{"id":"https://openalex.org/W4395006669","doi":"https://doi.org/10.3389/frobt.2024.1287446","title":"Soft bioreactor systems: a necessary step toward engineered MSK soft tissue?","display_name":"Soft bioreactor systems: a necessary step toward engineered MSK soft tissue?","publication_year":2024,"publication_date":"2024-04-22","ids":{"openalex":"https://openalex.org/W4395006669","doi":"https://doi.org/10.3389/frobt.2024.1287446","pmid":"https://pubmed.ncbi.nlm.nih.gov/38711813"},"language":"en","primary_location":{"id":"doi:10.3389/frobt.2024.1287446","is_oa":true,"landing_page_url":"https://doi.org/10.3389/frobt.2024.1287446","pdf_url":"https://www.frontiersin.org/articles/10.3389/frobt.2024.1287446/pdf?isPublishedV2=False","source":{"id":"https://openalex.org/S2595095599","display_name":"Frontiers in Robotics and AI","issn_l":"2296-9144","issn":["2296-9144"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Robotics and AI","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/articles/10.3389/frobt.2024.1287446/pdf?isPublishedV2=False","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5043797325","display_name":"Nicole Dvorak","orcid":"https://orcid.org/0000-0001-9495-2536"},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Nicole Dvorak","raw_affiliation_strings":["Botnar Institute of Musculoskeletal Sciences, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Botnar Institute of Musculoskeletal Sciences, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, United Kingdom","institution_ids":["https://openalex.org/I40120149"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100430587","display_name":"Zekun Liu","orcid":"https://orcid.org/0000-0003-1016-6752"},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Zekun Liu","raw_affiliation_strings":["Botnar Institute of Musculoskeletal Sciences, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Botnar Institute of Musculoskeletal Sciences, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, United Kingdom","institution_ids":["https://openalex.org/I40120149"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5048200279","display_name":"Pierre\u2010Alexis Mouthuy","orcid":"https://orcid.org/0000-0003-1192-6362"},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Pierre-Alexis Mouthuy","raw_affiliation_strings":["Botnar Institute of Musculoskeletal Sciences, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Botnar Institute of Musculoskeletal Sciences, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, United Kingdom","institution_ids":["https://openalex.org/I40120149"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I40120149"],"apc_list":{"value":2125,"currency":"USD","value_usd":2125},"apc_paid":{"value":2125,"currency":"USD","value_usd":2125},"fwci":1.8982,"has_fulltext":false,"cited_by_count":15,"citation_normalized_percentile":{"value":0.84861378,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":94,"max":99},"biblio":{"volume":"11","issue":null,"first_page":"1287446","last_page":"1287446"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11190","display_name":"3D Printing in Biomedical Research","score":0.9987999796867371,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11190","display_name":"3D Printing in Biomedical Research","score":0.9987999796867371,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":0.9980999827384949,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11068","display_name":"Tendon Structure and Treatment","score":0.9973000288009644,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bioreactor","display_name":"Bioreactor","score":0.8470656275749207},{"id":"https://openalex.org/keywords/soft-tissue","display_name":"Soft tissue","score":0.6574265360832214},{"id":"https://openalex.org/keywords/mechanotransduction","display_name":"Mechanotransduction","score":0.5972151756286621},{"id":"https://openalex.org/keywords/biomedical-engineering","display_name":"Biomedical engineering","score":0.564591109752655},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5536978244781494},{"id":"https://openalex.org/keywords/tissue-engineering","display_name":"Tissue