{"id":"https://openalex.org/W2901644353","doi":"https://doi.org/10.3390/computation6040058","title":"The Role of Dimensionality in Understanding Granuloma Formation","display_name":"The Role of Dimensionality in Understanding Granuloma Formation","publication_year":2018,"publication_date":"2018-11-14","ids":{"openalex":"https://openalex.org/W2901644353","doi":"https://doi.org/10.3390/computation6040058","mag":"2901644353","pmid":"https://pubmed.ncbi.nlm.nih.gov/31258937"},"language":"en","primary_location":{"id":"doi:10.3390/computation6040058","is_oa":true,"landing_page_url":"https://doi.org/10.3390/computation6040058","pdf_url":"https://www.mdpi.com/2079-3197/6/4/58/pdf?version=1542187738","source":{"id":"https://openalex.org/S2738402919","display_name":"Computation","issn_l":"2079-3197","issn":["2079-3197"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Computation","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/2079-3197/6/4/58/pdf?version=1542187738","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5012365542","display_name":"Simeone Marino","orcid":"https://orcid.org/0000-0002-0051-8198"},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Simeone Marino","raw_affiliation_strings":["Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, MI 48109, USA","Statistics Online Computational Resource (SOCR), Department of Health Behavior and Biological Sciences, University of Michigan, Ann Arbor, MI 48109, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, MI 48109, USA","institution_ids":["https://openalex.org/I27837315"]},{"raw_affiliation_string":"Statistics Online Computational Resource (SOCR), Department of Health Behavior and Biological Sciences, University of Michigan, Ann Arbor, MI 48109, USA","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017379122","display_name":"Caitlin Hult","orcid":"https://orcid.org/0000-0002-2641-2180"},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Caitlin Hult","raw_affiliation_strings":["Department of Chemical Engineering, University of Michigan, Ann Arbor, MI 48109, USA","Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, MI 48109, USA"],"raw_orcid":"https://orcid.org/0000-0002-2641-2180","affiliations":[{"raw_affiliation_string":"Department of Chemical Engineering, University of Michigan, Ann Arbor, MI 48109, USA","institution_ids":["https://openalex.org/I27837315"]},{"raw_affiliation_string":"Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, MI 48109, USA","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070317739","display_name":"Paul Wolberg","orcid":null},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Paul Wolberg","raw_affiliation_strings":["Department of Chemical Engineering, University of Michigan, Ann Arbor, MI 48109, USA","Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, MI 48109, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical Engineering, University of Michigan, Ann Arbor, MI 48109, USA","institution_ids":["https://openalex.org/I27837315"]},{"raw_affiliation_string":"Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, MI 48109, USA","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066699569","display_name":"Jennifer J. Linderman","orcid":"https://orcid.org/0000-0002-1519-5088"},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jennifer J. Linderman","raw_affiliation_strings":["Department of Chemical Engineering, University of Michigan, Ann Arbor, MI 48109, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical Engineering, University of Michigan, Ann Arbor, MI 48109, USA","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5067786863","display_name":"Denise E. Kirschner","orcid":"https://orcid.org/0000-0002-1053-2591"},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Denise E. Kirschner","raw_affiliation_strings":["Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI 48109, USA","Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, MI 48109, USA"],"raw_orcid":"https://orcid.org/0000-0002-1053-2591","affiliations":[{"raw_affiliation_string":"Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI 48109, USA","institution_ids":["https://openalex.org/I27837315"]},{"raw_affiliation_string":"Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, MI 48109, USA","institution_ids":["https://openalex.org/I27837315"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5067786863"],"corresponding_institution_ids":["https://openalex.org/I27837315"],"apc_list":{"value":1400,"currency":"CHF","value_usd":1515},"apc_paid":{"value":1400,"currency":"CHF","value_usd":1515},"fwci":1.1399,"has_fulltext":true,"cited_by_count":20,"citation_normalized_percentile":{"value":0.77648045,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"6","issue":"4","first_page":"58","last_page":"58"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10038","display_name":"Tuberculosis Research and Epidemiology","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10038","display_name":"Tuberculosis Research and