{"id":"https://openalex.org/W4380997522","doi":"https://doi.org/10.3390/computation11060118","title":"A Parallel Computing Approach to Gene Expression and Phenotype Correlation for Identifying Retinitis Pigmentosa Modifiers in Drosophila","display_name":"A Parallel Computing Approach to Gene Expression and Phenotype Correlation for Identifying Retinitis Pigmentosa Modifiers in Drosophila","publication_year":2023,"publication_date":"2023-06-14","ids":{"openalex":"https://openalex.org/W4380997522","doi":"https://doi.org/10.3390/computation11060118"},"language":"en","primary_location":{"id":"doi:10.3390/computation11060118","is_oa":true,"landing_page_url":"https://doi.org/10.3390/computation11060118","pdf_url":"https://www.mdpi.com/2079-3197/11/6/118/pdf?version=1686727959","source":{"id":"https://openalex.org/S2738402919","display_name":"Computation","issn_l":"2079-3197","issn":["2079-3197"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Computation","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/2079-3197/11/6/118/pdf?version=1686727959","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5092190312","display_name":"Chawin Metah","orcid":null},"institutions":[{"id":"https://openalex.org/I4210130184","display_name":"Purdue University Fort Wayne","ror":"https://ror.org/04c4hz115","country_code":"US","type":"education","lineage":["https://openalex.org/I4210130184"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chawin Metah","raw_affiliation_strings":["Department of Computer Science, Purdue University Fort Wayne, Fort Wayne, IN 46805, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Computer Science, Purdue University Fort Wayne, Fort Wayne, IN 46805, USA","institution_ids":["https://openalex.org/I4210130184"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064543594","display_name":"Amal Khalifa","orcid":"https://orcid.org/0000-0002-2054-7869"},"institutions":[{"id":"https://openalex.org/I4210130184","display_name":"Purdue University Fort Wayne","ror":"https://ror.org/04c4hz115","country_code":"US","type":"education","lineage":["https://openalex.org/I4210130184"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Amal Khalifa","raw_affiliation_strings":["Department of Computer Science, Purdue University Fort Wayne, Fort Wayne, IN 46805, USA"],"raw_orcid":"https://orcid.org/0000-0002-2054-7869","affiliations":[{"raw_affiliation_string":"Department of Computer Science, Purdue University Fort Wayne, Fort Wayne, IN 46805, USA","institution_ids":["https://openalex.org/I4210130184"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5012832646","display_name":"Rebecca A.S. Palu","orcid":"https://orcid.org/0000-0001-9444-8815"},"institutions":[{"id":"https://openalex.org/I4210130184","display_name":"Purdue University Fort Wayne","ror":"https://ror.org/04c4hz115","country_code":"US","type":"education","lineage":["https://openalex.org/I4210130184"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rebecca Palu","raw_affiliation_strings":["Department of Biology, Purdue University Fort Wayne, Fort Wayne, IN 46805, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, Purdue University Fort Wayne, Fort Wayne, IN 46805, USA","institution_ids":["https://openalex.org/I4210130184"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5064543594"],"corresponding_institution_ids":["https://openalex.org/I4210130184"],"apc_list":{"value":1400,"currency":"CHF","value_usd":1515},"apc_paid":{"value":1400,"currency":"CHF","value_usd":1515},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.25320424,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"11","issue":"6","first_page":"118","last_page":"118"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10691","display_name":"Retinal Development and Disorders","score":0.9991000294685364,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10691","display_name":"Retinal Development and Disorders","score":0.9991000294685364,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10207","display_name":"Advanced biosensing and bioanalysis