikidata.org/wiki/Q204833","display_name":"Enhanced Data Rates for GSM Evolution","level":2,"score":0.5621325969696045},{"id":"https://openalex.org/C182365436","wikidata":"https://www.wikidata.org/wiki/Q50701","display_name":"Variable (mathematics)","level":2,"score":0.5504136085510254},{"id":"https://openalex.org/C2777735758","wikidata":"https://www.wikidata.org/wiki/Q817765","display_name":"Path (computing)","level":2,"score":0.5304944515228271},{"id":"https://openalex.org/C67339327","wikidata":"https://www.wikidata.org/wiki/Q1502576","display_name":"Gene regulatory network","level":4,"score":0.45673298835754395},{"id":"https://openalex.org/C11413529","wikidata":"https://www.wikidata.org/wiki/Q8366","display_name":"Algorithm","level":1,"score":0.4343523383140564},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.43203508853912354},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2730062007904053},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.23724302649497986},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.23031938076019287},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.222804993391037},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.08918792009353638},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.08845019340515137},{"id":"https://openalex.org/C13280743","wikidata":"https://www.wikidata.org/wiki/Q131089","display_name":"Geodesy","level":1,"score":0.0},{"id":"https://openalex.org/C134306372","wikidata":"https://www.wikidata.org/wiki/Q7754","display_name":"Mathematical analysis","level":1,"score":0.0},{"id":"https://openalex.org/C205649164","wikidata":"https://www.wikidata.org/wiki/Q1071","display_name":"Geography","level":0,"score":0.0},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.3390/e24050693","is_oa":true,"landing_page_url":"https://doi.org/10.3390/e24050693","pdf_url":"https://www.mdpi.com/1099-4300/24/5/693/pdf?version=1652688426","source":{"id":"https://openalex.org/S195231649","display_name":"Entropy","issn_l":"1099-4300","issn":["1099-4300"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Entropy","raw_type":"journal-article"},{"id":"pmid:35626576","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35626576","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Entropy (Basel, Switzerland)","raw_type":null},{"id":"pmh:oai:doaj.org/article:dcaa0b1c45c9422a9295f339d7f85bc9","is_oa":true,"landing_page_url":"https://doaj.org/article/dcaa0b1c45c9422a9295f339d7f85bc9","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Entropy, Vol 24, Iss 5, p 693 (2022)","raw_type":"article"},{"id":"pmh:oai:mdpi.com:/1099-4300/24/5/693/","is_oa":true,"landing_page_url":"https://dx.doi.org/10.3390/e24050693","pdf_url":null,"source":{"id":"https://openalex.org/S4306400947","display_name":"MDPI (MDPI AG)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210097602","host_organization_name":"Multidisciplinary Digital Publishing Institute (Switzerland)","host_organization_lineage":["https://openalex.org/I4210097602"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Entropy; Volume 24; Issue 5; Pages: 693","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:9142129","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9142129","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Entropy (Basel)","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.3390/e24050693","is_oa":true,"landing_page_url":"https://doi.org/10.3390/e24050693","pdf_url":"https://www.mdpi.com/1099-4300/24/5/693/pdf?version=1652688426","source":{"id":"https://openalex.org/S195231649","display_name":"Entropy","issn_l":"1099-4300","issn":["1099-4300"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Entropy","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Partnerships for the goals","id":"https://metadata.un.org/sdg/17","score":0.5}],"awards":[{"id":"https://openalex.org/G2415776301","display_name":null,"funder_award_id":"11931019","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G4363365247","display_name":null,"funder_award_id":"61773401","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G8135024078","display_name":null,"funder_award_id":"11871238","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"pdf":true,"grobid_xml":false},"content_urls":{"pdf":"https://content.openalex.org/works/W4280601714.pdf"},"referenced_works_count":66,"referenced_works":["https://openalex.org/W1255676896","https://openalex.org/W1973268693","https://openalex.org/W1981331174","https://openalex.org/W1986688807","https://openalex.org/W1990587141","https://openalex.org/W1996264210","https://openalex.org/W1996822667","https://openalex.org/W2025183726