{"id":"https://openalex.org/W4392003043","doi":"https://doi.org/10.3389/fninf.2023.1244336","title":"Comparing feature selection and machine learning approaches for predicting CYP2D6 methylation from genetic variation","display_name":"Comparing feature selection and machine learning approaches for predicting CYP2D6 methylation from genetic variation","publication_year":2024,"publication_date":"2024-02-21","ids":{"openalex":"https://openalex.org/W4392003043","doi":"https://doi.org/10.3389/fninf.2023.1244336","pmid":"https://pubmed.ncbi.nlm.nih.gov/38449836"},"language":"en","primary_location":{"id":"doi:10.3389/fninf.2023.1244336","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fninf.2023.1244336","pdf_url":"https://www.frontiersin.org/articles/10.3389/fninf.2023.1244336/pdf?isPublishedV2=False","source":{"id":"https://openalex.org/S179816892","display_name":"Frontiers in Neuroinformatics","issn_l":"1662-5196","issn":["1662-5196"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Neuroinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/articles/10.3389/fninf.2023.1244336/pdf?isPublishedV2=False","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5104317722","display_name":"Wei Jing Fong","orcid":null},"institutions":[{"id":"https://openalex.org/I165932596","display_name":"National University of Singapore","ror":"https://ror.org/01tgyzw49","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Wei Jing Fong","raw_affiliation_strings":["Computational Biology, National University of Singapore, Singapore, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Computational Biology, National University of Singapore, Singapore, Singapore","institution_ids":["https://openalex.org/I165932596"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004602934","display_name":"Hong Ming Tan","orcid":"https://orcid.org/0000-0002-0363-0302"},"institutions":[{"id":"https://openalex.org/I165932596","display_name":"National University of Singapore","ror":"https://ror.org/01tgyzw49","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Hong Ming Tan","raw_affiliation_strings":["Computational Biology, National University of Singapore, Singapore, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Computational Biology, National University of Singapore, Singapore, Singapore","institution_ids":["https://openalex.org/I165932596"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100720830","display_name":"Rishabh Garg","orcid":"https://orcid.org/0000-0003-4224-4890"},"institutions":[{"id":"https://openalex.org/I165932596","display_name":"National University of Singapore","ror":"https://ror.org/01tgyzw49","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Rishabh Garg","raw_affiliation_strings":["Computational Biology, National University of Singapore, Singapore, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Computational Biology, National University of Singapore, Singapore, Singapore","institution_ids":["https://openalex.org/I165932596"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109306354","display_name":"Ai Ling Teh","orcid":null},"institutions":[{"id":"https://openalex.org/I115228651","display_name":"Agency for Science, Technology and Research","ror":"https://ror.org/036wvzt09","country_code":"SG","type":"government","lineage":["https://openalex.org/I115228651"]},{"id":"https://openalex.org/I4210101200","display_name":"Singapore Institute for Clinical Sciences","ror":"https://ror.org/015p9va32","country_code":"SG","type":"facility","lineage":["https://openalex.org/I115228651","https://openalex.org/I4210101200"]},{"id":"https://openalex.org/I4210148498","display_name":"Bioinformatics Institute","ror":"https://ror.org/044w3nw43","country_code":"SG","type":"facility","lineage":["https://openalex.org/I115228651","https://openalex.org/I2801752549","https://openalex.org/I4210148498"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Ai Ling Teh","raw_affiliation_strings":["Bioinformatics Institute (BII), Agency for Science, Technology and Research (A*STAR), Singapore, Singapore","Singapore Institute for Clinical Sciences (SICS), Agency for Science, Technology and Research (A*STAR), Singapore, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bioinformatics Institute (BII), Agency for Science, Technology and Research (A*STAR), Singapore, Singapore","institution_ids":["https://openalex.org/I115228651","https://openalex.org/I4210148498"]},{"raw_affiliation_string":"Singapore