{"id":"https://openalex.org/W4406188930","doi":"https://doi.org/10.3389/frai.2024.1444127","title":"Developing and validating a drug recommendation system based on tumor microenvironment and drug fingerprint","display_name":"Developing and validating a drug recommendation system based on tumor microenvironment and drug fingerprint","publication_year":2025,"publication_date":"2025-01-08","ids":{"openalex":"https://openalex.org/W4406188930","doi":"https://doi.org/10.3389/frai.2024.1444127","pmid":"https://pubmed.ncbi.nlm.nih.gov/39850847"},"language":"en","primary_location":{"id":"doi:10.3389/frai.2024.1444127","is_oa":true,"landing_page_url":"https://doi.org/10.3389/frai.2024.1444127","pdf_url":"https://www.frontiersin.org/journals/artificial-intelligence/articles/10.3389/frai.2024.1444127/pdf","source":{"id":"https://openalex.org/S4210197006","display_name":"Frontiers in Artificial Intelligence","issn_l":"2624-8212","issn":["2624-8212"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Artificial Intelligence","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/journals/artificial-intelligence/articles/10.3389/frai.2024.1444127/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100322838","display_name":"Yan Wang","orcid":"https://orcid.org/0000-0002-9232-2212"},"institutions":[{"id":"https://openalex.org/I4210127460","display_name":"Ningxia Medical University","ror":"https://ror.org/02h8a1848","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210127460"]},{"id":"https://openalex.org/I4210139449","display_name":"Ningxia Medical University General Hospital","ror":"https://ror.org/049dkqr57","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210139449"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yan Wang","raw_affiliation_strings":["Department of Medical Oncology, General Hospital of Ningxia Medical University, Yinchuan, China"],"affiliations":[{"raw_affiliation_string":"Department of Medical Oncology, General Hospital of Ningxia Medical University, Yinchuan, China","institution_ids":["https://openalex.org/I4210139449","https://openalex.org/I4210127460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001563179","display_name":"Xiaoye Jin","orcid":"https://orcid.org/0000-0002-4044-7486"},"institutions":[{"id":"https://openalex.org/I4210127460","display_name":"Ningxia Medical University","ror":"https://ror.org/02h8a1848","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210127460"]},{"id":"https://openalex.org/I4210139449","display_name":"Ningxia Medical University General Hospital","ror":"https://ror.org/049dkqr57","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210139449"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaoye Jin","raw_affiliation_strings":["Department of Medical Oncology, General Hospital of Ningxia Medical University, Yinchuan, China"],"affiliations":[{"raw_affiliation_string":"Department of Medical Oncology, General Hospital of Ningxia Medical University, Yinchuan, China","institution_ids":["https://openalex.org/I4210139449","https://openalex.org/I4210127460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035159374","display_name":"Rui Qiu","orcid":"https://orcid.org/0000-0002-3511-6164"},"institutions":[{"id":"https://openalex.org/I4210127460","display_name":"Ningxia Medical University","ror":"https://ror.org/02h8a1848","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210127460"]},{"id":"https://openalex.org/I4210139449","display_name":"Ningxia Medical University General Hospital","ror":"https://ror.org/049dkqr57","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210139449"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Rui Qiu","raw_affiliation_strings":["General Thoracic Surgery, General Hospital of Ningxia Medical University, Yinchuan, China"],"affiliations":[{"raw_affiliation_string":"General Thoracic Surgery, General Hospital of Ningxia Medical University, Yinchuan, China","institution_ids":["https://openalex.org/I4210139449","https://openalex.org/I4210127460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100736388","display_name":"Bo Ma","orcid":"https://orcid.org/0000-0003-4948-4897"},"institutions":[{"id":"https://openalex.org/I4210127460","display_name":"Ningxia Medical University","ror":"https://ror.org/02h8a1848","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210127460"]},{"id":"https://openalex.org/I4210139449","display_name":"Ningxia Medical University General Hospital","ror":"https://ror.org/049dkqr57","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210139449"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Bo Ma","raw_affiliation_strings":["General Thoracic Surgery, General Hospital of Ningxia Medical University, Yinchuan, China"],"affiliations":[{"raw_affiliation_string":"General Thoracic Surgery, General Hospital of Ningxia Medical