{"id":"https://openalex.org/W4220814564","doi":"https://doi.org/10.3390/data7030035","title":"Transcriptomic Response of Human Nosocomial Pathogen Pseudomonas aeruginosa Biofilms Following Continuous Exposure to Antibiotic-Impregnated Catheters","display_name":"Transcriptomic Response of Human Nosocomial Pathogen Pseudomonas aeruginosa Biofilms Following Continuous Exposure to Antibiotic-Impregnated Catheters","publication_year":2022,"publication_date":"2022-03-17","ids":{"openalex":"https://openalex.org/W4220814564","doi":"https://doi.org/10.3390/data7030035"},"language":"en","primary_location":{"id":"doi:10.3390/data7030035","is_oa":true,"landing_page_url":"https://doi.org/10.3390/data7030035","pdf_url":"https://www.mdpi.com/2306-5729/7/3/35/pdf?version=1647582547","source":{"id":"https://openalex.org/S4210226510","display_name":"Data","issn_l":"2306-5729","issn":["2306-5729"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Data","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/2306-5729/7/3/35/pdf?version=1647582547","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5040146249","display_name":"Kidon Sung","orcid":"https://orcid.org/0000-0002-7926-6156"},"institutions":[{"id":"https://openalex.org/I1304557061","display_name":"National Center for Toxicological Research","ror":"https://ror.org/05jmhh281","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1304557061","https://openalex.org/I1320320070"]},{"id":"https://openalex.org/I1320320070","display_name":"United States Food and Drug Administration","ror":"https://ror.org/034xvzb47","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1320320070"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Kidon Sung","raw_affiliation_strings":["Division of Microbiology, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR 72079, USA"],"affiliations":[{"raw_affiliation_string":"Division of Microbiology, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR 72079, USA","institution_ids":["https://openalex.org/I1304557061","https://openalex.org/I1320320070"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076634662","display_name":"Dan Li","orcid":"https://orcid.org/0000-0001-6394-7953"},"institutions":[{"id":"https://openalex.org/I1304557061","display_name":"National Center for Toxicological Research","ror":"https://ror.org/05jmhh281","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1304557061","https://openalex.org/I1320320070"]},{"id":"https://openalex.org/I1320320070","display_name":"United States Food and Drug Administration","ror":"https://ror.org/034xvzb47","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1320320070"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dan Li","raw_affiliation_strings":["Division of Bioinformatics and Biostatistics, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR 72079, USA"],"affiliations":[{"raw_affiliation_string":"Division of Bioinformatics and Biostatistics, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR 72079, USA","institution_ids":["https://openalex.org/I1304557061","https://openalex.org/I1320320070"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074893085","display_name":"Jung\u2010Whan Chon","orcid":"https://orcid.org/0000-0003-0758-6115"},"institutions":[{"id":"https://openalex.org/I1304557061","display_name":"National Center for Toxicological Research","ror":"https://ror.org/05jmhh281","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1304557061","https://openalex.org/I1320320070"]},{"id":"https://openalex.org/I1320320070","display_name":"United States Food and Drug Administration","ror":"https://ror.org/034xvzb47","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1320320070"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jungwhan Chon","raw_affiliation_strings":["Division of Microbiology, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR 72079, USA"],"affiliations":[{"raw_affiliation_string":"Division of Microbiology, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR 72079, USA","institution_ids":["https://openalex.org/I1304557061","https://openalex.org/I1320320070"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102796534","display_name":"Ohgew Kweon","orcid":"https://orcid.org/0000-0003-4772-0016"},"institutions":[{"id":"https://openalex.org/I1304557061","display_name":"National Center for Toxicological Research","ror":"https://ror.org/05jmhh281","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1304557061","https://openalex.org/I1320320070"]},{"id":"https://openalex.org/I1320320070","display_name":"United States Food and Drug Administration","ror":"https://ror.org/034xvzb47","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1320320070"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ohgew Kweon","raw_affiliation_strings":["Division of Microbiology, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR 72079, USA"],"affiliations":[{"raw_affiliation_string":"Division