{"id":"https://openalex.org/W4366223221","doi":"https://doi.org/10.3389/frai.2023.1153083","title":"Next generation immuno-oncology tumor profiling using a rapid, non-invasive, computational biophysics biomarker in early-stage breast cancer","display_name":"Next generation immuno-oncology tumor profiling using a rapid, non-invasive, computational biophysics biomarker in early-stage breast cancer","publication_year":2023,"publication_date":"2023-04-17","ids":{"openalex":"https://openalex.org/W4366223221","doi":"https://doi.org/10.3389/frai.2023.1153083","pmid":"https://pubmed.ncbi.nlm.nih.gov/37138891"},"language":"en","primary_location":{"id":"doi:10.3389/frai.2023.1153083","is_oa":true,"landing_page_url":"https://doi.org/10.3389/frai.2023.1153083","pdf_url":null,"source":{"id":"https://openalex.org/S4210197006","display_name":"Frontiers in Artificial Intelligence","issn_l":"2624-8212","issn":["2624-8212"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Artificial Intelligence","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.3389/frai.2023.1153083","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5039222783","display_name":"Daniel E. Cook","orcid":"https://orcid.org/0000-0003-3347-562X"},"institutions":[{"id":"https://openalex.org/I4210097780","display_name":"SimBiotic Software (United States)","ror":"https://ror.org/00tjkp068","country_code":"US","type":"company","lineage":["https://openalex.org/I4210097780"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daniel Cook","raw_affiliation_strings":["SimBioSys, Inc., Chicago, IL, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"SimBioSys, Inc., Chicago, IL, United States","institution_ids":["https://openalex.org/I4210097780"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044726515","display_name":"Matthew Biancalana","orcid":"https://orcid.org/0000-0002-1078-1838"},"institutions":[{"id":"https://openalex.org/I4210097780","display_name":"SimBiotic Software (United States)","ror":"https://ror.org/00tjkp068","country_code":"US","type":"company","lineage":["https://openalex.org/I4210097780"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Matthew Biancalana","raw_affiliation_strings":["SimBioSys, Inc., Chicago, IL, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"SimBioSys, Inc., Chicago, IL, United States","institution_ids":["https://openalex.org/I4210097780"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088544711","display_name":"Nicole Liadis","orcid":null},"institutions":[{"id":"https://openalex.org/I4210097780","display_name":"SimBiotic Software (United States)","ror":"https://ror.org/00tjkp068","country_code":"US","type":"company","lineage":["https://openalex.org/I4210097780"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nicole Liadis","raw_affiliation_strings":["SimBioSys, Inc., Chicago, IL, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"SimBioSys, Inc., Chicago, IL, United States","institution_ids":["https://openalex.org/I4210097780"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083063399","display_name":"Dorys Lopez Ramos","orcid":"https://orcid.org/0009-0008-1415-3135"},"institutions":[{"id":"https://openalex.org/I4210097780","display_name":"SimBiotic Software (United States)","ror":"https://ror.org/00tjkp068","country_code":"US","type":"company","lineage":["https://openalex.org/I4210097780"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dorys Lopez Ramos","raw_affiliation_strings":["SimBioSys, Inc., Chicago, IL, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"SimBioSys, Inc., Chicago, IL, United States","institution_ids":["https://openalex.org/I4210097780"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100385435","display_name":"Yuhan Zhang","orcid":"https://orcid.org/0009-0006-0178-9404"},"institutions":[{"id":"https://openalex.org/I4210097780","display_name":"SimBiotic Software (United States)","ror":"https://ror.org/00tjkp068","country_code":"US","type":"company","lineage":["https://openalex.org/I4210097780"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yuhan Zhang","raw_affiliation_strings":["SimBioSys, Inc., Chicago, IL, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"SimBioSys, Inc., Chicago, IL, United States","institution_ids":["https://openalex.org/I4210097780"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087002800","display_name":"Snehal Patel","orcid":"https://orcid.org/0000-0002-5002-7530"},"institutions":[{"id":"https://openalex.org/I4210097780","display_name":"SimBiotic Software (United States)","ror":"https://ror.org/00tjkp068","country_code":"US","type":"company","lineage":["https://openalex.org/I4210097780"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Snehal