{"id":"https://openalex.org/W4401101958","doi":"https://doi.org/10.3389/fninf.2024.1429670","title":"LYNSU: automated 3D neuropil segmentation of fluorescent images for Drosophila brains","display_name":"LYNSU: automated 3D neuropil segmentation of fluorescent images for Drosophila brains","publication_year":2024,"publication_date":"2024-07-29","ids":{"openalex":"https://openalex.org/W4401101958","doi":"https://doi.org/10.3389/fninf.2024.1429670","pmid":"https://pubmed.ncbi.nlm.nih.gov/39135968"},"language":"en","primary_location":{"id":"doi:10.3389/fninf.2024.1429670","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fninf.2024.1429670","pdf_url":"https://www.frontiersin.org/journals/neuroinformatics/articles/10.3389/fninf.2024.1429670/pdf","source":{"id":"https://openalex.org/S179816892","display_name":"Frontiers in Neuroinformatics","issn_l":"1662-5196","issn":["1662-5196"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Neuroinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/journals/neuroinformatics/articles/10.3389/fninf.2024.1429670/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5054558926","display_name":"Kai-Yi Hsu","orcid":"https://orcid.org/0000-0002-0548-5671"},"institutions":[{"id":"https://openalex.org/I25846049","display_name":"National Tsing Hua University","ror":"https://ror.org/00zdnkx70","country_code":"TW","type":"education","lineage":["https://openalex.org/I25846049"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Kai-Yi Hsu","raw_affiliation_strings":["Institute of Systems Neuroscience, College of Life Science, National Tsing Hua University, Hsinchu, Taiwan"],"affiliations":[{"raw_affiliation_string":"Institute of Systems Neuroscience, College of Life Science, National Tsing Hua University, Hsinchu, Taiwan","institution_ids":["https://openalex.org/I25846049"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108426212","display_name":"Chi-Tin Shih","orcid":null},"institutions":[{"id":"https://openalex.org/I169090423","display_name":"Tunghai University","ror":"https://ror.org/00zhvdn11","country_code":"TW","type":"education","lineage":["https://openalex.org/I169090423"]},{"id":"https://openalex.org/I25846049","display_name":"National Tsing Hua University","ror":"https://ror.org/00zdnkx70","country_code":"TW","type":"education","lineage":["https://openalex.org/I25846049"]}],"countries":["TW"],"is_corresponding":true,"raw_author_name":"Chi-Tin Shih","raw_affiliation_strings":["Brain Research Center, National Tsing Hua University, Hsinchu, Taiwan","Department of Applied Physics, Tunghai University, Taichung, Taiwan"],"affiliations":[{"raw_affiliation_string":"Brain Research Center, National Tsing Hua University, Hsinchu, Taiwan","institution_ids":["https://openalex.org/I25846049"]},{"raw_affiliation_string":"Department of Applied Physics, Tunghai University, Taichung, Taiwan","institution_ids":["https://openalex.org/I169090423"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045195849","display_name":"Nan-Yow Chen","orcid":"https://orcid.org/0000-0001-8139-6809"},"institutions":[{"id":"https://openalex.org/I4210107525","display_name":"National Center for High-Performance Computing","ror":"https://ror.org/01jpzd518","country_code":"TW","type":"facility","lineage":["https://openalex.org/I4210107525","https://openalex.org/I4210128167","https://openalex.org/I4210166867"]},{"id":"https://openalex.org/I4210166867","display_name":"National Institutes of Applied Research","ror":"https://ror.org/05wcstg80","country_code":"TW","type":"government","lineage":["https://openalex.org/I4210128167","https://openalex.org/I4210166867"]}],"countries":["TW"],"is_corresponding":true,"raw_author_name":"Nan-Yow Chen","raw_affiliation_strings":["National Applied Research Laboratories, National Center for High-Performance Computing, Hsinchu, Taiwan"],"affiliations":[{"raw_affiliation_string":"National Applied Research Laboratories, National Center for High-Performance Computing, Hsinchu, Taiwan","institution_ids":["https://openalex.org/I4210166867","https://openalex.org/I4210107525"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5030409860","display_name":"Chung\u2010Chuan Lo","orcid":"https://orcid.org/0000-0001-7737-7250"},"institutions":[{"id":"https://openalex.org/I25846049","display_name":"National Tsing Hua University","ror":"https://ror.org/00zdnkx70","country_code":"TW","type":"education","lineage":["https://openalex.org/I25846049"]}],"countries":["TW"],"is_corresponding":true,"raw_author_name":"Chung-Chuan