{"id":"https://openalex.org/W7124958721","doi":"https://doi.org/10.3390/computation14010025","title":"Embedding-Based Alignments Capture Structural and Sequence Domains of Distantly Related Multifunctional Human Proteins","display_name":"Embedding-Based Alignments Capture Structural and Sequence Domains of Distantly Related Multifunctional Human Proteins","publication_year":2026,"publication_date":"2026-01-20","ids":{"openalex":"https://openalex.org/W7124958721","doi":"https://doi.org/10.3390/computation14010025"},"language":"en","primary_location":{"id":"doi:10.3390/computation14010025","is_oa":true,"landing_page_url":"https://doi.org/10.3390/computation14010025","pdf_url":"https://www.mdpi.com/2079-3197/14/1/25/pdf?version=1768901748","source":{"id":"https://openalex.org/S2738402919","display_name":"Computation","issn_l":"2079-3197","issn":["2079-3197"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Computation","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/2079-3197/14/1/25/pdf?version=1768901748","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5107666120","display_name":"Gabriele Vazzana","orcid":null},"institutions":[{"id":"https://openalex.org/I9360294","display_name":"University of Bologna","ror":"https://ror.org/01111rn36","country_code":"IT","type":"education","lineage":["https://openalex.org/I9360294"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Gabriele Vazzana","raw_affiliation_strings":["Biocomputing Group, University of Bologna, 40126 Bologna, Italy"],"raw_orcid":"https://orcid.org/0009-0007-5669-0249","affiliations":[{"raw_affiliation_string":"Biocomputing Group, University of Bologna, 40126 Bologna, Italy","institution_ids":["https://openalex.org/I9360294"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085360324","display_name":"Matteo Manfredi","orcid":"https://orcid.org/0000-0001-5479-1723"},"institutions":[{"id":"https://openalex.org/I9360294","display_name":"University of Bologna","ror":"https://ror.org/01111rn36","country_code":"IT","type":"education","lineage":["https://openalex.org/I9360294"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Matteo Manfredi","raw_affiliation_strings":["Biocomputing Group, University of Bologna, 40126 Bologna, Italy"],"raw_orcid":"https://orcid.org/0000-0001-5479-1723","affiliations":[{"raw_affiliation_string":"Biocomputing Group, University of Bologna, 40126 Bologna, Italy","institution_ids":["https://openalex.org/I9360294"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5123449482","display_name":"Castrense Savojardo","orcid":null},"institutions":[{"id":"https://openalex.org/I9360294","display_name":"University of Bologna","ror":"https://ror.org/01111rn36","country_code":"IT","type":"education","lineage":["https://openalex.org/I9360294"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Castrense Savojardo","raw_affiliation_strings":["Biocomputing Group, University of Bologna, 40126 Bologna, Italy"],"raw_orcid":"https://orcid.org/0000-0002-7359-0633","affiliations":[{"raw_affiliation_string":"Biocomputing Group, University of Bologna, 40126 Bologna, Italy","institution_ids":["https://openalex.org/I9360294"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044479288","display_name":"Pier Luigi Martelli","orcid":"https://orcid.org/0000-0002-0274-5669"},"institutions":[{"id":"https://openalex.org/I4210148743","display_name":"Institute of Biomembranes, Bioenergetics and Molecular Biotechnologies","ror":"https://ror.org/05nzf7q96","country_code":"IT","type":"facility","lineage":["https://openalex.org/I4210148743","https://openalex.org/I4210155236"]},{"id":"https://openalex.org/I9360294","display_name":"University of Bologna","ror":"https://ror.org/01111rn36","country_code":"IT","type":"education","lineage":["https://openalex.org/I9360294"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Pier Luigi Martelli","raw_affiliation_strings":["Alma Climate Institute, University of Bologna, 40126 Bologna, Italy","Biocomputing Group, University of