Institute for Clinical Sciences (SICS), Agency for Science, Technology and Research (A*STAR), Singapore, Singapore","institution_ids":["https://openalex.org/I4210101200","https://openalex.org/I115228651"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101441882","display_name":"Hong Pan","orcid":"https://orcid.org/0000-0003-3040-3452"},"institutions":[{"id":"https://openalex.org/I115228651","display_name":"Agency for Science, Technology and Research","ror":"https://ror.org/036wvzt09","country_code":"SG","type":"government","lineage":["https://openalex.org/I115228651"]},{"id":"https://openalex.org/I4210101200","display_name":"Singapore Institute for Clinical Sciences","ror":"https://ror.org/015p9va32","country_code":"SG","type":"facility","lineage":["https://openalex.org/I115228651","https://openalex.org/I4210101200"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Hong Pan","raw_affiliation_strings":["Singapore Institute for Clinical Sciences (SICS), Agency for Science, Technology and Research (A*STAR), Singapore, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Singapore Institute for Clinical Sciences (SICS), Agency for Science, Technology and Research (A*STAR), Singapore, Singapore","institution_ids":["https://openalex.org/I4210101200","https://openalex.org/I115228651"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033198954","display_name":"Varsha Gupta","orcid":"https://orcid.org/0000-0003-1315-1062"},"institutions":[{"id":"https://openalex.org/I115228651","display_name":"Agency for Science, Technology and Research","ror":"https://ror.org/036wvzt09","country_code":"SG","type":"government","lineage":["https://openalex.org/I115228651"]},{"id":"https://openalex.org/I4210101200","display_name":"Singapore Institute for Clinical Sciences","ror":"https://ror.org/015p9va32","country_code":"SG","type":"facility","lineage":["https://openalex.org/I115228651","https://openalex.org/I4210101200"]},{"id":"https://openalex.org/I4210148498","display_name":"Bioinformatics Institute","ror":"https://ror.org/044w3nw43","country_code":"SG","type":"facility","lineage":["https://openalex.org/I115228651","https://openalex.org/I2801752549","https://openalex.org/I4210148498"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Varsha Gupta","raw_affiliation_strings":["Bioinformatics Institute (BII), Agency for Science, Technology and Research (A*STAR), Singapore, Singapore","Singapore Institute for Clinical Sciences (SICS), Agency for Science, Technology and Research (A*STAR), Singapore, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bioinformatics Institute (BII), Agency for Science, Technology and Research (A*STAR), Singapore, Singapore","institution_ids":["https://openalex.org/I115228651","https://openalex.org/I4210148498"]},{"raw_affiliation_string":"Singapore Institute for Clinical Sciences (SICS), Agency for Science, Technology and Research (A*STAR), Singapore, Singapore","institution_ids":["https://openalex.org/I4210101200","https://openalex.org/I115228651"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114129041","display_name":"B Karthik Krishna","orcid":null},"institutions":[{"id":"https://openalex.org/I165932596","display_name":"National University of Singapore","ror":"https://ror.org/01tgyzw49","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Bernadus Krishna","raw_affiliation_strings":["Computational Biology, National University of Singapore, Singapore, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Computational Biology, National University of Singapore, Singapore, Singapore","institution_ids":["https://openalex.org/I165932596"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023742885","display_name":"Zou Hui Chen","orcid":null},"institutions":[{"id":"https://openalex.org/I165932596","display_name":"National University of Singapore","ror":"https://ror.org/01tgyzw49","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Zou Hui Chen","raw_affiliation_strings":["Computational Biology, National University of Singapore, Singapore, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Computational Biology, National University of Singapore, Singapore, Singapore","institution_ids":["https://openalex.org/I165932596"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112566396","display_name":"n Purwanto","orcid":null},"institutions":[{"id":"https://openalex.org/I165932596","display_name":"National University of