{"id":"https://openalex.org/W1987227366","doi":"https://doi.org/10.3390/computation2040131","title":"Computational Models of the NF-KB Signalling Pathway","display_name":"Computational Models of the NF-KB Signalling Pathway","publication_year":2014,"publication_date":"2014-09-29","ids":{"openalex":"https://openalex.org/W1987227366","doi":"https://doi.org/10.3390/computation2040131","mag":"1987227366"},"language":"en","primary_location":{"id":"doi:10.3390/computation2040131","is_oa":true,"landing_page_url":"https://doi.org/10.3390/computation2040131","pdf_url":"https://www.mdpi.com/2079-3197/2/4/131/pdf?version=1412000586","source":{"id":"https://openalex.org/S2738402919","display_name":"Computation","issn_l":"2079-3197","issn":["2079-3197"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Computation","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/2079-3197/2/4/131/pdf?version=1412000586","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5072139660","display_name":"Richard A. Williams","orcid":"https://orcid.org/0000-0001-6333-9448"},"institutions":[{"id":"https://openalex.org/I52099693","display_name":"University of York","ror":"https://ror.org/04m01e293","country_code":"GB","type":"education","lineage":["https://openalex.org/I52099693"]},{"id":"https://openalex.org/I67415387","display_name":"Lancaster University","ror":"https://ror.org/04f2nsd36","country_code":"GB","type":"education","lineage":["https://openalex.org/I67415387"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Richard Williams","raw_affiliation_strings":["Department of Computer Science, University of York, Heslington, York, YO10 5GH, UK","Department of Management Science, Lancaster University Management School, Lancaster, LA1 4YX, UK","York Computational Immunology Laboratory, University of York, Heslington, York, YO10 5DD, UK"],"raw_orcid":"https://orcid.org/0000-0001-6333-9448","affiliations":[{"raw_affiliation_string":"Department of Computer Science, University of York, Heslington, York, YO10 5GH, UK","institution_ids":["https://openalex.org/I52099693"]},{"raw_affiliation_string":"Department of Management Science, Lancaster University Management School, Lancaster, LA1 4YX, UK","institution_ids":["https://openalex.org/I67415387"]},{"raw_affiliation_string":"York Computational Immunology Laboratory, University of York, Heslington, York, YO10 5DD, UK","institution_ids":["https://openalex.org/I52099693"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080582720","display_name":"Jon Timmis","orcid":"https://orcid.org/0000-0003-1055-0471"},"institutions":[{"id":"https://openalex.org/I52099693","display_name":"University of York","ror":"https://ror.org/04m01e293","country_code":"GB","type":"education","lineage":["https://openalex.org/I52099693"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Jon Timmis","raw_affiliation_strings":["Department of Electronics, University of York, Heslington, York, YO10 5DD, UK","York Computational Immunology Laboratory, University of York, Heslington, York, YO10 5DD, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Electronics, University of York, Heslington, York, YO10 5DD, UK","institution_ids":["https://openalex.org/I52099693"]},{"raw_affiliation_string":"York Computational Immunology Laboratory, University of York, Heslington, York, YO10 5DD, UK","institution_ids":["https://openalex.org/I52099693"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5072449375","display_name":"Eva E. Qwarnstr\u00f6m","orcid":"https://orcid.org/0000-0003-4417-8663"},"institutions":[{"id":"https://openalex.org/I91136226","display_name":"University of Sheffield","ror":"https://ror.org/05krs5044","country_code":"GB","type":"education","lineage":["https://openalex.org/I91136226"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Eva Qwarnstrom","raw_affiliation_strings":["Department of Cardiovascular Science, Sheffield University Medical School, Sheffield, S10 2RX, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiovascular Science, Sheffield University Medical School, Sheffield, S10 2RX, UK","institution_ids":["https://openalex.org/I91136226"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5072139660"],"corresponding_institution_ids":["https://openalex.org/I52099693","https://openalex.org/I67415387"],"apc_list":{"value":1400,"currency":"CHF","value_usd":1515},"apc_paid":{"value":1400,"currency":"CHF","value_usd":1515},"fwci":2.3466,"has_fulltext":false,"cited_by_count":56,"citation_normalized_percentile":{"value":0.87723467,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":94,"max":99},"biblio":{"volume":"2","issue":"4","first_page":"131","last_page":"158"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11591","display_name":"NF-\u03baB