Bologna, 40126 Bologna, Italy","Institute of Biomembrane and Bioenergetics, Italian National Research Council (IBIOM-CNR), 70126 Bari, Italy"],"raw_orcid":"https://orcid.org/0000-0002-0274-5669","affiliations":[{"raw_affiliation_string":"Alma Climate Institute, University of Bologna, 40126 Bologna, Italy","institution_ids":["https://openalex.org/I9360294"]},{"raw_affiliation_string":"Biocomputing Group, University of Bologna, 40126 Bologna, Italy","institution_ids":["https://openalex.org/I9360294"]},{"raw_affiliation_string":"Institute of Biomembrane and Bioenergetics, Italian National Research Council (IBIOM-CNR), 70126 Bari, Italy","institution_ids":["https://openalex.org/I4210148743"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5053410790","display_name":"Rita Casadio","orcid":"https://orcid.org/0000-0002-7462-7039"},"institutions":[{"id":"https://openalex.org/I4210148743","display_name":"Institute of Biomembranes, Bioenergetics and Molecular Biotechnologies","ror":"https://ror.org/05nzf7q96","country_code":"IT","type":"facility","lineage":["https://openalex.org/I4210148743","https://openalex.org/I4210155236"]},{"id":"https://openalex.org/I9360294","display_name":"University of Bologna","ror":"https://ror.org/01111rn36","country_code":"IT","type":"education","lineage":["https://openalex.org/I9360294"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Rita Casadio","raw_affiliation_strings":["Alma Climate Institute, University of Bologna, 40126 Bologna, Italy","Biocomputing Group, University of Bologna, 40126 Bologna, Italy","Institute of Biomembrane and Bioenergetics, Italian National Research Council (IBIOM-CNR), 70126 Bari, Italy"],"raw_orcid":"https://orcid.org/0000-0002-7462-7039","affiliations":[{"raw_affiliation_string":"Alma Climate Institute, University of Bologna, 40126 Bologna, Italy","institution_ids":["https://openalex.org/I9360294"]},{"raw_affiliation_string":"Biocomputing Group, University of Bologna, 40126 Bologna, Italy","institution_ids":["https://openalex.org/I9360294"]},{"raw_affiliation_string":"Institute of Biomembrane and Bioenergetics, Italian National Research Council (IBIOM-CNR), 70126 Bari, Italy","institution_ids":["https://openalex.org/I4210148743"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5044479288","https://openalex.org/A5053410790"],"corresponding_institution_ids":["https://openalex.org/I4210148743","https://openalex.org/I9360294"],"apc_list":{"value":1600,"currency":"CHF","value_usd":1782},"apc_paid":{"value":1600,"currency":"CHF","value_usd":1782},"fwci":3.2978,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.8573314,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":94,"max":97},"biblio":{"volume":"14","issue":"1","first_page":"25","last_page":"25"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12254","display_name":"Machine Learning in Bioinformatics","score":0.5110999941825867,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12254","display_name":"Machine Learning in Bioinformatics","score":0.5110999941825867,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.3212999999523163,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10519","display_name":"Advanced Proteomics Techniques and Applications","score":0.039900001138448715,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/human-proteins","display_name":"Human proteins","score":0.5995000004768372},{"id":"https://openalex.org/keywords/embedding","display_name":"Embedding","score":0.5864999890327454},{"id":"https://openalex.org/keywords/pairwise-comparison","display_name":"Pairwise comparison","score":0.5843999981880188},{"id":"https://openalex.org/keywords/sequence","display_name":"Sequence (biology)","score":0.5532000064849854},{"id":"https://openalex.org/keywords/representation","display_name":"Representation (politics)","score":0.508899986743927},{"id":"https://openalex.org/keywords/cluster-analysis","display_name":"Cluster analysis","score":0.5026000142097473},{"id":"https://openalex.org/keywords/set","display_name":"Set (abstract data type)","score":0.4966999888420105},{"id":"https://openalex.org/keywords/protein-sequencing","display_name":"Protein sequencing","score":0.45509999990463257},{"id":"https://openalex.org/keywords/sequence-alignment","display_name":"Sequence alignment","score":0.436599999666214},{"id":"https://openalex.org/keywords/pattern-recognition","display_name":"Pattern recognition (psychology)","score":0.4077000021934509}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6449000239372253},{"id":"https://openalex.org/C2911029443","wikidata":"https://www.wikidata.org/wiki/Q21296145","display_name":"Human proteins","level":3,"score":0.5995000004768372},{"id":"https://openalex.org/C41608201","wikidata":"https://www.wikidata.org/wiki/Q980509","display_name":"Embedding","level":2,"score":0.5864999890327454},{"id":"https://openalex.org/C184898388","wikidata":"https://www.wikidata.org/wiki/Q1435712","display_name":"Pairwise comparison","level":2,"score":0.5843999981880188},{"id":"https://openalex.org/C2778112365","wikidata":"https://www.wikidata.org/wiki/Q3511065","display_name":"Sequence (biology)","level":2,"score":0.5532000064849854},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5116000175476074},{"id":"https://openalex.org/C2776359362","wikidata":"https://www.wikidata.org/wiki/Q2145286","display_name":"Representation (politics)","level":3,"score":0.508899986743927},{"id":"https://openalex.org/C73555534","wikidata":"https://www.wikidata.org/wiki/Q622825","display_name":"Cluster analysis","level":2,"score":0.5026000142097473},{"id":"https://openalex.org/C177264268","wikidata":"https://www.wikidata.org/wiki/Q1514741","display_name":"Set (abstract data type)","level":2,"score":0.4966999888420105},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.49540001153945923},{"id":"https://openalex.org/C10010492","wikidata":"https://www.wikidata.org/wiki/Q3142557","display_name":"Protein sequencing","level":4,"score":0.45509999990463257},{"id":"https://openalex.org/C45484198","wikidata":"https://www.wikidata.org/wiki/Q827246","display_name":"Sequence alignment","level":4,"score":0.436599999666214},{"id":"https://openalex.org/C153180895","wikidata":"https://www.wikidata.org/wiki/Q7148389","display_name":"Pattern recognition (psychology)","level":2,"score":0.4077000021934509},{"id":"https://openalex.org/C144292202","wikidata":"https://www.wikidata.org/wiki/Q898273","display_name":"Protein domain","level":3,"score":0.38519999384880066},{"id":"https://openalex.org/C197077220","wikidata":"https://www.wikidata.org/wiki/Q720988","display_name":"Human genome","level":4,"score":0.3828999996185303},{"id":"https://openalex.org/C36503486","wikidata":"https://www.wikidata.org/wiki/Q11235244","display_name":"Domain (mathematical analysis)","level":2,"score":0.375900000333786},{"id":"https://openalex.org/C66746571","wikidata":"https://www.wikidata.org/wiki/Q1134833","display_name":"ENCODE","level":3,"score":0.3750999867916107},{"id":"https://openalex.org/C47701112","wikidata":"https://www.wikidata.org/wiki/Q735188","display_name":"Protein structure","level":2,"score":0.36149999499320984},{"id":"https://openalex.org/C108583219","wikidata":"https://www.wikidata.org/wiki/Q197536","display_name":"Deep learning","level":2,"score":0.3467999994754791},{"id":"https://openalex.org/C178180057","wikidata":"https://www.wikidata.org/wiki/Q7251477","display_name":"Protein superfamily","level":3,"score":0.33489999175071716},{"id":"https://openalex.org/C50644808","wikidata":"https://www.wikidata.org/wiki/Q192776","display_name":"Artificial neural network","level":2,"score":0.3206000030040741},{"id":"https://openalex.org/C2776321320","wikidata":"https://www.wikidata.org/wiki/Q857525","display_name":"Annotation","level":2,"score":0.3167000114917755},{"id":"https://openalex.org/C58773245","wikidata":"https://www.wikidata.org/wiki/Q4832556","display_name":"Structural Classification of Proteins