{"id":"https://openalex.org/W4406867213","doi":"https://doi.org/10.3390/computation13020029","title":"Bioinformatics-Driven Structural and Pharmacological Analysis of SLITRK1 in Tourette Syndrome: Impact of S656M Mutation Using Molecular Dynamics, Docking, and Reinforcement Learning","display_name":"Bioinformatics-Driven Structural and Pharmacological Analysis of SLITRK1 in Tourette Syndrome: Impact of S656M Mutation Using Molecular Dynamics, Docking, and Reinforcement Learning","publication_year":2025,"publication_date":"2025-01-27","ids":{"openalex":"https://openalex.org/W4406867213","doi":"https://doi.org/10.3390/computation13020029"},"language":"en","primary_location":{"id":"doi:10.3390/computation13020029","is_oa":true,"landing_page_url":"https://doi.org/10.3390/computation13020029","pdf_url":"https://www.mdpi.com/2079-3197/13/2/29/pdf?version=1737988270","source":{"id":"https://openalex.org/S2738402919","display_name":"Computation","issn_l":"2079-3197","issn":["2079-3197"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Computation","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/2079-3197/13/2/29/pdf?version=1737988270","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5030501964","display_name":"Emre Akta\u015f","orcid":"https://orcid.org/0000-0002-9422-3402"},"institutions":[{"id":"https://openalex.org/I4101805","display_name":"Y\u0131ld\u0131z Technical University","ror":"https://ror.org/0547yzj13","country_code":"TR","type":"education","lineage":["https://openalex.org/I4101805"]},{"id":"https://openalex.org/I48912391","display_name":"Istanbul Technical University","ror":"https://ror.org/059636586","country_code":"TR","type":"education","lineage":["https://openalex.org/I48912391"]}],"countries":["TR"],"is_corresponding":true,"raw_author_name":"Emre Akta\u015f","raw_affiliation_strings":["Faculty of Art and Science, Molecular Biology and Genetics, Y\u0131ld\u0131z Technical University, Istanbul 34220, T\u00fcrkiye","Faculty of Art and Science, Molecular Biology and Genetics, Y\u0131ld\u0131z Technical University, Istanbul, 34220, T\u00fcrkiye"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Art and Science, Molecular Biology and Genetics, Y\u0131ld\u0131z Technical University, Istanbul 34220, T\u00fcrkiye","institution_ids":["https://openalex.org/I48912391"]},{"raw_affiliation_string":"Faculty of Art and Science, Molecular Biology and Genetics, Y\u0131ld\u0131z Technical University, Istanbul, 34220, T\u00fcrkiye","institution_ids":["https://openalex.org/I4101805"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5116050006","display_name":"Alir\u0131za \u0130slim","orcid":null},"institutions":[{"id":"https://openalex.org/I4101805","display_name":"Y\u0131ld\u0131z Technical University","ror":"https://ror.org/0547yzj13","country_code":"TR","type":"education","lineage":["https://openalex.org/I4101805"]},{"id":"https://openalex.org/I48912391","display_name":"Istanbul Technical University","ror":"https://ror.org/059636586","country_code":"TR","type":"education","lineage":["https://openalex.org/I48912391"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Alir\u0131za \u0130slim","raw_affiliation_strings":["Faculty of Art and Science, Molecular Biology and Genetics, Y\u0131ld\u0131z Technical University, Istanbul 34220, T\u00fcrkiye","Faculty of Art and Science, Molecular Biology and Genetics, Y\u0131ld\u0131z Technical University, Istanbul, 34220, T\u00fcrkiye"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Art and Science, Molecular Biology and Genetics, Y\u0131ld\u0131z Technical University, Istanbul 34220, T\u00fcrkiye","institution_ids":["https://openalex.org/I48912391"]},{"raw_affiliation_string":"Faculty of Art and Science, Molecular Biology and Genetics, Y\u0131ld\u0131z Technical University, Istanbul, 34220, T\u00fcrkiye","institution_ids":["https://openalex.org/I4101805"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011324516","display_name":"Kevser K\u00fcbra K\u0131rbo\u011fa","orcid":"https://orcid.org/0000-0002-2917-8860"},"institutions":[{"id":"https://openalex.org/I169255954","display_name":"Bilecik \u015eeyh Edebali \u00dcniversitesi","ror":"https://ror.org/00dzfx204","country_code":"TR","type":"education","lineage":["https://openalex.org/I169255954"]}],"countries":["TR"],"is_corresponding":true,"raw_author_name":"Kevser K\u00fcbra K\u0131rbo\u011fa","raw_affiliation_strings":["Bioengineering Department, Faculty of Engineering, Bilecik Seyh Edebali University, Bilecik 11100, T\u00fcrkiye","Department of Bioengineering, Faculty of Engineering, Bilecik \u015eeyh Edebali University, TR 11100, Bilecik, T\u00fcrkiye"],"raw_orcid":"https://orcid.org/0000-0002-2917-8860","affiliations":[{"raw_affiliation_string":"Bioengineering Department, Faculty of Engineering, Bilecik Seyh Edebali University, Bilecik 11100, T\u00fcrkiye","institution_ids":["https://openalex.org/I169255954"]},{"raw_affiliation_string":"Department of Bioengineering, Faculty of Engineering, Bilecik \u015eeyh Edebali University, TR 11100, Bilecik, T\u00fcrkiye","institution_ids":["https://openalex.org/I169255954"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5116050007","display_name":"Derya Y\u0131ld\u0131z","orcid":"https://orcid.org/0000-0001-8772-0542"},"institutions":[{"id":"https://openalex.org/I4101805","display_name":"Y\u0131ld\u0131z Technical University","ror":"https://ror.org/0547yzj13","country_code":"TR","type":"education","lineage":["https://openalex.org/I4101805"]},{"id":"https://openalex.org/I48912391","display_name":"Istanbul Technical University","ror":"https://ror.org/059636586","country_code":"TR","type":"education","lineage":["https://openalex.org/I48912391"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Derya Y\u0131ld\u0131z","raw_affiliation_strings":["Faculty of Art and Science, Molecular Biology and Genetics, Y\u0131ld\u0131z Technical University, Istanbul 34220, T\u00fcrkiye","Faculty of Art and Science, Molecular Biology and Genetics, Y\u0131ld\u0131z Technical University, Istanbul, 34220, T\u00fcrkiye"],"raw_orcid":"https://orcid.org/0000-0001-8772-0542","affiliations":[{"raw_affiliation_string":"Faculty of Art and Science, Molecular Biology and Genetics, Y\u0131ld\u0131z Technical University, Istanbul 34220, T\u00fcrkiye","institution_ids":["https://openalex.org/I48912391"]},{"raw_affiliation_string":"Faculty of Art and Science, Molecular Biology and Genetics, Y\u0131ld\u0131z Technical University, Istanbul, 34220, T\u00fcrkiye","institution_ids":["https://openalex.org/I4101805"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011173125","display_name":"Nehir \u00d6zdemir \u00d6zgent\u00fcrk","orcid":"https://orcid.org/0000-0003-3809-6303"},"institutions":[{"id":"https://openalex.org/I4101805","display_name":"Y\u0131ld\u0131z Technical University","ror":"https://ror.org/0547yzj13","country_code":"TR","type":"education","lineage":["https://openalex.org/I4101805"]},{"id":"https://openalex.org/I48912391","display_name":"Istanbul Technical University","ror":"https://ror.org/059636586","country_code":"TR","type":"education","lineage":["https://openalex.org/I48912391"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Nehir \u00d6zdemir \u00d6zgent\u00fcrk","raw_affiliation_strings":["Faculty of Art and Science, Molecular Biology and Genetics, Y\u0131ld\u0131z Technical University, Istanbul 34220, T\u00fcrkiye","Faculty of Art and Science, Molecular Biology and Genetics, Y\u0131ld\u0131z Technical University, Istanbul, 34220, T\u00fcrkiye"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Art and Science, Molecular Biology and Genetics, Y\u0131ld\u0131z Technical University, Istanbul 34220, T\u00fcrkiye","institution_ids":["https://openalex.org/I48912391"]},{"raw_affiliation_string":"Faculty of Art and Science, Molecular Biology and Genetics, Y\u0131ld\u0131z Technical University, Istanbul, 34220, T\u00fcrkiye","institution_ids":["https://openalex.org/I4101805"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038721436","display_name":"Mithun Rudrapal","orcid":"https://orcid.org/0000-0002-8172-6633"},"institutions":[{"id":"https://openalex.org/I149313025","display_name":"Vignan's