Singapore","ror":"https://ror.org/01tgyzw49","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Natania Yovela Purwanto","raw_affiliation_strings":["Computational Biology, National University of Singapore, Singapore, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Computational Biology, National University of Singapore, Singapore, Singapore","institution_ids":["https://openalex.org/I165932596"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074315202","display_name":"Fabian Yap","orcid":"https://orcid.org/0000-0003-1083-7958"},"institutions":[{"id":"https://openalex.org/I4210112252","display_name":"KK Women's and Children's Hospital","ror":"https://ror.org/0228w5t68","country_code":"SG","type":"healthcare","lineage":["https://openalex.org/I4210112252"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Fabian Yap","raw_affiliation_strings":["KK Women's and Children's Hospital, Singapore, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"KK Women's and Children's Hospital, Singapore, Singapore","institution_ids":["https://openalex.org/I4210112252"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065566802","display_name":"Kok Hian Tan","orcid":"https://orcid.org/0000-0003-1945-0266"},"institutions":[{"id":"https://openalex.org/I4210112252","display_name":"KK Women's and Children's Hospital","ror":"https://ror.org/0228w5t68","country_code":"SG","type":"healthcare","lineage":["https://openalex.org/I4210112252"]},{"id":"https://openalex.org/I4210126319","display_name":"Duke-NUS Medical School","ror":"https://ror.org/02j1m6098","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596","https://openalex.org/I170897317","https://openalex.org/I4210126319"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Kok Hian Tan","raw_affiliation_strings":["Duke NUS Medical School, Singapore, Singapore","KK Women's and Children's Hospital, Singapore, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Duke NUS Medical School, Singapore, Singapore","institution_ids":["https://openalex.org/I4210126319"]},{"raw_affiliation_string":"KK Women's and Children's Hospital, Singapore, Singapore","institution_ids":["https://openalex.org/I4210112252"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036459230","display_name":"Kok Yen Jerry Chan","orcid":null},"institutions":[{"id":"https://openalex.org/I4210112252","display_name":"KK Women's and Children's Hospital","ror":"https://ror.org/0228w5t68","country_code":"SG","type":"healthcare","lineage":["https://openalex.org/I4210112252"]},{"id":"https://openalex.org/I4210126319","display_name":"Duke-NUS Medical School","ror":"https://ror.org/02j1m6098","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596","https://openalex.org/I170897317","https://openalex.org/I4210126319"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Kok Yen Jerry Chan","raw_affiliation_strings":["Duke NUS Medical School, Singapore, Singapore","KK Women's and Children's Hospital, Singapore, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Duke NUS Medical School, Singapore, Singapore","institution_ids":["https://openalex.org/I4210126319"]},{"raw_affiliation_string":"KK Women's and Children's Hospital, Singapore, Singapore","institution_ids":["https://openalex.org/I4210112252"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013087727","display_name":"Shiao\u2010Yng Chan","orcid":"https://orcid.org/0000-0002-3530-3023"},"institutions":[{"id":"https://openalex.org/I115228651","display_name":"Agency for Science, Technology and Research","ror":"https://ror.org/036wvzt09","country_code":"SG","type":"government","lineage":["https://openalex.org/I115228651"]},{"id":"https://openalex.org/I4210101200","display_name":"Singapore Institute for Clinical Sciences","ror":"https://ror.org/015p9va32","country_code":"SG","type":"facility","lineage":["https://openalex.org/I115228651","https://openalex.org/I4210101200"]},{"id":"https://openalex.org/I4210146690","display_name":"National University Hospital","ror":"https://ror.org/04fp9fm22","country_code":"SG","type":"healthcare","lineage":["https://openalex.org/I4210146690"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Shiao-Yng Chan","raw_affiliation_strings":["National University Hospital, Singapore, Singapore","Singapore Institute for Clinical Sciences (SICS), Agency for Science, Technology and Research (A*STAR), Singapore, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National University