{"id":"https://openalex.org/W4414781602","doi":"https://doi.org/10.3390/computers14100423","title":"Mapping the Chemical Space of Antiviral Peptides with Half-Space Proximal and Metadata Networks Through Interactive Data Mining","display_name":"Mapping the Chemical Space of Antiviral Peptides with Half-Space Proximal and Metadata Networks Through Interactive Data Mining","publication_year":2025,"publication_date":"2025-10-03","ids":{"openalex":"https://openalex.org/W4414781602","doi":"https://doi.org/10.3390/computers14100423"},"language":"en","primary_location":{"id":"doi:10.3390/computers14100423","is_oa":true,"landing_page_url":"https://doi.org/10.3390/computers14100423","pdf_url":"https://www.mdpi.com/2073-431X/14/10/423/pdf?version=1759484698","source":{"id":"https://openalex.org/S4210228075","display_name":"Computers","issn_l":"2073-431X","issn":["2073-431X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Computers","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/2073-431X/14/10/423/pdf?version=1759484698","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5054428985","display_name":"Daniela de Llano Garc\u00eda","orcid":"https://orcid.org/0000-0002-6910-7581"},"institutions":[{"id":"https://openalex.org/I3130401523","display_name":"Universidad Yachay Tech","ror":"https://ror.org/04jjswc10","country_code":"EC","type":"education","lineage":["https://openalex.org/I3130401523"]}],"countries":["EC"],"is_corresponding":false,"raw_author_name":"Daniela de Llano Garc\u00eda","raw_affiliation_strings":["School of Chemical Sciences and Engineering, Yachay Tech University, Hda. San Jos\u00e9 s/n y Proyecto Yachay, Urcuqu\u00ed 100119, Imbabura, Ecuador"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Chemical Sciences and Engineering, Yachay Tech University, Hda. San Jos\u00e9 s/n y Proyecto Yachay, Urcuqu\u00ed 100119, Imbabura, Ecuador","institution_ids":["https://openalex.org/I3130401523"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015398632","display_name":"Yovani Marrero\u2010Ponce","orcid":"https://orcid.org/0000-0003-2721-1142"},"institutions":[{"id":"https://openalex.org/I16097986","display_name":"Universitat de Val\u00e8ncia","ror":"https://ror.org/043nxc105","country_code":"ES","type":"education","lineage":["https://openalex.org/I16097986"]},{"id":"https://openalex.org/I69094615","display_name":"Universidad San Francisco de Quito","ror":"https://ror.org/01r2c3v86","country_code":"EC","type":"education","lineage":["https://openalex.org/I69094615"]},{"id":"https://openalex.org/I86613570","display_name":"Universidad Panamericana","ror":"https://ror.org/01n1q0h77","country_code":"MX","type":"education","lineage":["https://openalex.org/I86613570"]}],"countries":["EC","ES","MX"],"is_corresponding":true,"raw_author_name":"Yovani Marrero-Ponce","raw_affiliation_strings":["Computer Science Department, Universitat de Val\u00e8ncia, 46100 Valencia, Burjassot, Spain","Facultad de Ingenier\u00eda, Universidad Panamericana, Augusto Rodin No. 498, Insurgentes Mixcoac, Benito Ju\u00e1rez, Ciudad de M\u00e9xico 03920, Mexico","Grupo de Medicina Molecular y Traslacional (MeM&T), Colegio de Ciencias de la Salud (COCSA), Universidad San Francisco de Quito (USFQ), Escuela de Medicina, Edificio de Especialidades M\u00e9dicas, Quito 170157, Pichincha, Ecuador"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Computer Science Department, Universitat de Val\u00e8ncia, 46100 Valencia, Burjassot, Spain","institution_ids":["https://openalex.org/I16097986"]},{"raw_affiliation_string":"Facultad de Ingenier\u00eda, Universidad Panamericana, Augusto Rodin No. 498, Insurgentes Mixcoac, Benito Ju\u00e1rez, Ciudad de M\u00e9xico 03920, Mexico","institution_ids":["https://openalex.org/I86613570"]},{"raw_affiliation_string":"Grupo de Medicina Molecular y Traslacional (MeM&T), Colegio de Ciencias de la Salud (COCSA), Universidad San