Foundation for Science, Technology & Research","ror":"https://ror.org/03bzf1g85","country_code":"IN","type":"education","lineage":["https://openalex.org/I149313025"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Mithun Rudrapal","raw_affiliation_strings":["Department of Pharmaceutical Sciences, School of Biotechnology and Pharmaceutical Sciences, Vignan\u2019s Foundation for Science, Technology and Research, Guntur 522213, India"],"raw_orcid":"https://orcid.org/0000-0002-8172-6633","affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Sciences, School of Biotechnology and Pharmaceutical Sciences, Vignan\u2019s Foundation for Science, Technology and Research, Guntur 522213, India","institution_ids":["https://openalex.org/I149313025"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062601333","display_name":"Johra Khan","orcid":"https://orcid.org/0000-0002-0044-4758"},"institutions":[{"id":"https://openalex.org/I195631090","display_name":"Majmaah University","ror":"https://ror.org/01mcrnj60","country_code":"SA","type":"education","lineage":["https://openalex.org/I195631090"]}],"countries":["SA"],"is_corresponding":false,"raw_author_name":"Johra Khan","raw_affiliation_strings":["Department of Medical Laboratory Sciences, College of Applied Medical Sciences, Majmaah University, Al Majmaah 11932, Saudi Arabia"],"raw_orcid":"https://orcid.org/0000-0002-0044-4758","affiliations":[{"raw_affiliation_string":"Department of Medical Laboratory Sciences, College of Applied Medical Sciences, Majmaah University, Al Majmaah 11932, Saudi Arabia","institution_ids":["https://openalex.org/I195631090"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066823209","display_name":"Raghu Ram Achar","orcid":"https://orcid.org/0000-0001-8196-3703"},"institutions":[{"id":"https://openalex.org/I126824641","display_name":"JSS Academy of Higher Education and Research","ror":"https://ror.org/013x70191","country_code":"IN","type":"education","lineage":["https://openalex.org/I126824641"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Raghu Ram Achar","raw_affiliation_strings":["Division of Biochemistry, School of Life Sciences, JSS Academy of Higher Education & Research, Mysuru 570015, India"],"raw_orcid":"https://orcid.org/0000-0001-8196-3703","affiliations":[{"raw_affiliation_string":"Division of Biochemistry, School of Life Sciences, JSS Academy of Higher Education & Research, Mysuru 570015, India","institution_ids":["https://openalex.org/I126824641"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022322585","display_name":"Ekaterina Silina","orcid":"https://orcid.org/0000-0002-0246-5149"},"institutions":[{"id":"https://openalex.org/I17877952","display_name":"Sechenov University","ror":"https://ror.org/02yqqv993","country_code":"RU","type":"education","lineage":["https://openalex.org/I17877952"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Ekaterina Silina","raw_affiliation_strings":["Institute of Digital Biodesign and Modeling of Living Systems, I. M. Sechenov First Moscow State Medical University (Sechenov University), Moscow 119991, Russia"],"raw_orcid":"https://orcid.org/0000-0002-0246-5149","affiliations":[{"raw_affiliation_string":"Institute of Digital Biodesign and Modeling of Living Systems, I. M. Sechenov First Moscow State Medical University (Sechenov University), Moscow 119991, Russia","institution_ids":["https://openalex.org/I17877952"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003334302","display_name":"\u041d.