Hospital, Singapore, Singapore","institution_ids":["https://openalex.org/I4210146690"]},{"raw_affiliation_string":"Singapore Institute for Clinical Sciences (SICS), Agency for Science, Technology and Research (A*STAR), Singapore, Singapore","institution_ids":["https://openalex.org/I4210101200","https://openalex.org/I115228651"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025045708","display_name":"Nicole Goh","orcid":"https://orcid.org/0000-0003-2065-4346"},"institutions":[{"id":"https://openalex.org/I3089745140","display_name":"Yale-NUS College","ror":"https://ror.org/04g9wch13","country_code":"SG","type":"education","lineage":["https://openalex.org/I3089745140"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Nicole Goh","raw_affiliation_strings":["Yale-NUS College, Singapore, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Yale-NUS College, Singapore, Singapore","institution_ids":["https://openalex.org/I3089745140"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032428118","display_name":"Nikita Rane","orcid":null},"institutions":[{"id":"https://openalex.org/I4210140151","display_name":"Institute of Mental Health","ror":"https://ror.org/04c07bj87","country_code":"SG","type":"healthcare","lineage":["https://openalex.org/I4210140151"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Nikita Rane","raw_affiliation_strings":["Institute of Mental Health,Singapore, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Mental Health,Singapore, Singapore","institution_ids":["https://openalex.org/I4210140151"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114190139","display_name":"Ethel Siew Ee Tan","orcid":null},"institutions":[{"id":"https://openalex.org/I4210140151","display_name":"Institute of Mental Health","ror":"https://ror.org/04c07bj87","country_code":"SG","type":"healthcare","lineage":["https://openalex.org/I4210140151"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Ethel Siew Ee Tan","raw_affiliation_strings":["Institute of Mental Health,Singapore, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Mental Health,Singapore, Singapore","institution_ids":["https://openalex.org/I4210140151"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061924087","display_name":"Yuheng Jiang","orcid":"https://orcid.org/0000-0002-7160-0025"},"institutions":[{"id":"https://openalex.org/I4210140151","display_name":"Institute of Mental Health","ror":"https://ror.org/04c07bj87","country_code":"SG","type":"healthcare","lineage":["https://openalex.org/I4210140151"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Yuheng Jiang","raw_affiliation_strings":["Institute of Mental Health,Singapore, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Mental Health,Singapore, Singapore","institution_ids":["https://openalex.org/I4210140151"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101265338","display_name":"Mei Han","orcid":null},"institutions":[{"id":"https://openalex.org/I165932596","display_name":"National University of Singapore","ror":"https://ror.org/01tgyzw49","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Mei Han","raw_affiliation_strings":["Computational Biology, National University of Singapore, Singapore, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Computational Biology, National University of Singapore, Singapore, Singapore","institution_ids":["https://openalex.org/I165932596"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034400760","display_name":"Michael J. Meaney","orcid":"https://orcid.org/0000-0002-8605-1997"},"institutions":[{"id":"https://openalex.org/I115228651","display_name":"Agency for Science, Technology and Research","ror":"https://ror.org/036wvzt09","country_code":"SG","type":"government","lineage":["https://openalex.org/I115228651"]},{"id":"https://openalex.org/I4210101200","display_name":"Singapore Institute for Clinical Sciences","ror":"https://ror.org/015p9va32","country_code":"SG","type":"facility","lineage":["https://openalex.org/I115228651","https://openalex.org/I4210101200"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Michael Meaney","raw_affiliation_strings":["Singapore Institute for Clinical Sciences (SICS), Agency for Science, Technology and Research (A*STAR), Singapore, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Singapore Institute for Clinical Sciences (SICS), Agency for Science, Technology and Research (A*STAR), Singapore, Singapore","institution_ids":["https://openalex.org/I4210101200","https://openalex.org/I115228651"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042799106","display_name":"Dennis