of Microbiology, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR 72079, USA","institution_ids":["https://openalex.org/I1304557061","https://openalex.org/I1320320070"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017885039","display_name":"Minjae Kim","orcid":"https://orcid.org/0000-0002-3157-3544"},"institutions":[{"id":"https://openalex.org/I1304557061","display_name":"National Center for Toxicological Research","ror":"https://ror.org/05jmhh281","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1304557061","https://openalex.org/I1320320070"]},{"id":"https://openalex.org/I1320320070","display_name":"United States Food and Drug Administration","ror":"https://ror.org/034xvzb47","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1320320070"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Minjae Kim","raw_affiliation_strings":["Division of Microbiology, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR 72079, USA"],"affiliations":[{"raw_affiliation_string":"Division of Microbiology, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR 72079, USA","institution_ids":["https://openalex.org/I1304557061","https://openalex.org/I1320320070"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024782080","display_name":"Joshua Xu","orcid":"https://orcid.org/0000-0001-5313-5847"},"institutions":[{"id":"https://openalex.org/I1304557061","display_name":"National Center for Toxicological Research","ror":"https://ror.org/05jmhh281","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1304557061","https://openalex.org/I1320320070"]},{"id":"https://openalex.org/I1320320070","display_name":"United States Food and Drug Administration","ror":"https://ror.org/034xvzb47","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1320320070"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joshua Xu","raw_affiliation_strings":["Division of Bioinformatics and Biostatistics, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR 72079, USA"],"affiliations":[{"raw_affiliation_string":"Division of Bioinformatics and Biostatistics, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR 72079, USA","institution_ids":["https://openalex.org/I1304557061","https://openalex.org/I1320320070"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062665873","display_name":"Miseon Park","orcid":"https://orcid.org/0000-0002-1821-8230"},"institutions":[{"id":"https://openalex.org/I1304557061","display_name":"National Center for Toxicological Research","ror":"https://ror.org/05jmhh281","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1304557061","https://openalex.org/I1320320070"]},{"id":"https://openalex.org/I1320320070","display_name":"United States Food and Drug Administration","ror":"https://ror.org/034xvzb47","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1320320070"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Miseon Park","raw_affiliation_strings":["Division of Microbiology, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR 72079, USA"],"affiliations":[{"raw_affiliation_string":"Division of Microbiology, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR 72079, USA","institution_ids":["https://openalex.org/I1304557061","https://openalex.org/I1320320070"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101648493","display_name":"Saeed Khan","orcid":"https://orcid.org/0000-0003-3473-8815"},"institutions":[{"id":"https://openalex.org/I1304557061","display_name":"National Center for Toxicological Research","ror":"https://ror.org/05jmhh281","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1304557061","https://openalex.org/I1320320070"]},{"id":"https://openalex.org/I1320320070","display_name":"United States Food and Drug Administration","ror":"https://ror.org/034xvzb47","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1320320070"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Saeed A. Khan","raw_affiliation_strings":["Division of Microbiology, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR 72079, USA"],"affiliations":[{"raw_affiliation_string":"Division of Microbiology, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR 72079, USA","institution_ids":["https://openalex.org/I1304557061","https://openalex.org/I1320320070"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":8,"corresponding_author_ids":["https://openalex.org/A5040146249"],"corresponding_institution_ids":["https://openalex.org/I1304557061","https://openalex.org/I1320320070"],"apc_list":{"value":1600,"currency":"CHF","value_usd":1732},"apc_paid":{"value":1600,"currency":"CHF","value_usd":1732},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.02083004,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"7","issue":"3","first_page":"35","last_page":"35"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10593","display_name":"Bacterial biofilms and quorum