Francisco de Quito (USFQ), Escuela de Medicina, Edificio de Especialidades M\u00e9dicas, Quito 170157, Pichincha, Ecuador","institution_ids":["https://openalex.org/I69094615"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000044766","display_name":"Guillerm\u0131\u0301n Ag\u00fcero-Chapin","orcid":"https://orcid.org/0000-0002-9908-2418"},"institutions":[{"id":"https://openalex.org/I182534213","display_name":"Universidade do Porto","ror":"https://ror.org/043pwc612","country_code":"PT","type":"education","lineage":["https://openalex.org/I182534213"]}],"countries":["PT"],"is_corresponding":true,"raw_author_name":"Guillermin Ag\u00fcero-Chapin","raw_affiliation_strings":["CIIMAR\u2014Centro Interdisciplinar de Investiga\u00e7\u00e3o Marinha e Ambiental, Universidade do Porto, Terminal de Cruzeiros do Porto de Leix\u00f5es, Av. General Norton de Matos, s/n, 4450-208 Porto, Portugal","Departamento de Biologia, Faculdade de Ci\u00eancias, Universidade do Porto, Rua do Campo Alegre, s/n, 4169-007 Porto, Portugal"],"raw_orcid":"https://orcid.org/0000-0002-9908-2418","affiliations":[{"raw_affiliation_string":"CIIMAR\u2014Centro Interdisciplinar de Investiga\u00e7\u00e3o Marinha e Ambiental, Universidade do Porto, Terminal de Cruzeiros do Porto de Leix\u00f5es, Av. General Norton de Matos, s/n, 4450-208 Porto, Portugal","institution_ids":["https://openalex.org/I182534213"]},{"raw_affiliation_string":"Departamento de Biologia, Faculdade de Ci\u00eancias, Universidade do Porto, Rua do Campo Alegre, s/n, 4169-007 Porto, Portugal","institution_ids":["https://openalex.org/I182534213"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073052613","display_name":"Hortensia Rodr\u0131\u0301guez","orcid":"https://orcid.org/0000-0001-6910-5685"},"institutions":[{"id":"https://openalex.org/I3130401523","display_name":"Universidad Yachay Tech","ror":"https://ror.org/04jjswc10","country_code":"EC","type":"education","lineage":["https://openalex.org/I3130401523"]}],"countries":["EC"],"is_corresponding":false,"raw_author_name":"Hortensia Rodr\u00edguez","raw_affiliation_strings":["School of Chemical Sciences and Engineering, Yachay Tech University, Hda. San Jos\u00e9 s/n y Proyecto Yachay, Urcuqu\u00ed 100119, Imbabura, Ecuador"],"raw_orcid":"https://orcid.org/0000-0001-6910-5685","affiliations":[{"raw_affiliation_string":"School of Chemical Sciences and Engineering, Yachay Tech University, Hda. San Jos\u00e9 s/n y Proyecto Yachay, Urcuqu\u00ed 100119, Imbabura, Ecuador","institution_ids":["https://openalex.org/I3130401523"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067408837","display_name":"Francesc J. Ferri","orcid":"https://orcid.org/0000-0002-1543-3568"},"institutions":[{"id":"https://openalex.org/I16097986","display_name":"Universitat de Val\u00e8ncia","ror":"https://ror.org/043nxc105","country_code":"ES","type":"education","lineage":["https://openalex.org/I16097986"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Francesc J. Ferri","raw_affiliation_strings":["Computer Science Department, Universitat de Val\u00e8ncia, 46100 Valencia, Burjassot, Spain"],"raw_orcid":"https://orcid.org/0000-0002-1543-3568","affiliations":[{"raw_affiliation_string":"Computer Science Department, Universitat de Val\u00e8ncia, 46100 Valencia, Burjassot, Spain","institution_ids":["https://openalex.org/I16097986"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021576367","display_name":"Edgar M\u00e1rquez","orcid":"https://orcid.org/0000-0002-7503-1528"},"institutions":[{"id":"https://openalex.org/I142879360","display_name":"Universidad del Norte","ror":"https://ror.org/031e6xm45","country_code":"CO","type":"education","lineage":["https://openalex.org/I142879360"]}],"countries":["CO"],"is_corresponding":false,"raw_author_name":"Edgar A. M\u00e1rquez","raw_affiliation_strings":["Grupo de Investigaciones en Qu\u00edmica y Biolog\u00eda, Departamento de