techniques","score":0.9883999824523926,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11144","display_name":"melanin and skin pigmentation","score":0.9771000146865845,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/retinitis-pigmentosa","display_name":"Retinitis pigmentosa","score":0.5859741568565369},{"id":"https://openalex.org/keywords/phenotype","display_name":"Phenotype","score":0.5819050669670105},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.5535290837287903},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.4988422393798828},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.488429456949234},{"id":"https://openalex.org/keywords/drosophila","display_name":"Drosophila (subgenus)","score":0.45661941170692444},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.4298970103263855},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.42319029569625854},{"id":"https://openalex.org/keywords/genome-wide-association-study","display_name":"Genome-wide association study","score":0.42083248496055603},{"id":"https://openalex.org/keywords/expression","display_name":"Expression (computer science)","score":0.4120885729789734},{"id":"https://openalex.org/keywords/single-nucleotide-polymorphism","display_name":"Single-nucleotide polymorphism","score":0.14014029502868652},{"id":"https://openalex.org/keywords/genotype","display_name":"Genotype","score":0.11634561419487}],"concepts":[{"id":"https://openalex.org/C2781114197","wikidata":"https://www.wikidata.org/wiki/Q847057","display_name":"Retinitis pigmentosa","level":3,"score":0.5859741568565369},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.5819050669670105},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5535290837287903},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4988422393798828},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.488429456949234},{"id":"https://openalex.org/C2776041557","wikidata":"https://www.wikidata.org/wiki/Q3715451","display_name":"Drosophila (subgenus)","level":3,"score":0.45661941170692444},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.4298970103263855},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.42319029569625854},{"id":"https://openalex.org/C106208931","wikidata":"https://www.wikidata.org/wiki/Q1098876","display_name":"Genome-wide association study","level":5,"score":0.42083248496055603},{"id":"https://openalex.org/C90559484","wikidata":"https://www.wikidata.org/wiki/Q778379","display_name":"Expression (computer science)","level":2,"score":0.4120885729789734},{"id":"https://openalex.org/C153209595","wikidata":"https://www.wikidata.org/wiki/Q501128","display_name":"Single-nucleotide polymorphism","level":4,"score":0.14014029502868652},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.11634561419487},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.3390/computation11060118","is_oa":true,"landing_page_url":"https://doi.org/10.3390/computation11060118","pdf_url":"https://www.mdpi.com/2079-3197/11/6/118/pdf?version=1686727959","source":{"id":"https://openalex.org/S2738402919","display_name":"Computation","issn_l":"2079-3197","issn":["2079-3197"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Computation","raw_type":"journal-article"},{"id":"pmh:oai:doaj.org/article:3febf54c90334649a1310e007a7672cc","is_oa":true,"landing_page_url":"https://doaj.org/article/3febf54c90334649a1310e007a7672cc","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Computation, Vol 11, Iss 6, p 118 (2023)","raw_type":"article"},{"id":"pmh:oai:mdpi.com:/2079-3197/11/6/118/","is_oa":true,"landing_page_url":"https://dx.doi.org/10.3390/computation11060118","pdf_url":null,"source":{"id":"https://openalex.org/S4306400947","display_name":"MDPI (MDPI AG)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210097602","host_organization_name":"Multidisciplinary Digital Publishing Institute (Switzerland)","host_organization_lineage":["https://openalex.org/I4210097602"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Computation; Volume 11; Issue 6; Pages: 