Epidemiology","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11316","display_name":"Mycobacterium research and diagnosis","score":0.9991000294685364,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10147","display_name":"Antibiotic Resistance in Bacteria","score":0.9940000176429749,"subfield":{"id":"https://openalex.org/subfields/1313","display_name":"Molecular Medicine"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/granuloma","display_name":"Granuloma","score":0.8334366083145142},{"id":"https://openalex.org/keywords/context","display_name":"Context (archaeology)","score":0.7536883354187012},{"id":"https://openalex.org/keywords/mycobacterium-tuberculosis","display_name":"Mycobacterium tuberculosis","score":0.6048332452774048},{"id":"https://openalex.org/keywords/tuberculosis","display_name":"Tuberculosis","score":0.5744141340255737},{"id":"https://openalex.org/keywords/in-silico","display_name":"In silico","score":0.5620049238204956},{"id":"https://openalex.org/keywords/in-vivo","display_name":"In vivo","score":0.5557180047035217},{"id":"https://openalex.org/keywords/granuloma-formation","display_name":"Granuloma formation","score":0.5243709087371826},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.48392254114151},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.41240766644477844},{"id":"https://openalex.org/keywords/immunology","display_name":"Immunology","score":0.40317073464393616},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.3708629012107849},{"id":"https://openalex.org/keywords/neuroscience","display_name":"Neuroscience","score":0.34402239322662354},{"id":"https://openalex.org/keywords/pathology","display_name":"Pathology","score":0.34064990282058716},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.2789316475391388},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.12774479389190674}],"concepts":[{"id":"https://openalex.org/C2780140890","wikidata":"https://www.wikidata.org/wiki/Q1129338","display_name":"Granuloma","level":2,"score":0.8334366083145142},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.7536883354187012},{"id":"https://openalex.org/C2777975735","wikidata":"https://www.wikidata.org/wiki/Q130971","display_name":"Mycobacterium tuberculosis","level":3,"score":0.6048332452774048},{"id":"https://openalex.org/C2781069245","wikidata":"https://www.wikidata.org/wiki/Q12204","display_name":"Tuberculosis","level":2,"score":0.5744141340255737},{"id":"https://openalex.org/C2775905019","wikidata":"https://www.wikidata.org/wiki/Q192572","display_name":"In silico","level":3,"score":0.5620049238204956},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.5557180047035217},{"id":"https://openalex.org/C2909791061","wikidata":"https://www.wikidata.org/wiki/Q1129338","display_name":"Granuloma formation","level":3,"score":0.5243709087371826},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.48392254114151},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.41240766644477844},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.40317073464393616},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3708629012107849},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.34402239322662354},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.34064990282058716},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2789316475391388},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.12774479389190674},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[],"locations_count":6,"locations":[{"id":"doi:10.3390/computation6040058","is_oa":true,"landing_page_url":"https://doi.org/10.3390/computation6040058","pdf_url":"https://www.mdpi.com/2079-3197/6/4/58/pdf?version=1542187738","source":{"id":"https://openalex.org/S2738402919","display_name":"Computation","issn_l":"2079-3197","issn":["2079-3197"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Computation","raw_type":"journal-article"},{"id":"pmid:31258937","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31258937","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Computation (Basel, Switzerland)","raw_type":null},{"id":"pmh:oai:osti.gov:1630007","is_oa":true,"landing_page_url":"https://www.osti.gov/biblio/1630007","pdf_url":"https://www.osti.gov/servlets/purl/1630007","source":{"id":"https://openalex.org/S4306402487","display_name":"OSTI OAI (U.S. Department of Energy Office of Scientific and Technical Information)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I139351228","host_organization_name":"Office of Scientific and Technical Information","host_organization_lineage":["https://openalex.org/I139351228"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},{"id":"pmh:oai:doaj.org/article:8026a23dd2004eb49b91fbe7d078346d","is_oa":true,"landing_page_url":"https://doaj.org/article/8026a23dd2004eb49b91fbe7d078346d","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Computation, Vol 6, Iss 4, p 58 (2018)","raw_type":"article"},{"id":"pmh:oai:mdpi.com:/2079-3197/6/4/58/","is_oa":true,"landing_page_url":"http://dx.doi.org/10.3390/computation6040058","pdf_url":null,"source":{"id":"https://openalex.org/S4306400947","display_name":"MDPI (MDPI AG)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210097602","host_organization_name":"Multidisciplinary Digital Publishing Institute (Switzerland)","host_organization_lineage":["https://openalex.org/I4210097602"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Computation","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:6599587","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6599587","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Computation (Basel)","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.3390/computation6040058","is_oa":true,"landing_page_url":"https://doi.org/10.3390/computation6040058","pdf_url":"https://www.mdpi.com/2079-3197/6/4/58/pdf?version=1542187738","source":{"id":"https://openalex.org/S2738402919","display_name":"Computation","issn_l":"2079-3197","issn":["2079-3197"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Computation","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.7099999785423279}],"awards":[{"id":"https://openalex.org/G1286236842","display_name":null,"funder_award_id":"-AC02-05CH11231","funder_id":"https://openalex.org/F4320306084","funder_display_name":"U.S. Department of Energy"},{"id":"https://openalex.org/G2294011902","display_name":null,"funder_award_id":"R01 HL110811","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G2490815038","display_name":null,"funder_award_id":"R01 HL110811","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G3083819904","display_name":null,"funder_award_id":"05CH11231","funder_id":"https://openalex.org/F4320306084","funder_display_name":"U.S. Department of Energy"},{"id":"https://openalex.org/G3773639861","display_name":null,"funder_award_id":"R01 AI123093","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G3944918260","display_name":null,"funder_award_id":"DE-AC02-05CH11231","funder_id":"https://openalex.org/F4320332359","funder_display_name":"Office of Science"},{"id":"https://openalex.org/G4053009245","display_name":null,"funder_award_id":"MCB140228","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G4501827968","display_name":null,"funder_award_id":"AC02-05CH11231","funder_id":"https://openalex.org/F4320332359","funder_display_name":"Office of Science"},{"id":"https://openalex.org/G4565140552","display_name":null,"funder_award_id":"-AC02-05CH11231","funder_id":"https://openalex.org/F4320332359","funder_display_name":"Office of Science"},{"id":"https://openalex.org/G4800746616","display_name":null,"funder_award_id":"DE-AC02-05CH11231","funder_id":"https://openalex.org/F4320308154","funder_display_name":"Department of Energy, Labor and Economic Growth"},{"id":"https://openalex.org/G498139845","display_name":null,"funder_award_id":"DE-AC02","funder_id":"https://openalex.org/F4320332359","funder_display_name":"Office of Science"},{"id":"https://openalex.org/G51731447","display_name":null,"funder_award_id":"AI123093","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G5304124434","display_name":null,"funder_award_id":"HL110811","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G577720359","display_name":null,"funder_award_id":"U01 HL131072","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G593958671","display_name":null,"funder_award_id":"R01 AI123093","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G6348972864","display_name":null,"funder_award_id":"AC02-05CH11231","funder_id":"https://openalex.org/F4320306084","funder_display_name":"U.S. Department of Energy"},{"id":"https://openalex.org/G6558272803","display_name":null,"funder_award_id":"DE-AC02","funder_id":"https://openalex.org/F4320306084","funder_display_name":"U.S. Department of Energy"},{"id":"https://openalex.org/G7060852724","display_name":null,"funder_award_id":"U01HL131072","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G7233692708","display_name":null,"funder_award_id":"DE-AC02-05CH11231","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G7538560101","display_name":null,"funder_award_id":"DE-AC02-05CH11231","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G969889393","display_name":null,"funder_award_id":"DE-AC02-","funder_id":"https://openalex.org/F4320306084","funder_display_name":"U.S. Department of Energy"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320306084","display_name":"U.S. Department of Energy","ror":"https://ror.org/01bj3aw27"},{"id":"https://openalex.org/F4320308154","display_name":"Department of Energy, Labor and Economic Growth","ror":"https://ror.org/054a0at43"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332359","display_name":"Office of