Patel","raw_affiliation_strings":["SimBioSys, Inc., Chicago, IL, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"SimBioSys, Inc., Chicago, IL, United States","institution_ids":["https://openalex.org/I4210097780"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013297291","display_name":"J.R. Peterson","orcid":"https://orcid.org/0000-0003-0989-5288"},"institutions":[{"id":"https://openalex.org/I4210097780","display_name":"SimBiotic Software (United States)","ror":"https://ror.org/00tjkp068","country_code":"US","type":"company","lineage":["https://openalex.org/I4210097780"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joseph R. Peterson","raw_affiliation_strings":["SimBioSys, Inc., Chicago, IL, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"SimBioSys, Inc., Chicago, IL, United States","institution_ids":["https://openalex.org/I4210097780"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102788918","display_name":"John R. Pfeiffer","orcid":"https://orcid.org/0000-0001-8258-8757"},"institutions":[{"id":"https://openalex.org/I4210097780","display_name":"SimBiotic Software (United States)","ror":"https://ror.org/00tjkp068","country_code":"US","type":"company","lineage":["https://openalex.org/I4210097780"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John R. Pfeiffer","raw_affiliation_strings":["SimBioSys, Inc., Chicago, IL, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"SimBioSys, Inc., Chicago, IL, United States","institution_ids":["https://openalex.org/I4210097780"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061391746","display_name":"John A. Cole","orcid":null},"institutions":[{"id":"https://openalex.org/I4210097780","display_name":"SimBiotic Software (United States)","ror":"https://ror.org/00tjkp068","country_code":"US","type":"company","lineage":["https://openalex.org/I4210097780"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John A. Cole","raw_affiliation_strings":["SimBioSys, Inc., Chicago, IL, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"SimBioSys, Inc., Chicago, IL, United States","institution_ids":["https://openalex.org/I4210097780"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5074667589","display_name":"Anuja K. Antony","orcid":"https://orcid.org/0009-0002-7074-7727"},"institutions":[{"id":"https://openalex.org/I4210097780","display_name":"SimBiotic Software (United States)","ror":"https://ror.org/00tjkp068","country_code":"US","type":"company","lineage":["https://openalex.org/I4210097780"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Anuja K. Antony","raw_affiliation_strings":["SimBioSys, Inc., Chicago, IL, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"SimBioSys, Inc., Chicago, IL, United States","institution_ids":["https://openalex.org/I4210097780"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5074667589"],"corresponding_institution_ids":["https://openalex.org/I4210097780"],"apc_list":{"value":2125,"currency":"USD","value_usd":2125},"apc_paid":{"value":2125,"currency":"USD","value_usd":2125},"fwci":0.6811,"has_fulltext":true,"cited_by_count":6,"citation_normalized_percentile":{"value":0.68494123,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":94,"max":98},"biblio":{"volume":"6","issue":null,"first_page":"1153083","last_page":"1153083"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.38359999656677246,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.38359999656677246,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12422","display_name":"Radiomics and Machine Learning in Medical Imaging","score":0.3506999909877777,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11289","display_name":"Single-cell and spatial transcriptomics","score":0.04390000179409981,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/breast-cancer","display_name":"Breast cancer","score":0.6760215759277344},{"id":"https://openalex.org/keywords/biomarker","display_name":"Biomarker","score":0.5737852454185486},{"id":"https://openalex.org/keywords/oncology","display_name":"Oncology","score":0.5607687830924988},{"id":"https://openalex.org/keywords/profiling","display_name":"Profiling (computer programming)","score":0.5493688583374023},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.5476030111312866},{"id":"https://openalex.org/keywords/stage","display_name":"Stage (stratigraphy)","score":0.4558069705963135},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.4361996054649353},{"id":"https://openalex.org/keywords/cancer","display_name":"Cancer","score":0.36093437671661377},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.21388298273086548},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.1263570487499237}],"concepts":[{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.6760215759277344},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.5737852454185486},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.5607687830924988},{"id":"https://openalex.org/C187191949","wikidata":"https://www.wikidata.org/wiki/Q1138496","display_name":"Profiling (computer programming)","level":2,"score":0.5493688583374023},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5476030111312866},{"id":"https://openalex.org/C146357865","wikidata":"https://www.wikidata.org/wiki/Q1123245","display_name":"Stage (stratigraphy)","level":2,"score":0.4558069705963135},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4361996054649353},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.36093437671661377},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.21388298273086548},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.1263570487499237},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3389/frai.2023.1153083","is_oa":true,"landing_page_url":"https://doi.org/10.3389/frai.2023.1153083","pdf_url":null,"source":{"id":"https://openalex.org/S4210197006","display_name":"Frontiers in Artificial Intelligence","issn_l":"2624-8212","issn":["2624-8212"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Artificial Intelligence","raw_type":"journal-article"},{"id":"pmid:37138891","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37138891","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in artificial intelligence","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10149754","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10149754","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10149754/pdf/frai-06-1153083.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Front Artif Intell","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:be8738fdce2d43f1bb22f5d1661eba9f","is_oa":true,"landing_page_url":"https://doaj.org/article/be8738fdce2d43f1bb22f5d1661eba9f","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Artificial Intelligence, Vol 6 (2023)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/frai.2023.1153083","is_oa":true,"landing_page_url":"https://doi.org/10.3389/frai.2023.1153083","pdf_url":null,"source":{"id":"https://openalex.org/S4210197006","display_name":"Frontiers in Artificial Intelligence","issn_l":"2624-8212","issn":["2624-8212"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Artificial Intelligence","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.800000011920929,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":52,"referenced_works":["https://openalex.org/W2034269086","https://openalex.org/W2044702943","https://openalex.org/W2079936875","https://openalex.org/W2096283457","https://openalex.org/W2112434826","https://openalex.org/W2117692326","https://openalex.org/W2136859769","https://openalex.org/W2215044613","https://openalex.org/W2233686346","https://openalex.org/W2560367415","https://openalex.org/W2909799373","https://openalex.org/W2943781197","https://openalex.org/W2945057866","https://openalex.org/W2982130750","https://openalex.org/W2982677033","https://openalex.org/W2998369814","https://openalex.org/W2998795792","https://openalex.org/W3000282923","https://openalex.org/W3000311037","https://openalex.org/W3005738019","https://openalex.org/W3006930853","https://openalex.org/W3010374810","https://openalex.org/W3018812011","https://openalex.org/W3022879989","https://openalex.org/W3038464575","https://openalex.org/W3088712245","https://openalex.org/W3092128963","https://openalex.org/W3095454157","https://openalex.org/W3112742208","https://openalex.org/W3173708769","https://openalex.org/W3187890850","https://openalex.org/W3199721029","https://openalex.org/W3202940825","https://openalex.org/W3207245637","https://openalex.org/W3207557929","https://openalex.org/W4205542251","https://openalex.org/W4206662285","https://openalex.org/W4210259304","https://openalex.org/W4212865994","https://openalex.org/W4220760684","https://openalex.org/W4225014905","https://openalex.org/W4225529913","https://openalex.org/W4225922055","https://openalex.org/W4226021421","https://openalex.org/W4281563307","https://openalex.org/W4282048214","https://openalex.org/W4283759126","https://openalex.org/W4289550364","https://openalex.org/W4293870361","https://openalex.org/W4294586439","https://openalex.org/W4310725957","https://openalex.org/W4311298376"],"related_works":["https://openalex.org/W2161444195","https://openalex.org/W