University, Yinchuan, China","institution_ids":["https://openalex.org/I4210139449","https://openalex.org/I4210127460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100394006","display_name":"Sheng Zhang","orcid":"https://orcid.org/0000-0002-0692-8999"},"institutions":[{"id":"https://openalex.org/I4210127460","display_name":"Ningxia Medical University","ror":"https://ror.org/02h8a1848","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210127460"]},{"id":"https://openalex.org/I4210139449","display_name":"Ningxia Medical University General Hospital","ror":"https://ror.org/049dkqr57","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210139449"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Sheng Zhang","raw_affiliation_strings":["General Thoracic Surgery, General Hospital of Ningxia Medical University, Yinchuan, China"],"affiliations":[{"raw_affiliation_string":"General Thoracic Surgery, General Hospital of Ningxia Medical University, Yinchuan, China","institution_ids":["https://openalex.org/I4210139449","https://openalex.org/I4210127460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103102617","display_name":"Xuyang Song","orcid":"https://orcid.org/0000-0002-4961-0956"},"institutions":[{"id":"https://openalex.org/I4210127460","display_name":"Ningxia Medical University","ror":"https://ror.org/02h8a1848","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210127460"]},{"id":"https://openalex.org/I4210139449","display_name":"Ningxia Medical University General Hospital","ror":"https://ror.org/049dkqr57","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210139449"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xuyang Song","raw_affiliation_strings":["General Thoracic Surgery, General Hospital of Ningxia Medical University, Yinchuan, China"],"affiliations":[{"raw_affiliation_string":"General Thoracic Surgery, General Hospital of Ningxia Medical University, Yinchuan, China","institution_ids":["https://openalex.org/I4210139449","https://openalex.org/I4210127460"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101807003","display_name":"Jinxi He","orcid":"https://orcid.org/0000-0001-8377-5474"},"institutions":[{"id":"https://openalex.org/I4210127460","display_name":"Ningxia Medical University","ror":"https://ror.org/02h8a1848","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210127460"]},{"id":"https://openalex.org/I4210139449","display_name":"Ningxia Medical University General Hospital","ror":"https://ror.org/049dkqr57","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210139449"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Jinxi He","raw_affiliation_strings":["General Thoracic Surgery, General Hospital of Ningxia Medical University, Yinchuan, China"],"affiliations":[{"raw_affiliation_string":"General Thoracic Surgery, General Hospital of Ningxia Medical University, Yinchuan, China","institution_ids":["https://openalex.org/I4210139449","https://openalex.org/I4210127460"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5101807003"],"corresponding_institution_ids":["https://openalex.org/I4210127460","https://openalex.org/I4210139449"],"apc_list":{"value":1150,"currency":"USD","value_usd":1150},"apc_paid":{"value":1150,"currency":"USD","value_usd":1150},"fwci":3.2452,"has_fulltext":true,"cited_by_count":2,"citation_normalized_percentile":{"value":0.90059908,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":91,"max":99},"biblio":{"volume":"7","issue":null,"first_page":"1444127","last_page":"1444127"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9991000294685364,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9991000294685364,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10755","display_name":"HER2/EGFR in Cancer Research","score":0.9909999966621399,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11190","display_name":"3D Printing in Biomedical Research","score":0.9871000051498413,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/drug","display_name":"Drug","score":0.7872547507286072},{"id":"https://openalex.org/keywords/fingerprint","display_name":"Fingerprint (computing)","score":0.6522641181945801},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.4278596043586731},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.42545953392982483},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.3977188467979431},{"id":"https://openalex.org/keywords/pharmacology","display_name":"Pharmacology","score":0.33016741275787354},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.2179032266139984},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.11269494891166687}],"concepts":[{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.7872547507286072},{"id":"https://openalex.org/C2777826928","wikidata":"https://www.wikidata.org/wiki/Q3745713","display_name":"Fingerprint (computing)","level":2,"score":0.6522641181945801},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4278596043586731},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.42545953392982483},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3977188467979431},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.33016741275787354},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2179032266139984},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.11269494891166687}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3389/frai.2024.1444127","is_oa":true,"landing_page_url":"https://doi.org/10.3389/frai.2024.1444127","pdf_url":"https://www.frontiersin.org/journals/artificial-intelligence/articles/10.3389/frai.2024.1444127/pdf","source":{"id":"https://openalex.org/S4210197006","display_name":"Frontiers in Artificial Intelligence","issn_l":"2624-8212","issn":["2624-8212"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Artificial Intelligence","raw_type":"journal-article"},{"id":"pmid:39850847","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/39850847","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in artificial intelligence","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:11755346","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11755346","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11755346/pdf/frai-07-1444127.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Front Artif Intell","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:6d6eb5bb9ed74715ae84cf1c9dffd469","is_oa":true,"landing_page_url":"https://doaj.org/article/6d6eb5bb9ed74715ae84cf1c9dffd469","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Artificial Intelligence, Vol 7 (2025)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/frai.2024.1444127","is_oa":true,"landing_page_url":"https://doi.org/10.3389/frai.2024.1444127","pdf_url":"https://www.frontiersin.org/journals/artificial-intelligence/articles/10.3389/frai.2024.1444127/pdf","source":{"id":"https://openalex.org/S4210197006","display_name":"Frontiers in Artificial Intelligence","issn_l":"2624-8212","issn":["2624-8212"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Artificial Intelligence","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.6200000047683716}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4406188930.pdf","grobid_xml":"https://content.openalex.org/works/W4406188930.grobid-xml"},"referenced_works_count":41,"referenced_works":["https://openalex.org/W2416657206","https://openalex.org/W2731227355","https://openalex.org/W2900879758","https://openalex.org/W2944102963","https://openalex.org/W3001878481","https://openalex.org/W3003119869","https://openalex.org/W3005410912","https://openalex.org/W3030172556","https://openalex.org/W3048965072","https://openalex.org/W3112951420","https://openalex.org/W3134220725","https://openalex.org/W3134835510","https://openalex.org/W3154648057","https://openalex.org/W3156413581","https://openalex.org/W3174257788","https://openalex.org/W3181803118","https://openalex.org/W3189860492","https://openalex.org/W3195038684","https://openalex.org/W3196885036","https://openalex.org/W3197859722","https://openalex.org/W3200428569","https://openalex.org/W3214112664","https://openalex.org/W4200151051","https://openalex.org/W4220786742","https://openalex.org/W4220899591","https://openalex.org/W4285616761","https://openalex.org/W4285807163","https://openalex.org/W4291016560","https://openalex.org/W4306412305","https://openalex.org/W4309660361","https://openalex.org/W4310668250","https://openalex.org/W4311669723","https://openalex.org/W4313950064","https://openalex.org/W4315490524","https://openalex.org/W4319915103","https://openalex.org/W4323364240","https://openalex.org/W4360619137","https://openalex.org/W4362720298","https://openalex.org/W4379514015","https://openalex.org/W4384564636","https://openalex.org/W4386293515"],"related_works":["https://openalex.org/W2899084033","https://openalex.org/W2748952813","https://openalex.org/W3031052312","https://openalex.org/W4389568370","https://openalex.org/W3032375762","https://openalex.org/W1995515455","https://openalex.org/W2080531066","https://openalex.org/W3108674512","https://openalex.org/W1506200166","https://openalex.org/W1489783725"],"abstract_inverted_index":{"The":[0],"model":[1],"demonstrates":[2],"strong":[3],"performance":[4],"across":[5],"preclinical":[6,20],"datasets,":[7],"showing":[8],"its":[9],"potential":[10],"for":[11,32],"real-world":[12],"application":[13],"in":[14],"personalized":[15],"cancer":[16],"therapy.":[17],"By":[18],"bridging":[19],"IC<sub>50</sub>":[21],"and":[22],"clinical":[23],"BOR":[24],"endpoints,":[25],"this":[26],"approach":[27],"provides":[28],"a":[29],"promising":[30],"tool":[31],"optimizing":[33],"patient-specific":[34],"treatments.":[35]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1}],"updated_date":"2026-03-14T08:43:22.919905","created_date":"2025-10-10T00:00:00"}