","https://openalex.org/W2062029454","https://openalex.org/W2076513103","https://openalex.org/W2105129830","https://openalex.org/W2106927126","https://openalex.org/W2107495112","https://openalex.org/W2109384743","https://openalex.org/W2111384508","https://openalex.org/W2115984935","https://openalex.org/W2121695897","https://openalex.org/W2122708083","https://openalex.org/W2125258701","https://openalex.org/W2134240743","https://openalex.org/W2140469676","https://openalex.org/W2142237411","https://openalex.org/W2144191802","https://openalex.org/W2146152876","https://openalex.org/W2161409973","https://openalex.org/W2161922735","https://openalex.org/W2162142896","https://openalex.org/W2169053773","https://openalex.org/W2295131019","https://openalex.org/W2337819340","https://openalex.org/W2410378998","https://openalex.org/W2511261572","https://openalex.org/W2518061852","https://openalex.org/W2561884319","https://openalex.org/W2734670755","https://openalex.org/W2750804603","https://openalex.org/W2757234574","https://openalex.org/W2774965730","https://openalex.org/W2779550985","https://openalex.org/W2795460076","https://openalex.org/W2801948330","https://openalex.org/W2890417315","https://openalex.org/W2895035285","https://openalex.org/W2896688833","https://openalex.org/W2905480919","https://openalex.org/W2915554882","https://openalex.org/W2929810236","https://openalex.org/W2943683582","https://openalex.org/W2951424836","https://openalex.org/W2952535935","https://openalex.org/W2981958531","https://openalex.org/W2996140569","https://openalex.org/W2998742848","https://openalex.org/W2998917483","https://openalex.org/W3005127469","https://openalex.org/W3022382224","https://openalex.org/W3024161231","https://openalex.org/W3043074120","https://openalex.org/W3093659935","https://openalex.org/W3094912974","https://openalex.org/W3098590676","https://openalex.org/W3103538164","https://openalex.org/W3127245931","https://openalex.org/W3170261942","https://openalex.org/W3173733404","https://openalex.org/W6679948214"],"related_works":["https://openalex.org/W2378211422","https://openalex.org/W2745001401","https://openalex.org/W4321353415","https://openalex.org/W2130974462","https://openalex.org/W2028665553","https://openalex.org/W2950199998","https://openalex.org/W2560421304","https://openalex.org/W2951387065","https://openalex.org/W4385727351","https://openalex.org/W4306798985"],"abstract_inverted_index":{"One":[0],"of":[1,29,74,77,85,182],"the":[2,37,44,50,54,65,72,75,99,112,116,121,126,129,133,147,154,183,188],"key":[3],"challenges":[4],"in":[5,53,120,151],"systems":[6],"biology":[7],"and":[8,19,92,124,160],"molecular":[9,195],"sciences":[10],"is":[11,143,191],"how":[12],"to":[13,34,70,110],"infer":[14],"regulatory":[15,38,164,196],"relationships":[16],"between":[17,136],"genes":[18,137],"proteins":[20],"using":[21,89,98,115,175],"high-throughout":[22],"omics":[23],"datasets.":[24],"Although":[25],"a":[26,61,83,95,161],"wide":[27],"range":[28],"methods":[30],"have":[31],"been":[32],"designed":[33],"reverse":[35],"engineer":[36],"networks,":[39,123],"recent":[40],"studies":[41],"show":[42],"that":[43,187],"inferred":[45,122,167,184],"network":[46,96],"may":[47],"depend":[48],"on":[49,103],"variable":[51,78,87,105],"order":[52],"dataset.":[55],"In":[56],"this":[57],"work,":[58],"we":[59],"develop":[60],"new":[62],"algorithm,":[63],"called":[64],"statistical":[66],"path-consistency":[67],"algorithm":[68,101],"(SPCA),":[69],"solve":[71],"problem":[73],"dependence":[76],"order.":[79,106],"This":[80],"method":[81,142,190],"generates":[82],"number":[84],"different":[86],"orders":[88],"random":[90],"samples,":[91],"then":[93],"infers":[94],"by":[97,146,174],"path-consistent":[100],"based":[102],"each":[104],"We":[107],"propose":[108],"measures":[109],"determine":[111],"edge":[113,118],"weights":[114,119,131],"corresponding":[117],"choose":[125],"edges":[127],"with":[128,171],"largest":[130],"as":[132],"putative":[134],"regulations":[135],"or":[138],"proteins.":[139],"The":[140,166,180],"developed":[141,189],"rigorously":[144],"assessed":[145],"six":[148],"benchmark":[149],"networks":[150,168,185],"DREAM":[152],"challenges,":[153],"mitogen-activated":[155],"protein":[156],"(MAP)":[157],"kinase":[158],"pathway,":[159],"cancer-specific":[162],"gene":[163],"network.":[165],"are":[169],"compared":[170],"those":[172],"obtained":[173],"two":[176],"up-to-date":[177],"inference":[178],"methods.":[179],"accuracy":[181],"shows":[186],"effective":[192],"for":[193],"discovering":[194],"systems.":[197]},"counts_by_year":[],"updated_date":"2026-05-22T06:13:13.366637","created_date":"2025-10-10T00:00:00"}