\u0415. \u041c\u0430\u043d\u0442\u0443\u0440\u043e\u0432\u0430","orcid":"https://orcid.org/0000-0003-4281-1947"},"institutions":[{"id":"https://openalex.org/I337778094","display_name":"Pirogov Russian National Research Medical University","ror":"https://ror.org/018159086","country_code":"RU","type":"education","lineage":["https://openalex.org/I337778094","https://openalex.org/I4210117042"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Natalia Manturova","raw_affiliation_strings":["Department of Surgery, Pirogov Russian National Research Medical University, Moscow 117997, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Pirogov Russian National Research Medical University, Moscow 117997, Russia","institution_ids":["https://openalex.org/I337778094"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5054276336","display_name":"Victor Stupin","orcid":"https://orcid.org/0000-0002-9522-8061"},"institutions":[{"id":"https://openalex.org/I337778094","display_name":"Pirogov Russian National Research Medical University","ror":"https://ror.org/018159086","country_code":"RU","type":"education","lineage":["https://openalex.org/I337778094","https://openalex.org/I4210117042"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Victor Stupin","raw_affiliation_strings":["Department of Surgery, Pirogov Russian National Research Medical University, Moscow 117997, Russia"],"raw_orcid":"https://orcid.org/0000-0002-9522-8061","affiliations":[{"raw_affiliation_string":"Department of Surgery, Pirogov Russian National Research Medical University, Moscow 117997, Russia","institution_ids":["https://openalex.org/I337778094"]}]}],"institutions":[],"countries_distinct_count":4,"institutions_distinct_count":11,"corresponding_author_ids":["https://openalex.org/A5011324516","https://openalex.org/A5030501964","https://openalex.org/A5038721436"],"corresponding_institution_ids":["https://openalex.org/I149313025","https://openalex.org/I169255954","https://openalex.org/I4101805","https://openalex.org/I48912391"],"apc_list":{"value":1400,"currency":"CHF","value_usd":1515},"apc_paid":{"value":1400,"currency":"CHF","value_usd":1515},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.01801104,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"13","issue":"2","first_page":"29","last_page":"29"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11123","display_name":"Obsessive-Compulsive Spectrum Disorders","score":0.9800000190734863,"subfield":{"id":"https://openalex.org/subfields/3203","display_name":"Clinical Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},"topics":[{"id":"https://openalex.org/T11123","display_name":"Obsessive-Compulsive Spectrum Disorders","score":0.9800000190734863,"subfield":{"id":"https://openalex.org/subfields/3203","display_name":"Clinical Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/reinforcement-learning","display_name":"Reinforcement learning","score":0.6096707582473755},{"id":"https://openalex.org/keywords/docking","display_name":"Docking (animal)","score":0.5903359651565552},{"id":"https://openalex.org/keywords/tourette-syndrome","display_name":"Tourette syndrome","score":0.4960955083370209},{"id":"https://openalex.org/keywords/mutation","display_name":"Mutation","score":0.4705277681350708},{"id":"https://openalex.org/keywords/reinforcement","display_name":"Reinforcement","score":0.4306848645210266},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.4112124741077423},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.3507038950920105},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.3173312544822693},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.3171056807041168},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.31006568670272827},{"id":"https://openalex.org/keywords/psychology","display_name":"Psychology","score":0.22243201732635498},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.1749507486820221},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.11665171384811401},{"id":"https://openalex.org/keywords/psychiatry","display_name":"Psychiatry","score":0.09063756465911865}],"concepts":[{"id":"https://openalex.org/C97541855","wikidata":"https://www.wikidata.org/wiki/Q830687","display_name":"Reinforcement learning","level":2,"score":0.6096707582473755},{"id":"https://openalex.org/C41685203","wikidata":"https://www.wikidata.org/wiki/Q1974042","display_name":"Docking (animal)","level":2,"score":0.5903359651565552},{"id":"https://openalex.org/C2777026814","wikidata":"https://www.wikidata.org/wiki/Q191779","display_name":"Tourette