Lo","raw_affiliation_strings":["Brain Research Center, National Tsing Hua University, Hsinchu, Taiwan","Institute of Systems Neuroscience, College of Life Science, National Tsing Hua University, Hsinchu, Taiwan"],"affiliations":[{"raw_affiliation_string":"Brain Research Center, National Tsing Hua University, Hsinchu, Taiwan","institution_ids":["https://openalex.org/I25846049"]},{"raw_affiliation_string":"Institute of Systems Neuroscience, College of Life Science, National Tsing Hua University, Hsinchu, Taiwan","institution_ids":["https://openalex.org/I25846049"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5030409860","https://openalex.org/A5045195849","https://openalex.org/A5108426212"],"corresponding_institution_ids":["https://openalex.org/I169090423","https://openalex.org/I25846049","https://openalex.org/I4210107525","https://openalex.org/I4210166867"],"apc_list":{"value":2950,"currency":"USD","value_usd":2950},"apc_paid":{"value":2950,"currency":"USD","value_usd":2950},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.11583088,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"18","issue":null,"first_page":"1429670","last_page":"1429670"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10423","display_name":"Neurobiology and Insect Physiology Research","score":0.9973999857902527,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10423","display_name":"Neurobiology and Insect Physiology Research","score":0.9973999857902527,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12859","display_name":"Cell Image Analysis Techniques","score":0.9922000169754028,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10540","display_name":"Advanced Fluorescence Microscopy Techniques","score":0.9726999998092651,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/neuropil","display_name":"Neuropil","score":0.9496535062789917},{"id":"https://openalex.org/keywords/drosophila","display_name":"Drosophila (subgenus)","score":0.6518471837043762},{"id":"https://openalex.org/keywords/segmentation","display_name":"Segmentation","score":0.5938827991485596},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.48641085624694824},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.4816250205039978},{"id":"https://openalex.org/keywords/neuroscience","display_name":"Neuroscience","score":0.4470668137073517},{"id":"https://openalex.org/keywords/computer-vision","display_name":"Computer vision","score":0.43993157148361206},{"id":"https://openalex.org/keywords/fluorescence","display_name":"Fluorescence","score":0.43741676211357117},{"id":"https://openalex.org/keywords/pattern-recognition","display_name":"Pattern recognition (psychology)","score":0.3374866545200348},{"id":"https://openalex.org/keywords/anatomy","display_name":"Anatomy","score":0.33645135164260864},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.30859076976776123},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.05226430296897888},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.04275035858154297},{"id":"https://openalex.org/keywords/central-nervous-system","display_name":"Central nervous system","score":0.04094401001930237},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.04031452536582947}],"concepts":[{"id":"https://openalex.org/C2777831001","wikidata":"https://www.wikidata.org/wiki/Q1981429","display_name":"Neuropil","level":3,"score":0.9496535062789917},{"id":"https://openalex.org/C2776041557","wikidata":"https://www.wikidata.org/wiki/Q3715451","display_name":"Drosophila (subgenus)","level":3,"score":0.6518471837043762},{"id":"https://openalex.org/C89600930","wikidata":"https://www.wikidata.org/wiki/Q1423946","display_name":"Segmentation","level":2,"score":0.5938827991485596},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.48641085624694824},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.4816250205039978},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.4470668137073517},{"id":"https://openalex.org/C31972630","wikidata":"https://www.wikidata.org/wiki/Q844240","display_name":"Computer vision","level":1,"score":0.43993157148361206},{"id":"https://openalex.org/C91881484","wikidata":"https://www.wikidata.org/wiki/Q191807","display_name":"Fluorescence","level":2,"score":0.43741676211357117},{"id":"https://openalex.org/C153180895","wikidata":"https://www.wikidata.org/wiki/Q7148389","display_name":"Pattern