engineering","score":0.5386549830436707},{"id":"https://openalex.org/keywords/materials-science","display_name":"Materials science","score":0.4026806652545929},{"id":"https://openalex.org/keywords/biochemical-engineering","display_name":"Biochemical engineering","score":0.3979288339614868},{"id":"https://openalex.org/keywords/nanotechnology","display_name":"Nanotechnology","score":0.3346385359764099},{"id":"https://openalex.org/keywords/cell-biology","display_name":"Cell biology","score":0.18340927362442017},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.16377288103103638},{"id":"https://openalex.org/keywords/engineering","display_name":"Engineering","score":0.16011154651641846},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.12911880016326904},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.12735068798065186},{"id":"https://openalex.org/keywords/pathology","display_name":"Pathology","score":0.11288520693778992}],"concepts":[{"id":"https://openalex.org/C168170006","wikidata":"https://www.wikidata.org/wiki/Q864699","display_name":"Bioreactor","level":2,"score":0.8470656275749207},{"id":"https://openalex.org/C136948725","wikidata":"https://www.wikidata.org/wiki/Q1458306","display_name":"Soft tissue","level":2,"score":0.6574265360832214},{"id":"https://openalex.org/C181104049","wikidata":"https://www.wikidata.org/wiki/Q11936292","display_name":"Mechanotransduction","level":2,"score":0.5972151756286621},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.564591109752655},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5536978244781494},{"id":"https://openalex.org/C49892992","wikidata":"https://www.wikidata.org/wiki/Q1540285","display_name":"Tissue engineering","level":2,"score":0.5386549830436707},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.4026806652545929},{"id":"https://openalex.org/C183696295","wikidata":"https://www.wikidata.org/wiki/Q2487696","display_name":"Biochemical engineering","level":1,"score":0.3979288339614868},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.3346385359764099},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.18340927362442017},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.16377288103103638},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.16011154651641846},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.12911880016326904},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.12735068798065186},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.11288520693778992},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.3389/frobt.2024.1287446","is_oa":true,"landing_page_url":"https://doi.org/10.3389/frobt.2024.1287446","pdf_url":"https://www.frontiersin.org/articles/10.3389/frobt.2024.1287446/pdf?isPublishedV2=False","source":{"id":"https://openalex.org/S2595095599","display_name":"Frontiers in Robotics and AI","issn_l":"2296-9144","issn":["2296-9144"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Robotics and AI","raw_type":"journal-article"},{"id":"pmid:38711813","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38711813","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in robotics and AI","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:11070535","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11070535","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Front Robot AI","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:454c61a53b104352bae2936499ac2d19","is_oa":true,"landing_page_url":"https://doaj.org/article/454c61a53b104352bae2936499ac2d19","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Robotics and AI, Vol 11 (2024)","raw_type":"article"},{"id":"pmh:oai:ora.ox.ac.uk:uuid:026d6f50-71c0-4ae7-a506-fab4a8c6fa71","is_oa":true,"landing_page_url":"https://ora.ox.ac.uk/objects/uuid:026d6f50-71c0-4ae7-a506-fab4a8c6fa71","pdf_url":null,"source":{"id":"https://openalex.org/S4306402636","display_name":"Oxford University Research Archive (ORA) (University of Oxford)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I40120149","host_organization_name":"University of Oxford","host_organization_lineage":["https://openalex.org/I40120149"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Jisc