{"id":"https://openalex.org/W7153018175","doi":"https://doi.org/10.3389/fncom.2026.1761735","title":"Adaptation modulates effective connectivity and network stability","display_name":"Adaptation modulates effective connectivity and network stability","publication_year":2026,"publication_date":"2026-04-10","ids":{"openalex":"https://openalex.org/W7153018175","doi":"https://doi.org/10.3389/fncom.2026.1761735","pmid":"https://pubmed.ncbi.nlm.nih.gov/42038529"},"language":"en","primary_location":{"id":"doi:10.3389/fncom.2026.1761735","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fncom.2026.1761735","pdf_url":null,"source":{"id":"https://openalex.org/S19778766","display_name":"Frontiers in Computational Neuroscience","issn_l":"1662-5188","issn":["1662-5188"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Computational Neuroscience","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.3389/fncom.2026.1761735","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5054372953","display_name":"Thomas J. Richner","orcid":"https://orcid.org/0000-0001-6230-1464"},"institutions":[{"id":"https://openalex.org/I4210125099","display_name":"Mayo Clinic in Arizona","ror":"https://ror.org/03jp40720","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210125099"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Thomas J. Richner","raw_affiliation_strings":["Department of Neurology, Mayo Clinic"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Mayo Clinic","institution_ids":["https://openalex.org/I4210125099"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015866149","display_name":"Martynas Dervinis","orcid":"https://orcid.org/0000-0002-4676-7456"},"institutions":[{"id":"https://openalex.org/I4210125099","display_name":"Mayo Clinic in Arizona","ror":"https://ror.org/03jp40720","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210125099"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Martynas Dervinis","raw_affiliation_strings":["Department of Neurology, Mayo Clinic"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Mayo Clinic","institution_ids":["https://openalex.org/I4210125099"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5077007979","display_name":"Brian N. Lundstrom","orcid":"https://orcid.org/0000-0002-5310-5549"},"institutions":[{"id":"https://openalex.org/I4210125099","display_name":"Mayo Clinic in Arizona","ror":"https://ror.org/03jp40720","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210125099"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brian Nils Lundstrom","raw_affiliation_strings":["Department of Neurology, Mayo Clinic"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Mayo Clinic","institution_ids":["https://openalex.org/I4210125099"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5054372953"],"corresponding_institution_ids":["https://openalex.org/I4210125099"],"apc_list":{"value":2950,"currency":"USD","value_usd":2950},"apc_paid":{"value":2950,"currency":"USD","value_usd":2950},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.72276388,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"20","issue":null,"first_page":"1761735","last_page":"1761735"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10581","display_name":"Neural dynamics and brain function","score":0.3862999975681305,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10581","display_name":"Neural dynamics and brain function","score":0.3862999975681305,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10241","display_name":"Functional Brain Connectivity Studies","score":0.23510000109672546,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10502","display_name":"Advanced Memory and Neural Computing","score":0.18019999563694,"subfield":{"id":"https://openalex.org/subfields/2208","display_name":"Electrical and Electronic Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/edge-of-chaos","display_name":"Edge of chaos","score":0.6624000072479248},{"id":"https://openalex.org/keywords/adaptation","display_name":"Adaptation (eye)","score":0.5889000296592712},{"id":"https://openalex.org/keywords/stability","display_name":"Stability (learning theory)","score":0.49869999289512634},{"id":"https://openalex.org/keywords/nonlinear-system","display_name":"Nonlinear system","score":0.48730000853538513},{"id":"https://openalex.org/keywords/network-dynamics","display_name":"Network dynamics","score":0.390500009059906},{"id":"https://openalex.org/keywords/enhanced-data-rates-for-gsm-evolution","display_name":"Enhanced Data Rates for GSM Evolution","score":0.3831000030040741},{"id":"https://openalex.org/keywords/network-model","display_name":"Network model","score":0.34450000524520874}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6769999861717224},{"id":"https://openalex.org/C2780713532","wikidata":"https://www.wikidata.org/wiki/Q93158","display_name":"Edge of chaos","level":2,"score":0.6624000072479248},{"id":"https://openalex.org/C139807058","wikidata":"https://www.wikidata.org/wiki/Q352374","display_name":"Adaptation (eye)","level":2,"score":0.5889000296592712},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.5336999893188477},{"id":"https://openalex.org/C112972136","wikidata":"https://www.wikidata.org/wiki/Q7595718","display_name":"Stability (learning theory)","level":2,"score":0.49869999289512634},{"id":"https://openalex.org/C158622935","wikidata":"https://www.wikidata.org/wiki/Q660848","display_name":"Nonlinear system","level":2,"score":0.48730000853538513},{"id":"https://openalex.org/C123757187","wikidata":"https://www.wikidata.org/wiki/Q9195957","display_name":"Network dynamics","level":2,"score":0.390500009059906},{"id":"https://openalex.org/C162307627","wikidata":"https://www.wikidata.org/wiki/Q204833","display_name":"Enhanced Data Rates for GSM Evolution","level":2,"score":0.3831000030040741},{"id":"https://openalex.org/C104122410","wikidata":"https://www.wikidata.org/wiki/Q1416406","display_name":"Network model","level":2,"score":0.34450000524520874},{"id":"https://openalex.org/C79379906","wikidata":"https://www.wikidata.org/wiki/Q3174497","display_name":"Dynamical systems theory","level":2,"score":0.3424000144004822},{"id":"https://openalex.org/C2780791683","wikidata":"https://www.wikidata.org/wiki/Q846785","display_name":"Action (physics)","level":2,"score":0.33649998903274536},{"id":"https://openalex.org/C98229152","wikidata":"https://www.wikidata.org/wiki/Q1551556","display_name":"Synaptic plasticity","level":3,"score":0.3260999917984009},{"id":"https://openalex.org/C2985799443","wikidata":"https://www.wikidata.org/wiki/Q4955838","display_name":"Brain stimulation","level":3,"score":0.3012999892234802},{"id":"https://openalex.org/C118403218","wikidata":"https://www.wikidata.org/wiki/Q43283","display_name":"Biological neural network","level":2,"score":0.29809999465942383},{"id":"https://openalex.org/C66024118","wikidata":"https://www.wikidata.org/wiki/Q1122506","display_name":"Computational model","level":2,"score":0.29350000619888306},{"id":"https://openalex.org/C2988224531","wikidata":"https://www.wikidata.org/wiki/Q20830730","display_name":"Network structure","level":2,"score":0.2689000070095062},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.2630000114440918},{"id":"https://openalex.org/C2780196419","wikidata":"https://www.wikidata.org/wiki/Q1762173","display_name":"Nerve net","level":2,"score":0.2515999972820282}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3389/fncom.2026.1761735","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fncom.2026.1761735","pdf_url":null,"source":{"id":"https://openalex.org/S19778766","display_name":"Frontiers in Computational Neuroscience","issn_l":"1662-5188","issn":["1662-5188"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Computational Neuroscience","raw_type":"journal-article"},{"id":"pmid:42038529","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42038529","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in computational neuroscience","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:13106433","is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13106433/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13106433/pdf/fncom-20-1761735.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Front Comput Neurosci","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:f791fff0d60242eeb4f045a45918a767","is_oa":true,"landing_page_url":"https://doaj.org/article/f791fff0d60242eeb4f045a45918a767","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Computational Neuroscience, Vol 20 (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fncom.2026.1761735","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fncom.2026.1761735","pdf_url":null,"source":{"id":"https://openalex.org/S19778766","display_name":"Frontiers in Computational Neuroscience","issn_l":"1662-5188","issn":["1662-5188"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Computational Neuroscience","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G703744241","display_name":null,"funder_award_id":"R01NS129622","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G7271691952","display_name":null,"funder_award_id":"K23NS112339","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G7831195159","display_name":null,"funder_award_id":"K23NS112339","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":68,"referenced_works":["https://openalex.org/W1501028655","https://openalex.org/W1502722314","https://openalex.org/W1956522588","https://openalex.org/W1968134101","https://openalex.org/W1970738437","https://openalex.org/W1978458868","https://openalex.org/W1978845507","https://openalex.org/W1978864992","https://openalex.org/W1982101672","https://openalex.org/W1989032589","https://openalex.org/W1991630689","https://openalex.org/W1999329764","https://openalex.org/W2000470900","https://openalex.org/W2022995207","https://openalex.org/W2027802883","https://openalex.org/W2031543773","https://openalex.org/W2032641870","https