118","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.3390/computation11060118","is_oa":true,"landing_page_url":"https://doi.org/10.3390/computation11060118","pdf_url":"https://www.mdpi.com/2079-3197/11/6/118/pdf?version=1686727959","source":{"id":"https://openalex.org/S2738402919","display_name":"Computation","issn_l":"2079-3197","issn":["2079-3197"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Computation","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320309036","display_name":"Purdue University","ror":"https://ror.org/02dqehb95"}],"has_content":{"pdf":true,"grobid_xml":false},"content_urls":{"pdf":"https://content.openalex.org/works/W4380997522.pdf"},"referenced_works_count":22,"referenced_works":["https://openalex.org/W1572687140","https://openalex.org/W1913238940","https://openalex.org/W1989367702","https://openalex.org/W2074414424","https://openalex.org/W2098734857","https://openalex.org/W2102907886","https://openalex.org/W2114104545","https://openalex.org/W2117925179","https://openalex.org/W2124097252","https://openalex.org/W2145416275","https://openalex.org/W2161106528","https://openalex.org/W2236822143","https://openalex.org/W2258515607","https://openalex.org/W2408017125","https://openalex.org/W2762459254","https://openalex.org/W2977969847","https://openalex.org/W3033491782","https://openalex.org/W3163193915","https://openalex.org/W4211099883","https://openalex.org/W4213367076","https://openalex.org/W4223459560","https://openalex.org/W4309214333"],"related_works":["https://openalex.org/W2041896872","https://openalex.org/W4233329698","https://openalex.org/W2402796057","https://openalex.org/W4205637362","https://openalex.org/W584015088","https://openalex.org/W2040119765","https://openalex.org/W7340977","https://openalex.org/W2029841208","https://openalex.org/W2284557216","https://openalex.org/W2159831739"],"abstract_inverted_index":{"As":[0],"a":[1,10,16,38,70,125],"genetic":[2],"eye":[3],"disorder,":[4],"retinitis":[5],"pigmentosa":[6],"(RP)":[7],"has":[8],"been":[9],"focus":[11],"of":[12,42,45,83,108,133,173],"researchers":[13],"to":[14,36,73,120,128],"find":[15],"diagnosis":[17],"through":[18],"either":[19],"genome-wide":[20],"association":[21],"(GWA)":[22],"or":[23],"RNAseq":[24,30,49,89],"analysis.":[25],"In":[26,159],"fact,":[27],"GWA":[28],"and":[29,61,115,176],"are":[31],"considered":[32],"two":[33],"complementary":[34],"approaches":[35],"gaining":[37],"more":[39,161,178],"comprehensive":[40],"understanding":[41],"the":[43,55,59,62,81,84,93,99,113,116,122,130,134,150,171,174],"genetics":[44],"different":[46,182],"diseases.":[47],"However,":[48],"analysis":[50,175],"can":[51],"provide":[52],"information":[53],"about":[54],"specific":[56],"mechanisms":[57],"underlying":[58],"disease":[60],"potential":[63],"targets":[64],"for":[65,165],"therapy.":[66],"This":[67],"research":[68],"proposes":[69],"new":[71],"approach":[72],"differential":[74],"gene":[75,100],"expression":[76,101],"(DGE)":[77],"analysis,":[78],"which":[79,137],"is":[80,103],"heart":[82],"core-analysis":[85],"phase":[86],"in":[87,106],"any":[88],"study.":[90],"Based":[91],"on":[92,124],"Drosophila":[94],"Genetic":[95],"Reference":[96],"Panel":[97],"(DGRP),":[98],"dataset":[102],"computationally":[104],"analyzed":[105],"light":[107],"eye-size":[109],"phenotypes.":[110],"We":[111],"utilized":[112],"foreach":[114],"doParallel":[117],"R":[118],"packages":[119],"run":[121],"code":[123],"multicore":[126],"machine":[127],"reduce":[129],"running":[131,151],"time":[132,141,152],"original":[135],"algorithm,":[136],"exhibited":[138],"an":[139,146],"exponential":[140],"complexity.":[142],"Experimental":[143],"results":[144],"showed":[145],"outstanding":[147],"performance,":[148],"reducing":[149],"by":[153,169],"95%":[154],"while":[155],"using":[156],"32":[157],"processes.":[158],"addition,":[160],"candidate":[162],"modifier":[163],"genes":[164],"RP":[166],"were":[167],"identified":[168],"increasing":[170],"scope":[172],"considering":[177],"datasets":[179],"that":[180],"represent":[181],"phenotype":[183],"models.":[184]},"counts_by_year":[],"updated_date":"2026-01-21T23:30:37.877113","created_date":"2023-06-17T00:00:00"}