Qu\u00edmica y Biolog\u00eda, Facultad de Ciencias B\u00e1sicas, Universidad del Norte, Carrera 51B, Km 5, V\u00eda Puerto Colombia, Barranquilla 081007, Colombia"],"raw_orcid":"https://orcid.org/0000-0002-7503-1528","affiliations":[{"raw_affiliation_string":"Grupo de Investigaciones en Qu\u00edmica y Biolog\u00eda, Departamento de Qu\u00edmica y Biolog\u00eda, Facultad de Ciencias B\u00e1sicas, Universidad del Norte, Carrera 51B, Km 5, V\u00eda Puerto Colombia, Barranquilla 081007, Colombia","institution_ids":["https://openalex.org/I142879360"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023483486","display_name":"Jos\u00e9 R. Mora","orcid":"https://orcid.org/0000-0001-6128-9504"},"institutions":[{"id":"https://openalex.org/I69094615","display_name":"Universidad San Francisco de Quito","ror":"https://ror.org/01r2c3v86","country_code":"EC","type":"education","lineage":["https://openalex.org/I69094615"]}],"countries":["EC"],"is_corresponding":false,"raw_author_name":"Jos\u00e9 R. Mora","raw_affiliation_strings":["Grupo de Medicina Molecular y Traslacional (MeM&T), Colegio de Ciencias de la Salud (COCSA), Universidad San Francisco de Quito (USFQ), Escuela de Medicina, Edificio de Especialidades M\u00e9dicas, Quito 170157, Pichincha, Ecuador"],"raw_orcid":"https://orcid.org/0000-0001-6128-9504","affiliations":[{"raw_affiliation_string":"Grupo de Medicina Molecular y Traslacional (MeM&T), Colegio de Ciencias de la Salud (COCSA), Universidad San Francisco de Quito (USFQ), Escuela de Medicina, Edificio de Especialidades M\u00e9dicas, Quito 170157, Pichincha, Ecuador","institution_ids":["https://openalex.org/I69094615"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022859780","display_name":"F\u00e9lix Mart\u00ednez-Rios","orcid":"https://orcid.org/0000-0002-2346-5922"},"institutions":[{"id":"https://openalex.org/I86613570","display_name":"Universidad Panamericana","ror":"https://ror.org/01n1q0h77","country_code":"MX","type":"education","lineage":["https://openalex.org/I86613570"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"Felix Martinez-Rios","raw_affiliation_strings":["Facultad de Ingenier\u00eda, Universidad Panamericana, Augusto Rodin No. 498, Insurgentes Mixcoac, Benito Ju\u00e1rez, Ciudad de M\u00e9xico 03920, Mexico"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Facultad de Ingenier\u00eda, Universidad Panamericana, Augusto Rodin No. 498, Insurgentes Mixcoac, Benito Ju\u00e1rez, Ciudad de M\u00e9xico 03920, Mexico","institution_ids":["https://openalex.org/I86613570"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5040406602","display_name":"Yunierkis P\u00e9rez\u2010Castillo","orcid":"https://orcid.org/0000-0002-3710-0035"},"institutions":[{"id":"https://openalex.org/I4210102282","display_name":"Universidad de Las Am\u00e9ricas","ror":"https://ror.org/0198j4566","country_code":"EC","type":"education","lineage":["https://openalex.org/I4210102282"]}],"countries":["EC"],"is_corresponding":false,"raw_author_name":"Yunierkis P\u00e9rez-Castillo","raw_affiliation_strings":["Bio-Cheminformatics Research Group and Escuela de Ciencias F\u00edsicas y Matem\u00e1ticas, Universidad de Las Am\u00e9ricas, Quito 170504, Pichincha, Ecuador"],"raw_orcid":"https://orcid.org/0000-0002-3710-0035","affiliations":[{"raw_affiliation_string":"Bio-Cheminformatics Research Group and Escuela de Ciencias F\u00edsicas y Matem\u00e1ticas, Universidad de Las Am\u00e9ricas, Quito 170504, Pichincha, Ecuador","institution_ids":["https://openalex.org/I4210102282"]}]}],"institutions":[],"countries_distinct_count":5,"institutions_distinct_count":9,"corresponding_author_ids":["https://openalex.org/A5000044766","https://openalex.org/A5015398632"],"corresponding_institution_ids":["https://openalex.org/I16097986","https://openalex.org/I182534213","https://openalex.org/I69094615","https://openalex.org/I86613570"],"apc_list":{"value":1600,"currency":"CHF","value_usd":1732},"apc_paid":{"value":1600,"currency":"CHF","value_usd":1732},"fwci":0.6802,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.73949913,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":95},"biblio":{"volume":"14","issue":"10","first_page":"423","last_page":"423"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13326","display_name":"Biochemical