Publications Router","raw_type":"Journal article"}],"best_oa_location":{"id":"doi:10.3389/frobt.2024.1287446","is_oa":true,"landing_page_url":"https://doi.org/10.3389/frobt.2024.1287446","pdf_url":"https://www.frontiersin.org/articles/10.3389/frobt.2024.1287446/pdf?isPublishedV2=False","source":{"id":"https://openalex.org/S2595095599","display_name":"Frontiers in Robotics and AI","issn_l":"2296-9144","issn":["2296-9144"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Robotics and AI","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G5019173372","display_name":null,"funder_award_id":"EP/S003509/1","funder_id":"https://openalex.org/F4320334627","funder_display_name":"Engineering and Physical Sciences Research Council"},{"id":"https://openalex.org/G892181760","display_name":"Developing a humanoid bioreactor for tendon tissue engineering","funder_award_id":"EP/S003509/1","funder_id":"https://openalex.org/F4320334627","funder_display_name":"Engineering and Physical Sciences Research Council"}],"funders":[{"id":"https://openalex.org/F4320334627","display_name":"Engineering and Physical Sciences Research Council","ror":"https://ror.org/0439y7842"}],"has_content":{"grobid_xml":false,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4395006669.pdf"},"referenced_works_count":97,"referenced_works":["https://openalex.org/W1965498876","https://openalex.org/W1971379590","https://openalex.org/W1983289006","https://openalex.org/W1985670094","https://openalex.org/W2003363236","https://openalex.org/W2009376981","https://openalex.org/W2014518303","https://openalex.org/W2015288910","https://openalex.org/W2019856728","https://openalex.org/W2031584504","https://openalex.org/W2045189754","https://openalex.org/W2046684918","https://openalex.org/W2048597798","https://openalex.org/W2049461839","https://openalex.org/W2052924574","https://openalex.org/W2054635074","https://openalex.org/W2054958748","https://openalex.org/W2056657609","https://openalex.org/W2060527458","https://openalex.org/W2061523780","https://openalex.org/W2061801043","https://openalex.org/W2063406754","https://openalex.org/W2064712328","https://openalex.org/W2068728232","https://openalex.org/W2073525296","https://openalex.org/W2076922024","https://openalex.org/W2079574144","https://openalex.org/W2085543001","https://openalex.org/W2088165442","https://openalex.org/W2092899908","https://openalex.org/W2097122352","https://openalex.org/W2107275638","https://openalex.org/W2107648723","https://openalex.org/W2125029135","https://openalex.org/W2135994829","https://openalex.org/W2143873872","https://openalex.org/W2148569407","https://openalex.org/W2150387617","https://openalex.org/W2152002380","https://openalex.org/W2159036527","https://openalex.org/W2166647329","https://openalex.org/W2251612691","https://openalex.org/W2293592835","https://openalex.org/W2417076365","https://openalex.org/W2508739522","https://openalex.org/W2515634125","https://openalex.org/W2525001998","https://openalex.org/W2526364304","https://openalex.org/W2536317493","https://openalex.org/W2552580603","https://openalex.org/W2560150837","https://openalex.org/W2561609334","https://openalex.org/W2574063486","https://openalex.org/W2589073573","https://openalex.org/W2609841734","https://openalex.org/W2610630393","https://openalex.org/W2611750397","https://openalex.org/W2666165171","https://openalex.org/W2738764043","https://openalex.org/W2741282806","https://openalex.org/W2753413765","https://openalex.org/W2758001714","https://openalex.org/W2762502468","https://openalex.org/W2770569110","https://openalex.org/W2782195676","https://openalex.org/W2799344841","https://openalex.org/W2804579221","https://openalex.org/W2891077138","https://openalex.org/W2904564429","https://openalex.org/W2907538915","https://openalex.org/W2914507740","https://openalex.org/W2915926893","https://openalex.org/W2935837026","https://openalex.org/W3016833507","https://openalex.org/W3122106955","https://openalex.org/W3148153035","https://openalex.org/W3169374567","https://openalex.org/W3188269205","https://openalex.org/W3194244841","https://openalex.org/W3204548867","https://openalex.org/W4206371638","