{"id":"https://openalex.org/W4315649530","doi":"https://doi.org/10.3389/fninf.2022.1032538","title":"Predicting in vitro single-neuron firing rates upon pharmacological perturbation using Graph Neural Networks","display_name":"Predicting in vitro single-neuron firing rates upon pharmacological perturbation using Graph Neural Networks","publication_year":2023,"publication_date":"2023-01-11","ids":{"openalex":"https://openalex.org/W4315649530","doi":"https://doi.org/10.3389/fninf.2022.1032538","pmid":"https://pubmed.ncbi.nlm.nih.gov/36713289"},"language":"en","primary_location":{"id":"doi:10.3389/fninf.2022.1032538","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fninf.2022.1032538","pdf_url":"https://www.frontiersin.org/articles/10.3389/fninf.2022.1032538/pdf","source":{"id":"https://openalex.org/S179816892","display_name":"Frontiers in Neuroinformatics","issn_l":"1662-5196","issn":["1662-5196"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Neuroinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","datacite","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/articles/10.3389/fninf.2022.1032538/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100379031","display_name":"Taehoon Kim","orcid":"https://orcid.org/0000-0002-5701-2956"},"institutions":[{"id":"https://openalex.org/I35440088","display_name":"ETH Zurich","ror":"https://ror.org/05a28rw58","country_code":"CH","type":"education","lineage":["https://openalex.org/I2799323385","https://openalex.org/I35440088"]}],"countries":["CH"],"is_corresponding":true,"raw_author_name":"Taehoon Kim","raw_affiliation_strings":["Bioengineering Laboratory, Department of Biosystems Science and Engineering, ETH Zurich, Basel, Switzerland","Machine Learning and Computational Biology Laboratory, Department of Biosystems Science and Engineering, ETH Zurich, Basel, Switzerland"],"affiliations":[{"raw_affiliation_string":"Bioengineering Laboratory, Department of Biosystems Science and Engineering, ETH Zurich, Basel, Switzerland","institution_ids":["https://openalex.org/I35440088"]},{"raw_affiliation_string":"Machine Learning and Computational Biology Laboratory, Department of Biosystems Science and Engineering, ETH Zurich, Basel, Switzerland","institution_ids":["https://openalex.org/I35440088"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085221831","display_name":"Dexiong Chen","orcid":null},"institutions":[{"id":"https://openalex.org/I35440088","display_name":"ETH Zurich","ror":"https://ror.org/05a28rw58","country_code":"CH","type":"education","lineage":["https://openalex.org/I2799323385","https://openalex.org/I35440088"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Dexiong Chen","raw_affiliation_strings":["Machine Learning and Computational Biology Laboratory, Department of Biosystems Science and Engineering, ETH Zurich, Basel, Switzerland"],"affiliations":[{"raw_affiliation_string":"Machine Learning and Computational Biology Laboratory, Department of Biosystems Science and Engineering, ETH Zurich, Basel, Switzerland","institution_ids":["https://openalex.org/I35440088"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033999727","display_name":"Philipp Hornauer","orcid":"https://orcid.org/0000-0003-2265-6679"},"institutions":[{"id":"https://openalex.org/I35440088","display_name":"ETH Zurich","ror":"https://ror.org/05a28rw58","country_code":"CH","type":"education","lineage":["https://openalex.org/I2799323385","https://openalex.org/I35440088"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Philipp Hornauer","raw_affiliation_strings":["Bioengineering Laboratory, Department of Biosystems Science and Engineering, ETH Zurich, Basel, Switzerland"],"affiliations":[{"raw_affiliation_string":"Bioengineering Laboratory, Department of Biosystems Science and Engineering, ETH Zurich, Basel, Switzerland","institution_ids":["https://openalex.org/I35440088"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089452879","display_name":"Vishalini Emmenegger","orcid":"https://orcid.org/0000-0003-3195-7772"},"institutions":[{"id":"https://openalex.org/I35440088","display_name":"ETH Zurich","ror":"https://ror.org/05a28rw58","country_code":"CH","type":"education","lineage":["https://openalex.org/I2799323385","https://openalex.org/I35440088"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Vishalini Emmenegger","raw_affiliation_strings":["Bioengineering