database","level":3,"score":0.3125},{"id":"https://openalex.org/C119145174","wikidata":"https://www.wikidata.org/wiki/Q7251429","display_name":"Protein Data Bank","level":3,"score":0.3100000023841858},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.30820000171661377},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2976999878883362},{"id":"https://openalex.org/C167625842","wikidata":"https://www.wikidata.org/wiki/Q899763","display_name":"Peptide sequence","level":3,"score":0.2912999987602234},{"id":"https://openalex.org/C4668613","wikidata":"https://www.wikidata.org/wiki/Q4116110","display_name":"Structural alignment","level":5,"score":0.27410000562667847},{"id":"https://openalex.org/C97931131","wikidata":"https://www.wikidata.org/wiki/Q5282087","display_name":"Discriminative model","level":2,"score":0.26989999413490295},{"id":"https://openalex.org/C51632099","wikidata":"https://www.wikidata.org/wiki/Q3985153","display_name":"Training set","level":2,"score":0.2680000066757202},{"id":"https://openalex.org/C11413529","wikidata":"https://www.wikidata.org/wiki/Q8366","display_name":"Algorithm","level":1,"score":0.2669000029563904},{"id":"https://openalex.org/C12267149","wikidata":"https://www.wikidata.org/wiki/Q282453","display_name":"Support vector machine","level":2,"score":0.26030001044273376},{"id":"https://openalex.org/C5349765","wikidata":"https://www.wikidata.org/wiki/Q5282866","display_name":"Distance matrices in phylogeny","level":2,"score":0.258899986743927},{"id":"https://openalex.org/C36464697","wikidata":"https://www.wikidata.org/wiki/Q451553","display_name":"Visualization","level":2,"score":0.25690001249313354},{"id":"https://openalex.org/C58489278","wikidata":"https://www.wikidata.org/wiki/Q1172284","display_name":"Data set","level":2,"score":0.2563000023365021},{"id":"https://openalex.org/C89566754","wikidata":"https://www.wikidata.org/wiki/Q2273828","display_name":"Genome project","level":4,"score":0.2547000050544739},{"id":"https://openalex.org/C171897839","wikidata":"https://www.wikidata.org/wiki/Q417841","display_name":"Protein family","level":3,"score":0.2535000145435333}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.3390/computation14010025","is_oa":true,"landing_page_url":"https://doi.org/10.3390/computation14010025","pdf_url":"https://www.mdpi.com/2079-3197/14/1/25/pdf?version=1768901748","source":{"id":"https://openalex.org/S2738402919","display_name":"Computation","issn_l":"2079-3197","issn":["2079-3197"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Computation","raw_type":"journal-article"},{"id":"pmh:oai:cris.unibo.it:11585/1049151","is_oa":true,"landing_page_url":"https://hdl.handle.net/11585/1049151","pdf_url":null,"source":{"id":"https://openalex.org/S4306402579","display_name":"Archivio istituzionale della ricerca (Alma Mater Studiorum Universit\u00e0 di Bologna)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210117483","host_organization_name":"Istituto di Ematologia di Bologna","host_organization_lineage":["https://openalex.org/I4210117483"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:doaj.org/article:789e6b1bc0084ef28fefd4132bf8cd82","is_oa":true,"landing_page_url":"https://doaj.org/article/789e6b1bc0084ef28fefd4132bf8cd82","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Computation, Vol 14, Iss 1, p 25 (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3390/computation14010025","is_oa":true,"landing_page_url":"https://doi.org/10.3390/computation14010025","pdf_url":"https://www.mdpi.com/2079-3197/14/1/25/pdf?version=1768901748","source":{"id":"https://openalex.org/S2738402919","display_name":"Computation","issn_l":"2079-3197","issn":["2079-3197"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Computation","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G1016895160","display_name":null,"funder_award_id":"PNRR-M4C2","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G1033601615","display_name":null,"funder_award_id":"PE00000019","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G5356239126","display_name":null,"funder_award_id":"CN00000013","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G6621254219","display_name":null,"funder_award_id":"CUP