{"id":"https://openalex.org/W4411664784","doi":"https://doi.org/10.3389/fbinf.2025.1594971","title":"Identification of immune and major depressive disorder-related diagnostic markers for early nonalcoholic fatty liver disease by WGCNA and machine learning","display_name":"Identification of immune and major depressive disorder-related diagnostic markers for early nonalcoholic fatty liver disease by WGCNA and machine learning","publication_year":2025,"publication_date":"2025-06-26","ids":{"openalex":"https://openalex.org/W4411664784","doi":"https://doi.org/10.3389/fbinf.2025.1594971","pmid":"https://pubmed.ncbi.nlm.nih.gov/40689242"},"language":"en","primary_location":{"id":"doi:10.3389/fbinf.2025.1594971","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fbinf.2025.1594971","pdf_url":"https://www.frontiersin.org/journals/bioinformatics/articles/10.3389/fbinf.2025.1594971/pdf","source":{"id":"https://openalex.org/S4210219554","display_name":"Frontiers in Bioinformatics","issn_l":"2673-7647","issn":["2673-7647"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/journals/bioinformatics/articles/10.3389/fbinf.2025.1594971/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Yuyun Jia","orcid":null},"institutions":[{"id":"https://openalex.org/I4210111013","display_name":"Nanjing Drum Tower Hospital","ror":"https://ror.org/026axqv54","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210111013"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yuyun Jia","raw_affiliation_strings":["Department of Gastroenterology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, China"],"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, China","institution_ids":["https://openalex.org/I4210111013"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046826953","display_name":"Yanping Cao","orcid":"https://orcid.org/0000-0003-4787-9748"},"institutions":[{"id":"https://openalex.org/I4210111013","display_name":"Nanjing Drum Tower Hospital","ror":"https://ror.org/026axqv54","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210111013"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yanping Cao","raw_affiliation_strings":["Department of Gastroenterology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, China"],"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, China","institution_ids":["https://openalex.org/I4210111013"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079974540","display_name":"Qin Yin","orcid":"https://orcid.org/0000-0002-8149-9362"},"institutions":[{"id":"https://openalex.org/I4210111013","display_name":"Nanjing Drum Tower Hospital","ror":"https://ror.org/026axqv54","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210111013"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qin Yin","raw_affiliation_strings":["Department of Gastroenterology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, China"],"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, China","institution_ids":["https://openalex.org/I4210111013"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053580135","display_name":"Xue\u2013Qian Li","orcid":"https://orcid.org/0000-0002-1197-3743"},"institutions":[{"id":"https://openalex.org/I4210111013","display_name":"Nanjing Drum Tower Hospital","ror":"https://ror.org/026axqv54","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210111013"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xueqian Li","raw_affiliation_strings":["Department of Gastroenterology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, China"],"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, China","institution_ids":["https://openalex.org/I4210111013"]}]},{"author_position":"last","author":{"id":null,"display_name":"Xiu Wen","orcid":null},"institutions":[{"id":"https://openalex.org/I4210111013","display_name":"Nanjing Drum Tower Hospital","ror":"https://ror.org/026axqv54","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210111013"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiu Wen","raw_affiliation_strings":["Department of Gastroenterology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, China"],"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, China","institution_ids":["https://openalex.org/I4210111013"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210111013"],"apc_list":{"value":1900,"currency":"USD","value_usd":1900},"apc_paid":{"value":1900,"currency":"USD","value_usd":1900},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.20733737,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"5","issue":null,"first_page":"1594971","last_page":"1594971"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10351","display_name":"Liver Disease Diagnosis and Treatment","score":0.9995999932289124,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10351","display_name":"Liver Disease Diagnosis and Treatment","score":0.9995999932289124,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10151","display_name":"Hepatitis C virus research","score":0.9761999845504761,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nonalcoholic-fatty-liver-disease","display_name":"Nonalcoholic fatty liver disease","score":0.8000122308731079},{"id":"https://openalex.org/keywords/identification","display_name":"Identification (biology)","score":0.7201004028320312},{"id":"https://openalex.org/keywords/disease","display_name":"Disease","score":0.6006004214286804},{"id":"https://openalex.org/keywords/immune-system","display_name":"Immune system","score":0.528117299079895},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.38747167587280273},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.37994059920310974},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.3258068561553955},{"id":"https://openalex.org/keywords/fatty-liver","display_name":"Fatty