Laboratory, Department of Biosystems Science and Engineering, ETH Zurich, Basel, Switzerland"],"affiliations":[{"raw_affiliation_string":"Bioengineering Laboratory, Department of Biosystems Science and Engineering, ETH Zurich, Basel, Switzerland","institution_ids":["https://openalex.org/I35440088"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062756417","display_name":"Julian Bartram","orcid":"https://orcid.org/0000-0001-7513-1716"},"institutions":[{"id":"https://openalex.org/I35440088","display_name":"ETH Zurich","ror":"https://ror.org/05a28rw58","country_code":"CH","type":"education","lineage":["https://openalex.org/I2799323385","https://openalex.org/I35440088"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Julian Bartram","raw_affiliation_strings":["Bioengineering Laboratory, Department of Biosystems Science and Engineering, ETH Zurich, Basel, Switzerland"],"affiliations":[{"raw_affiliation_string":"Bioengineering Laboratory, Department of Biosystems Science and Engineering, ETH Zurich, Basel, Switzerland","institution_ids":["https://openalex.org/I35440088"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049228752","display_name":"Silvia Ronchi","orcid":"https://orcid.org/0000-0001-6012-4759"},"institutions":[{"id":"https://openalex.org/I35440088","display_name":"ETH Zurich","ror":"https://ror.org/05a28rw58","country_code":"CH","type":"education","lineage":["https://openalex.org/I2799323385","https://openalex.org/I35440088"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Silvia Ronchi","raw_affiliation_strings":["Bioengineering Laboratory, Department of Biosystems Science and Engineering, ETH Zurich, Basel, Switzerland"],"affiliations":[{"raw_affiliation_string":"Bioengineering Laboratory, Department of Biosystems Science and Engineering, ETH Zurich, Basel, Switzerland","institution_ids":["https://openalex.org/I35440088"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000470100","display_name":"Andreas Hierlemann","orcid":"https://orcid.org/0000-0002-3838-2468"},"institutions":[{"id":"https://openalex.org/I35440088","display_name":"ETH Zurich","ror":"https://ror.org/05a28rw58","country_code":"CH","type":"education","lineage":["https://openalex.org/I2799323385","https://openalex.org/I35440088"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Andreas Hierlemann","raw_affiliation_strings":["Bioengineering Laboratory, Department of Biosystems Science and Engineering, ETH Zurich, Basel, Switzerland"],"affiliations":[{"raw_affiliation_string":"Bioengineering Laboratory, Department of Biosystems Science and Engineering, ETH Zurich, Basel, Switzerland","institution_ids":["https://openalex.org/I35440088"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016153537","display_name":"Manuel Schr\u00f6ter","orcid":"https://orcid.org/0000-0002-9347-9203"},"institutions":[{"id":"https://openalex.org/I35440088","display_name":"ETH Zurich","ror":"https://ror.org/05a28rw58","country_code":"CH","type":"education","lineage":["https://openalex.org/I2799323385","https://openalex.org/I35440088"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Manuel Schr\u00f6ter","raw_affiliation_strings":["Bioengineering Laboratory, Department of Biosystems Science and Engineering, ETH Zurich, Basel, Switzerland"],"affiliations":[{"raw_affiliation_string":"Bioengineering Laboratory, Department of Biosystems Science and Engineering, ETH Zurich, Basel, Switzerland","institution_ids":["https://openalex.org/I35440088"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5047763166","display_name":"Damian Roqueiro","orcid":"https://orcid.org/0000-0002-9195-5915"},"institutions":[{"id":"https://openalex.org/I12708293","display_name":"SIB Swiss Institute of Bioinformatics","ror":"https://ror.org/002n09z45","country_code":"CH","type":"nonprofit","lineage":["https://openalex.org/I12708293"]},{"id":"https://openalex.org/I35440088","display_name":"ETH Zurich","ror":"https://ror.org/05a28rw58","country_code":"CH","type":"education","lineage":["https://openalex.org/I2799323385","https://openalex.org/I35440088"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Damian Roqueiro","raw_affiliation_strings":["Machine Learning and Computational Biology Laboratory, Department of Biosystems Science and Engineering, ETH Zurich, Basel, Switzerland","SIB Swiss Institute of Bioinformatics, Zurich, Switzerland"],"affiliations":[{"raw_affiliation_string":"Machine