{"id":"https://openalex.org/W2075875029","doi":"https://doi.org/10.3389/fninf.2012.00013","title":"The importance of combining MRI and large-scale digital histology in neuroimaging studies of brain connectivity and disease","display_name":"The importance of combining MRI and large-scale digital histology in neuroimaging studies of brain connectivity and disease","publication_year":2012,"publication_date":"2012-01-01","ids":{"openalex":"https://openalex.org/W2075875029","doi":"https://doi.org/10.3389/fninf.2012.00013","mag":"2075875029","pmid":"https://pubmed.ncbi.nlm.nih.gov/22536182"},"language":"en","primary_location":{"id":"doi:10.3389/fninf.2012.00013","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fninf.2012.00013","pdf_url":"https://www.frontiersin.org/articles/10.3389/fninf.2012.00013/pdf","source":{"id":"https://openalex.org/S179816892","display_name":"Frontiers in Neuroinformatics","issn_l":"1662-5196","issn":["1662-5196"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Neuroinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/articles/10.3389/fninf.2012.00013/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5068380907","display_name":"Jacopo Annese","orcid":null},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California, San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Jacopo Annese","raw_affiliation_strings":["Department of Radiology and Biomedical Imaging, The Brain Observatory, University of California, San Diego CA, USA","UC San Diego, The Brain Observatory, 3510 Dunhill Street, San Diego, 92121, CA, United States"],"affiliations":[{"raw_affiliation_string":"Department of Radiology and Biomedical Imaging, The Brain Observatory, University of California, San Diego CA, USA","institution_ids":[]},{"raw_affiliation_string":"UC San Diego, The Brain Observatory, 3510 Dunhill Street, San Diego, 92121, CA, United States","institution_ids":["https://openalex.org/I36258959"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5068380907"],"corresponding_institution_ids":["https://openalex.org/I36258959"],"apc_list":{"value":2950,"currency":"USD","value_usd":2950},"apc_paid":{"value":2950,"currency":"USD","value_usd":2950},"fwci":5.5792,"has_fulltext":true,"cited_by_count":44,"citation_normalized_percentile":{"value":0.96060877,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"6","issue":null,"first_page":"13","last_page":"13"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11304","display_name":"Advanced Neuroimaging Techniques and Applications","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11304","display_name":"Advanced Neuroimaging Techniques and Applications","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10241","display_name":"Functional Brain Connectivity Studies","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10378","display_name":"Advanced MRI Techniques and Applications","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/neuroimaging","display_name":"Neuroimaging","score":0.8166922330856323},{"id":"https://openalex.org/keywords/perspective","display_name":"Perspective (graphical)","score":0.48935192823410034},{"id":"https://openalex.org/keywords/neuroscience","display_name":"Neuroscience","score":0.4266369640827179},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.3768112361431122},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.3614048361778259},{"id":"https://openalex.org/keywords/psychology","display_name":"Psychology","score":0.2701038420200348},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.21231606602668762}],"concepts":[{"id":"https://openalex.org/C58693492","wikidata":"https://www.wikidata.org/wiki/Q551875","display_name":"Neuroimaging","level":2,"score":0.8166922330856323},{"id":"https://openalex.org/C12713177","wikidata":"https://www.wikidata.org/wiki/Q1900281","display_name":"Perspective (graphical)","level":2,"score":0.48935192823410034},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.4266369640827179},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3768112361431122},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3614048361778259},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.2701038420200348},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.21231606602668762}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3389/fninf.2012.00013","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fninf.2012.00013","pdf_url":"https://www.frontiersin.org/articles/10.3389/fninf.2012.00013/pdf","source":{"id":"https://openalex.org/S179816892","display_name":"Frontiers in Neuroinformatics","issn_l":"1662-5196","issn":["1662-5196"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Neuroinformatics","raw_type":"journal-article"},{"id":"pmid:22536182","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22536182","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in