{"id":"https://openalex.org/W2768459304","doi":"https://doi.org/10.3390/computation5040046","title":"Dynamic Data-Driven Modeling for Ex Vivo Data Analysis: Insights into Liver Transplantation and Pathobiology","display_name":"Dynamic Data-Driven Modeling for Ex Vivo Data Analysis: Insights into Liver Transplantation and Pathobiology","publication_year":2017,"publication_date":"2017-11-23","ids":{"openalex":"https://openalex.org/W2768459304","doi":"https://doi.org/10.3390/computation5040046","mag":"2768459304"},"language":"en","primary_location":{"id":"doi:10.3390/computation5040046","is_oa":true,"landing_page_url":"https://doi.org/10.3390/computation5040046","pdf_url":"https://www.mdpi.com/2079-3197/5/4/46/pdf?version=1511447762","source":{"id":"https://openalex.org/S2738402919","display_name":"Computation","issn_l":"2079-3197","issn":["2079-3197"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Computation","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/2079-3197/5/4/46/pdf?version=1511447762","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5015564704","display_name":"David Sadowsky","orcid":null},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David Sadowsky","raw_affiliation_strings":["Department of Surgery, University of Pittsburgh, Pittsburgh, PA 15213, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, University of Pittsburgh, Pittsburgh, PA 15213, USA","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084664970","display_name":"Andrew Abboud","orcid":"https://orcid.org/0000-0003-1527-1535"},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andrew Abboud","raw_affiliation_strings":["Department of Surgery, University of Pittsburgh, Pittsburgh, PA 15213, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, University of Pittsburgh, Pittsburgh, PA 15213, USA","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049815470","display_name":"Anthony R. Cyr","orcid":"https://orcid.org/0000-0002-1958-0426"},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anthony Cyr","raw_affiliation_strings":["Department of Surgery, University of Pittsburgh, Pittsburgh, PA 15213, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, University of Pittsburgh, Pittsburgh, PA 15213, USA","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009555100","display_name":"Lena Vodovotz","orcid":null},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lena Vodovotz","raw_affiliation_strings":["Department of Surgery, University of Pittsburgh, Pittsburgh, PA 15213, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, University of Pittsburgh, Pittsburgh, PA 15213, USA","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111452889","display_name":"Paulo Fontes","orcid":null},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]},{"id":"https://openalex.org/I4210132005","display_name":"Anderson Orthopaedic Clinic","ror":"https://ror.org/030mgn080","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210132005"]},{"id":"https://openalex.org/I4210155891","display_name":"McGowan Institute for Regenerative Medicine","ror":"https://ror.org/04js6xx21","country_code":"US","type":"facility","lineage":["https://openalex.org/I170201317","https://openalex.org/I4210098814","https://openalex.org/I4210134769","https://openalex.org/I4210155891"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Paulo Fontes","raw_affiliation_strings":["Department of Surgery, Thomas E. Starzl Transplantation Institute, Pittsburgh, PA 15213, USA","Department of Surgery, University of Pittsburgh, Pittsburgh, PA 15213, USA","McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Thomas E. Starzl Transplantation Institute, Pittsburgh, PA 15213, USA","institution_ids":["https://openalex.org/I4210132005"]},{"raw_affiliation_string":"Department of Surgery, University of Pittsburgh, Pittsburgh, PA 15213, USA","institution_ids":["https://openalex.org/I170201317"]},{"raw_affiliation_string":"McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA","institution_ids":["https://openalex.org/I170201317","https://openalex.org/I4210155891"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001656066","display_name":"Rub\u00e9n Zamora","orcid":"https://orcid.org/0000-0003-3882-9087"},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ruben Zamora","raw_affiliation_strings":["Department of Surgery, University of Pittsburgh, Pittsburgh, PA 15213, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, University of Pittsburgh, Pittsburgh, PA 15213, USA","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5073022985","display_name":"Yoram Vodovotz","orcid":"https://orcid.org/0000-0002-4389-8768"},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]},{"id":"https://openalex.org/I4210155891","display_name":"McGowan Institute for Regenerative Medicine","ror":"https://ror.org/04js6xx21","country_code":"US","type":"facility","lineage":["https://openalex.org/I170201317","https://openalex.org/I4210098814","https://openalex.org/I4210134769","https://openalex.org/I4210155891"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Yoram Vodovotz","raw_affiliation_strings":["Department of Surgery, University of Pittsburgh, Pittsburgh, PA 