recognition (psychology)","level":2,"score":0.3374866545200348},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.33645135164260864},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.30859076976776123},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.05226430296897888},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.04275035858154297},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.04094401001930237},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.04031452536582947},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3389/fninf.2024.1429670","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fninf.2024.1429670","pdf_url":"https://www.frontiersin.org/journals/neuroinformatics/articles/10.3389/fninf.2024.1429670/pdf","source":{"id":"https://openalex.org/S179816892","display_name":"Frontiers in Neuroinformatics","issn_l":"1662-5196","issn":["1662-5196"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Neuroinformatics","raw_type":"journal-article"},{"id":"pmid:39135968","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/39135968","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in neuroinformatics","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:11317296","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11317296","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11317296/pdf/fninf-18-1429670.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Front Neuroinform","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:61bf91e5636846aa95a9072585ae4cc3","is_oa":true,"landing_page_url":"https://doaj.org/article/61bf91e5636846aa95a9072585ae4cc3","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Neuroinformatics, Vol 18 (2024)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fninf.2024.1429670","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fninf.2024.1429670","pdf_url":"https://www.frontiersin.org/journals/neuroinformatics/articles/10.3389/fninf.2024.1429670/pdf","source":{"id":"https://openalex.org/S179816892","display_name":"Frontiers in Neuroinformatics","issn_l":"1662-5196","issn":["1662-5196"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Neuroinformatics","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G1133774806","display_name":null,"funder_award_id":"111-2311-B-007 -011 -MY3","funder_id":"https://openalex.org/F4320331164","funder_display_name":"National Science and Technology Council"},{"id":"https://openalex.org/G1497744952","display_name":null,"funder_award_id":"111-2221-E-492-022-","funder_id":"https://openalex.org/F4320331164","funder_display_name":"National Science and Technology Council"},{"id":"https://openalex.org/G2822332529","display_name":null,"funder_award_id":"112-2321-B-002-025 -","funder_id":"https://openalex.org/F4320331164","funder_display_name":"National Science and Technology Council"},{"id":"https://openalex.org/G4219974610","display_name":null,"funder_award_id":"112-2112-M-029-003","funder_id":"https://openalex.org/F4320331164","funder_display_name":"National Science and Technology Council"}],"funders":[{"id":"https://openalex.org/F4320331164","display_name":"National Science and Technology Council","ror":"https://ror.org/00wnb9798"}],"has_content":{"grobid_xml":false,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4401101958.pdf"},"referenced_works_count":39,"referenced_works":["https://openalex.org/W1999453501","https://openalex.org/W2152255315","https://openalex.org/W2167703052","https://openalex.org/W2169331639","https://openalex.org/W2171911690","https://openalex.org/W2395611524","https://openalex.org/W2567599812","https://openalex.org/W2778860560","https://openalex.org/W2885788335","https://openalex.org/W2901434856","https://openalex.org/W2927159910","https://openalex.org/W2949650786","https://openalex.org/W2978751237","https://openalex.org/W2980723154","https://openalex.org/W2999465534","https://openalex.org/W3009445070","https://openalex.org/W3011390968","https://openalex.org/W3081818272","https://openalex.org/W3098816831","https://openalex.org/W3114097778","https://openalex.org/W3138181109","https://openalex.org/W3164956625","https://openalex.org/W3168819595","https://openalex.org/W3180949453","https://openalex.org/W3215529416","https://openalex.org/W4200357479","https://openalex.org/W4281555405","https://openalex.org/W4284664944","https://openalex.org/W4298329379","https://openalex.org/W4300424419