sensing","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10593","display_name":"Bacterial biofilms and quorum sensing","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11103","display_name":"Antimicrobial Peptides and Activities","score":0.9944000244140625,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10257","display_name":"Oral microbiology and periodontitis research","score":0.9898999929428101,"subfield":{"id":"https://openalex.org/subfields/3506","display_name":"Periodontics"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/biofilm","display_name":"Biofilm","score":0.8407445549964905},{"id":"https://openalex.org/keywords/clindamycin","display_name":"Clindamycin","score":0.758060097694397},{"id":"https://openalex.org/keywords/pseudomonas-aeruginosa","display_name":"Pseudomonas aeruginosa","score":0.7471868991851807},{"id":"https://openalex.org/keywords/microbiology","display_name":"Microbiology","score":0.7447355389595032},{"id":"https://openalex.org/keywords/kegg","display_name":"KEGG","score":0.6984158158302307},{"id":"https://openalex.org/keywords/antibiotic-resistance","display_name":"Antibiotic resistance","score":0.637444794178009},{"id":"https://openalex.org/keywords/antibiotics","display_name":"Antibiotics","score":0.598910927772522},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.5475457906723022},{"id":"https://openalex.org/keywords/bacteria","display_name":"Bacteria","score":0.48121359944343567},{"id":"https://openalex.org/keywords/rifampicin","display_name":"Rifampicin","score":0.45549142360687256},{"id":"https://openalex.org/keywords/human-pathogen","display_name":"Human pathogen","score":0.43749117851257324},{"id":"https://openalex.org/keywords/transcriptome","display_name":"Transcriptome","score":0.37449780106544495},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.33289724588394165},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.23682186007499695},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.06951895356178284}],"concepts":[{"id":"https://openalex.org/C58123911","wikidata":"https://www.wikidata.org/wiki/Q467410","display_name":"Biofilm","level":3,"score":0.8407445549964905},{"id":"https://openalex.org/C2777458120","wikidata":"https://www.wikidata.org/wiki/Q422273","display_name":"Clindamycin","level":3,"score":0.758060097694397},{"id":"https://openalex.org/C2777637488","wikidata":"https://www.wikidata.org/wiki/Q31856","display_name":"Pseudomonas aeruginosa","level":3,"score":0.7471868991851807},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.7447355389595032},{"id":"https://openalex.org/C152724338","wikidata":"https://www.wikidata.org/wiki/Q909442","display_name":"KEGG","level":5,"score":0.6984158158302307},{"id":"https://openalex.org/C94665300","wikidata":"https://www.wikidata.org/wiki/Q63391344","display_name":"Antibiotic resistance","level":3,"score":0.637444794178009},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.598910927772522},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5475457906723022},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.48121359944343567},{"id":"https://openalex.org/C2778607973","wikidata":"https://www.wikidata.org/wiki/Q422652","display_name":"Rifampicin","level":3,"score":0.45549142360687256},{"id":"https://openalex.org/C24527192","wikidata":"https://www.wikidata.org/wiki/Q17149729","display_name":"Human pathogen","level":3,"score":0.43749117851257324},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.37449780106544495},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.33289724588394165},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.23682186007499695},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.06951895356178284}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3390/data7030035","is_oa":true,"landing_page_url":"https://doi.org/10.3390/data7030035","pdf_url":"https://www.mdpi.com/2306-5729/7/3/35/pdf?version=1647582547","source":{"id":"https://openalex.org/S4210226510","display_name":"Data","issn_l":"2306-5729","issn":["2306-5729"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Data","raw_type":"journal-article"},{"id":"pmh:oai:RePEc:gam:jdataj:v:7:y:2022:i:3:p:35-:d:773013","is_oa":false,"landing_page_url":"https://www.mdpi.com/2306-5729/7/3/35/","pdf_url":null,"source":{"id":"https://openalex.org/S4306401271","display_name":"RePEc: Research Papers in Economics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I77793887","host_organization_name":"Federal Reserve Bank of St. Louis","host_organization_lineage":["https://openalex.org/I77793887"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"pmh:oai:doaj.org/article:50befb9ae0cc45ffb19ce60ddf527d34","is_oa":true,"landing_page_url":"https://doaj.org/article/50befb9ae0cc45ffb19ce60ddf527d34","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Data, Vol 7, Iss 3, p 35 (2022)","raw_type":"article"},{"id":"pmh:oai:mdpi.com:/2306-5729/7/3/35/","is_oa":true,"landing_page_url":"https://dx.doi.org/10.3390/data7030035","pdf_url":null,"source":{"id":"https://openalex.org/S4306400947","display_name":"MDPI (MDPI AG)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210097602","host_organization_name":"Multidisciplinary Digital Publishing Institute (Switzerland)","host_organization_lineage":["https://openalex.org/I4210097602"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Data; Volume 7; Issue 3; Pages: 35","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.3390/data7030035","is_oa":true,"landing_page_url":"https://doi.org/10.3390/data7030035","pdf_url":"https://www.mdpi.com/2306-5729/7/3/35/pdf?version=1647582547","source":{"id":"https://openalex.org/S4210226510","display_name":"Data","issn_l":"2306-5729","issn":["2306-5729"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Data","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G5023988369","display_name":null,"funder_award_id":"E0759901","funder_id":"https://openalex.org/F4320332163","funder_display_name":"U.S. Food and Drug Administration"}],"funders":[{"id":"https://openalex.org/F4320332163","display_name":"U.S. Food and Drug Administration","ror":"https://ror.org/034xvzb47"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4220814564.pdf","grobid_xml":"https://content.openalex.org/works/W4220814564.grobid-xml"},"referenced_works_count":25,"referenced_works":["https://openalex.org/W169847975","https://openalex.org/W1978589498","https://openalex.org/W1997142624","https://openalex.org/W2000812746","https://openalex.org/W2034094342","https://openalex.org/W2038329167","https://openalex.org/W2069362245","https://openalex.org/W2114104545","https://openalex.org/W2122781588","https://openalex.org/W2131271579","https://openalex.org/W2134526812","https://openalex.org/W2144440398","https://openalex.org/W2151046640","https://openalex.org/W2155606054","https://openalex.org/W2170551349","https://openalex.org/W2323326409","https://openalex.org/W2481424576","https://openalex.org/W2594019989","https://openalex.org/W2603755876","https://openalex.org/W2787483916","https://openalex.org/W2887056633","https://openalex.org/W2894327003","https://openalex.org/W2908418786","https://openalex.org/W2969443468","https://openalex.org/W6606926205"],"related_works":["https://openalex.org/W1964572291","https://openalex.org/W4387948744","https://openalex.org/W1987520879","https://openalex.org/W2352732738","https://openalex.org/W2123060905","https://openalex.org/W2559588208","https://openalex.org/W157130824","https://openalex.org/W1984964356","https://openalex.org/W3120676751","https://openalex.org/W1923384484"],"abstract_inverted_index":{"Biofilms":[0],"are":[1,156],"complex":[2],"surface-attached":[3],"bacterial":[4,54],"communities":[5],"that":[6],"serve":[7],"as":[8],"a":[9,28,98],"protective":[10],"survival":[11],"strategy":[12],"to":[13,15,31,52,86,89],"adapt":[14],"an":[16],"environment.":[17],"Bacterial":[18],"contamination":[19],"and":[20,34,91,105,113,125,144,149],"biofilm":[21,100,114],"formation":[22],"on":[23],"implantable":[24],"medical":[25],"devices":[26],"pose":[27],"serious":[29],"threat":[30],"human":[32],"health,":[33],"these":[35],"biofilms":[36,83],"have":[37,49,57],"become":[38],"the":[39,61,69,160],"most":[40],"important":[41],"source":[42],"of":[43,64,71,80,138,147],"nosocomial":[44],"infections.":[45],"Although":[46],"antimicrobial-impregnated":[47],"catheters":[48,96],"been":[50,58],"employed":[51],"prevent":[53],"infection,":[55],"there":[56],"concerns":[59],"about":[60],"potential":[62],"emergence":[63],"antibiotic":[65],"resistance.":[66],"To":[67],"investigate":[68],"risk":[70],"developing":[72],"resistance,":[73],"we":[74],"performed":[75],"RNA-sequencing":[76],"gene":[77],"expression":[78],"profiling":[79],"P.":[81],"aeruginosa":[82],"in":[84,97,111],"response":[85],"chronic":[87],"exposure":[88],"clindamycin":[90],"rifampicin":[92],"eluted":[93],"from":[94],"antibiotic-coated":[95],"CDC":[99],"bioreactor.":[101],"There":[102],"were":[103,133],"877":[104],"178":[106],"differentially":[107,130],"expressed":[108,131],"genes":[109,132],"identified":[110],"planktonic":[112],"cells":[115],"after":[116],"growth":[117],"for":[118],"144":[119],"h":[120],"with":[121,163],"control":[122],"(without":[123],"antibiotic-impregnation)":[124],"clindamycin/rifampicin-impregnated":[126],"catheters,":[127],"respectively.":[128],"The":[129,154],"further":[134],"analyzed":[135],"by":[136],"Clusters":[137],"Orthologous":[139],"Groups":[140],"(COGs)":[141],"functional":[142],"classification":[143],"Kyoto":[145],"Encyclopedia":[146],"Genes":[148],"Genomes":[150],"(KEGG)":[151],"pathway":[152],"analyses.":[153],"data":[155],"publicly":[157],"available":[158],"through":[159],"GEO":[161],"database":[162],"accession":[164],"number":[165],"GSE153546.":[166]},"counts_by_year":[],"updated_date":"2026-04-05T17:49:38.594831","created_date":"2022-04-03T00:00:00"}