{"id":"https://openalex.org/W4413181688","doi":"https://doi.org/10.3389/fncom.2025.1639829","title":"Maximum likelihood estimation of spatially dependent interactions in large populations of cortical neurons","display_name":"Maximum likelihood estimation of spatially dependent interactions in large populations of cortical neurons","publication_year":2025,"publication_date":"2025-08-13","ids":{"openalex":"https://openalex.org/W4413181688","doi":"https://doi.org/10.3389/fncom.2025.1639829","pmid":"https://pubmed.ncbi.nlm.nih.gov/40880619"},"language":"en","primary_location":{"id":"doi:10.3389/fncom.2025.1639829","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fncom.2025.1639829","pdf_url":null,"source":{"id":"https://openalex.org/S19778766","display_name":"Frontiers in Computational Neuroscience","issn_l":"1662-5188","issn":["1662-5188"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Computational Neuroscience","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.3389/fncom.2025.1639829","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111568442","display_name":"C. Godin","orcid":"https://orcid.org/0000-0002-0520-5975"},"institutions":[{"id":"https://openalex.org/I153718931","display_name":"University of Ottawa","ror":"https://ror.org/03c4mmv16","country_code":"CA","type":"education","lineage":["https://openalex.org/I153718931"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Camille Godin","raw_affiliation_strings":["School of Psychology, University of Ottawa, Ottawa, ON, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Psychology, University of Ottawa, Ottawa, ON, Canada","institution_ids":["https://openalex.org/I153718931"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5019855901","display_name":"Jean\u2010Philippe Thivierge","orcid":"https://orcid.org/0000-0003-2457-7173"},"institutions":[{"id":"https://openalex.org/I153718931","display_name":"University of Ottawa","ror":"https://ror.org/03c4mmv16","country_code":"CA","type":"education","lineage":["https://openalex.org/I153718931"]}],"countries":["CA"],"is_corresponding":true,"raw_author_name":"J. P. Thivierge","raw_affiliation_strings":["Brain and Mind Research Institute, University of Ottawa, Ottawa, ON, Canada","School of Psychology, University of Ottawa, Ottawa, ON, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Brain and Mind Research Institute, University of Ottawa, Ottawa, ON, Canada","institution_ids":["https://openalex.org/I153718931"]},{"raw_affiliation_string":"School of Psychology, University of Ottawa, Ottawa, ON, Canada","institution_ids":["https://openalex.org/I153718931"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5019855901"],"corresponding_institution_ids":["https://openalex.org/I153718931"],"apc_list":{"value":3295,"currency":"USD","value_usd":3295},"apc_paid":{"value":3295,"currency":"USD","value_usd":3295},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.15958614,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"19","issue":null,"first_page":"1639829","last_page":"1639829"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10581","display_name":"Neural dynamics and brain function","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10581","display_name":"Neural dynamics and brain function","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11513","display_name":"stochastic dynamics and bifurcation","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/3109","display_name":"Statistical and Nonlinear Physics"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11601","display_name":"Neuroscience and Neural Engineering","score":0.991599977016449,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6270167231559753},{"id":"https://openalex.org/keywords/spike","display_name":"Spike (software development)","score":0.5492595434188843},{"id":"https://openalex.org/keywords/evoked-activity","display_name":"Evoked activity","score":0.485176146030426},{"id":"https://openalex.org/keywords/poisson-distribution","display_name":"Poisson distribution","score":0.47309163212776184},{"id":"https://openalex.org/keywords/spatial-ecology","display_name":"Spatial ecology","score":0.461574912071228},{"id":"https://openalex.org/keywords/spike-train","display_name":"Spike train","score":0.43785709142684937},{"id":"https://openalex.org/keywords/scale","display_name":"Scale (ratio)","score":0.4163638949394226},{"id":"https://openalex.org/keywords/cortical-neurons","display_name":"Cortical