Signaling Pathways","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11591","display_name":"NF-\u03baB Signaling Pathways","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11503","display_name":"Cytokine Signaling Pathways and Interactions","score":0.9991000294685364,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.9987999796867371,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/signalling","display_name":"Signalling","score":0.6920644640922546},{"id":"https://openalex.org/keywords/transcription-factor","display_name":"Transcription factor","score":0.6781575679779053},{"id":"https://openalex.org/keywords/cell-biology","display_name":"Cell biology","score":0.6508034467697144},{"id":"https://openalex.org/keywords/signal-transduction","display_name":"Signal transduction","score":0.637437105178833},{"id":"https://openalex.org/keywords/nf-\u03bab","display_name":"NF-\u03baB","score":0.5354355573654175},{"id":"https://openalex.org/keywords/hedgehog-signaling-pathway","display_name":"Hedgehog signaling pathway","score":0.5328792929649353},{"id":"https://openalex.org/keywords/innate-immune-system","display_name":"Innate immune system","score":0.5169329047203064},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.5030104517936707},{"id":"https://openalex.org/keywords/acquired-immune-system","display_name":"Acquired immune system","score":0.46719881892204285},{"id":"https://openalex.org/keywords/nucleus","display_name":"Nucleus","score":0.46567246317863464},{"id":"https://openalex.org/keywords/inflammation","display_name":"Inflammation","score":0.43683740496635437},{"id":"https://openalex.org/keywords/cytoplasm","display_name":"Cytoplasm","score":0.4366075098514557},{"id":"https://openalex.org/keywords/nfkb1","display_name":"NFKB1","score":0.43421879410743713},{"id":"https://openalex.org/keywords/signalling-pathways","display_name":"Signalling pathways","score":0.4180935323238373},{"id":"https://openalex.org/keywords/immune-system","display_name":"Immune system","score":0.38585683703422546},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.3385511040687561},{"id":"https://openalex.org/keywords/immunology","display_name":"Immunology","score":0.1690293848514557},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.1679743528366089}],"concepts":[{"id":"https://openalex.org/C39743133","wikidata":"https://www.wikidata.org/wiki/Q3262595","display_name":"Signalling","level":2,"score":0.6920644640922546},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.6781575679779053},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6508034467697144},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.637437105178833},{"id":"https://openalex.org/C2777730290","wikidata":"https://www.wikidata.org/wiki/Q411114","display_name":"NF-\u03baB","level":3,"score":0.5354355573654175},{"id":"https://openalex.org/C88498014","wikidata":"https://www.wikidata.org/wiki/Q14859918","display_name":"Hedgehog signaling pathway","level":3,"score":0.5328792929649353},{"id":"https://openalex.org/C136449434","wikidata":"https://www.wikidata.org/wiki/Q428253","display_name":"Innate immune system","level":3,"score":0.5169329047203064},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5030104517936707},{"id":"https://openalex.org/C193419808","wikidata":"https://www.wikidata.org/wiki/Q1645075","display_name":"Acquired immune system","level":3,"score":0.46719881892204285},{"id":"https://openalex.org/C2780723820","wikidata":"https://www.wikidata.org/wiki/Q1934178","display_name":"Nucleus","level":2,"score":0.46567246317863464},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.43683740496635437},{"id":"https://openalex.org/C190062978","wikidata":"https://www.wikidata.org/wiki/Q79899","display_name":"Cytoplasm","level":2,"score":0.4366075098514557},{"id":"https://openalex.org/C123298856","wikidata":"https://www.wikidata.org/wiki/Q15317427","display_name":"NFKB1","level":4,"score":0.43421879410743713},{"id":"https://openalex.org/C3018449070","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signalling pathways","level":3,"score":0.4180935323238373},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.38585683703422546},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3385511040687561},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.1690293848514557},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1679743528366089}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3390/computation2040131","is_oa":true,"landing_page_url":"https://doi.org/10.3390/computation2040131","pdf_url":"https://www.mdpi.com/2079-3197/2/4/131/pdf?version=1412000586","source":{"id":"https://openalex.org/S2738402919","display_name":"Computation","issn_l":"2079-3197","issn":["2079-3197"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Computation","raw_type":"journal-article"},{"id":"pmh:oai:eprints.lancs.ac.uk:71124","is_oa":true,"landing_page_url":null,"pdf_url":"https://eprints.lancs.ac.uk/id/eprint/71124/1/Williams_2014_NFkB_Model_Review.pdf","source":{"id":"https://openalex.org/S4306401916","display_name":"Lancaster