Wang","orcid":"https://orcid.org/0000-0003-0068-1005"},"institutions":[{"id":"https://openalex.org/I115228651","display_name":"Agency for Science, Technology and Research","ror":"https://ror.org/036wvzt09","country_code":"SG","type":"government","lineage":["https://openalex.org/I115228651"]},{"id":"https://openalex.org/I4210101200","display_name":"Singapore Institute for Clinical Sciences","ror":"https://ror.org/015p9va32","country_code":"SG","type":"facility","lineage":["https://openalex.org/I115228651","https://openalex.org/I4210101200"]},{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB","SG"],"is_corresponding":false,"raw_author_name":"Dennis Wang","raw_affiliation_strings":["National Heart and Lung Institute, Imperial College London, London, United Kingdom","Singapore Institute for Clinical Sciences (SICS), Agency for Science, Technology and Research (A*STAR), Singapore, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Heart and Lung Institute, Imperial College London, London, United Kingdom","institution_ids":["https://openalex.org/I47508984"]},{"raw_affiliation_string":"Singapore Institute for Clinical Sciences (SICS), Agency for Science, Technology and Research (A*STAR), Singapore, Singapore","institution_ids":["https://openalex.org/I4210101200","https://openalex.org/I115228651"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047721714","display_name":"Jussi Keppo","orcid":"https://orcid.org/0000-0002-4571-5566"},"institutions":[{"id":"https://openalex.org/I165932596","display_name":"National University of Singapore","ror":"https://ror.org/01tgyzw49","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Jussi Keppo","raw_affiliation_strings":["Computational Biology, National University of Singapore, Singapore, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Computational Biology, National University of Singapore, Singapore, Singapore","institution_ids":["https://openalex.org/I165932596"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5066056403","display_name":"Geoffrey Chern-Yee Tan","orcid":"https://orcid.org/0000-0002-9678-4609"},"institutions":[{"id":"https://openalex.org/I165932596","display_name":"National University of Singapore","ror":"https://ror.org/01tgyzw49","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596"]},{"id":"https://openalex.org/I4210140151","display_name":"Institute of Mental Health","ror":"https://ror.org/04c07bj87","country_code":"SG","type":"healthcare","lineage":["https://openalex.org/I4210140151"]}],"countries":["SG"],"is_corresponding":true,"raw_author_name":"Geoffrey Chern-Yee Tan","raw_affiliation_strings":["Computational Biology, National University of Singapore, Singapore, Singapore","Institute of Mental Health,Singapore, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Computational Biology, National University of Singapore, Singapore, Singapore","institution_ids":["https://openalex.org/I165932596"]},{"raw_affiliation_string":"Institute of Mental Health,Singapore, Singapore","institution_ids":["https://openalex.org/I4210140151"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":22,"corresponding_author_ids":["https://openalex.org/A5066056403"],"corresponding_institution_ids":["https://openalex.org/I165932596","https://openalex.org/I4210140151"],"apc_list":{"value":2950,"currency":"USD","value_usd":2950},"apc_paid":{"value":2950,"currency":"USD","value_usd":2950},"fwci":0.4301,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.59399411,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":95},"biblio":{"volume":"17","issue":null,"first_page":"1244336","last_page":"1244336"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.337799996137619,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.337799996137619,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.30320000648498535,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11642","display_name":"Genomics and Rare Diseases","score":0.07569999992847443,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/single-nucleotide-polymorphism","display_name":"Single-nucleotide polymorphism","score":0.6721869111061096},{"id":"https://openalex.org/keywords/genome-wide-association-study","display_name":"Genome-wide association study","score":0.5909318327903748},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.49352753162384033},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.49308058619499207},{"id":"https://openalex.org/keywords/dna-methylation","display_name":"DNA