{"id":"https://openalex.org/W4414392959","doi":"https://doi.org/10.3389/fbinf.2025.1633494","title":"Association between dysregulated expression of Ca2+ and ROS-related genes and breast cancer patient survival","display_name":"Association between dysregulated expression of Ca2+ and ROS-related genes and breast cancer patient survival","publication_year":2025,"publication_date":"2025-09-22","ids":{"openalex":"https://openalex.org/W4414392959","doi":"https://doi.org/10.3389/fbinf.2025.1633494","pmid":"https://pubmed.ncbi.nlm.nih.gov/41059483"},"language":"en","primary_location":{"id":"doi:10.3389/fbinf.2025.1633494","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fbinf.2025.1633494","pdf_url":"https://www.frontiersin.org/journals/bioinformatics/articles/10.3389/fbinf.2025.1633494/pdf","source":{"id":"https://openalex.org/S4210219554","display_name":"Frontiers in Bioinformatics","issn_l":"2673-7647","issn":["2673-7647"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/journals/bioinformatics/articles/10.3389/fbinf.2025.1633494/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5032934482","display_name":"Sof\u0131\u0301a Ramos","orcid":"https://orcid.org/0000-0001-5846-6194"},"institutions":[{"id":"https://openalex.org/I88596544","display_name":"Universidade Lus\u00f3fona","ror":"https://ror.org/05xxfer42","country_code":"PT","type":"education","lineage":["https://openalex.org/I88596544"]},{"id":"https://openalex.org/I189268942","display_name":"Universidad de Alcal\u00e1","ror":"https://ror.org/04pmn0e78","country_code":"ES","type":"education","lineage":["https://openalex.org/I189268942"]}],"countries":["ES","PT"],"is_corresponding":false,"raw_author_name":"Sofia Ramos","raw_affiliation_strings":["CBIOS, Universidade Lus\u00f3fona's Research Center for Biosciences and Health Technologies, Lisbon, Portugal","Departamento de Ciencias Biom\u00e9dicas, Universidad de Alcal\u00e1 de Henares, Alcal\u00e1 de Henares, Madrid, Spain"],"affiliations":[{"raw_affiliation_string":"CBIOS, Universidade Lus\u00f3fona's Research Center for Biosciences and Health Technologies, Lisbon, Portugal","institution_ids":["https://openalex.org/I88596544"]},{"raw_affiliation_string":"Departamento de Ciencias Biom\u00e9dicas, Universidad de Alcal\u00e1 de Henares, Alcal\u00e1 de Henares, Madrid, Spain","institution_ids":["https://openalex.org/I189268942"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060837702","display_name":"Jo\u00e3o Greg\u00f3rio","orcid":null},"institutions":[{"id":"https://openalex.org/I88596544","display_name":"Universidade Lus\u00f3fona","ror":"https://ror.org/05xxfer42","country_code":"PT","type":"education","lineage":["https://openalex.org/I88596544"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Jo\u00e3o Greg\u00f3rio","raw_affiliation_strings":["CBIOS, Universidade Lus\u00f3fona's Research Center for Biosciences and Health Technologies, Lisbon, Portugal"],"affiliations":[{"raw_affiliation_string":"CBIOS, Universidade Lus\u00f3fona's Research Center for Biosciences and Health Technologies, Lisbon, Portugal","institution_ids":["https://openalex.org/I88596544"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086067574","display_name":"Ana Sofia Fernandes","orcid":"https://orcid.org/0000-0003-3913-7859"},"institutions":[{"id":"https://openalex.org/I88596544","display_name":"Universidade Lus\u00f3fona","ror":"https://ror.org/05xxfer42","country_code":"PT","type":"education","lineage":["https://openalex.org/I88596544"]}],"countries":["PT"],"is_corresponding":true,"raw_author_name":"Ana Sofia Fernandes","raw_affiliation_strings":["CBIOS, Universidade Lus\u00f3fona's Research Center for Biosciences and Health Technologies, Lisbon, Portugal"],"affiliations":[{"raw_affiliation_string":"CBIOS, Universidade Lus\u00f3fona's Research Center for Biosciences and Health Technologies, Lisbon, Portugal","institution_ids":["https://openalex.org/I88596544"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5065417198","display_name":"Nuno Saraiva","orcid":"https://orcid.org/0000-0003-1333-9137"},"institutions":[{"id":"https://openalex.org/I88596544","display_name":"Universidade Lus\u00f3fona","ror":"https://ror.org/05xxfer42","country_code":"PT","type":"education","lineage":["https://openalex.org/I88596544"]}],"countries":["PT"],"is_corresponding":true,"raw_author_name":"Nuno Saraiva","raw_affiliation_strings":["CBIOS, Universidade Lus\u00f3fona's Research Center for Biosciences and Health Technologies, Lisbon, Portugal"],"affiliations":[{"raw_affiliation_string":"CBIOS, Universidade Lus\u00f3fona's Research Center for Biosciences and Health Technologies, Lisbon, Portugal","institution_ids":["https://openalex.org/I88596544"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5065417198","https://openalex.org/A5086067574"],"corresponding_institution_ids":["https://openalex.org/I88596544"],"apc_list":{"value":1900,"currency":"USD","value_usd":1900},"apc_paid":{"value":1900,"currency":"USD","value_usd":1900},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.21558729,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"5","issue":null,"first_page":"1633494","last_page":"1633494"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11332","display_name":"Genomics, phytochemicals, and