EPrints (Lancaster University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I67415387","host_organization_name":"Lancaster University","host_organization_lineage":["https://openalex.org/I67415387"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"PeerReviewed"},{"id":"pmh:oai:doaj.org/article:99a4c82794454972832950dcb063338a","is_oa":false,"landing_page_url":"https://doaj.org/article/99a4c82794454972832950dcb063338a","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Computation, Vol 2, Iss 4, Pp 131-158 (2014)","raw_type":"article"},{"id":"pmh:oai:mdpi.com:/2079-3197/2/4/131/","is_oa":true,"landing_page_url":"http://dx.doi.org/10.3390/computation2040131","pdf_url":null,"source":{"id":"https://openalex.org/S4306400947","display_name":"MDPI (MDPI AG)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210097602","host_organization_name":"Multidisciplinary Digital Publishing Institute (Switzerland)","host_organization_lineage":["https://openalex.org/I4210097602"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Computation","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.3390/computation2040131","is_oa":true,"landing_page_url":"https://doi.org/10.3390/computation2040131","pdf_url":"https://www.mdpi.com/2079-3197/2/4/131/pdf?version=1412000586","source":{"id":"https://openalex.org/S2738402919","display_name":"Computation","issn_l":"2079-3197","issn":["2079-3197"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Computation","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.41999998688697815,"display_name":"Good health and well-being"}],"awards":[{"id":"https://openalex.org/G313042574","display_name":null,"funder_award_id":"EP/E053505/1","funder_id":"https://openalex.org/F4320334627","funder_display_name":"Engineering and Physical Sciences Research Council"},{"id":"https://openalex.org/G4044129774","display_name":null,"funder_award_id":"BB/J009687/1","funder_id":"https://openalex.org/F4320334629","funder_display_name":"Biotechnology and Biological Sciences Research Council"},{"id":"https://openalex.org/G6301007903","display_name":"Defining TILRR regulation of distinct IL-1RI responses using systems biology","funder_award_id":"BB/J009687/1","funder_id":"https://openalex.org/F4320334629","funder_display_name":"Biotechnology and Biological Sciences Research Council"},{"id":"https://openalex.org/G8633764714","display_name":null,"funder_award_id":"MC_PC_13076","funder_id":"https://openalex.org/F4320334626","funder_display_name":"Medical Research Council"}],"funders":[{"id":"https://openalex.org/F4320320005","display_name":"Royal Academy of Engineering","ror":"https://ror.org/0526snb40"},{"id":"https://openalex.org/F4320320006","display_name":"Royal Society","ror":"https://ror.org/03wnrjx87"},{"id":"https://openalex.org/F4320334626","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517"},{"id":"https://openalex.org/F4320334627","display_name":"Engineering and Physical Sciences Research Council","ror":"https://ror.org/0439y7842"},{"id":"https://openalex.org/F4320334629","display_name":"Biotechnology and Biological Sciences Research Council","ror":"https://ror.org/00cwqg982"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1987227366.pdf","grobid_xml":"https://content.openalex.org/works/W1987227366.grobid-xml"},"referenced_works_count":100,"referenced_works":["https://openalex.org/W173128540","https://openalex.org/W401126157","https://openalex.org/W1480466711","https://openalex.org/W1501881225","https://openalex.org/W1521031916","https://openalex.org/W1524850258","https://openalex.org/W1533021978","https://openalex.org/W1553576586","https://openalex.org/W1575277508","https://openalex.org/W1584846756","https://openalex.org/W1588012429","https://openalex.org/W1596801838","https://openalex.org/W1617394022","https://openalex.org/W1641228030","https://openalex.org/W1690786280","https://openalex.org/W1909009735","https://openalex.org/W1911781926","https://openalex.org/W1944506262","https://openalex.org/W1963861745","https://openalex.org/W1964287788","https://openalex.org/W1971201122","https://openalex.org/W1973489125","https://openalex.org/W1977357030","https://openalex.org/W1978279802","https://openalex.org/W1978486653","https://openalex.org/W1982528660","https://openalex.org/W1984387148","https://openalex.org/W1993936200","https://openalex.org/W1997050095","https://openalex.org/W1997310261","https://openalex.org/W1998463022","https://openalex.org/W2000035140","https://openalex.org/W2002629524","https://openalex.org/W2005758722","https://openalex.org/W2007875429","https://openalex.org/W2015926834","https://openalex.org/W2026932044","https://openalex.org/W2027540628","https://openalex.org/W2028613920","https://openalex.org/W2036904266","https://openalex.org/W2038890616","https://openalex.org/W2051312368","https://openalex.org/W2062368346","https://openalex.org/W2062711706","https://openalex.org/W2063116863","https://openalex.org/W2068854551","https://openalex.org/W2070880568","https://openalex.org/W2071073792","https://openalex.org/W2071420454","https://openalex.org/W2071857026","https://openalex.org/W2074097004","https://openalex.org/W2081880634","https://openalex.org/W2086667809","https://openalex.org/W2088094960","https://openalex.org/W2088469845","https://openalex.org/W2090255520","https://openalex.org/W2092829569","https://openalex.org/W2094900722","https://openalex.org/W2095774239","https://openalex.org/W2102288941","https://openalex.org/W2102486760","https://openalex.org/W2106043531","https://openalex.org/W2106877484","https://openalex.org/W2107865650","https://openalex.org/W2108834847","https://openalex.org/W2109975391","https://openalex.org/W2116094765","https://openalex.org/W2117056464","https://openalex.org/W2119027455","https://openalex.org/W2121775312","https://openalex.org/W2121905328","https://openalex.org/W2124343538","https://openalex.org/W2125937596","https://openalex.org/W2127680889","https://openalex.org/W2129242841","https://openalex.org/W2130091936","https://openalex.org/W2133554538","https://openalex.org/W2133667940","https://openalex.org/W2137401479","https://openalex.org/W2139749780","https://openalex.org/W2141204041","https://openalex.org/W2142541950","https://openalex.org/W2143784594","https://openalex.org/W2144014493","https://openalex.org/W2144244247","https://openalex.org/W2147921405","https://openalex.org/W2154200460","https://openalex.org/W2154401739","https://openalex.org/W2155418451","https://openalex.org/W2157307003","https://openalex.org/W2166781237","https://openalex.org/W2169377408","https://openalex.org/W2411288489","https://openalex.org/W2950775714","https://openalex.org/W2999065750","https://openalex.org/W3011439212","https://openalex.org/W3125263381","https://openalex.org/W3151878581","https://openalex.org/W4229554495","https://openalex.org/W4252563654"],"related_works":["https://openalex.org/W2092427118","https://openalex.org/W2102030350","https://openalex.org/W2058539798","https://openalex.org/W1492131881","https://openalex.org/W4253354843","https://openalex.org/W2114018997","https://openalex.org/W2087709298","https://openalex.org/W2165025106","https://openalex.org/W4386778658","https://openalex.org/W2969844295"],"abstract_inverted_index":{"In":[0],"this":[1],"review":[2,103],"article,":[3],"we":[4],"discuss":[5],"the":[6,13,52,61,67,71,78,95,99],"current":[7],"state":[8],"of":[9,12,34,64,73,89,94,113],"computational":[10,90],"modelling":[11],"nuclear":[14],"factor-kappa":[15],"B":[16],"(NF-\u039aB)":[17],"signalling":[18,43,96],"pathway.":[19],"NF-\u039aB":[20,42,65,114],"is":[21,26,45],"a":[22,32,87],"transcription":[23,72],"factor,":[24],"which":[25],"ubiquitous":[27],"within":[28,60],"cells":[29],"and":[30,39,80],"controls":[31],"number":[33,88],"immune":[35,82],"responses,":[36],"including":[37],"inflammation":[38],"apoptosis.":[40],"The":[41],"pathway":[44,97],"tightly":[46],"regulated,":[47],"commencing":[48],"with":[49],"activation":[50],"at":[51],"cell":[53],"membrane,":[54],"signal":[55],"transduction":[56],"through":[57],"various":[58,74],"components":[59],"cytoplasm,":[62],"translocation":[63],"into":[66],"nucleus":[68],"and,":[69],"finally,":[70],"genes":[75],"relating":[76],"to":[77],"innate":[79],"adaptive":[81],"responses.":[83],"There":[84],"have":[85,108],"been":[86],"(mathematical)":[91],"models":[92],"developed":[93],"over":[98],"past":[100],"decade.":[101],"This":[102],"describes":[104],"how":[105],"these":[106],"approaches":[107],"helped":[109],"advance":[110],"our":[111],"understanding":[112],"control.":[115]},"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":7},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":7},{"year":2016,"cited_by_count":11},{"year":2015,"cited_by_count":3}],"updated_date":"2026-05-06T08:25:59.206177","created_date":"2025-10-10T00:00:00"}