15213, USA","McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, University of Pittsburgh, Pittsburgh, PA 15213, USA","institution_ids":["https://openalex.org/I170201317"]},{"raw_affiliation_string":"McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA","institution_ids":["https://openalex.org/I170201317","https://openalex.org/I4210155891"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5073022985"],"corresponding_institution_ids":["https://openalex.org/I170201317","https://openalex.org/I4210155891"],"apc_list":{"value":1600,"currency":"CHF","value_usd":1782},"apc_paid":{"value":1600,"currency":"CHF","value_usd":1782},"fwci":0.1636,"has_fulltext":true,"cited_by_count":2,"citation_normalized_percentile":{"value":0.55435178,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"5","issue":"4","first_page":"46","last_page":"46"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10351","display_name":"Liver Disease Diagnosis and Treatment","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10351","display_name":"Liver Disease Diagnosis and Treatment","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10999","display_name":"Organ Transplantation Techniques and Outcomes","score":0.9957000017166138,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10337","display_name":"Liver Disease and Transplantation","score":0.9767000079154968,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ex-vivo","display_name":"Ex vivo","score":0.8246901035308838},{"id":"https://openalex.org/keywords/transplantation","display_name":"Transplantation","score":0.5706028938293457},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5704972743988037},{"id":"https://openalex.org/keywords/liver-transplantation","display_name":"Liver transplantation","score":0.49096086621284485},{"id":"https://openalex.org/keywords/organ-transplantation","display_name":"Organ transplantation","score":0.45824500918388367},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.3316161036491394},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.3233552873134613},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.3227466940879822},{"id":"https://openalex.org/keywords/in-vivo","display_name":"In vivo","score":0.3073781132698059},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.267137348651886},{"id":"https://openalex.org/keywords/surgery","display_name":"Surgery","score":0.1374584436416626}],"concepts":[{"id":"https://openalex.org/C26291073","wikidata":"https://www.wikidata.org/wiki/Q310484","display_name":"Ex vivo","level":3,"score":0.8246901035308838},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.5706028938293457},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5704972743988037},{"id":"https://openalex.org/C2779609443","wikidata":"https://www.wikidata.org/wiki/Q1368191","display_name":"Liver transplantation","level":3,"score":0.49096086621284485},{"id":"https://openalex.org/C168444539","wikidata":"https://www.wikidata.org/wiki/Q105196","display_name":"Organ transplantation","level":3,"score":0.45824500918388367},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3316161036491394},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3233552873134613},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3227466940879822},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.3073781132698059},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.267137348651886},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.1374584436416626},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3390/computation5040046","is_oa":true,"landing_page_url":"https://doi.org/10.3390/computation5040046","pdf_url":"https://www.mdpi.com/2079-3197/5/4/46/pdf?version=1511447762","source":{"id":"https://openalex.org/S2738402919","display_name":"Computation","issn_l":"2079-3197","issn":["2079-3197"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Computation","raw_type":"journal-article"},{"id":"pmh:oai:d-scholarship.pitt.edu:40155","is_oa":false,"landing_page_url":"https://d-scholarship.pitt.edu/40155/1/computation-05-00046.pdf","pdf_url":"https://d-scholarship.pitt.edu/40155/1/computation-05-00046.pdf","source":{"id":"https://openalex.org/S4306402372","display_name":"D-Scholarship@Pitt (University of Pittsburgh)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I170201317","host_organization_name":"University of Pittsburgh","host_organization_lineage":["https://openalex.org/I170201317"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Article"},{"id":"pmh:oai:doaj.org/article:56e467e02055462da9abf03c28e38f9d","is_oa":true,"landing_page_url":"https://doaj.org/article/56e467e02055462da9abf03c28e38f9d","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Computation, Vol 5, Iss 4, p 46 (2017)","raw_type":"article"},{"id":"pmh:oai:mdpi.com:/2079-3197/5/4/46/","is_oa":true,"landing_page_url":"https://dx.doi.org/10.3390/computation5040046","pdf_url":null,"source":{"id":"https://openalex.org/S4306400947","display_name":"MDPI (MDPI AG)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210097602","host_organization_name":"Multidisciplinary Digital Publishing Institute (Switzerland)","host_organization_lineage":["https://openalex.org/I4210097602"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Computation; Volume 