methylation","score":0.4616844058036804},{"id":"https://openalex.org/keywords/feature-selection","display_name":"Feature selection","score":0.4570903182029724},{"id":"https://openalex.org/keywords/cpg-site","display_name":"CpG site","score":0.44569823145866394},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.44345003366470337},{"id":"https://openalex.org/keywords/heritability","display_name":"Heritability","score":0.4278075397014618},{"id":"https://openalex.org/keywords/elastic-net-regularization","display_name":"Elastic net regularization","score":0.42703312635421753},{"id":"https://openalex.org/keywords/genetic-association","display_name":"Genetic association","score":0.4147889018058777},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.2532110810279846},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.2357485592365265},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.21372780203819275},{"id":"https://openalex.org/keywords/genotype","display_name":"Genotype","score":0.19943007826805115},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.061403632164001465}],"concepts":[{"id":"https://openalex.org/C153209595","wikidata":"https://www.wikidata.org/wiki/Q501128","display_name":"Single-nucleotide polymorphism","level":4,"score":0.6721869111061096},{"id":"https://openalex.org/C106208931","wikidata":"https://www.wikidata.org/wiki/Q1098876","display_name":"Genome-wide association study","level":5,"score":0.5909318327903748},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.49352753162384033},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.49308058619499207},{"id":"https://openalex.org/C190727270","wikidata":"https://www.wikidata.org/wiki/Q874745","display_name":"DNA methylation","level":4,"score":0.4616844058036804},{"id":"https://openalex.org/C148483581","wikidata":"https://www.wikidata.org/wiki/Q446488","display_name":"Feature selection","level":2,"score":0.4570903182029724},{"id":"https://openalex.org/C140173407","wikidata":"https://www.wikidata.org/wiki/Q1138358","display_name":"CpG site","level":5,"score":0.44569823145866394},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.44345003366470337},{"id":"https://openalex.org/C161890455","wikidata":"https://www.wikidata.org/wiki/Q1503548","display_name":"Heritability","level":2,"score":0.4278075397014618},{"id":"https://openalex.org/C203868755","wikidata":"https://www.wikidata.org/wiki/Q5353562","display_name":"Elastic net regularization","level":3,"score":0.42703312635421753},{"id":"https://openalex.org/C186413461","wikidata":"https://www.wikidata.org/wiki/Q744727","display_name":"Genetic association","level":5,"score":0.4147889018058777},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.2532110810279846},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2357485592365265},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.21372780203819275},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.19943007826805115},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.061403632164001465}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3389/fninf.2023.1244336","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fninf.2023.1244336","pdf_url":"https://www.frontiersin.org/articles/10.3389/fninf.2023.1244336/pdf?isPublishedV2=False","source":{"id":"https://openalex.org/S179816892","display_name":"Frontiers in Neuroinformatics","issn_l":"1662-5196","issn":["1662-5196"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Neuroinformatics","raw_type":"journal-article"},{"id":"pmid:38449836","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38449836","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in neuroinformatics","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:10915285","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10915285","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10915285/pdf/fninf-17-1244336.