and Structural Characterization","score":0.9915000200271606,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T13326","display_name":"Biochemical and Structural Characterization","score":0.9915000200271606,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9833999872207642,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12254","display_name":"Machine Learning in Bioinformatics","score":0.9818999767303467,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/metadata","display_name":"Metadata","score":0.7785999774932861},{"id":"https://openalex.org/keywords/chemical-space","display_name":"Chemical space","score":0.6798999905586243},{"id":"https://openalex.org/keywords/redundancy","display_name":"Redundancy (engineering)","score":0.58160001039505},{"id":"https://openalex.org/keywords/modular-design","display_name":"Modular design","score":0.553600013256073},{"id":"https://openalex.org/keywords/biological-data","display_name":"Biological data","score":0.5253000259399414},{"id":"https://openalex.org/keywords/data-integration","display_name":"Data integration","score":0.49810001254081726},{"id":"https://openalex.org/keywords/drug-discovery","display_name":"Drug discovery","score":0.42149999737739563},{"id":"https://openalex.org/keywords/biological-database","display_name":"Biological database","score":0.4156999886035919},{"id":"https://openalex.org/keywords/knowledge-extraction","display_name":"Knowledge extraction","score":0.4097999930381775}],"concepts":[{"id":"https://openalex.org/C93518851","wikidata":"https://www.wikidata.org/wiki/Q180160","display_name":"Metadata","level":2,"score":0.7785999774932861},{"id":"https://openalex.org/C99726746","wikidata":"https://www.wikidata.org/wiki/Q906396","display_name":"Chemical space","level":3,"score":0.6798999905586243},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6184999942779541},{"id":"https://openalex.org/C152124472","wikidata":"https://www.wikidata.org/wiki/Q1204361","display_name":"Redundancy (engineering)","level":2,"score":0.58160001039505},{"id":"https://openalex.org/C101468663","wikidata":"https://www.wikidata.org/wiki/Q1620158","display_name":"Modular design","level":2,"score":0.553600013256073},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.525600016117096},{"id":"https://openalex.org/C201797286","wikidata":"https://www.wikidata.org/wiki/Q4914986","display_name":"Biological data","level":2,"score":0.5253000259399414},{"id":"https://openalex.org/C72634772","wikidata":"https://www.wikidata.org/wiki/Q386824","display_name":"Data integration","level":2,"score":0.49810001254081726},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4921000003814697},{"id":"https://openalex.org/C74187038","wikidata":"https://www.wikidata.org/wiki/Q1418791","display_name":"Drug discovery","level":2,"score":0.42149999737739563},{"id":"https://openalex.org/C20901353","wikidata":"https://www.wikidata.org/wiki/Q4117139","display_name":"Biological database","level":2,"score":0.4156999886035919},{"id":"https://openalex.org/C120567893","wikidata":"https://www.wikidata.org/wiki/Q1582085","display_name":"Knowledge extraction","level":2,"score":0.4097999930381775},{"id":"https://openalex.org/C7545210","wikidata":"https://www.wikidata.org/wiki/Q838123","display_name":"Data redundancy","level":2,"score":0.37610000371932983},{"id":"https://openalex.org/C103278499","wikidata":"https://www.wikidata.org/wiki/Q254465","display_name":"Similarity (geometry)","level":3,"score":0.37059998512268066},{"id":"https://openalex.org/C82714645","wikidata":"https://www.wikidata.org/wiki/Q438331","display_name":"Template","level":2,"score":0.34860000014305115},{"id":"https://openalex.org/C24259465","wikidata":"https://www.wikidata.org/wiki/Q2272153","display_name":"Chemical similarity","level":3,"score":0.34689998626708984},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.29339998960494995},{"id":"https://openalex.org/C89429830","wikidata":"https://www.wikidata.org/wiki/Q735710","display_name":"Scaffold","level":2,"score":0.29179999232292175},{"id":"https://openalex.org/C28225019","wikidata":"https://www.wikidata.org/wiki/Q4915005","display_name":"Biological network","level":2,"score":0.28780001401901245},{"id":"https://openalex.org/C23123220","wikidata":"https://www.wikidata.org/wiki/Q816826","display_name":"Information retrieval","level":1,"score":0.2791000008583069},{"id":"https://openalex.org/C124978682","wikidata":"https://www.wikidata.org/wiki/Q1201019","display_name":"Proof of concept","level":2,"score":0.27570000290870667},{"id":"https://openalex.org/C160920958","wikidata":"https://www.wikidata.org/wiki/Q7662746","display_name":"Synthetic data","level":2,"score":0.27390000224113464},{"id":"https://openalex.org/C2777466982","wikidata":"https://www.wikidata.org/wiki/Q5227287","display_name":"Data extraction","level":3,"score":0.2711000144481659},{"id":"https://openalex.org/C60984968","wikidata":"https://www.wikidata.org/wiki/Q389172","display_name":"Cyclic peptide","level":3,"score":0.27090001106262207},{"id":"https://openalex.org/C2779281246","wikidata":"https://www.wikidata.org/wiki/Q172847","display_name":"Peptide","level":2,"score":0.2667999863624573},{"id":"https://openalex.org/C137314826","wikidata":"https://www.wikidata.org/wiki/Q2330408","display_name":"Data mapping","level":2,"score":0.26100000739097595},{"id":"https://openalex.org/C2778112365","wikidata":"https://www.wikidata.org/wiki/Q3511065","display_name":"Sequence (biology)","level":2,"score":0.2603999972343445},{"id":"https://openalex.org/C195807954","wikidata":"https://www.wikidata.org/wiki/Q1662562","display_name":"Information extraction","level":2,"score":0.2572999894618988},{"id":"https://openalex.org/C1668388","wikidata":"https://www.wikidata.org/wiki/Q1149776","display_name":"Data management","level":2,"score":0.2563999891281128},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.2531999945640564},{"id":"https://openalex.org/C67186912","wikidata":"https://www.wikidata.org/wiki/Q367664","display_name":"Data modeling","level":2,"score":0.251800000667572}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.3390/computers14100423","is_oa":true,"landing_page_url":"https://doi.org/10.3390/computers14100423","pdf_url":"https://www.mdpi.com/2073-431X/14/10/423/pdf?version=1759484698","source":{"id":"https://openalex.org/S4210228075","display_name":"Computers","issn_l":"2073-431X","issn":["2073-431X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Computers","raw_type":"journal-article"},{"id":"pmh:oai:doaj.org/article:ffe6ae069aec40999b733d0e6a423406","is_oa":true,"landing_page_url":"https://doaj.org/article/ffe6ae069aec40999b733d0e6a423406","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Computers, Vol 14, Iss 10, p 423 (2025)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3390/computers14100423","is_oa":true,"landing_page_url":"https://doi.org/10.3390/computers14100423","pdf_url":"https://www.mdpi.com/2073-431X/14/10/423/pdf?version=1759484698","source":{"id":"https://openalex.org/S4210228075","display_name":"Computers","issn_l":"2073-431X","issn":["2073-431X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Computers","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G2261371540","display_name":"Interdisciplinary Centre of Marine and Environmental