Learning and Computational Biology Laboratory, Department of Biosystems Science and Engineering, ETH Zurich, Basel, Switzerland","institution_ids":["https://openalex.org/I35440088"]},{"raw_affiliation_string":"SIB Swiss Institute of Bioinformatics, Zurich, Switzerland","institution_ids":["https://openalex.org/I12708293"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":9,"corresponding_author_ids":["https://openalex.org/A5100379031"],"corresponding_institution_ids":["https://openalex.org/I35440088"],"apc_list":{"value":2950,"currency":"USD","value_usd":2950},"apc_paid":{"value":2496,"currency":"EUR","value_usd":2691},"fwci":1.072,"has_fulltext":false,"cited_by_count":6,"citation_normalized_percentile":{"value":0.74127881,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":99},"biblio":{"volume":"16","issue":null,"first_page":"1032538","last_page":"1032538"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10581","display_name":"Neural dynamics and brain function","score":0.9991999864578247,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10581","display_name":"Neural dynamics and brain function","score":0.9991999864578247,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11601","display_name":"Neuroscience and Neural Engineering","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10502","display_name":"Advanced Memory and Neural Computing","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/2208","display_name":"Electrical and Electronic Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6628855466842651},{"id":"https://openalex.org/keywords/neuron","display_name":"Neuron","score":0.607506513595581},{"id":"https://openalex.org/keywords/bicuculline","display_name":"Bicuculline","score":0.47921639680862427},{"id":"https://openalex.org/keywords/neuroscience","display_name":"Neuroscience","score":0.4453222155570984},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.4163423776626587},{"id":"https://openalex.org/keywords/gabaa-receptor","display_name":"GABAA receptor","score":0.3590744137763977},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.18326923251152039},{"id":"https://openalex.org/keywords/receptor","display_name":"Receptor","score":0.09461891651153564}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6628855466842651},{"id":"https://openalex.org/C2778794669","wikidata":"https://www.wikidata.org/wiki/Q43054","display_name":"Neuron","level":2,"score":0.607506513595581},{"id":"https://openalex.org/C2780763569","wikidata":"https://www.wikidata.org/wiki/Q3639734","display_name":"Bicuculline","level":4,"score":0.47921639680862427},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.4453222155570984},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.4163423776626587},{"id":"https://openalex.org/C168258287","wikidata":"https://www.wikidata.org/wiki/Q60147","display_name":"GABAA receptor","level":3,"score":0.3590744137763977},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.18326923251152039},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.09461891651153564},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[],"locations_count":6,"locations":[{"id":"doi:10.3389/fninf.2022.1032538","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fninf.2022.1032538","pdf_url":"https://www.frontiersin.org/articles/10.3389/fninf.2022.1032538/pdf","source":{"id":"https://openalex.org/S179816892","display_name":"Frontiers in Neuroinformatics","issn_l":"1662-5196","issn":["1662-5196"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Neuroinformatics","raw_type":"journal-article"},{"id":"pmid:36713289","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36713289","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in neuroinformatics","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:9874697","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9874697","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Front Neuroinform","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:b05e4ae6374a485f94b68e66c1cce8f6","is_oa":true,"landing_page_url":"https://doaj.org/article/b05e4ae6374a485f94b68e66c1cce8f6","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Neuroinformatics, Vol 16 (2023)","raw_type":"article"},{"id":"pmh:oai:www.research-collection.ethz.ch:20.500.11850/595172","is_oa":true,"landing_page_url":"http://hdl.handle.net/20.500.11850/595172","pdf_url":null,"source":{"id":"https://openalex.org/S4306402302","display_name":"Repository