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Front Neuroinform","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:cd3cce60e8594b42a755148bff730273","is_oa":false,"landing_page_url":"https://doaj.org/article/cd3cce60e8594b42a755148bff730273","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Neuroinformatics, Vol 17 (2024)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fninf.2023.1244336","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fninf.2023.1244336","pdf_url":"https://www.frontiersin.org/articles/10.3389/fninf.2023.1244336/pdf?isPublishedV2=False","source":{"id":"https://openalex.org/S179816892","display_name":"Frontiers in Neuroinformatics","issn_l":"1662-5196","issn":["1662-5196"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Neuroinformatics","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.7099999785423279,"id":"https://metadata.un.org/sdg/16","display_name":"Peace, Justice and strong institutions"}],"awards":[{"id":"https://openalex.org/G7002477465","display_name":null,"funder_award_id":"RIE2025","funder_id":"https://openalex.org/F4320320696","funder_display_name":"Agency for Science, Technology and Research"},{"id":"https://openalex.org/G7751699605","display_name":null,"funder_award_id":"MOH-000504","funder_id":"https://openalex.org/F4320320671","funder_display_name":"National Research Foundation"},{"id":"https://openalex.org/G8939886613","display_name":null,"funder_award_id":"21718","funder_id":"https://openalex.org/F4320320696","funder_display_name":"Agency for Science, Technology and Research"}],"funders":[{"id":"https://openalex.org/F4320320671","display_name":"National Research Foundation","ror":"https://ror.org/05s0g1g46"},{"id":"https://openalex.org/F4320320696","display_name":"Agency for Science, Technology and Research","ror":"https://ror.org/036wvzt09"},{"id":"https://openalex.org/F4320322836","display_name":"Ministry of Health, British Columbia","ror":"https://ror.org/05smbmp94"},{"id":"https://openalex.org/F4320334626","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517"},{"id":"https://openalex.org/F4320334737","display_name":"National Medical Research Council","ror":"https://ror.org/04x3cxs03"}],"has_content":{"grobid_xml":false,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4392003043.pdf"},"referenced_works_count":79,"referenced_works":["https://openalex.org/W897821268","https://openalex.org/W1505191356","https://openalex.org/W1975528145","https://openalex.org/W1993273815","https://openalex.org/W2017316872","https://openalex.org/W2018838463","https://openalex.org/W2019983262","https://openalex.org/W2023853169","https://openalex.org/W2029530775","https://openalex.org/W2043842514","https://openalex.org/W2063575312","https://openalex.org/W2065020285","https://openalex.org/W2069298307","https://openalex.org/W2069998829","https://openalex.org/W2079847480","https://openalex.org/W2081182312","https://openalex.org/W2088794999","https://openalex.org/W2092590432","https://openalex.org/W2098867544","https://openalex.org/W2099085143","https://openalex.org/W2101870168","https://openalex.org/W2106814405","https://openalex.org/W2107665951","https://openalex.org/W2108343924","https://openalex.org/W2108730026","https://openalex.org/W2109185359","https://openalex.org/W2110065044","https://openalex.org/W2124317383","https://openalex.org/W2125700595","https://openalex.org/W2134803671","https://openalex.org/W2136940727","https://openalex.org/W2138848739","https://openalex.org/W2141105144","https://openalex.org/W2147477044","https://openalex.org/W2148987122","https://openalex.org/W2156065196","https://openalex.org/W2156908740","https://openalex.org/W2157867661","https://openalex.org/W2162530578","https://openalex.org/W2167101736","https://openalex.org/W2170538199","https://openalex.org/W2262088625","https://openalex.org/W2264585211","https://openalex.org/W2308244787","https://openalex.org/W2316537321","https://openalex.org/W2334107927","https://openalex.org/W2341698020","https://openalex.org/W2409412146","https://openalex.org/W2502759836","https://openalex.org/W2511515754","https://openalex.org/W2529024004","https://openalex.org/W2553059833","https://openalex.org/W2803323905","https://openalex.org/W2807295499","https://openalex.org/W2808263729","https://openalex.org/W2883945062","https://openalex.org/W2884941664","https://openalex.org/W2889928866","https://openalex.org/W2897546067","https://openalex.org/W2922844241","https://openalex.org/W2953379433","https://openalex.org/W2964136462","https://openalex.org/W2980520436","https://openalex.org/W2981792167","https://openalex.org/W2991034145","https://openalex.org/W3014921497","https://openalex.org/W3023037609","https://openalex.org/W3029991133","https://openalex.org/W3036943654","https://openalex.org/W3038453058","https://openalex.org/W3038965454","https://openalex.org/W3094108931","https://openalex.org/W3157163