oxidative stress","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11332","display_name":"Genomics, phytochemicals, and oxidative stress","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.9936000108718872,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11150","display_name":"Endoplasmic Reticulum Stress and Disease","score":0.9919999837875366,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.6762999892234802},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.5770999789237976},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"Breast cancer","score":0.5343000292778015},{"id":"https://openalex.org/keywords/cancer","display_name":"Cancer","score":0.4609000086784363},{"id":"https://openalex.org/keywords/population","display_name":"Population","score":0.4505000114440918},{"id":"https://openalex.org/keywords/gene-expression-profiling","display_name":"Gene expression profiling","score":0.44760000705718994},{"id":"https://openalex.org/keywords/regulation-of-gene-expression","display_name":"Regulation of gene expression","score":0.4214000105857849},{"id":"https://openalex.org/keywords/transcriptome","display_name":"Transcriptome","score":0.3824999928474426}],"concepts":[{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.6762999892234802},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.5770999789237976},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5638999938964844},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.5343000292778015},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4609000086784363},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.4505000114440918},{"id":"https://openalex.org/C18431079","wikidata":"https://www.wikidata.org/wiki/Q1502169","display_name":"Gene expression profiling","level":4,"score":0.44760000705718994},{"id":"https://openalex.org/C165864922","wikidata":"https://www.wikidata.org/wiki/Q411391","display_name":"Regulation of gene expression","level":3,"score":0.4214000105857849},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.38989999890327454},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.3824999928474426},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.37549999356269836},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3637000024318695},{"id":"https://openalex.org/C106208931","wikidata":"https://www.wikidata.org/wiki/Q1098876","display_name":"Genome-wide association study","level":5,"score":0.34049999713897705},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.33629998564720154},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.3156000077724457},{"id":"https://openalex.org/C186413461","wikidata":"https://www.wikidata.org/wiki/Q744727","display_name":"Genetic association","level":5,"score":0.3138999938964844},{"id":"https://openalex.org/C68443243","wikidata":"https://www.wikidata.org/wiki/Q2786686","display_name":"Quartile","level":3,"score":0.31360000371932983},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.30730000138282776},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.2971999943256378},{"id":"https://openalex.org/C10515644","wikidata":"https://www.wikidata.org/wiki/Q543310","display_name":"Survival analysis","level":2,"score":0.29670000076293945},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.2896000146865845},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.2678000032901764},{"id":"https://openalex.org/C9927688","wikidata":"https://www.wikidata.org/wiki/Q4915012","display_name":"Biological pathway","level":4,"score":0.2644999921321869},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.26260000467300415},{"id":"https://openalex.org/C67339327","wikidata":"https://www.wikidata.org/wiki/Q1502576","display_name":"Gene regulatory network","level":4,"score":0.25859999656677246},{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.2549000084400177}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.3389/fbinf.2025.1633494","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fbinf.2025.1633494","pdf_url":"https://www.frontiersin.org/journals/bioinformatics/articles/10.3389/fbinf.2025.1633494/pdf","source":{"id":"https://openalex.org/S4210219554","display_name":"Frontiers in Bioinformatics","issn_l":"2673-7647","issn":["2673-7647"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Bioinformatics","raw_type":"journal-article"},{"id":"pmid:41059483","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41059483","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in bioinformatics","raw_type":null},{"id":"pmh:oai:doaj.org/article:a16c74dd210e4b348ccc90f0bdb6c0a1","is_oa":true,"landing_page_url":"https://doaj.org/article/a16c74dd210e4b348ccc90f0bdb6c0a1","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Bioinformatics, Vol 5 (2025)","raw_type":"article"},{"id":"pmh:oai:europepmc.org:11307028","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/12498015","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:12498015","is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12498015/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Front