https://openalex.org/W4213055289","https://openalex.org/W4221085690","https://openalex.org/W4224238526","https://openalex.org/W4240820104","https://openalex.org/W4253886253","https://openalex.org/W4281740091","https://openalex.org/W4292483049","https://openalex.org/W4293072238","https://openalex.org/W4295008352","https://openalex.org/W4295897009","https://openalex.org/W4308871335","https://openalex.org/W4378783149","https://openalex.org/W4385476004","https://openalex.org/W4388778083","https://openalex.org/W4390882130","https://openalex.org/W4391830932"],"related_works":["https://openalex.org/W1980740090","https://openalex.org/W2818141943","https://openalex.org/W1847492452","https://openalex.org/W2100993833","https://openalex.org/W4285187183","https://openalex.org/W2552994593","https://openalex.org/W2892231651","https://openalex.org/W19926866","https://openalex.org/W2092409665","https://openalex.org/W2376673900"],"abstract_inverted_index":{"A":[0],"key":[1],"objective":[2],"of":[3,33,79,106,119,126,132,233,244,254,265,274],"tissue":[4,73,138,182,277],"engineering":[5],"(TE)":[6],"is":[7,56],"to":[8,38,71,93,142,158,168,171,261,271],"produce":[9],"in":[10,21,42,86,102,140,149,226,247],"vitro":[11],"funcional":[12],"grafts":[13,109],"that":[14,60,204,214],"can":[15,64,205,215],"replace":[16],"damaged":[17],"tissues":[18,48],"or":[19,195],"organs":[20],"patients.":[22],"TE":[23],"uses":[24],"bioreactors,":[25,163],"which":[26,164,223],"are":[27,89,165,257],"controlled":[28],"environments,":[29],"allowing":[30],"the":[31,87,103,111,124,145,156,218,262],"application":[32,125],"physical":[34],"and":[35,53,75,97,135,177,207,220,237,240,251,268],"biochemical":[36],"cues":[37],"relevant":[39,174],"cells":[40],"growing":[41],"biomaterials.":[43],"For":[44],"soft":[45,188,197,202,211,221,245,276],"musculoskeletal":[46],"(MSK)":[47],"such":[49,199,255],"as":[50,200],"tendons,":[51],"ligaments":[52],"cartilage,":[54],"it":[55],"now":[57],"well":[58],"established":[59],"applied":[61,85],"mechanical":[62,83],"stresses":[63,84,131,176],"be":[65,99],"incorporated":[66],"into":[67],"those":[68,94],"bioreactor":[69],"systems":[70,256],"support":[72],"growth":[74],"maturation":[76],"via":[77],"activation":[78],"mechanotransduction":[80],"pathways.":[81],"However,":[82],"laboratory":[88],"often":[90,166],"oversimplified":[91],"compared":[92],"found":[95],"physiologically":[96,173],"may":[98],"a":[100],"factor":[101],"slow":[104],"progression":[105],"engineered":[107,278],"MSK":[108,248],"towards":[110],"clinic.":[112],"In":[113],"recent":[114,242],"years,":[115],"an":[116],"increasing":[117],"number":[118],"studies":[120,153],"have":[121,154,190],"focused":[122],"on":[123,137,181],"complex":[127],"loading":[128],"conditions,":[129],"applying":[130],"different":[133],"types":[134,232],"direction":[136],"constructs,":[139],"order":[141],"better":[143],"mimic":[144],"cellular":[146],"environment":[147],"experienced":[148],"vivo":[150],".":[151,228],"Such":[152],"highlighted":[155],"need":[157],"improve":[159],"upon":[160],"traditional":[161,234],"rigid":[162,235],"limited":[167],"uniaxial":[169],"loading,":[170],"apply":[172],"multiaxial":[175],"elucidate":[178],"their":[179,238,269],"influence":[180],"maturation.":[183],"To":[184],"address":[185],"this":[186],"need,":[187],"bioreactors":[189,236,246],"emerged.":[191],"They":[192],"employ":[193],"one":[194],"more":[196],"components,":[198],"flexible":[201],"chambers":[203],"twist":[206],"bend":[208,216],"with":[209,217],"actuation,":[210],"compliant":[212],"actuators":[213],"construct,":[219],"sensors":[222],"record":[224],"measurements":[225],"situ":[227],"This":[229],"review":[230],"examines":[231],"shortcomings,":[239],"highlights":[241],"advances":[243],"TE.":[249],"Challenges":[250],"future":[252],"applications":[253],"discussed,":[258],"drawing":[259],"attention":[260],"exciting":[263],"prospect":[264],"these":[266],"platforms":[267],"ability":[270],"aid":[272],"development":[273],"functional":[275],"grafts.":[279]},"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":2}],"updated_date":"2026-07-23T08:03:31.855105","created_date":"2025-10-10T00:00:00"}