syndrome","level":2,"score":0.4960955083370209},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.4705277681350708},{"id":"https://openalex.org/C67203356","wikidata":"https://www.wikidata.org/wiki/Q1321905","display_name":"Reinforcement","level":2,"score":0.4306848645210266},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4112124741077423},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3507038950920105},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.3173312544822693},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3171056807041168},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.31006568670272827},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.22243201732635498},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.1749507486820221},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.11665171384811401},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.09063756465911865},{"id":"https://openalex.org/C77805123","wikidata":"https://www.wikidata.org/wiki/Q161272","display_name":"Social psychology","level":1,"score":0.0},{"id":"https://openalex.org/C159110408","wikidata":"https://www.wikidata.org/wiki/Q121176","display_name":"Nursing","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.3390/computation13020029","is_oa":true,"landing_page_url":"https://doi.org/10.3390/computation13020029","pdf_url":"https://www.mdpi.com/2079-3197/13/2/29/pdf?version=1737988270","source":{"id":"https://openalex.org/S2738402919","display_name":"Computation","issn_l":"2079-3197","issn":["2079-3197"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Computation","raw_type":"journal-article"},{"id":"pmh:oai:doaj.org/article:0a9fc72505c44b46b6c75c762ef9807b","is_oa":true,"landing_page_url":"https://doaj.org/article/0a9fc72505c44b46b6c75c762ef9807b","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Computation, Vol 13, Iss 2, p 29 (2025)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3390/computation13020029","is_oa":true,"landing_page_url":"https://doi.org/10.3390/computation13020029","pdf_url":"https://www.mdpi.com/2079-3197/13/2/29/pdf?version=1737988270","source":{"id":"https://openalex.org/S2738402919","display_name":"Computation","issn_l":"2079-3197","issn":["2079-3197"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Computation","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4406867213.pdf","grobid_xml":"https://content.openalex.org/works/W4406867213.grobid-xml"},"referenced_works_count":79,"referenced_works":["https://openalex.org/W243303449","https://openalex.org/W1531981710","https://openalex.org/W1653739410","https://openalex.org/W1803102843","https://openalex.org/W1964010911","https://openalex.org/W1968790827","https://openalex.org/W1971108880","https://openalex.org/W1975490662","https://openalex.org/W1986608731","https://openalex.org/W1999287489","https://openalex.org/W2015115860","https://openalex.org/W2030776726","https://openalex.org/W2042825217","https://openalex.org/W2062298132","https://openalex.org/W2069261633","https://openalex.org/W2070496155","https://openalex.org/W2075460992","https://openalex.org/W2085002173","https://openalex.org/W2088239473","https://openalex.org/W2110425545","https://openalex.org/W2124088653","https://openalex.org/W2132540199","https://openalex.org/W2132629607","https://openalex.org/W2136513422","https://openalex.org/W2145317354","https://openalex.org/W2145339207","https://openalex.org/W2153745204","https://openalex.org/W2160569176","https://openalex.org/W2376573086","https://openalex.org/W2562860543","https://openalex.org/W2578119541","https://openalex.org/W2612969216","https://openalex.org/W2621897082","https://openalex.org/W2626566121","https://openalex.org/W2757441893","https://openalex.org/W2770465122","https://openalex.org/W2900569176","https://openalex.org/W2912126500","https://openalex.org/W2916378975","https://openalex.org/W2943985522","https://openalex.org/W2949375861","https://openalex.org/W2951283121","https://openalex.org/W2980568898","https://openalex.org/W2997234557","https://openalex.org/W3008431985","https://openalex.org/W3008920080","https://openalex.org