2503350049","https://openalex.org/W2329386257","https://openalex.org/W2589019771","https://openalex.org/W2985540061","https://openalex.org/W2533581028","https://openalex.org/W2185012154","https://openalex.org/W2792951836","https://openalex.org/W2989121736","https://openalex.org/W2892677547"],"abstract_inverted_index":{"Background":[0],"Immuno-oncology":[1],"(IO)":[2],"therapies":[3],"targeting":[4],"the":[5,29,37,104,126,158,188,232],"PD-1/PD-L1":[6,127],"axis,":[7],"such":[8],"as":[9,17,155,157,317,319],"immune":[10],"checkpoint":[11],"inhibitor":[12],"(ICI)":[13],"antibodies,":[14],"have":[15],"emerged":[16],"promising":[18],"treatments":[19],"for":[20,67,263,267,338],"early-stage":[21],"breast":[22,222],"cancer":[23,223,289,309],"(ESBC).":[24],"Despite":[25],"immunotherapy's":[26],"clinical":[27,238,348],"significance,":[28],"number":[30],"of":[31,49,56,92,125,152,161,199,261,272,328,342],"benefiting":[32],"patients":[33,201],"remains":[34],"small,":[35,196],"and":[36,46,58,76,87,112,147,179,191,205,225,265,295,344],"therapy":[38],"can":[39],"prompt":[40],"severe":[41],"immune-related":[42],"events.":[43],"Current":[44],"pathologic":[45,208],"transcriptomic":[47,72],"predictions":[48],"IO":[50,100,162,273,332,340],"response":[51,101,210],"are":[52,74],"limited":[53],"in":[54,194,212,219,227,235,246,287,323],"terms":[55],"accuracy":[57],"rely":[59],"on":[60],"single-site":[61],"biopsies,":[62],"which":[63],"cannot":[64],"fully":[65],"account":[66],"tumor":[68,131,153],"heterogeneity.":[69],"In":[70],"addition,":[71],"analyses":[73],"costly":[75],"time-consuming.":[77],"We":[78,164,186,230],"therefore":[79],"constructed":[80],"a":[81,181,195,236,299,325],"computational":[82,314],"biomarker":[83,160,190,294,315,336],"coupling":[84],"biophysical":[85,139,305],"simulations":[86],"artificial":[88],"intelligence-based":[89],"tissue":[90],"segmentation":[91],"dynamic":[93],"contrast-enhanced":[94],"magnetic":[95],"resonance":[96],"imaging":[97],"(DCE-MRIs),":[98],"enabling":[99],"prediction":[102],"across":[103],"entire":[105],"tumor.":[106],"Methods":[107],"By":[108],"analyzing":[109],"both":[110,288],"single-cell":[111],"whole-tissue":[113],"RNA-seq":[114],"data":[115],"from":[116,142,282],"non-IO-treated":[117],"ESBC":[118],"patients,":[119],"we":[120,257],"associated":[121],"gene":[122],"expression":[123,134],"levels":[124,322],"axis":[128],"with":[129,270],"local":[130],"biology.":[132],"PD-L1":[133,320],"was":[135],"then":[136],"linked":[137],"to":[138,144,177,277,307,311,351],"features":[140],"derived":[141,281],"DCE-MRIs":[143],"generate":[145],"spatially-":[146],"temporally-resolved":[148],"atlases":[149],"(virtual":[150],"tumors)":[151],"biology,":[154],"well":[156,318],"TumorIO":[159,166,183,189,192,233,293,296,335],"response.":[163],"quantified":[165],"within":[167],"patient":[168],"virtual":[169,237],"tumors":[170,269,343],"(n":[171,202,240],"=":[172,203,241],"63)":[173],"using":[174,303],"integrative":[175,304],"modeling":[176],"train":[178],"develop":[180],"corresponding":[182],"Score.":[184],"Results":[185],"validated":[187],"Score":[193,234,297],"independent":[197],"cohort":[198,249],"IO-treated":[200],"17)":[204],"correctly":[206],"predicted":[207,258],"complete":[209],"(pCR)":[211],"15/17":[213],"individuals":[214],"(88.2%":[215],"accuracy),":[216],"comprising":[217],"10/12":[218],"triple":[220],"negative":[221],"(TNBC)":[224],"5/5":[226],"HR+/HER2-":[228,268],"tumors.":[229],"applied":[231],"trial":[239],"292)":[242],"simulating":[243],"ICI":[244,286],"administration":[245],"an":[247],"IO-na\u00efve":[248],"that":[250],"underwent":[251],"standard":[252],"chemotherapy.":[253],"Using":[254],"this":[255],"approach,":[256],"pCR":[259,279,329],"rates":[260,280],"67.1%":[262],"TNBC":[264],"17.9%":[266],"addition":[271],"therapy;":[274],"comparing":[275],"favorably":[276],"empiric":[278],"published":[283],"trials":[284],"utilizing":[285],"subtypes.":[290],"Conclusion":[291],"The":[292,334],"represent":[298],"next":[300],"generation":[301],"approach":[302],"analysis":[306],"assess":[308],"responsiveness":[310],"immunotherapy.":[312],"This":[313],"performs":[316],"transcript":[321],"identifying":[324],"patient's":[326],"likelihood":[327],"following":[330],"anti-PD-1":[331],"therapy.":[333],"allows":[337],"rapid":[339],"profiling":[341],"may":[345],"confer":[346],"high":[347],"decision":[349],"impact":[350],"further":[352],"enable":[353],"personalized":[354],"oncologic":[355],"care.":[356]},"counts_by_year":[{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":2}],"updated_date":"2026-08-28T12:50:07.497085","created_date":"2025-10-10T00:00:00"}