liver","score":0.283757746219635},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.2594754993915558},{"id":"https://openalex.org/keywords/immunology","display_name":"Immunology","score":0.23853561282157898},{"id":"https://openalex.org/keywords/ecology","display_name":"Ecology","score":0.10027638077735901}],"concepts":[{"id":"https://openalex.org/C2776954865","wikidata":"https://www.wikidata.org/wiki/Q1546498","display_name":"Nonalcoholic fatty liver disease","level":4,"score":0.8000122308731079},{"id":"https://openalex.org/C116834253","wikidata":"https://www.wikidata.org/wiki/Q2039217","display_name":"Identification (biology)","level":2,"score":0.7201004028320312},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.6006004214286804},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.528117299079895},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.38747167587280273},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.37994059920310974},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3258068561553955},{"id":"https://openalex.org/C2778772119","wikidata":"https://www.wikidata.org/wiki/Q6058862","display_name":"Fatty liver","level":3,"score":0.283757746219635},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2594754993915558},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.23853561282157898},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.10027638077735901}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3389/fbinf.2025.1594971","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fbinf.2025.1594971","pdf_url":"https://www.frontiersin.org/journals/bioinformatics/articles/10.3389/fbinf.2025.1594971/pdf","source":{"id":"https://openalex.org/S4210219554","display_name":"Frontiers in Bioinformatics","issn_l":"2673-7647","issn":["2673-7647"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Bioinformatics","raw_type":"journal-article"},{"id":"pmid:40689242","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40689242","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in bioinformatics","raw_type":null},{"id":"pmh:oai:doaj.org/article:970f27a3e9f047f2a095d6c60a521200","is_oa":true,"landing_page_url":"https://doaj.org/article/970f27a3e9f047f2a095d6c60a521200","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Bioinformatics, Vol 5 (2025)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:12271764","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/12271764","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Front Bioinform","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.3389/fbinf.2025.1594971","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fbinf.2025.1594971","pdf_url":"https://www.frontiersin.org/journals/bioinformatics/articles/10.3389/fbinf.2025.1594971/pdf","source":{"id":"https://openalex.org/S4210219554","display_name":"Frontiers in Bioinformatics","issn_l":"2673-7647","issn":["2673-7647"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4411664784.pdf"},"referenced_works_count":54,"referenced_works":["https://openalex.org/W1591183787","https://openalex.org/W1967206613","https://openalex.org/W2034957678","https://openalex.org/W2064245474","https://openalex.org/W2169353806","https://openalex.org/W2290257786","https://openalex.org/W2731772132","https://openalex.org/W2911080438","https://openalex.org/W2973874240","https://openalex.org/W3016487776","https://openalex.org/W3049514734","https://openalex.org/W3063389502","https://openalex.org/W3105990167","https://openalex.org/W3115349904","https://openalex.org/W3124032441","https://openalex.org/W3176741930","https://openalex.org/W3199044409","https://openalex.org/W4200434061","https://openalex.org/W4213020415","https://openalex.org/W4221019135","https://openalex.org/W4285741997","https://openalex.org/W4294216483","https://openalex.org/W4311574913","https://openalex.org/W4367299431","https://openalex.org/W4376616107","https://openalex.org/W4386143179","https://openalex.org/W4386947491","https://openalex.org/W4391972850","https://openalex.org/W4393216162","https://openalex.org/W4395067121","https://openalex.org/W4396226314","https://openalex.org/W4401122255","https://openalex.org/W4401345921","https://openalex.org/W4401494485","https://openalex.org/W4402052663","https://openalex.org/W4402251496","https://openalex.org/W4404493924","https://openalex.org/W4404567953","https://openalex.org/W4405366397","https://openalex.org/W4405591931","https://openalex.org/W4405983122","https://openalex.org/W4406053244","https://openalex.org/W4407046006","https://openalex.org/W4407195989","https://openalex.org/W4407281991","https://openalex.org/W4407633973","https://openalex.org/W4408131282","https://openalex.org/W4408177269","https://openalex.org/W4408265481","https://openalex.org/W4408297464","https://openalex.org/W4408407090","https://openalex.org/W4408421679","https://openalex.org/W4409235363","https://openalex.org/W4409523079"],"related_works":["https://openalex.org/W2789871051","https://openalex.org/W2411601854","https://openalex.org/W3029098362","https://openalex.org/W2350745226","https://openalex.org/W3178651159","https://openalex.org/W2369510609","https://openalex.org/W2109188472","https://openalex.org/W561124343","https://openalex.org/W1989961712","https://openalex.org/W2068041970"],"abstract_inverted_index":{"This":[0],"study":[1,32],"established":[2],"a":[3,19,34],"predictive":[4],"model":[5],"for":[6,38],"early-stage":[7],"NAFLD":[8],"through":[9],"the":[10],"integration":[11],"of":[12],"bioinformatics":[13],"and":[14,23],"machine":[15],"learning":[16],"approaches,":[17],"with":[18],"focus":[20],"on":[21],"immune-":[22],"MDD-related":[24],"genes.":[25],"The":[26],"eight-gene":[27],"signature":[28],"identified":[29],"in":[30,46],"this":[31],"represents":[33],"novel":[35],"diagnostic":[36],"tool":[37],"precision":[39],"medicine,":[40],"enabling":[41],"targeted":[42],"psychological":[43],"nursing":[44],"intervention":[45],"comorbid":[47],"populations.":[48]},"counts_by_year":[],"updated_date":"2026-04-21T08:09:41.155169","created_date":"2025-10-10T00:00:00"}