Research","funder_award_id":"UIDP/04423/2020","funder_id":"https://openalex.org/F4320334779","funder_display_name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia"},{"id":"https://openalex.org/G7552417000","display_name":"Interdisciplinary Centre of Marine and Environmental Research","funder_award_id":"UIDB/04423/2020","funder_id":"https://openalex.org/F4320334779","funder_display_name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia"}],"funders":[{"id":"https://openalex.org/F4320326549","display_name":"Universidad San Francisco de Quito","ror":"https://ror.org/01r2c3v86"},{"id":"https://openalex.org/F4320334779","display_name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","ror":"https://ror.org/00snfqn58"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4414781602.pdf","grobid_xml":"https://content.openalex.org/works/W4414781602.grobid-xml"},"referenced_works_count":116,"referenced_works":["https://openalex.org/W1498477232","https://openalex.org/W1562252382","https://openalex.org/W1709815505","https://openalex.org/W1925139611","https://openalex.org/W1931581539","https://openalex.org/W1963923865","https://openalex.org/W1965513749","https://openalex.org/W1967239647","https://openalex.org/W1978043888","https://openalex.org/W1981554779","https://openalex.org/W1990435000","https://openalex.org/W1992603413","https://openalex.org/W1992983658","https://openalex.org/W1995390287","https://openalex.org/W1996014455","https://openalex.org/W2015490529","https://openalex.org/W2019521836","https://openalex.org/W2019856128","https://openalex.org/W2023519836","https://openalex.org/W2026361605","https://openalex.org/W2027263440","https://openalex.org/W2028338755","https://openalex.org/W2028695285","https://openalex.org/W2029780190","https://openalex.org/W2048955140","https://openalex.org/W2052033556","https://openalex.org/W2052374539","https://openalex.org/W2052486528","https://openalex.org/W2054945796","https://openalex.org/W2055752079","https://openalex.org/W2056685270","https://openalex.org/W2057198647","https://openalex.org/W2064158873","https://openalex.org/W2067537093","https://openalex.org/W2071744657","https://openalex.org/W2074231493","https://openalex.org/W2077350268","https://openalex.org/W2085008471","https://openalex.org/W2086709746","https://openalex.org/W2093554999","https://openalex.org/W2100965251","https://openalex.org/W2110768169","https://openalex.org/W2112090702","https://openalex.org/W2131275757","https://openalex.org/W2131681506","https://openalex.org/W2140000393","https://openalex.org/W2140952049","https://openalex.org/W2142607414","https://openalex.org/W2151105172","https://openalex.org/W2151936673","https://openalex.org/W2157635833","https://openalex.org/W2162857162","https://openalex.org/W2167482691","https://openalex.org/W2167820873","https://openalex.org/W2168010371","https://openalex.org/W2220780917","https://openalex.org/W2222575139","https://openalex.org/W2270192120","https://openalex.org/W2314450753","https://openalex.org/W2319112298","https://openalex.org/W2588463038","https://openalex.org/W2724823461","https://openalex.org/W2739354616","https://openalex.org/W2739980134","https://openalex.org/W2789857505","https://openalex.org/W2884875215","https://openalex.org/W2896635684","https://openalex.org/W2897249806","https://openalex.org/W2937346329","https://openalex.org/W2968179778","https://openalex.org/W2987724682","https://openalex.org/W3004637128","https://openalex.org/W3026181439","https://openalex.org/W3081615418","https://openalex.org/W3092320736","https://openalex.org/W3094421290","https://openalex.org/W3099768174","https://openalex.org/W3106188259","https://openalex.org/W3117455535","https://openalex.org/W3122585911","https://openalex.org/W3134945627","https://openalex.org/W3136918052","https://openalex.org/W3139099049","https://openalex.org/W3139265997","https://openalex.org/W3144526075","https://openalex.org/W3164698295","https://openalex.org/W3171010532","https://openalex.org/W3185