834","https://openalex.org/W3203588026","https://openalex.org/W4214905211","https://openalex.org/W4283699682","https://openalex.org/W4292622945","https://openalex.org/W4308334505","https://openalex.org/W6745609711"],"related_works":["https://openalex.org/W2594299395","https://openalex.org/W2066467839","https://openalex.org/W2111842731","https://openalex.org/W2170506381","https://openalex.org/W2765794416","https://openalex.org/W2039666944","https://openalex.org/W1531630856","https://openalex.org/W2924960962","https://openalex.org/W1486217206","https://openalex.org/W1992310781"],"abstract_inverted_index":{"Introduction":[0],"Pharmacogenetics":[1],"currently":[2],"supports":[3],"clinical":[4,316],"decision-making":[5],"on":[6],"the":[7,43,67,94,105,146,150,325],"basis":[8],"of":[9,13,69,133,145,152,213,232,254,287,298,309,327],"a":[10,16,27,60,211,285],"limited":[11],"number":[12,286],"variants":[14],"in":[15,91,121,306,312],"few":[17],"genes":[18],"and":[19,49,73,126,140,149,164,174,190,243,249,268,274,284,334],"may":[20,322],"benefit":[21],"paediatric":[22],"prescribing":[23,51],"where":[24,218],"there":[25],"is":[26,59],"need":[28],"for":[29,168,261,292,302],"more":[30],"precise":[31],"dosing.":[32,336],"Integrating":[33],"genomic":[34],"information":[35],"such":[36],"as":[37,118],"methylation":[38,101,305],"into":[39,160],"pharmacogenetic":[40],"models":[41,231,301],"holds":[42],"potential":[44],"to":[45,79,89,195,204,222,236,258,324,330],"improve":[46,259,331],"their":[47],"accuracy":[48],"consequently":[50],"decisions.":[52],"Cytochrome":[53],"P450":[54],"2D6":[55],"(":[56],"CYP2D6":[57,90,115,147,303],")":[58],"highly":[61],"polymorphic":[62],"gene":[63,148],"conventionally":[64],"associated":[65,113,207],"with":[66,114,208],"metabolism":[68],"commonly":[70],"used":[71,117],"drugs":[72],"endogenous":[74],"substrates.":[75],"We":[76,129],"thus":[77],"sought":[78],"predict":[80],"epigenetic":[81],"loci":[82],"from":[83,93,135],"single":[84],"nucleotide":[85],"polymorphisms":[86],"(SNPs)":[87],"related":[88],"children":[92,308],"GUSTO":[95],"cohort.":[96],"Methods":[97],"Buffy":[98],"coat":[99],"DNA":[100],"was":[102,180,202],"quantified":[103],"using":[104,182],"Illumina":[106],"Infinium":[107],"Methylation":[108],"EPIC":[109],"beadchip.":[110],"CpG":[111,209,225,282,304],"sites":[112,283],"were":[116,158,193,216,290],"outcome":[119],"variables":[120,289],"Linear":[122,247],"Regression,":[123],"Elastic":[124,171,229],"Net":[125,172,230],"XGBoost":[127,175,250],"models.":[128,251],"compared":[130],"feature":[131,266,272],"selection":[132],"SNPs":[134,141,206,215,220],"GWAS":[136,201],"mQTLs,":[137],"GTEx":[138],"eQTLs":[139],"within":[142],"2":[143],"MB":[144],"impact":[151],"adding":[153],"demographic":[154],"data.":[155],"The":[156,252,270,296],"samples":[157],"split":[159],"training":[161],"(75%)":[162],"sets":[163,167,267],"test":[165],"(25%)":[166],"validation.":[169,185],"In":[170],"model":[173],"models,":[176],"optimal":[177],"hyperparameter":[178],"search":[179],"done":[181],"10-fold":[183],"cross":[184],"Root":[186],"Mean":[187],"Square":[188],"Error":[189],"R-squared":[191],"values":[192],"obtained":[194],"investigate":[196],"each":[197,293],"models\u2019":[198],"performance.":[199],"When":[200],"performed":[203],"determine":[205],"sites,":[210],"total":[212],"15":[214],"identified":[217,291],"several":[219],"appeared":[221,235,257],"influence":[223],"multiple":[224],"sites.":[226],"Results":[227],"Overall,":[228],"genetic":[233],"features":[234,256],"perform":[237],"marginally":[238],"better":[239,245],"than":[240,246],"heritability":[241],"estimates":[242],"substantially":[244,280],"Regression":[248],"addition":[253],"nongenetic":[255],"performance":[260],"some":[262],"but":[263],"not":[264],"all":[265],"probes.":[269],"best":[271],"set":[273,326],"Machine":[275],"Learning":[276],"(ML)":[277],"approach":[278],"differed":[279],"between":[281],"top":[288],"model.":[294],"Discussion":[295],"development":[297],"SNP-based":[299],"prediction":[300],"Singaporean":[307],"varying":[310],"ethnicities":[311],"this":[313],"study":[314],"has":[315],"application.":[317],"With":[318],"further":[319],"validation,":[320],"they":[321],"add":[323],"tools":[328],"available":[329],"precision":[332],"medicine":[333],"pharmacogenetics-based":[335]},"counts_by_year":[{"year":2025,"cited_by_count":1}],"updated_date":"2026-05-21T06:26:12.895304","created_date":"2024-02-22T00:00:00"}
