{"id":"https://openalex.org/W7118782326","doi":"https://doi.org/10.3389/fbinf.2025.1690932","title":"Altered circRNAs: a novel potential mechanism for the functions of extracellular vesicles derived from platelet-rich plasma","display_name":"Altered circRNAs: a novel potential mechanism for the functions of extracellular vesicles derived from platelet-rich plasma","publication_year":2026,"publication_date":"2026-01-08","ids":{"openalex":"https://openalex.org/W7118782326","doi":"https://doi.org/10.3389/fbinf.2025.1690932","pmid":"https://pubmed.ncbi.nlm.nih.gov/41584514"},"language":"en","primary_location":{"id":"doi:10.3389/fbinf.2025.1690932","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fbinf.2025.1690932","pdf_url":"https://public-pages-files-2025.frontiersin.org/journals/bioinformatics/articles/10.3389/fbinf.2025.1690932/pdf","source":{"id":"https://openalex.org/S4210219554","display_name":"Frontiers in Bioinformatics","issn_l":"2673-7647","issn":["2673-7647"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://public-pages-files-2025.frontiersin.org/journals/bioinformatics/articles/10.3389/fbinf.2025.1690932/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5062762524","display_name":"Lifeng Niu","orcid":null},"institutions":[{"id":"https://openalex.org/I199305430","display_name":"Nantong University","ror":"https://ror.org/02afcvw97","country_code":"CN","type":"education","lineage":["https://openalex.org/I199305430"]},{"id":"https://openalex.org/I4210086801","display_name":"Affiliated Hospital of Nantong University","ror":"https://ror.org/001rahr89","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210086801"]},{"id":"https://openalex.org/I4210166889","display_name":"Anyang Hospital of Traditional Chinese Medicine","ror":"https://ror.org/02x5sw589","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210166889"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lifeng Niu","raw_affiliation_strings":["Department of Orthopedics, Nantong Hospital of Nanjing University of Chinese Medicine, Nantong, China","Department of Orthopedics, Nantong Hospital of Traditional Chinese Medicine, Nantong, China"],"affiliations":[{"raw_affiliation_string":"Department of Orthopedics, Nantong Hospital of Nanjing University of Chinese Medicine, Nantong, China","institution_ids":["https://openalex.org/I199305430","https://openalex.org/I4210086801"]},{"raw_affiliation_string":"Department of Orthopedics, Nantong Hospital of Traditional Chinese Medicine, Nantong, China","institution_ids":["https://openalex.org/I4210166889"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109465122","display_name":"Yanli Wang","orcid":null},"institutions":[{"id":"https://openalex.org/I4210142484","display_name":"Second Affiliated Hospital of Jilin University","ror":"https://ror.org/03x6hbh34","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210142484"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yanli Wang","raw_affiliation_strings":["Department of Orthopedics, The Second Hospital of Jilin University, Changchun, China"],"affiliations":[{"raw_affiliation_string":"Department of Orthopedics, The Second Hospital of Jilin University, Changchun, China","institution_ids":["https://openalex.org/I4210142484"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5122112617","display_name":"Yao Gao","orcid":null},"institutions":[{"id":"https://openalex.org/I4210142484","display_name":"Second Affiliated Hospital of Jilin University","ror":"https://ror.org/03x6hbh34","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210142484"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yao Gao","raw_affiliation_strings":["Department of Orthopaedic Rehabilitation and Pain, The Second Hospital of Jilin University, Changchun, China"],"affiliations":[{"raw_affiliation_string":"Department of Orthopaedic Rehabilitation and Pain, The Second Hospital of Jilin University, Changchun, China","institution_ids":["https://openalex.org/I4210142484"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5122279786","display_name":"Jun Zhang","orcid":null},"institutions":[{"id":"https://openalex.org/I4210142484","display_name":"Second Affiliated Hospital of Jilin University","ror":"https://ror.org/03x6hbh34","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210142484"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Jun