/W3014537365","https://openalex.org/W3015438624","https://openalex.org/W3081286612","https://openalex.org/W3081464678","https://openalex.org/W3093053585","https://openalex.org/W3115142961","https://openalex.org/W3133753929","https://openalex.org/W3135655664","https://openalex.org/W3137606728","https://openalex.org/W3186610719","https://openalex.org/W3206919605","https://openalex.org/W3209545809","https://openalex.org/W3215238479","https://openalex.org/W4205482958","https://openalex.org/W4214717370","https://openalex.org/W4221099386","https://openalex.org/W4289274885","https://openalex.org/W4295088922","https://openalex.org/W4313016101","https://openalex.org/W4313482928","https://openalex.org/W4318614730","https://openalex.org/W4368357625","https://openalex.org/W4378640129","https://openalex.org/W4381715030","https://openalex.org/W4382632093","https://openalex.org/W4384568481","https://openalex.org/W4386363130","https://openalex.org/W4387439313","https://openalex.org/W4390876420","https://openalex.org/W4391810305","https://openalex.org/W4394014753","https://openalex.org/W4394769044","https://openalex.org/W4405035146"],"related_works":["https://openalex.org/W4310083477","https://openalex.org/W2328553770","https://openalex.org/W2920061524","https://openalex.org/W1977959518","https://openalex.org/W2038908348","https://openalex.org/W2107890255","https://openalex.org/W2106552856","https://openalex.org/W2145821588","https://openalex.org/W2086122291","https://openalex.org/W1987513656"],"abstract_inverted_index":{"SLITRK1":[0,63,126],"is":[1,10],"a":[2,34,132,175],"critical":[3],"protein":[4],"involved":[5],"in":[6,170],"neural":[7],"development":[8],"and":[9,28,41,59,72,94,110,146,154,173],"associated":[11],"with":[12,33,66,128,135],"various":[13,125],"neurological":[14,184],"disorders,":[15],"including":[16,51],"Tourette":[17,87,171],"Syndrome.":[18],"This":[19,157],"study":[20,158],"investigates":[21],"the":[22,79,100,115,120,136],"structural":[23,153],"dynamics,":[24],"intrinsic":[25,52],"disorder":[26,53],"propensity,":[27],"pharmacological":[29],"interactions":[30],"of":[31,62,82,163],"SLITRK1,":[32,164],"particular":[35],"focus":[36],"on":[37],"amino":[38],"acid":[39],"substitutions":[40],"their":[42],"pathological":[43],"implications.":[44],"A":[45],"comprehensive":[46],"computational":[47],"framework":[48],"was":[49],"employed,":[50],"region":[54],"analysis,":[55],"transmembrane":[56],"topology":[57],"predictions,":[58],"stability":[60],"assessments":[61],"variants.":[64],"Integrated":[65],"reinforcement":[67,129],"learning":[68,130],"(RL),":[69],"molecular":[70,147],"docking":[71],"dynamics":[73,148],"simulations":[74],"were":[75,141],"used":[76],"to":[77,181],"evaluate":[78],"pharmacotherapeutic":[80],"potential":[81],"drugs":[83],"commonly":[84],"prescribed":[85],"for":[86,177],"Syndrome,":[88],"such":[89],"as":[90],"Pimozide,":[91],"Aripiprazole,":[92],"Risperidone,":[93],"Haloperidol.":[95],"Structural":[96],"analyses":[97],"revealed":[98],"that":[99],"S656M":[101],"mutation":[102],"significantly":[103],"alters":[104],"SLITRK1\u2019s":[105],"3D":[106],"conformation,":[107],"biological":[108],"functions,":[109],"drug":[111],"binding":[112,122],"profiles.":[113],"Among":[114],"tested":[116],"drugs,":[117],"Aripiprazole":[118],"exhibited":[119],"highest":[121],"affinity":[123],"across":[124],"variants,":[127],"highlighting":[131],"notable":[133],"interaction":[134],"S659K":[137],"mutation.":[138],"These":[139],"findings":[140],"supported":[142],"by":[143],"Ramachandran":[144],"plot":[145],"analyses,":[149],"which":[150],"identified":[151],"mutation-induced":[152],"dynamic":[155],"changes.":[156],"provides":[159],"an":[160],"integrative":[161],"analysis":[162],"offering":[165],"insights":[166],"into":[167],"its":[168],"role":[169],"Syndrome":[172],"laying":[174],"foundation":[176],"targeted":[178],"therapeutic":[179],"strategies":[180],"mitigate":[182],"SLITRK1-related":[183],"disorders.":[185]},"counts_by_year":[],"updated_date":"2026-03-13T14:20:09.374765","created_date":"2025-10-10T00:00:00"}