neuroinformatics","raw_type":null},{"id":"pmh:oai:doaj.org/article:cf85a3ba244d4543929ed1a9b200d12e","is_oa":true,"landing_page_url":"https://doaj.org/article/cf85a3ba244d4543929ed1a9b200d12e","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Neuroinformatics, Vol 6 (2012)","raw_type":"article"},{"id":"pmh:oai:europepmc.org:2340658","is_oa":false,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3334523","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"}],"best_oa_location":{"id":"doi:10.3389/fninf.2012.00013","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fninf.2012.00013","pdf_url":"https://www.frontiersin.org/articles/10.3389/fninf.2012.00013/pdf","source":{"id":"https://openalex.org/S179816892","display_name":"Frontiers in Neuroinformatics","issn_l":"1662-5196","issn":["1662-5196"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Neuroinformatics","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320337350","display_name":"National Eye Institute","ror":"https://ror.org/03wkg3b53"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2075875029.pdf","grobid_xml":"https://content.openalex.org/works/W2075875029.grobid-xml"},"referenced_works_count":29,"referenced_works":["https://openalex.org/W197001706","https://openalex.org/W1541538865","https://openalex.org/W1546562392","https://openalex.org/W1964086303","https://openalex.org/W1973920032","https://openalex.org/W1997314079","https://openalex.org/W1997804531","https://openalex.org/W1998117253","https://openalex.org/W2000038982","https://openalex.org/W2000567868","https://openalex.org/W2004293194","https://openalex.org/W2026527241","https://openalex.org/W2045718731","https://openalex.org/W2073741319","https://openalex.org/W2084397284","https://openalex.org/W2110431535","https://openalex.org/W2126047962","https://openalex.org/W2131304820","https://openalex.org/W2132551870","https://openalex.org/W2146693559","https://openalex.org/W2148043860","https://openalex.org/W2151130155","https://openalex.org/W2155149585","https://openalex.org/W4255894213","https://openalex.org/W4285719527","https://openalex.org/W4292666818","https://openalex.org/W6632495414","https://openalex.org/W6649847123","https://openalex.org/W6676529902"],"related_works":["https://openalex.org/W2748952813","https://openalex.org/W3031052312","https://openalex.org/W4389568370","https://openalex.org/W3032375762","https://openalex.org/W1995515455","https://openalex.org/W2080531066","https://openalex.org/W2586801360","https://openalex.org/W3108674512","https://openalex.org/W1506200166","https://openalex.org/W1489783725"],"abstract_inverted_index":{"One":[0],"of":[1,43,66,77,110,126,160,163],"the":[2,11,15,52,64,91,95,111,135,140,158],"major":[3],"issues":[4],"hindering":[5],"a":[6,60,122],"comprehensive":[7],"connectivity":[8,165],"model":[9],"for":[10,138],"human":[12],"brain":[13,65,164],"is":[14,82,119],"difficulty":[16],"in":[17,41,94,157],"linking":[18],"Magnetic":[19],"Resonance":[20],"Imaging":[21],"(MRI)":[22],"measurements":[23],"to":[24,120,151],"anatomical":[25],"evidence":[26],"produced":[27],"by":[28,102],"histological":[29,80],"methods.":[30],"In":[31],"vivo":[32],"and":[33,47,79,130,154,166],"postmortem":[34,72],"neuroimaging":[35,123],"methodologies":[36],"are":[37,99],"still":[38],"largely":[39],"incompatible":[40],"terms":[42],"sample":[44],"size,":[45],"scale,":[46],"resolution.":[48,116],"To":[49],"help":[50],"bridge":[51],"hiatus":[53],"between":[54,142],"different":[55,88,143],"approaches":[56],"we":[57],"have":[58],"established":[59],"program":[61],"that":[62,107],"characterizes":[63],"individual":[67],"subjects,":[68],"combining":[69],"MRI":[70,78],"with":[71],"neuroanatomy.":[73],"The":[74,117],"direct":[75],"correlation":[76],"features":[81],"possible,":[83],"because":[84],"registered":[85],"images":[86,109],"from":[87],"modalities":[89],"represent":[90],"same":[92,96],"regions":[93],"brain.":[97],"Comparisons":[98],"also":[100],"facilitated":[101],"large-scale,":[103],"digital":[104],"microscopy":[105],"techniques":[106],"afford":[108],"whole-brain":[112],"sections":[113],"at":[114],"cellular":[115],"goal":[118],"create":[121],"catalog":[124],"representative":[125],"discrete":[127],"age":[128],"groups":[129],"specific":[131],"neurological":[132],"conditions.":[133],"Individually,":[134],"datasets":[136],"allow":[137],"investigating":[139],"relationship":[141],"modalities;":[144],"combined,":[145],"they":[146],"provide":[147],"sufficient":[148],"predictive":[149],"power":[150],"inform":[152],"analyzes":[153],"interpretations":[155],"made":[156],"context":[159],"non-invasive":[161],"studies":[162],"disease.":[167]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":10},{"year":2012,"cited_by_count":3}],"updated_date":"2026-01-13T01:12:25.745995","created_date":"2025-10-10T00:00:00"}