5; Issue 4; Pages: 46","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.3390/computation5040046","is_oa":true,"landing_page_url":"https://doi.org/10.3390/computation5040046","pdf_url":"https://www.mdpi.com/2079-3197/5/4/46/pdf?version=1511447762","source":{"id":"https://openalex.org/S2738402919","display_name":"Computation","issn_l":"2079-3197","issn":["2079-3197"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Computation","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Life in Land","score":0.5899999737739563,"id":"https://metadata.un.org/sdg/15"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2768459304.pdf","grobid_xml":"https://content.openalex.org/works/W2768459304.grobid-xml"},"referenced_works_count":76,"referenced_works":["https://openalex.org/W107112274","https://openalex.org/W1503760388","https://openalex.org/W1508894455","https://openalex.org/W1534340623","https://openalex.org/W1560867514","https://openalex.org/W1580635337","https://openalex.org/W1599065434","https://openalex.org/W1923511646","https://openalex.org/W1967292815","https://openalex.org/W1971722198","https://openalex.org/W1972304270","https://openalex.org/W1979315534","https://openalex.org/W1989019965","https://openalex.org/W2000394721","https://openalex.org/W2017030127","https://openalex.org/W2019227199","https://openalex.org/W2022556133","https://openalex.org/W2032347458","https://openalex.org/W2040405602","https://openalex.org/W2044347649","https://openalex.org/W2050375893","https://openalex.org/W2052321589","https://openalex.org/W2058671720","https://openalex.org/W2063309666","https://openalex.org/W2070010170","https://openalex.org/W2081479262","https://openalex.org/W2083214591","https://openalex.org/W2092597346","https://openalex.org/W2093417823","https://openalex.org/W2099113859","https://openalex.org/W2100463095","https://openalex.org/W2101693240","https://openalex.org/W2122621434","https://openalex.org/W2124288003","https://openalex.org/W2128190429","https://openalex.org/W2130088939","https://openalex.org/W2134621607","https://openalex.org/W2137842908","https://openalex.org/W2138994599","https://openalex.org/W2143420371","https://openalex.org/W2144546857","https://openalex.org/W2144656637","https://openalex.org/W2150486297","https://openalex.org/W2158826503","https://openalex.org/W2162780863","https://openalex.org/W2166533942","https://openalex.org/W2171111703","https://openalex.org/W2171571559","https://openalex.org/W2224296977","https://openalex.org/W2242480328","https://openalex.org/W2279123229","https://openalex.org/W2283817617","https://openalex.org/W2324221245","https://openalex.org/W2339255799","https://openalex.org/W2400699296","https://openalex.org/W2412311284","https://openalex.org/W2423391616","https://openalex.org/W2480139510","https://openalex.org/W2499783388","https://openalex.org/W2506452038","https://openalex.org/W2513924918","https://openalex.org/W2514873437","https://openalex.org/W2547138902","https://openalex.org/W2549362979","https://openalex.org/W2560651831","https://openalex.org/W2600403006","https://openalex.org/W2607541887","https://openalex.org/W4233520648","https://openalex.org/W4256259255","https://openalex.org/W4321429306","https://openalex.org/W6634829682","https://openalex.org/W6658852395","https://openalex.org/W6667937544","https://openalex.org/W6676169714","https://openalex.org/W6680151621","https://openalex.org/W6715592094"],"related_works":["https://openalex.org/W2602761843","https://openalex.org/W2914484697","https://openalex.org/W2360419293","https://openalex.org/W4253456829","https://openalex.org/W2241854100","https://openalex.org/W2274125404","https://openalex.org/W2795155943","https://openalex.org/W2067912714","https://openalex.org/W2044992177","https://openalex.org/W1978003501"],"abstract_inverted_index":{"Extracorporeal":[0],"organ":[1,36,102],"perfusion,":[2],"in":[3,8,74],"which":[4],"organs":[5],"are":[6],"preserved":[7],"an":[9,15],"isolated,":[10],"ex":[11,100],"vivo":[12,101],"environment":[13],"over":[14],"extended":[16],"time-span,":[17],"is":[18,62],"a":[19,45,63],"concept":[20],"that":[21],"has":[22],"led":[23],"to":[24,33,39,48,90],"the":[25,68,83],"development":[26],"of":[27,52,66,85],"numerous":[28],"alternative":[29],"preservation":[30],"protocols":[31,42],"designed":[32],"better":[34],"maintain":[35],"viability":[37],"prior":[38],"transplantation.":[40],"These":[41],"offer":[43],"researchers":[44],"novel":[46],"opportunity":[47],"obtain":[49],"extensive":[50,69],"sampling":[51],"isolated":[53],"organs,":[54],"free":[55],"from":[56,99],"systemic":[57],"influences.":[58],"Data-driven":[59],"computational":[60,88],"modeling":[61,89],"primary":[64],"means":[65],"integrating":[67],"and":[70,93],"multivariate":[71],"data":[72,97],"obtained":[73,98],"this":[75,78],"fashion.":[76],"In":[77],"review,":[79],"we":[80],"focus":[81],"on":[82,96],"application":[84],"dynamic":[86],"data-driven":[87],"liver":[91],"pathophysiology":[92],"transplantation":[94],"based":[95],"perfusion.":[103]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2020,"cited_by_count":1}],"updated_date":"2026-08-11T07:18:39.950985","created_date":"2025-10-10T00:00:00"}