Zhang","raw_affiliation_strings":["Department of Orthopedics, The Second Hospital of Jilin University, Changchun, China"],"affiliations":[{"raw_affiliation_string":"Department of Orthopedics, The Second Hospital of Jilin University, Changchun, China","institution_ids":["https://openalex.org/I4210142484"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5122112617","https://openalex.org/A5122279786"],"corresponding_institution_ids":["https://openalex.org/I4210142484"],"apc_list":{"value":1900,"currency":"USD","value_usd":1900},"apc_paid":{"value":1900,"currency":"USD","value_usd":1900},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.03766967,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"5","issue":null,"first_page":"1690932","last_page":"1690932"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10773","display_name":"Extracellular vesicles in disease","score":0.9717000126838684,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10773","display_name":"Extracellular vesicles in disease","score":0.9717000126838684,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11765","display_name":"Circular RNAs in diseases","score":0.014000000432133675,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10176","display_name":"Mesenchymal stem cell research","score":0.00430000014603138,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/kegg","display_name":"KEGG","score":0.7368999719619751},{"id":"https://openalex.org/keywords/secretion","display_name":"Secretion","score":0.5485000014305115},{"id":"https://openalex.org/keywords/extracellular","display_name":"Extracellular","score":0.5250999927520752},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.5091000199317932},{"id":"https://openalex.org/keywords/microvesicles","display_name":"Microvesicles","score":0.5054000020027161},{"id":"https://openalex.org/keywords/signal-transduction","display_name":"Signal transduction","score":0.5045999884605408},{"id":"https://openalex.org/keywords/rna","display_name":"RNA","score":0.46000000834465027},{"id":"https://openalex.org/keywords/extracellular-vesicles","display_name":"Extracellular vesicles","score":0.4113999903202057},{"id":"https://openalex.org/keywords/mechanism","display_name":"Mechanism (biology)","score":0.39259999990463257},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.39169999957084656}],"concepts":[{"id":"https://openalex.org/C152724338","wikidata":"https://www.wikidata.org/wiki/Q909442","display_name":"KEGG","level":5,"score":0.7368999719619751},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6535999774932861},{"id":"https://openalex.org/C49039625","wikidata":"https://www.wikidata.org/wiki/Q84230","display_name":"Secretion","level":2,"score":0.5485000014305115},{"id":"https://openalex.org/C28406088","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Extracellular","level":2,"score":0.5250999927520752},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5091000199317932},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5077999830245972},{"id":"https://openalex.org/C20518536","wikidata":"https://www.wikidata.org/wiki/Q6840469","display_name":"Microvesicles","level":4,"score":0.5054000020027161},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.5045999884605408},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.46000000834465027},{"id":"https://openalex.org/C2992929900","wikidata":"https://www.wikidata.org/wiki/Q21097485","display_name":"Extracellular vesicles","level":2,"score":0.4113999903202057},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.40130001306533813},{"id":"https://openalex.org/C89611455","wikidata":"https://www.wikidata.org/wiki/Q6804646","display_name":"Mechanism (biology)","level":2,"score":0.39259999990463257},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.39169999957084656},{"id":"https://openalex.org/C150555746","wikidata":"https://www.wikidata.org/wiki/Q210973","display_name":"Cell signaling","level":3,"score":0.37610000371932983},{"id":"https://openalex.org/C186738567","wikidata":"https://www.wikidata.org/wiki/Q412841","display_name":"Tissue factor","level":3,"score":0.3675000071525574},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.36489999294281006},{"id":"https://openalex.org/C2908689518","wikidata":"https://www.wikidata.org/wiki/Q21097485","display_name":"Extracellular