://openalex.org/W2042489792","https://openalex.org/W2042765770","https://openalex.org/W2043231452","https://openalex.org/W2049546703","https://openalex.org/W2052918609","https://openalex.org/W2056661320","https://openalex.org/W2057755457","https://openalex.org/W2059668389","https://openalex.org/W2068958889","https://openalex.org/W2084553132","https://openalex.org/W2092883504","https://openalex.org/W2102892532","https://openalex.org/W2104853116","https://openalex.org/W2105398397","https://openalex.org/W2112246162","https://openalex.org/W2115900486","https://openalex.org/W2128084896","https://openalex.org/W2129046573","https://openalex.org/W2141394518","https://openalex.org/W2142329149","https://openalex.org/W2144102924","https://openalex.org/W2150706548","https://openalex.org/W2177218873","https://openalex.org/W2296682098","https://openalex.org/W2320432931","https://openalex.org/W2510030309","https://openalex.org/W2620205825","https://openalex.org/W2883380036","https://openalex.org/W2938654194","https://openalex.org/W2949311293","https://openalex.org/W2975518817","https://openalex.org/W3028721182","https://openalex.org/W3111903563","https://openalex.org/W3185986431","https://openalex.org/W3193174973","https://openalex.org/W3202059234","https://openalex.org/W4220896689","https://openalex.org/W4225347760","https://openalex.org/W4241278178","https://openalex.org/W4282961622","https://openalex.org/W4283328497","https://openalex.org/W4295136077","https://openalex.org/W4297809694","https://openalex.org/W4321436536","https://openalex.org/W4386119495","https://openalex.org/W4388489573","https://openalex.org/W4392016167","https://openalex.org/W4400651955","https://openalex.org/W4409310167","https://openalex.org/W4409311339","https://openalex.org/W4410522311"],"related_works":[],"abstract_inverted_index":{"The":[0],"brain":[1,108,146,182,240],"is":[2,62],"a":[3,31,87],"highly":[4],"recurrent,":[5],"nonlinear":[6,96],"network":[7,76,88,102],"hypothesized":[8],"to":[9,29,42,99,116,169,195,208,215,245],"remain":[10],"near":[11,147],"the":[12,70,75,95,101,107,141,145,148,221,247],"edge":[13,149],"of":[14,34,46,74,121,150,176,180,250],"chaos":[15,151],"for":[16],"optimal":[17],"performance.":[18],"Excitation":[19],"and":[20,37,55,134,152,164,186,191,237],"inhibition":[21],"must":[22,109],"be":[23,243],"balanced":[24],"precisely":[25],"within":[26],"every":[27,204],"neuron":[28],"ensure":[30],"consistent":[32],"level":[33,120],"dynamical":[35,154],"stability":[36,71],"rich":[38],"dynamics":[39],"during":[40],"transition":[41],"chaos.":[43],"However,":[44],"analysis":[45],"biologically":[47],"realistic":[48],"synaptic":[49,65,136,165],"weight":[50],"matrices":[51],"suggests":[52],"that":[53,60,68,125,226,238],"sparsity":[54],"low-dimensional":[56,82],"structure":[57],"interact":[58,93,212],"such":[59],"there":[61],"no":[63],"known":[64],"balancing":[66],"rule":[67],"constrains":[69],"(i.e.,":[72],"eigenvalues)":[73],"while":[77],"also":[78],"preserving":[79],"computationally":[80],"useful,":[81],"structure.":[83],"Further,":[84],"even":[85],"if":[86],"were":[89],"well-balanced,":[90],"external":[91],"stimuli":[92],"with":[94,213],"activation":[97],"functions":[98],"unbalance":[100],"in":[103,189],"real":[104],"time.":[105],"Therefore,":[106],"utilize":[110],"dynamic,":[111],"rather":[112],"than":[113],"static,":[114],"mechanisms":[115,168],"actively":[117],"regulate":[118],"its":[119],"stability.":[122],"We":[123,224],"propose":[124],"two":[126],"specific":[127],"adaptation":[128,132,210,228],"mechanisms,":[129],"spike":[130],"frequency":[131],"(SFA)":[133],"short-term":[135],"depression":[137],"(STD),":[138],"continuously":[139],"modulate":[140],"effective":[142],"connectivity,":[143],"keeping":[144],"reducing":[153],"fluctuations":[155],"caused":[156],"by":[157,234],"stimuli.":[158],"This":[159,172],"theoretical":[160],"framework":[161],"links":[162],"intrinsic":[163],"negative":[166],"feedback":[167],"network-level":[170],"dynamics.":[171],"offers":[173],"an":[174,184],"explanation":[175],"why":[177],"data-driven":[178],"modeling":[179],"human":[181],"signals,":[183],"exciting":[185],"useful":[187],"method":[188],"epilepsy":[190],"anesthesiology":[192],"research,":[193],"seems":[194],"require":[196],"linear":[197],"time-varying":[198],"(LTV)":[199],"models":[200],"which":[201],"are":[202],"refit":[203],"half":[205],"second:":[206],"difficult":[207],"observe":[209],"processes":[211],"nonlinearities":[214],"make":[216],"connectivity":[217],"effectively":[218],"dynamic":[219],"at":[220],"macroelectrode":[222],"scale.":[223],"suggest":[225],"compromised":[227],"may":[229],"underlie":[230],"neurological":[231],"conditions":[232],"characterized":[233],"altered":[235],"excitability,":[236],"targeted":[239],"stimulation":[241],"could":[242],"used":[244],"probe":[246],"regulatory":[248],"action":[249],"adaptation.":[251]},"counts_by_year":[],"updated_date":"2026-05-06T08:25:59.206177","created_date":"2026-04-11T00:00:00"}