Science","ror":"https://ror.org/00mmn6b08"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"pdf":true,"grobid_xml":false},"content_urls":{"pdf":"https://content.openalex.org/works/W2901644353.pdf"},"referenced_works_count":32,"referenced_works":["https://openalex.org/W1489810600","https://openalex.org/W1799454977","https://openalex.org/W1804428368","https://openalex.org/W1921088252","https://openalex.org/W2003081219","https://openalex.org/W2005832207","https://openalex.org/W2006433225","https://openalex.org/W2035588631","https://openalex.org/W2035592397","https://openalex.org/W2043532115","https://openalex.org/W2046177867","https://openalex.org/W2048340356","https://openalex.org/W2051139401","https://openalex.org/W2067267791","https://openalex.org/W2068034671","https://openalex.org/W2071857026","https://openalex.org/W2072878147","https://openalex.org/W2103406125","https://openalex.org/W2104941073","https://openalex.org/W2111746777","https://openalex.org/W2117793307","https://openalex.org/W2141890333","https://openalex.org/W2142603939","https://openalex.org/W2152803686","https://openalex.org/W2160556418","https://openalex.org/W2164081168","https://openalex.org/W2164309428","https://openalex.org/W2312385578","https://openalex.org/W2569832249","https://openalex.org/W2618154116","https://openalex.org/W2885534843","https://openalex.org/W2901644353"],"related_works":["https://openalex.org/W2972094210","https://openalex.org/W4308058527","https://openalex.org/W2110949356","https://openalex.org/W4210506554","https://openalex.org/W1538374398","https://openalex.org/W2050407936","https://openalex.org/W2042252940","https://openalex.org/W2411061500","https://openalex.org/W3160640465","https://openalex.org/W2394233015"],"abstract_inverted_index":{"Within":[0],"the":[1,19,22,27,45,55,58,61,88,93,118,135,151,159,195,257,278,299,315],"first":[2,46,119,152],"2\u20133":[3],"months":[4,48],"of":[5,21,29,40,49,57,95,109,197,210,247,270,280,317],"a":[6,121,166,281],"Mycobacterium":[7],"tuberculosis":[8,30],"(Mtb)":[9],"infection,":[10],"2\u20134":[11],"mm":[12],"spherical":[13],"structures":[14],"called":[15],"granulomas":[16,188],"develop":[17],"in":[18,33,44,78,81,87,112,184,194,202,208,237,284],"lungs":[20],"infected":[23],"hosts.":[24],"These":[25],"are":[26,233,242,272,293],"hallmark":[28],"(TB)":[31],"infection":[32,307],"humans":[34],"and":[35,67,74,80,115,129,180,189,217,229,239,245,268,297,322,336],"non-human":[36,140],"primates.":[37],"A":[38],"cascade":[39],"immunological":[41],"events":[42],"occurs":[43],"3":[47],"granuloma":[50,65,96,110,149],"formation":[51,111],"that":[52,199,207,256,277],"likely":[53],"shapes":[54],"outcome":[56,308],"infection.":[59,156],"Understanding":[60],"main":[62,251],"mechanisms":[63,212,232,305],"driving":[64,213,306],"development":[66],"function":[68],"is":[69,173,200,260,286,301],"key":[70],"to":[71,91,133,139,158,174,176,294,302,328,332],"generating":[72],"treatments":[73],"vaccines.":[75],"In":[76],"vitro,":[77],"vivo,":[79],"silico":[82],"studies":[83],"have":[84],"been":[85],"performed":[86,296],"past":[89],"decades":[90],"address":[92],"complexity":[94],"dynamics.":[97],"This":[98],"study":[99],"builds":[100],"on":[101,145],"our":[102,170,330],"previous":[103],"2D":[104,179,216,238,282],"spatio-temporal":[105],"hybrid":[106],"computational":[107,161],"model":[108,259,318],"TB":[113,187],"(GranSim)":[114],"presents":[116],"for":[117,186],"time":[120],"more":[122],"realistic":[123],"3D":[124,137,167,181,198,218,258],"implementation.":[125],"We":[126],"use":[127,279],"uncertainty":[128],"sensitivity":[130],"analysis":[131],"techniques":[132],"calibrate":[134],"new":[136],"resolution":[138,283],"primate":[141],"(NHP)":[142],"experimental":[143,323],"data":[144,324],"bacterial":[146,214,310],"levels":[147],"per":[148],"during":[150],"100":[153],"days":[154],"post":[155],"Due":[157],"large":[160,289],"cost":[162],"associated":[163],"with":[164],"running":[165],"agent-based":[168],"model,":[169],"major":[171,211,304],"goal":[172,300],"assess":[175],"what":[177,190],"extent":[178],"simulations":[182],"differ":[183],"predictions":[185],"can":[191],"be":[192,295,326],"learned":[193],"context":[196],"missed":[201],"2D.":[203],"Our":[204],"findings":[205],"suggest":[206],"terms":[209],"burden,":[215],"models":[219],"return":[220],"very":[221,234],"similar":[222],"results.":[223],"For":[224],"example,":[225],"Mtb":[226],"growth":[227],"rates":[228],"molecular":[230,333],"regulation":[231],"important":[235],"both":[236],"3D,":[240],"as":[241],"cellular":[243,266],"movement":[244,269],"modulation":[246],"cell":[248],"recruitment.":[249],"The":[250],"difference":[252],"we":[253,275],"found":[254],"was":[255],"less":[261],"affected":[262],"by":[263],"crowding":[264],"when":[265,288],"recruitment":[267],"cells":[271],"increased.":[273],"Overall,":[274],"conclude":[276],"GranSim":[285],"warranted":[287],"scale":[290,334],"pilot":[291],"runs":[292],"if":[298],"determine":[303],"(e.g.,":[309],"load).":[311],"To":[312],"comprehensively":[313],"compare":[314],"roles":[316],"dimensionality,":[319],"further":[320],"tests":[321],"will":[325],"needed":[327],"expand":[329],"conclusions":[331],"dynamics":[335],"multi-scale":[337],"resolutions.":[338]},"counts_by_year":[{"year":2024,"cited_by_count":7},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1}],"updated_date":"2026-07-05T07:55:05.734416","created_date":"2025-10-10T00:00:00"}