Bioinform","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.3389/fbinf.2025.1633494","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fbinf.2025.1633494","pdf_url":"https://www.frontiersin.org/journals/bioinformatics/articles/10.3389/fbinf.2025.1633494/pdf","source":{"id":"https://openalex.org/S4210219554","display_name":"Frontiers in Bioinformatics","issn_l":"2673-7647","issn":["2673-7647"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":false},"content_urls":{"pdf":"https://content.openalex.org/works/W4414392959.pdf"},"referenced_works_count":48,"referenced_works":["https://openalex.org/W63177590","https://openalex.org/W1007539167","https://openalex.org/W1165140024","https://openalex.org/W1966439678","https://openalex.org/W1993839684","https://openalex.org/W1996311090","https://openalex.org/W2012598982","https://openalex.org/W2020033048","https://openalex.org/W2034269086","https://openalex.org/W2038001959","https://openalex.org/W2078394930","https://openalex.org/W2106259279","https://openalex.org/W2112268703","https://openalex.org/W2140525205","https://openalex.org/W2142254608","https://openalex.org/W2150140277","https://openalex.org/W2157090718","https://openalex.org/W2275678839","https://openalex.org/W2334551212","https://openalex.org/W2336310263","https://openalex.org/W2579283515","https://openalex.org/W2592624900","https://openalex.org/W2736730167","https://openalex.org/W2791564057","https://openalex.org/W2795989238","https://openalex.org/W2808688129","https://openalex.org/W2898904270","https://openalex.org/W2920835552","https://openalex.org/W2942201801","https://openalex.org/W2946657092","https://openalex.org/W2966094674","https://openalex.org/W2997022986","https://openalex.org/W3005689864","https://openalex.org/W3006611984","https://openalex.org/W3025256204","https://openalex.org/W3108920603","https://openalex.org/W3139288294","https://openalex.org/W3168173367","https://openalex.org/W3190429855","https://openalex.org/W4214901572","https://openalex.org/W4224218755","https://openalex.org/W4281570946","https://openalex.org/W4283205726","https://openalex.org/W4319015144","https://openalex.org/W4385364069","https://openalex.org/W4393935425","https://openalex.org/W4398216825","https://openalex.org/W4408579775"],"related_works":[],"abstract_inverted_index":{"The":[0,82],"intricate":[1],"interplay":[2],"between":[3,90,117],"Ca<sup>2+</sup>":[4,22],"and":[5,23,67,105,119,122,175,225],"reactive":[6],"oxygen":[7],"species":[8],"(ROS)":[9],"signalling":[10],"systems":[11],"influences":[12],"numerous":[13],"cellular":[14,103],"pathways.":[15],"Dysregulated":[16],"expression":[17,116,144,153,161,205,215],"of":[18,51,93,96,143,154,169,189,193,207,216],"genes":[19,97,109,159,217],"associated":[20,198,212],"with":[21,127,160,166,199,213],"ROS":[24],"homeostasis":[25],"can":[26],"significantly":[27],"impact":[28],"cancer":[29,45],"progression.":[30],"Despite":[31],"extensive":[32],"research,":[33],"various":[34],"underlying":[35],"mechanisms":[36],"remain":[37],"elusive,":[38],"lacking":[39],"a":[40,75,155,176,190,232],"comprehensive":[41],"unified":[42],"perspective.":[43],"Breast":[44],"(BC)":[46],"remains":[47],"the":[48,57,88,135,146,167,186,204],"leading":[49],"cause":[50],"cancer-related":[52],"deaths":[53],"among":[54],"women,":[55],"highlighting":[56],"pressing":[58],"need":[59],"to":[60,86,219,235],"discover":[61],"novel":[62],"regulatory":[63],"mechanisms,":[64],"therapeutic":[65],"targets,":[66],"potential":[68,234],"biomarkers.":[69],"In":[70],"this":[71],"study,":[72],"we":[73],"employed":[74],"bioinformatic":[76],"approach":[77,230],"based":[78],"on":[79],"data":[80],"from":[81],"Cancer":[83],"Genome":[84],"Atlas":[85],"assess":[87],"association":[89,126],"combined":[91],"dysregulation":[92,188,206],"specific":[94],"pairs":[95,172,195,210],"involved":[98],"in":[99,114,123],"redox-":[100],"or":[101,151,163,240],"Ca<sup>2+</sup>-related":[102],"homeostases":[104],"patient":[106,128,201],"outcome.":[107],"These":[108],"were":[110,173],"selected":[111,191],"by":[112],"differences":[113],"their":[115,124],"normal":[118],"tumour":[120],"tissues":[121],"individual":[125],"survival":[129,133],"rates.":[130],"Cumulative":[131],"proportion":[132],"at":[134],"5-year":[136],"post-diagnosis":[137],"was":[138,180],"calculated":[139],"for":[140,243],"each":[141],"quartile":[142],"within":[145],"population":[147],"exhibiting":[148],"either":[149],"high":[150],"low":[152],"second":[156],"gene.":[157],"Additional":[158],"positively":[162],"negatively":[164],"correlated":[165],"set":[168],"relevant":[170],"gene":[171,177,194,209],"identified,":[174],"enrichment":[178],"analysis":[179],"performed.":[181],"Our":[182],"results":[183],"show":[184],"that":[185],"simultaneous":[187],"number":[192],"is":[196,211],"substantially":[197],"BC":[200],"survival.":[202],"Notably,":[203],"these":[208],"altered":[214],"linked":[218],"cell":[220,223,226],"cycle":[221],"regulation,":[222],"adhesion,":[224],"projection":[227],"processes.":[228],"This":[229],"exhibits":[231],"significant":[233],"identify":[236],"new":[237],"prognostic":[238],"biomarkers":[239],"drug":[241],"targets":[242],"BC.":[244]},"counts_by_year":[],"updated_date":"2026-04-21T08:09:41.155169","created_date":"2025-09-23T00:00:00"}