vesicle","level":5,"score":0.35510000586509705},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3472000062465668},{"id":"https://openalex.org/C2775893923","wikidata":"https://www.wikidata.org/wiki/Q17113455","display_name":"Circular RNA","level":4,"score":0.34360000491142273},{"id":"https://openalex.org/C165864922","wikidata":"https://www.wikidata.org/wiki/Q411391","display_name":"Regulation of gene expression","level":3,"score":0.3208000063896179},{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.31690001487731934},{"id":"https://openalex.org/C9927688","wikidata":"https://www.wikidata.org/wiki/Q4915012","display_name":"Biological pathway","level":4,"score":0.3091999888420105},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3027999997138977},{"id":"https://openalex.org/C137620995","wikidata":"https://www.wikidata.org/wiki/Q155769","display_name":"Wnt signaling pathway","level":3,"score":0.2948000133037567},{"id":"https://openalex.org/C192989942","wikidata":"https://www.wikidata.org/wiki/Q68685","display_name":"Metabolic pathway","level":3,"score":0.28760001063346863},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.2867000102996826},{"id":"https://openalex.org/C2777292125","wikidata":"https://www.wikidata.org/wiki/Q409166","display_name":"Thrombin","level":3,"score":0.2831000089645386},{"id":"https://openalex.org/C2781261824","wikidata":"https://www.wikidata.org/wiki/Q903634","display_name":"Exosome","level":5,"score":0.271699994802475},{"id":"https://openalex.org/C118131993","wikidata":"https://www.wikidata.org/wiki/Q423671","display_name":"Transforming growth factor","level":2,"score":0.26899999380111694},{"id":"https://openalex.org/C2775960820","wikidata":"https://www.wikidata.org/wiki/Q408378","display_name":"Growth factor","level":3,"score":0.26489999890327454},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.26420000195503235},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.2612999975681305},{"id":"https://openalex.org/C130316041","wikidata":"https://www.wikidata.org/wiki/Q189206","display_name":"Vesicle","level":3,"score":0.250900000333786}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.3389/fbinf.2025.1690932","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fbinf.2025.1690932","pdf_url":"https://public-pages-files-2025.frontiersin.org/journals/bioinformatics/articles/10.3389/fbinf.2025.1690932/pdf","source":{"id":"https://openalex.org/S4210219554","display_name":"Frontiers in Bioinformatics","issn_l":"2673-7647","issn":["2673-7647"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Bioinformatics","raw_type":"journal-article"},{"id":"pmid:41584514","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41584514","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in bioinformatics","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:12823818","is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12823818/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Front Bioinform","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.3389/fbinf.2025.1690932","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fbinf.2025.1690932","pdf_url":"https://public-pages-files-2025.frontiersin.org/journals/bioinformatics/articles/10.3389/fbinf.2025.1690932/pdf","source":{"id":"https://openalex.org/S4210219554","display_name":"Frontiers in Bioinformatics","issn_l":"2673-7647","issn":["2673-7647"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":false},"content_urls":{"pdf":"https://content.openalex.org/works/W7118782326.pdf"},"referenced_works_count":46,"referenced_works":["https://openalex.org/W1582760249","https://openalex.org/W1846631206","https://openalex.org/W1991525001","https://openalex.org/W2000315116","https://openalex.org/W2064165694","https://openalex.org/W2091510848","https://openalex.org/W2092632463","https://openalex.org/W2133784336","https://openalex.org/W2333202252","https://openalex.org/W2510968112","https://openalex.org/W2551533129","https://openalex.org/W2565891399","https://openalex.org/W2573584439","https://openalex.org/W2601436215","https://openalex.org/W2741872490","https://openalex.org/W2770010368","https://openalex.org/W2782983171","https://openalex.org/W2893474159","https://openalex.org/W2947421493","https://openalex.org/W2954167484","https://openalex.org/W2975