neurons","score":0.41445350646972656},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.3816826641559601},{"id":"https://openalex.org/keywords/neuroscience","display_name":"Neuroscience","score":0.36521434783935547},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.16141486167907715},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.15697193145751953},{"id":"https://openalex.org/keywords/cartography","display_name":"Cartography","score":0.11395436525344849},{"id":"https://openalex.org/keywords/geography","display_name":"Geography","score":0.07583627104759216}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6270167231559753},{"id":"https://openalex.org/C2781390188","wikidata":"https://www.wikidata.org/wiki/Q25203449","display_name":"Spike (software development)","level":2,"score":0.5492595434188843},{"id":"https://openalex.org/C2780454244","wikidata":"https://www.wikidata.org/wiki/Q5418564","display_name":"Evoked activity","level":3,"score":0.485176146030426},{"id":"https://openalex.org/C100906024","wikidata":"https://www.wikidata.org/wiki/Q205692","display_name":"Poisson distribution","level":2,"score":0.47309163212776184},{"id":"https://openalex.org/C158709400","wikidata":"https://www.wikidata.org/wiki/Q3578586","display_name":"Spatial ecology","level":2,"score":0.461574912071228},{"id":"https://openalex.org/C2909946758","wikidata":"https://www.wikidata.org/wiki/Q194277","display_name":"Spike train","level":3,"score":0.43785709142684937},{"id":"https://openalex.org/C2778755073","wikidata":"https://www.wikidata.org/wiki/Q10858537","display_name":"Scale (ratio)","level":2,"score":0.4163638949394226},{"id":"https://openalex.org/C2983650178","wikidata":"https://www.wikidata.org/wiki/Q75839","display_name":"Cortical neurons","level":2,"score":0.41445350646972656},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.3816826641559601},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.36521434783935547},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.16141486167907715},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.15697193145751953},{"id":"https://openalex.org/C58640448","wikidata":"https://www.wikidata.org/wiki/Q42515","display_name":"Cartography","level":1,"score":0.11395436525344849},{"id":"https://openalex.org/C205649164","wikidata":"https://www.wikidata.org/wiki/Q1071","display_name":"Geography","level":0,"score":0.07583627104759216},{"id":"https://openalex.org/C24998067","wikidata":"https://www.wikidata.org/wiki/Q4114622","display_name":"Stimulation","level":2,"score":0.0},{"id":"https://openalex.org/C115903868","wikidata":"https://www.wikidata.org/wiki/Q80993","display_name":"Software engineering","level":1,"score":0.0},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.0},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3389/fncom.2025.1639829","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fncom.2025.1639829","pdf_url":null,"source":{"id":"https://openalex.org/S19778766","display_name":"Frontiers in Computational Neuroscience","issn_l":"1662-5188","issn":["1662-5188"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Computational Neuroscience","raw_type":"journal-article"},{"id":"pmid:40880619","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40880619","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in computational neuroscience","raw_type":null},{"id":"pmh:oai:doaj.org/article:6b27d71de8284345b28538e6ce7de538","is_oa":true,"landing_page_url":"https://doaj.org/article/6b27d71de8284345b28538e6ce7de538","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Computational Neuroscience, Vol 19 (2025)","raw_type":"article"},{"id":"pmh:oai:europepmc.org:11189198","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/12380633","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"}],"best_oa_location":{"id":"doi:10.3389/fncom.2025.1639829","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fncom.2025.1639829","pdf_url":null,"source":{"id":"https://openalex.org/S19778766","display_name":"Frontiers in Computational Neuroscience","issn_l":"1662-5188","issn":["1662-5188"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Computational Neuroscience","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320334593","display_name":"Natural Sciences and Engineering Research Council of