for Publications and Research Data (ETH Zurich)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I35440088","host_organization_name":"ETH Zurich","host_organization_lineage":["https://openalex.org/I35440088"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Neuroinformatics, 16","raw_type":"info:eu-repo/semantics/publishedVersion"},{"id":"doi:10.3929/ethz-b-000595172","is_oa":true,"landing_page_url":"https://doi.org/10.3929/ethz-b-000595172","pdf_url":null,"source":{"id":"https://openalex.org/S7407051236","display_name":"ETH Z\u00fcrich Research Collection","issn_l":null,"issn":[],"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":null,"raw_source_name":null,"raw_type":"article-journal"}],"best_oa_location":{"id":"doi:10.3389/fninf.2022.1032538","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fninf.2022.1032538","pdf_url":"https://www.frontiersin.org/articles/10.3389/fninf.2022.1032538/pdf","source":{"id":"https://openalex.org/S179816892","display_name":"Frontiers in Neuroinformatics","issn_l":"1662-5196","issn":["1662-5196"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Neuroinformatics","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320321652","display_name":"Eidgen\u00f6ssische Technische Hochschule Z\u00fcrich","ror":"https://ror.org/05a28rw58"}],"has_content":{"pdf":true,"grobid_xml":false},"content_urls":{"pdf":"https://content.openalex.org/works/W4315649530.pdf"},"referenced_works_count":106,"referenced_works":["https://openalex.org/W113243015","https://openalex.org/W165729115","https://openalex.org/W1832906682","https://openalex.org/W1970391837","https://openalex.org/W1973703467","https://openalex.org/W1981743373","https://openalex.org/W1987971958","https://openalex.org/W1991282027","https://openalex.org/W1996874802","https://openalex.org/W2002923643","https://openalex.org/W2034039836","https://openalex.org/W2038573700","https://openalex.org/W2061960110","https://openalex.org/W2078204079","https://openalex.org/W2084713110","https://openalex.org/W2101219946","https://openalex.org/W2101234009","https://openalex.org/W2101446007","https://openalex.org/W2105031232","https://openalex.org/W2116341502","https://openalex.org/W2128432504","https://openalex.org/W2133903921","https://openalex.org/W2155338866","https://openalex.org/W2290847742","https://openalex.org/W2298642101","https://openalex.org/W2344855436","https://openalex.org/W2467288641","https://openalex.org/W2551596589","https://openalex.org/W2604314403","https://openalex.org/W2622672190","https://openalex.org/W2624407581","https://openalex.org/W2747329762","https://openalex.org/W2756203131","https://openalex.org/W2761083746","https://openalex.org/W2766284800","https://openalex.org/W2786016794","https://openalex.org/W2786672974","https://openalex.org/W2787337315","https://openalex.org/W2807021761","https://openalex.org/W2888829050","https://openalex.org/W2902921475","https://openalex.org/W2903871660","https://openalex.org/W2905224888","https://openalex.org/W2908573463","https://openalex.org/W2911077895","https://openalex.org/W2914050157","https://openalex.org/W2914721378","https://openalex.org/W2952121911","https://openalex.org/W2952292616","https://openalex.org/W2952915411","https://openalex.org/W2963396480","https://openalex.org/W2964113829","https://openalex.org/W2964236544","https://openalex.org/W2970119293","https://openalex.org/W2972317931","https://openalex.org/W2979481854","https://openalex.org/W2979869864","https://openalex.org/W2991165231","https://openalex.org/W2996451395","https://openalex.org/W3011242681","https://openalex.org/W3011385830","https://openalex.org/W3034889226","https://openalex.org/W3036548566","https://openalex.org/W3038203542","https://openalex.org/W3093274093","https://openalex.org/W3100157108","https://openalex.org/W3100848837","https://openalex.org/W3103720336","https://openalex.org/W3104326162","https://openalex.org/W3108823960","https://openalex.org/W3124713481","https://openalex.org/W3132748161","https://openalex.org/W3154391875","https://openalex.org/W3179895881","https://openalex.org/W3189729281","https://openalex.org/W3199008037","https://openalex.org/W3201662917","https://openalex.org/W3204640165","https://openalex.org/W3213228399","https://openalex