J33C22002920006","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G889028276","display_name":null,"funder_award_id":"J33C22002920006","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"}],"funders":[{"id":"https://openalex.org/F4320320300","display_name":"European Commission","ror":"https://ror.org/00k4n6c32"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7124958721.pdf","grobid_xml":"https://content.openalex.org/works/W7124958721.grobid-xml"},"referenced_works_count":29,"referenced_works":["https://openalex.org/W2102245393","https://openalex.org/W2126016150","https://openalex.org/W2130479394","https://openalex.org/W2148101168","https://openalex.org/W2161151688","https://openalex.org/W2479531384","https://openalex.org/W2750791471","https://openalex.org/W3146944767","https://openalex.org/W3177828909","https://openalex.org/W4210623056","https://openalex.org/W4213112325","https://openalex.org/W4282971549","https://openalex.org/W4309506674","https://openalex.org/W4309858927","https://openalex.org/W4321748128","https://openalex.org/W4327550249","https://openalex.org/W4375858802","https://openalex.org/W4386496033","https://openalex.org/W4386784493","https://openalex.org/W4387326064","https://openalex.org/W4390590489","https://openalex.org/W4392235646","https://openalex.org/W4401966068","https://openalex.org/W4402993368","https://openalex.org/W4404343451","https://openalex.org/W4404531735","https://openalex.org/W4406852107","https://openalex.org/W4410813744","https://openalex.org/W4416148377"],"related_works":[],"abstract_inverted_index":{"Protein":[0],"embedding":[1,73],"is":[2,25,34,68,112,137],"a":[3,28,35,140,151],"protein":[4,24,89],"representation":[5],"that":[6,134,163],"carries":[7],"along":[8],"the":[9,23,41,44,104,125,158,178],"information":[10],"derived":[11],"from":[12],"filtering":[13],"large":[14,20,45,57],"volumes":[15,58],"of":[16,43,47,59,106,124,142],"sequences":[17],"stored":[18],"in":[19,30,97,102],"archives.":[21],"Routinely,":[22],"represented":[26],"by":[27],"matrix":[29],"which":[31],"each":[32,168],"residue":[33],"context-specific":[36],"vector":[37],"whose":[38],"dimensions":[39],"reflect":[40],"size":[42],"architectures":[46],"neural":[48],"networks":[49],"(transformers)":[50],"trained":[51],"with":[52],"deep":[53],"learning":[54],"algorithms":[55],"on":[56,157],"sequences.":[60],"A":[61],"recently":[62],"introduced":[63],"method":[64],"(Embedding-Based":[65],"Alignment,":[66],"EBA)":[67],"particularly":[69,101],"suited":[70],"for":[71,81],"pairwise":[72],"comparisons":[74],"and,":[75],"as":[76,177],"we":[77,132],"report":[78],"here,":[79],"allows":[80],"remote":[82,165],"homolog":[83],"detection":[84],"under":[85],"specific":[86],"constraints,":[87],"including":[88],"sequence":[90],"length":[91],"similarity.":[92],"Multifunctional":[93],"proteins":[94,162],"are":[95,164],"present":[96],"different":[98],"species.":[99],"However,":[100],"humans,":[103],"problem":[105],"their":[107],"structural":[108,173],"and":[109,154,170,174],"functional":[110,175],"annotation":[111],"urgent":[113],"since,":[114],"according":[115],"to":[116,122,139,167],"recent":[117],"statistics,":[118],"they":[119],"comprise":[120],"up":[121],"50%":[123],"human":[126,146],"reference":[127,159],"proteome.":[128],"In":[129],"this":[130],"paper":[131],"show":[133],"when":[135],"EBA":[136],"applied":[138],"set":[141],"randomly":[143],"selected":[144],"multifunctional":[145],"proteins,":[147],"it":[148],"retrieves,":[149],"after":[150],"clustering":[152],"procedure":[153],"rigorous":[155],"validation":[156],"Swiss-Prot":[160],"database,":[161],"homologs":[166],"other":[169],"carry":[171],"similar":[172],"features":[176],"query":[179],"protein.":[180]},"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-08-18T07:49:30.821534","created_date":"2026-01-21T00:00:00"}