433118","https://openalex.org/W3188372451","https://openalex.org/W3195918345","https://openalex.org/W3197178642","https://openalex.org/W3204852504","https://openalex.org/W3216979156","https://openalex.org/W4210528977","https://openalex.org/W4212959738","https://openalex.org/W4214618924","https://openalex.org/W4231877163","https://openalex.org/W4281682445","https://openalex.org/W4282045748","https://openalex.org/W4282575211","https://openalex.org/W4282976570","https://openalex.org/W4285043746","https://openalex.org/W4285393303","https://openalex.org/W4298005832","https://openalex.org/W4307565334","https://openalex.org/W4308834846","https://openalex.org/W4309955041","https://openalex.org/W4311658464","https://openalex.org/W4312209996","https://openalex.org/W4322629147","https://openalex.org/W4323981276","https://openalex.org/W4362609000","https://openalex.org/W4376277283","https://openalex.org/W4386022032","https://openalex.org/W4402391328","https://openalex.org/W4403141839"],"related_works":[],"abstract_inverted_index":{"Antiviral":[0],"peptides":[1],"(AVPs)":[2],"are":[3],"promising":[4],"therapeutic":[5,195],"candidates,":[6],"yet":[7],"the":[8,15,24,39,56],"rapid":[9],"growth":[10],"of":[11,26],"sequence":[12],"data":[13,44],"and":[14,51,62,79,90,116,133,144,190,193],"field\u2019s":[16],"emphasis":[17],"on":[18],"predictors":[19],"have":[20],"left":[21],"a":[22],"gap:":[23],"lack":[25],"an":[27,182],"integrated":[28,183],"view":[29],"linking":[30],"peptide":[31],"chemistry":[32],"with":[33,104,129],"biological":[34],"context.":[35],"Here,":[36],"we":[37,99],"map":[38],"AVP":[40,131,165,188],"landscape":[41],"through":[42],"interactive":[43],"mining":[45],"using":[46],"Half-Space":[47],"Proximal":[48],"Networks":[49,53],"(HSPNs)":[50],"Metadata":[52],"(MNs)":[54],"in":[55],"StarPep":[57],"toolbox.":[58],"HSPNs":[59],"minimize":[60],"edges":[61],"avoid":[63],"fixed":[64],"thresholds,":[65],"reducing":[66],"computational":[67,157],"cost":[68],"while":[69,83,168],"enabling":[70],"high-resolution":[71],"analysis.":[72],"A":[73],"threshold-free":[74],"HSPN":[75],"resolved":[76],"eight":[77],"chemically":[78],"biologically":[80],"distinct":[81],"communities,":[82],"MNs":[84],"contextualized":[85],"AVPs":[86],"by":[87],"source,":[88],"function,":[89],"target,":[91],"revealing":[92],"structural\u2013functional":[93],"relationships.":[94],"To":[95],"capture":[96],"diversity":[97],"compactly,":[98],"applied":[100],"centrality-guided":[101],"scaffold":[102],"extraction":[103],"redundancy":[105],"removal":[106],"(90\u201350%":[107],"identity),":[108],"producing":[109],"four":[110],"representative":[111,161],"subsets":[112],"suitable":[113],"for":[114,175],"modeling":[115],"similarity":[117],"searches.":[118],"Alignment-free":[119],"motif":[120],"discovery":[121,189],"yielded":[122],"33":[123],"validated":[124],"motifs,":[125],"including":[126],"10":[127],"overlapping":[128],"reported":[130],"signatures":[132],"23":[134],"apparently":[135],"novel.":[136],"Motifs":[137],"displayed":[138],"category-specific":[139],"enrichment":[140],"across":[141],"antimicrobial":[142],"classes,":[143],"sequences":[145],"carrying":[146],"multiple":[147],"motifs":[148,169],"(\u22654\u20135)":[149],"consistently":[150],"showed":[151],"higher":[152],"predicted":[153],"antiviral":[154],"probabilities.":[155],"Beyond":[156],"insights,":[158],"scaffolds":[159],"provide":[160,181],"\u201centry":[162],"points\u201d":[163],"into":[164],"chemical":[166],"space,":[167],"serve":[170],"as":[171],"modular":[172],"building":[173],"blocks":[174],"rational":[176],"design.":[177,196],"Together,":[178],"these":[179],"resources":[180],"framework":[184],"that":[185],"may":[186],"inform":[187],"support":[191],"scaffold-":[192],"motif-guided":[194]},"counts_by_year":[{"year":2025,"cited_by_count":1}],"updated_date":"2026-05-06T08:25:59.206177","created_date":"2025-10-10T00:00:00"}