.org/W4200315833","https://openalex.org/W4205171160","https://openalex.org/W4205560034","https://openalex.org/W4206967482","https://openalex.org/W4210792599","https://openalex.org/W4220898047","https://openalex.org/W4240040082","https://openalex.org/W4255306344","https://openalex.org/W4281291033","https://openalex.org/W4287661632","https://openalex.org/W4287683513","https://openalex.org/W4287714251","https://openalex.org/W4290039438","https://openalex.org/W4294558607","https://openalex.org/W4297809694","https://openalex.org/W4297830346","https://openalex.org/W4300830895","https://openalex.org/W4322614752","https://openalex.org/W6675354045","https://openalex.org/W6713411898","https://openalex.org/W6726873649","https://openalex.org/W6743410771","https://openalex.org/W6760045743","https://openalex.org/W6769917006","https://openalex.org/W6910593837","https://openalex.org/W6948371823","https://openalex.org/W6950116551"],"related_works":["https://openalex.org/W2109881210","https://openalex.org/W2081033826","https://openalex.org/W2057684971","https://openalex.org/W1995018226","https://openalex.org/W2345141651","https://openalex.org/W2258986451","https://openalex.org/W2170438466","https://openalex.org/W1842929407","https://openalex.org/W2039958681","https://openalex.org/W1998348153"],"abstract_inverted_index":{"Modern":[0],"Graph":[1],"Neural":[2],"Networks":[3],"(GNNs)":[4],"provide":[5],"opportunities":[6],"to":[7,26,76,114,136,261],"study":[8,262],"the":[9,12,60,67,91,109,150,175,201,204,225,244,251,257],"determinants":[10],"underlying":[11],"complex":[13,263],"activity":[14,52,133],"patterns":[15],"of":[16,31,39,49,53,62,81,94,108,153,171,180,203,210,247,259],"biological":[17],"neuronal":[18,34,132],"networks.":[19],"In":[20],"this":[21],"study,":[22],"we":[23],"applied":[24],"GNNs":[25,75,260],"a":[27,78,103,137,141,161,181,221],"large-scale":[28],"electrophysiological":[29],"dataset":[30,214,222],"rodent":[32],"primary":[33],"networks":[35,57],"obtained":[36,86],"by":[37,102],"means":[38],"high-density":[40],"microelectrode":[41],"arrays":[42],"(HD-MEAs).":[43],"HD-MEAs":[44],"allow":[45],"for":[46,128,166],"long-term":[47],"recording":[48],"extracellular":[50],"spiking":[51],"individual":[54,172],"neurons":[55,173,255],"and":[56,58,69,83,118,156,220,256],"enable":[59],"extraction":[61],"physiologically":[63],"relevant":[64],"features":[65,85,155],"at":[66],"single-neuron":[68,82,98,117,197],"population":[70],"level.":[71],"We":[72,199],"employed":[73],"established":[74],"generate":[77],"combined":[79],"representation":[80,152],"connectivity":[84,120,253],"from":[87,160],"HD-MEA":[88,211],"data,":[89],"with":[90,139,184,215,218,224],"ultimate":[92],"goal":[93],"predicting":[95,129,167],"changes":[96,130,170],"in":[97,131,134],"firing":[99,168],"rate":[100,169],"induced":[101],"pharmacological":[104],"perturbation.":[105,176],"The":[106],"aim":[107],"main":[110],"prediction":[111,191,235,239],"task":[112],"was":[113,164],"assess":[115],"whether":[116],"functional":[119,157,252],"features,":[121],"inferred":[122],"under":[123],"baseline":[124,162],"conditions,":[125],"were":[126],"informative":[127,165],"response":[135],"perturbation":[138],"Bicuculline,":[140],"GABA":[142,226],"<sub><i>A</i></sub>":[143,227],"receptor":[144,228],"antagonist.":[145],"Our":[146,241],"results":[147,205,242],"suggest":[148],"that":[149,193],"joint":[151],"node":[154],"connectivity,":[158],"extracted":[159],"recording,":[163],"after":[174],"Specifically,":[177],"our":[178],"implementation":[179],"GNN":[182],"model":[183],"inductive":[185],"learning":[186],"capability":[187],"(GraphSAGE)":[188],"outperformed":[189],"other":[190,238],"models":[192,232],"relied":[194],"only":[195],"on":[196,206],"features.":[198],"tested":[200],"generalizability":[202],"two":[207],"additional":[208],"datasets":[209],"recordings-a":[212],"second":[213],"cultures":[216],"perturbed":[217,223],"Bicuculline":[219],"antagonist":[229],"Gabazine.":[230],"GraphSAGE":[231],"showed":[233],"improved":[234],"accuracy":[236],"over":[237],"models.":[240],"demonstrate":[243],"added":[245],"value":[246],"taking":[248],"into":[249],"account":[250],"between":[254,265],"potential":[258],"interactions":[264],"neurons.":[266]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2}],"updated_date":"2026-03-20T23:20:44.827607","created_date":"2023-01-12T00:00:00"}