814571","https://openalex.org/W2988452724","https://openalex.org/W3204069241","https://openalex.org/W4308571570","https://openalex.org/W4388488558","https://openalex.org/W4390155060","https://openalex.org/W4390451094","https://openalex.org/W4390701847","https://openalex.org/W4390812884","https://openalex.org/W4391598096","https://openalex.org/W4391779560","https://openalex.org/W4392337759","https://openalex.org/W4392830629","https://openalex.org/W4393964863","https://openalex.org/W4395043914","https://openalex.org/W4399226355","https://openalex.org/W4399929643","https://openalex.org/W4400286698","https://openalex.org/W4400913192","https://openalex.org/W4401181895","https://openalex.org/W4401947385","https://openalex.org/W4402677863","https://openalex.org/W4403150829","https://openalex.org/W4404157974","https://openalex.org/W4404993457","https://openalex.org/W4405748675"],"related_works":[],"abstract_inverted_index":{"Platelet-rich":[0],"plasma":[1,106],"(PRP)":[2],"has":[3],"been":[4],"widely":[5],"applied":[6],"in":[7,33,84,142,190,269,279],"clinical":[8,288],"practice":[9],"for":[10,42,90,98,286,297],"tissue":[11,37],"repair":[12,38],"and":[13,39,76,95,123,150,172,176,209,233,292],"regeneration.":[14],"Recent":[15],"studies":[16],"have":[17],"reported":[18],"that":[19,113,195,213],"large":[20],"amounts":[21],"of":[22,36,51,68,93,101,125,170,188,206,222,242,263,267,271,290],"extracellular":[23],"vesicles":[24],"(EVs)":[25],"derived":[26,103],"from":[27,104,132],"PRP":[28,114],"(PRP-EVs)":[29],"are":[30],"also":[31],"involved":[32],"the":[34,43,48,62,91,99,121,185,203,219,225,239,254,264,272,284,287],"functions":[35,221,266],"regeneration,":[40],"except":[41],"secreted":[44],"growth":[45,227],"factors.":[46],"However,":[47],"relevant":[49],"mechanisms":[50,67],"PRP-EVs":[52,69,94,143,223,268,291],"remain":[53],"unknown.":[54],"In":[55,237,250],"this":[56,85,252,280],"study,":[57,86],"we":[58,111],"attempted":[59],"to":[60,134,183,202,257],"reveal":[61],"potential":[63,186,261],"circular":[64],"RNA":[65,72],"(circRNA)":[66],"using":[70],"high-throughput":[71],"sequencing":[73],"(RNA-seq)":[74],"technique":[75],"bioinformatics":[77],"analysis.":[78],"Six":[79],"healthy":[80],"donors":[81,89,97],"were":[82,140,158,163,181,214,224,246],"enrolled":[83],"including":[87],"three":[88,96],"isolation":[92,100],"EVs":[102],"blood":[105],"(plasma-EVs).":[107],"As":[108],"a":[109,145,259],"result,":[110],"confirmed":[112],"activation":[115],"by":[116],"thrombin":[117],"could":[118],"significantly":[119],"promote":[120],"formation":[122],"secretion":[124],"EVs,":[126],"particularly":[127],"those":[128],"with":[129,144,218],"diameters":[130],"ranging":[131],"50":[133],"200":[135],"nm.":[136],"Moreover,":[137],"144":[138],"circRNAs":[139,157,162,189,198,245],"altered":[141,197,273],"fold":[146],"change":[147],"\u2265":[148],"2.0":[149],"p-value":[151],"\u2264":[152],"0.05.":[153],"Among":[154],"these,":[155],"89":[156],"upregulated,":[159],"whereas":[160],"55":[161],"downregulated.":[164],"Gene":[165],"Ontology":[166],"(GO),":[167],"Kyoto":[168],"Encyclopedia":[169],"Genes":[171],"Genomes":[173],"(KEGG)":[174],"pathway,":[175],"circRNA-miRNA-mRNA":[177],"interaction":[178],"network":[179],"analyses":[180],"performed":[182],"predict":[184],"roles":[187],"PRP-EVs.":[191],"GO":[192],"analysis":[193],"indicated":[194],"these":[196],"might":[199],"be":[200],"related":[201],"physiological":[204],"processes":[205],"cell":[207],"genesis":[208],"development.":[210],"The":[211],"pathways":[212],"most":[215],"strongly":[216],"correlated":[217],"biological":[220,265],"transforming":[226],"factor":[228],"\u03b2":[229],"(TGF-\u03b2)":[230],"signaling":[231,235],"pathway":[232],"HIF-1":[234],"pathway.":[236],"addition,":[238],"expression":[240],"levels":[241],"five":[243],"selected":[244],"verified":[247],"through":[248],"RT-qPCR.":[249],"conclusion,":[251],"is":[253],"first":[255],"study":[256,281],"explain":[258],"novel":[260,295],"mechanism":[262],"terms":[270],"circRNAs.":[274],"Taken":[275],"together,":[276],"our":[277],"findings":[278],"may":[282],"lay":[283],"groundwork":[285],"application":[289],"provide":[293],"possible":[294],"targets":[296],"further":[298],"research.":[299]},"counts_by_year":[],"updated_date":"2026-04-21T08:09:41.155169","created_date":"2026-01-08T00:00:00"}