Canada","ror":"https://ror.org/01h531d29"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":71,"referenced_works":["https://openalex.org/W1964049834","https://openalex.org/W1965391749","https://openalex.org/W1966894829","https://openalex.org/W1968222074","https://openalex.org/W1981729928","https://openalex.org/W1985392528","https://openalex.org/W1985431741","https://openalex.org/W2006687001","https://openalex.org/W2011523140","https://openalex.org/W2011525418","https://openalex.org/W2015541987","https://openalex.org/W2018305040","https://openalex.org/W2026864246","https://openalex.org/W2041601616","https://openalex.org/W2041782669","https://openalex.org/W2046031057","https://openalex.org/W2051217769","https://openalex.org/W2066537321","https://openalex.org/W2069519142","https://openalex.org/W2079790369","https://openalex.org/W2082445321","https://openalex.org/W2087790185","https://openalex.org/W2137064976","https://openalex.org/W2137761603","https://openalex.org/W2142373488","https://openalex.org/W2142438562","https://openalex.org/W2142858796","https://openalex.org/W2145631310","https://openalex.org/W2149250320","https://openalex.org/W2150908477","https://openalex.org/W2152556184","https://openalex.org/W2156326104","https://openalex.org/W2164653071","https://openalex.org/W2167845354","https://openalex.org/W2172053542","https://openalex.org/W2179178098","https://openalex.org/W2263267311","https://openalex.org/W2490286622","https://openalex.org/W2503929286","https://openalex.org/W2595012769","https://openalex.org/W2611240880","https://openalex.org/W2761083746","https://openalex.org/W2792995884","https://openalex.org/W2885162916","https://openalex.org/W2911077895","https://openalex.org/W2915809455","https://openalex.org/W2937274403","https://openalex.org/W2951369399","https://openalex.org/W2951744060","https://openalex.org/W2953091345","https://openalex.org/W2954124637","https://openalex.org/W3007736625","https://openalex.org/W3033814985","https://openalex.org/W3098199605","https://openalex.org/W3101262985","https://openalex.org/W3150161641","https://openalex.org/W3169965801","https://openalex.org/W3195093253","https://openalex.org/W4220896689","https://openalex.org/W4282943948","https://openalex.org/W4389109495","https://openalex.org/W4393306590","https://openalex.org/W4393950490","https://openalex.org/W4396515103","https://openalex.org/W4401306101","https://openalex.org/W4403780034","https://openalex.org/W4407021641","https://openalex.org/W6745035490","https://openalex.org/W6757504550","https://openalex.org/W6758148181","https://openalex.org/W6800172385"],"related_works":["https://openalex.org/W2383615955","https://openalex.org/W2056756835","https://openalex.org/W2187212244","https://openalex.org/W2775582103","https://openalex.org/W2329992713","https://openalex.org/W2062974934","https://openalex.org/W1558157446","https://openalex.org/W2173049006","https://openalex.org/W2014837149","https://openalex.org/W2046943246"],"abstract_inverted_index":{"Understanding":[0],"how":[1],"functional":[2,47,103],"connectivity":[3],"between":[4],"cortical":[5,88],"neurons":[6],"varies":[7],"with":[8,74],"spatial":[9,21,100,109],"distance":[10],"is":[11,23],"crucial":[12],"for":[13],"characterizing":[14],"large-scale":[15,83],"neural":[16,113],"dynamics.":[17],"However,":[18],"inferring":[19],"these":[20],"patterns":[22],"challenging":[24],"when":[25],"spike":[26,61],"trains":[27,62],"are":[28],"collected":[29],"from":[30,50,64,86],"large":[31],"populations":[32],"of":[33,111],"neurons.":[34,76,89],"Here,":[35],"we":[36],"present":[37],"a":[38,65],"maximum":[39],"likelihood":[40],"estimation":[41],"(MLE)":[42],"framework":[43],"to":[44,82],"quantify":[45],"distance-dependent":[46],"interactions":[48],"directly":[49],"observed":[51],"spiking":[52],"activity.":[53],"We":[54,77],"validate":[55],"this":[56],"method":[57],"using":[58],"both":[59],"synthetic":[60],"generated":[63],"linear":[66],"Poisson":[67],"model":[68],"and":[69],"biologically":[70],"realistic":[71],"simulations":[72],"performed":[73],"Izhikevich":[75],"then":[78],"apply":[79],"the":[80,94,108],"approach":[81,97],"electrophysiological":[84],"recordings":[85],"V1":[87],"Our":[90],"results":[91],"show":[92],"that":[93],"proposed":[95],"MLE":[96],"robustly":[98],"captures":[99],"decay":[101],"in":[102],"connectivity,":[104],"providing":[105],"insights":[106],"into":[107],"structure":[110],"population-level":[112],"interactions.":[114]},"counts_by_year":[],"updated_date":"2026-07-23T08:03:31.855105","created_date":"2025-10-10T00:00:00"}