","https://openalex.org/W4302362619","https://openalex.org/W4304959187","https://openalex.org/W4308909683","https://openalex.org/W4316096019","https://openalex.org/W4318046676","https://openalex.org/W4320487943","https://openalex.org/W4366450291","https://openalex.org/W4388033291","https://openalex.org/W4391654869"],"related_works":["https://openalex.org/W3011015593","https://openalex.org/W3129538072","https://openalex.org/W4200293758","https://openalex.org/W2087283879","https://openalex.org/W2228671310","https://openalex.org/W2099934459","https://openalex.org/W2016942876","https://openalex.org/W2072194705","https://openalex.org/W2886692978","https://openalex.org/W1973601487"],"abstract_inverted_index":{"The":[0,319],"brain":[1,37,47,52,89,101,119,309],"atlas,":[2],"which":[3],"provides":[4],"information":[5],"about":[6,235],"the":[7,26,55,69,72,87,94,109,136,141,157,172,177,250,269,274,277,281,296,322,325,336],"distribution":[8,28],"of":[9,29,57,71,132,197,247,258,276,284,306,324,335],"genes,":[10],"proteins,":[11],"neurons,":[12],"or":[13,210],"anatomical":[14,330],"regions,":[15],"plays":[16],"a":[17,50,117,164,192,213,223,240,244,255],"crucial":[18],"role":[19],"in":[20,86,168,189,328],"contemporary":[21],"neuroscience":[22],"research.":[23],"To":[24,74,253],"analyze":[25],"spatial":[27,64],"those":[30],"substances":[31],"based":[32],"on":[33,206],"images":[34,48,92,153,198],"from":[35,93,199,268],"different":[36],"samples,":[38,310],"we":[39,78,139,175,260],"often":[40],"need":[41],"to":[42,49,63,104,116,144,181,218,229,238,263,272,290],"warp":[43],"and":[44,59,114,127,148,294,300,332],"register":[45],"individual":[46,110],"standard":[51,118],"template.":[53,120],"However,":[54],"process":[56],"warping":[58,113],"registration":[60],"may":[61],"lead":[62],"errors,":[65],"thereby":[66],"severely":[67],"reducing":[68],"accuracy":[70,166,188,216],"analysis.":[73],"address":[75],"this":[76],"issue,":[77],"develop":[79],"an":[80],"automated":[81],"method":[82,232,327],"for":[83,90,156,302],"segmenting":[84],"neuropils":[85,147,209],"<i>Drosophila</i>":[88,266,337],"fluorescence":[91],"<i>FlyCircuit</i>":[95,270],"database.":[96],"This":[97,161],"technique":[98],"allows":[99],"future":[100],"atlas":[102],"studies":[103],"be":[105],"conducted":[106],"accurately":[107],"at":[108],"level":[111,246],"without":[112],"aligning":[115],"Our":[121,231],"method,":[122],"LYNSU":[123,184,205,289],"(Locating":[124],"by":[125,129],"YOLO":[126],"Segmenting":[128],"U-Net),":[130],"consists":[131],"two":[133],"stages.":[134],"In":[135,171],"first":[137],"stage,":[138,174],"use":[140,256],"YOLOv7":[142],"model":[143,180],"quickly":[145],"locate":[146],"rapidly":[149],"extract":[150],"small-scale":[151],"3D":[152,178,224],"as":[154,249],"input":[155],"second":[158,173],"stage":[159,162],"model.":[160],"achieves":[163],"99.4%":[165],"rate":[167],"neuropil":[169,241],"localization.":[170],"employ":[176],"U-Net":[179],"segment":[182,239,291],"neuropils.":[183],"can":[185],"achieve":[186],"high":[187,214],"segmentation":[190,215],"using":[191],"small":[193],"training":[194],"set":[195],"consisting":[196],"merely":[200],"16":[201],"brains.":[202],"We":[203,287],"demonstrate":[204,254],"six":[207],"distinct":[208],"structures,":[211],"achieving":[212,243],"comparable":[217],"professional":[219],"manual":[220],"annotations":[221],"with":[222],"Intersection-over-Union":[225],"(IoU)":[226],"reaching":[227],"up":[228],"0.869.":[230],"takes":[233],"only":[234],"7":[236],"s":[237],"while":[242],"similar":[245],"performance":[248],"human":[251],"annotators.":[252],"case":[257],"LYNSU,":[259],"applied":[261],"it":[262],"all":[264],"female":[265],"brains":[267],"database":[271],"investigate":[273],"asymmetry":[275],"mushroom":[278],"bodies":[279],"(MBs),":[280],"learning":[282],"center":[283],"fruit":[285],"flies.":[286],"used":[288],"bilateral":[292,313],"MBs":[293],"compare":[295],"volumes":[297],"between":[298],"left":[299],"right":[301],"each":[303],"individual.":[304],"Notably,":[305],"8,703":[307],"valid":[308],"10.14%":[311],"showed":[312],"volume":[314],"differences":[315],"that":[316],"exceeded":[317],"10%.":[318],"study":[320],"demonstrated":[321],"potential":[323],"proposed":[326],"high-throughput":[329],"analysis":[331],"connectomics":[333],"construction":[334],"brain.":[338]},"counts_by_year":[],"updated_date":"2026-03-11T06:11:40.159057","created_date":"2025-10-10T00:00:00"}
